acid-phosphatase and Mandibular-Neoplasms

Ghost cell odontogenic carcinoma is a rare neoplastic variant of calcifying odontogenic cyst, with aggressive growth characteristics. A painful swelling in the jaws with local paraesthesia is the most common symptom. Although it often causes irregular destruction of the adjacent bone, immunohistochemical expression of tartrate-resistant acid phosphatase (TRAP) and vitronectin receptor has not previously been described in this carcinoma.. This article describes a ghost cell odontogenic carcinoma affecting the mandible of a 55-year-old man. The patient was treated by segmental mandibulectomy and there was no evidence of recurrence or metastasis for 1.8 years. Cytological features including the immunohistochemical expression of TRAP and vitronectin receptor were studied.. Specimens revealed varying sized islands of anucleate cell clusters with homogenous, pale eosinophilic cytoplasm, so called ghost cells, admixed with sheets of tumour. TRAP and vitronectin receptor were detected in the ghost cells, but they were not expressed in the tumour cells. Our findings suggest that some of the cytokines produced by ghost cells may play important roles in causing extensive bone resorption in the ghost cell odontogenic carcinoma.

Topics: Acid Phosphatase; Biomarkers, Tumor; Bone Resorption; Cytoplasm; Follow-Up Studies; Humans; Immunohistochemistry; Integrin alphaVbeta3; Isoenzymes; Keratins; Male; Mandibular Neoplasms; Middle Aged; Odontogenic Cyst, Calcifying; Osteoclasts; Tartrate-Resistant Acid Phosphatase

Four cases of granular-cell ameloblastoma were studied by light and electron microscopy, histochemistry and electron enzyme histochemistry. Microscopically, granular cells commonly occurred in a follicular pattern, but, in one case, they were in a plexiform pattern. The high activity of acid phosphatase and electron microscopic features revealed that the cytoplasmic granularity was ascribed to the high content of lysosomes. It was speculated that granular-cell ameloblastoma occurs due to the altered dysfunction of tumor cells, and the age factor is related to the pathogenesis of this tumor.

Topics: Acid Phosphatase; Aged; Alkaline Phosphatase; Ameloblastoma; Glucuronidase; Humans; Male; Mandibular Neoplasms; Microscopy, Electron; Middle Aged; Naphthols

Topics: Acid Phosphatase; Alkaline Phosphatase; Humans; Male; Mandibular Neoplasms; Middle Aged; Neoplasm Metastasis; Prostatic Neoplasms

Topics: Acid Phosphatase; Adolescent; Adult; Aged; Alkaline Phosphatase; Diagnosis, Differential; Female; Glucosephosphate Dehydrogenase; Glucuronidase; Histocytochemistry; Humans; Isocitrate Dehydrogenase; L-Lactate Dehydrogenase; Malate Dehydrogenase; Male; Mandibular Neoplasms; Maxillary Neoplasms; Myxoma; NAD; Radiography; Succinate Dehydrogenase

Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Extremities; Female; Histocytochemistry; Male; Mandibular Neoplasms; Mice; Neoplasms, Radiation-Induced; Osteoblasts; Osteoclasts; Osteosarcoma; Pelvis; Radium; Ribs; Sacrum; Sarcoma, Experimental; Skull Neoplasms; Spinal Neoplasms; Tail

Topics: Acid Phosphatase; Adult; Alkaline Phosphatase; Bone Neoplasms; Breast Neoplasms; False Positive Reactions; Female; Humans; Iron Isotopes; Lung Neoplasms; Male; Mandibular Neoplasms; Mouth Neoplasms; Neoplasm Metastasis; Osteosarcoma; Pelvic Neoplasms; Pharyngeal Neoplasms; Prostatic Neoplasms; Radionuclide Imaging; Spinal Neoplasms; Strontium Isotopes

Topics: Acid Phosphatase; Adolescent; Adult; Alkaline Phosphatase; Bone Neoplasms; Child; Child, Preschool; Esterases; Female; Femoral Neoplasms; Fibroma; Fibrosarcoma; Fibrous Dysplasia of Bone; Glucuronidase; Humans; Humerus; Hydrolases; Infant, Newborn; Leucyl Aminopeptidase; Male; Mandibular Neoplasms; Middle Aged; Osteosarcoma; Tibia

Topics: Acid Phosphatase; Adult; Aged; Alkaline Phosphatase; Bone Diseases; Calcium; Female; Humans; Male; Mandibular Neoplasms; Maxillary Neoplasms; Middle Aged; Phosphorus