acid-phosphatase and Lupus-Erythematosus--Discoid

Cytochemical examinations of the activity of the lymphocyte and neutrophil acid phosphatase (AP), a lysosomal marker enzyme, was carried out in patients with discoid lupus erythematosus to assess the function of the cellular lysosomal system. The lymphocytic and neutrophilic AP activities were found reduced both at the expense of reduced number of reacting cells and of the enzyme level in these formed elements.

Topics: Acid Phosphatase; Clinical Enzyme Tests; Histocytochemistry; Humans; Leukocytes; Lupus Erythematosus, Discoid; Lysosomes; Neutrophils

Skin and oral lesions of chronic discoid lupus erythematosus from 6 patients have been investigated histologically and histochemically. Intra-individual comparisons between skin and oral lesions and intrasection comparisons between clinically affected and unaffected regions were performed. Enzyme histochemical recordings consisted of oxido-reductase and hydrolase activities. A high degree of correlation was noted in the intra-individual comparisons. The intrasection comparisons provided information concerning metabolic dynamics of the disease. The data obtained support the view that serious vascular changes are involved in the development of the changes in the overlying epithelium. The enzyme histochemical results agreed generally with histological data and proved to be a valuable diagnostic aid.

Topics: Acid Phosphatase; Adenosine Triphosphatases; Basement Membrane; Cell Movement; Chronic Disease; Glucosephosphate Dehydrogenase; Glutamate Dehydrogenase; Histocytochemistry; Humans; Hydro-Lyases; Keratosis; Leucyl Aminopeptidase; Lupus Erythematosus, Discoid; Lymphocytes; Mouth Mucosa; NADH, NADPH Oxidoreductases; Oxidoreductases; Skin

Topics: Acid Phosphatase; Adolescent; Adult; Alkaline Phosphatase; Female; Humans; Leukocytes; Lupus Erythematosus, Discoid; Lupus Erythematosus, Systemic; Male; Middle Aged; Peroxidases

Topics: Acid Phosphatase; Acute Disease; Adenosine Triphosphatases; Alkaline Phosphatase; Asparaginase; Bone Marrow; Bone Marrow Cells; Carcinoma; Depression, Chemical; Esterases; Hodgkin Disease; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukocyte Count; Leukocytes; Lupus Erythematosus, Discoid; Lymphatic Diseases; Multiple Myeloma; Peroxidases; Stimulation, Chemical