acid-phosphatase and Liver-Cirrhosis

Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Bone Marrow; Escherichia coli; Gastric Mucosa; Humans; Kidney; Liver; Liver Cirrhosis; Liver Neoplasms; Male; Nucleic Acids; Nucleotides; Plants; Prostatic Neoplasms; Rickets

Topics: Acid Phosphatase; Adenosine Triphosphatases; Alkaline Phosphatase; Animals; Deoxyribonucleases; Dihydrolipoamide Dehydrogenase; Electron Transport Complex IV; Esterases; Glucose-6-Phosphatase; Glucosephosphate Dehydrogenase; Glutamate Dehydrogenase; Histocytochemistry; Humans; Isoenzymes; L-Lactate Dehydrogenase; Leucyl Aminopeptidase; Liver; Liver Cirrhosis; Liver Neoplasms; Microscopy, Electron; Nucleotidases; Phosphotransferases; Ribonucleases; Succinate Dehydrogenase

Hepatic fibrosis is associated with the activation of stellate cells (HSCs), the major source of extracellular matrix (ECM) proteins. Transforming growth factor-beta (TGF-beta), signaling via Smad3, is the most profibrogenic cytokine and the major promoter of ECM synthesis. Halofuginone, an inhibitor of liver fibrosis, inhibits TGF-beta-dependent Smad3 phosphorylation in human HSCs in culture. We have used transcriptional profiling to evaluate the effect of halofuginone on gene expression during the progression of thioacetamide (TAA)-induced liver fibrosis in the rat and have focused on genes that are associated with TGF-beta. TAA treatment causes alterations in the expression of 7% of liver genes. Halofuginone treatment prevents the changes in the expression of 41% of these genes and results in the inhibition of HSC activation and collagen synthesis. During the early stages of the disease, halofuginone affects genes involved in alcohol, lipid, protein, and phosphate metabolism and cell adhesion and, at later stages, in the cell cycle (cell development, differentiation, cell proliferation, and apoptosis). The activation of TGF-beta-dependent genes, such as tartrate-resistant acid phosphatase, its putative substrate osteopontin, stellate cell activation-association protein, and fibrillin-1, during chemically induced fibrosis is prevented by halofuginone. This study thus highlights the role of TGF-beta signaling in liver fibrosis and especially its potential for pharmacological intervention. Halofuginone, which has demonstrated efficacy and tolerance in animals and humans, could become an effective and novel therapy for liver fibrosis.

Topics: Acid Phosphatase; Animals; Antineoplastic Agents; Cluster Analysis; Cytoglobin; Disease Progression; Fibrillin-1; Fibrillins; Gene Expression Profiling; Gene Expression Regulation; Globins; Hepatocytes; Humans; Isoenzymes; Liver Cirrhosis; Male; Microfilament Proteins; Nuclear Proteins; Osteopontin; Phosphorylation; Piperidines; Quinazolinones; Rats; Rats, Wistar; Signal Transduction; Smad2 Protein; Smad3 Protein; Substrate Specificity; Tartrate-Resistant Acid Phosphatase; Thioacetamide; Transforming Growth Factor beta

Chromosomal rearrangements unraveled by spectral karyotyping (SKY) indicated frequent chromosome 19 translocations in hepatocellular carcinoma (HCC). In an effort to characterize the aberrant 19 rearrangements in HCC, we performed positional mapping by fluorescence in-situ hybridization (FISH) in 10 HCC cell lines. SKY analysis indicated structural rearrangements of chromosome 19 in 6 cell lines, 4 of which demonstrated recurring 19p translocations with different partner chromosomes. Using fluorescence-labeled BAC probes, physical mapping indicated a breakpoint cluster between 19p13.12 and 19p12. A corresponding transcriptional mapping by cDNA array on 19p suggested the differential expression of a single downregulated gene ACP5 (tartrate-resistant acid phosphatase type 5). Quantitative RT-PCR confirmed the reduced expression of ACP5 and indicated a strong correlation of its repressed expression only in cell lines that contain a 19p rearrangement (p = 0.004). We further examined the expression of ACP5 in a cohort of 82 primary tumors and 74 matching nonmalignant liver tissues. In the primary HCC examined, a reduction of ACP5 transcripts by 2 to as much as 1,000-fold was suggested in 67% of tumors (55/82 cases). When compared to adjacent nonmalignant tissues, 46% of tumors (34/74 cases) demonstrated a lower expression level (p = 0.015). On closer examination, a high significance of ACP5 repression was suggested in the cirrhotic HCC subgroup that was derived from chronic hepatitis B infected patients (55%; 30/54 cases; p = 0.001). Functional examination of ACP5 ectopic expression in HCC cells further demonstrated a significant growth inhibitory effect of ACP5 on tumor cell survival (p < 0.001). In our study, the novel finding of common ACP5 downregulation in HCC may provide basis for further investigations on the role of acid phosphatase in hepatocarcinogenesis.

Topics: Acid Phosphatase; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Hepatocellular; Chromosomes, Human, Pair 19; Down-Regulation; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Isoenzymes; Karyotyping; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Tartrate-Resistant Acid Phosphatase; Translocation, Genetic; Tumor Cells, Cultured

Topics: Acid Phosphatase; Adult; Blood Cell Count; Female; Humans; Hypersplenism; Hypertension, Portal; Liver Cirrhosis; Macrophages; Male; Middle Aged; Phagocytosis; Splenomegaly

Serum concentrations of prostate specific antigen (PSA) and prostatic acid phosphatase (PAP) were measured in 51 liver cirrhosis, 37 chronic active hepatitis (CAH) patients and 26 healthy individuals. Elevated PSA levels have been found in 2 of cirrhotic patients while no increase has been detected in CAH and controls. Serum PAP levels have been observed slightly increased in 2 patients with cirrhosis, 2 patients with CAH and 1 control case. Mean PSA and mean PAP values showed no significant difference between groups (p > 0.05). Serum PSA and PAP levels are reliable in diagnosing and monitoring prostate cancer in chronic liver patients and maintain their specificity in this situation.

Topics: Acid Phosphatase; Adolescent; Adult; Hepatitis, Chronic; Humans; Liver Cirrhosis; Male; Middle Aged; Prostate; Prostate-Specific Antigen

The distribution of acid phosphatase in liver cirrhosis, as well as in its reverse development, was investigated in mice using histochemistry and electron histochemistry methods. Histochemistry demonstrated a sharp activity increase of acid phosphatase (as compared with the same in the material of partial hepatectomy) in liver cells (especially hepatocytes) during liver cirrhosis regression 10 days after a partial hepatectomy. Electron histochemistry has shown the enzyme withdraw out of hepatocytes and connective tissue cells of fibrotic stratum in the extra-cell medium. The reaction product localized on the neighbouring collagen fibres giving evidence that during reverse development of liver cirrhosis the lisosomal enzyme release from specified cells by means of exocytosis and they are involved in the lysis of collagen.

Topics: Acid Phosphatase; Animals; Carbon Tetrachloride Poisoning; Hepatectomy; Histocytochemistry; Liver; Liver Cirrhosis; Liver Regeneration; Lysosomes; Male; Mice; Microscopy, Electron; Time Factors

Topics: Acid Phosphatase; Acute Disease; Animals; Ca(2+) Mg(2+)-ATPase; Female; Hepatitis, Viral, Human; Humans; Jaundice; Liver; Liver Cirrhosis; Lysosomes; Rats

Cholesterol ester storage disease is a rare, inherited metabolic disorder of lipid associated with acid cholesteryl ester hydrolase deficiency. Thus far, 15 cases have been reported in the world literature. Reported here is the autopsy study of the oldest patient with this disease. The lipid storage occurred in the forms of birefringent needle-shaped crystals limited to hepatocytes and non-birefringent autofluorescent granules accumulated within the foam cells of the hepatic portal triads, duodenum, and ovaries. The cholesterol content of the liver was 16 times normal, primarily caused by increased cholesterol ester. Only trace cholesteryl ester hydrolase activity was demonstrated in the liver. An additional unique finding in our case was the presence of mesenteric lipodystrophy. Whether these two rare disorders observed in our patient represent unrelated conditions or have an etiologic association remains unknown.

Topics: Acid Phosphatase; Cholesterol Esters; Coronary Disease; Female; Humans; Lipid Metabolism, Inborn Errors; Liver; Liver Cirrhosis; Mesentery; Middle Aged; Portal System; Sterol Esterase; Whipple Disease

A reference group (252 males, 436 females) and a group of patients with primary hyperparathyroidism (34 males, 67 females) and cirrhosis of the liver (33 males) were subjected to a multivariate data assessment; the analyses were performed on the Technicon autoanalyzer SMA 12/60 (sodium, potassium, chloride, total protein, albumin, inorganic phosphorus, cholesterol, urea nitrogen, calcium, creatinine, bilirubin, uric acid) and the SMA 6 plus (iron, copper, magnesium, alkaline phosphatase, acid phosphatase, glucose). A multivariate test statistic containing age as a regressor variable was used, thus correcting for age. Derivation of the test statistic required multivariate normality of the distributions of the clinical-chemical values, a condition which is generally not fulfilled in the data of patients. In order to arrive at the multivariate normality of the distributions, we applied the X-transformation of van der Waerden [1965) Mathematische Statistik, Springer Verlag, Berlin--Göttingen-Heidelberg) to the marginal values. We introduced the concept of group-conformity behaviour of the patient data. According to our definition, a patient behaves in conformity with a given group of patients with respect to a clinical-chemical value, if the patients' value deviates from the estimated age-specific expected value of the reference group and the deviation lies in the same direction as that of the mean value of the respective group of patients. Using this procedure, disease-specific deviation patterns were determined from the data, thus enabling us to make clear separations of the patient groups from the reference group and from each other. Furthermore, the computed deviation patterns throw light upon the pathobiochemical modifications of the parameters in the examined diseases.

Topics: Acid Phosphatase; Analysis of Variance; Autoanalysis; Blood Chemical Analysis; Female; Humans; Hyperparathyroidism; Liver Cirrhosis; Male; Models, Biological; Reference Values; Regression Analysis

Serum activities of two lysosomal enzymes, beta-glucuronidase and acid phosphatase, were estimated in 66 patients with liver cell carcinoma, 10 with secondary liver cancer, 14 with cirrhosis of the liver, and 9 normal controls. A substantial increase in the enzyme activities was found in patients with liver cell carcinoma but not in those with secondary liver cancer. The degree of the enzyme elevations paralleled the stage of hepatoma. Although the serum activities of both enzymes were also elevated in patients with liver cirrhosis, the elevations were significantly higher in hepatoma than in liver cirrhosis. Possible mechanisms for the elevation of serum lysosomal enzyme activities in hepatoma are discussed, but further studies are necessary to elucidate the biological and clinicopathological significance of estimating serum lysosomal acid hydrolases in patients with primary liver cell carcinoma.

Topics: Acid Phosphatase; Adult; Aged; Alanine Transaminase; alpha-Fetoproteins; Aspartate Aminotransferases; Carcinoma, Hepatocellular; Female; Glucuronidase; Hepatitis B Surface Antigens; Humans; L-Lactate Dehydrogenase; Liver Cirrhosis; Liver Neoplasms; Lysosomes; Male; Middle Aged

Serum activities of lysosomal enzymes beta-glucuronidase and acid phosphatase were serially estimated in 14 patients with and without cirrhosis of the liver who underwent 40% to 80% hepatic resection. Substantial increases in enzyme activities were observed two to eight weeks after operation in ten of 11 patients who did not suffer from postoperative liver failure. Regeneration of the residual livers was almost satisfactory in all 11, as evidenced by clinical, roentgenologic, and histologic findings. In three patients with advanced cirrhosis who died of hepatic failure 21 to 39 days after extensive hepatic resection, there was neither the enzymatic reaction nor evidence of regeneration of the liver remnants. In the light of this study and our previous experimental studies, serial determination of the lysosomal enzyme activities in blood is probably a beneficial biochemical index for detection of progressive hepatic regeneration.

Topics: Acid Phosphatase; Adult; Aged; Carcinoma, Hepatocellular; Female; Glucuronidase; Hepatectomy; Humans; Liver Cirrhosis; Liver Function Tests; Liver Neoplasms; Liver Regeneration; Male; Middle Aged

Topics: Acid Phosphatase; Adolescent; Alkaline Phosphatase; Child; Child, Preschool; Chronic Disease; Female; Hepatitis B; Hepatitis, Chronic; Humans; Liver Cirrhosis; Lymphocytes; Male; Succinate Dehydrogenase

An enzyme histochemical study was performed to investigate abnormal enzyme activity in human hepatocellular carcinoma (HCC) and, by application of these staining reactions to noncancerous liver disorders, to clarify the true nature of putative percancerous lesions. The enzyme activity of hepatocytes in cirrhotic livers, hepatitis B virus (HBV)-positive cells, and dysplastic liver cells was investigated. Although the tumor cells in HCC gave an intensively positive reaction for gamma-glutamyl transpeptidase activity at the cytoplasm and the whole-cell membrane, they were essentially deficient in glucose-6-phosphatase, alkaline phosphatase, acid phosphatase, and nonspecific esterase activities. Cirrhotic liver showed loss of the orderly zonal difference of enzyme activity that is present in normal liver. However, a pattern of enzyme deviation similar to that of HCC was not recognized anywhere. Neither HBV-positive hepatocytes nor dysplastic liver cells were shown enzymatically to be direct precusors of HCC.

Topics: Acid Phosphatase; Adolescent; Adult; Aged; Alkaline Phosphatase; Carcinoma, Hepatocellular; Cytoplasm; Female; gamma-Glutamyltransferase; Glucose-6-Phosphatase; Hepatitis B Surface Antigens; Humans; Liver; Liver Cirrhosis; Liver Diseases; Liver Neoplasms; Male; Middle Aged; Precancerous Conditions

The authors have measured the activity of acid phosphatase, beta-glucuronaidase and cathepsin-D in tthe sera of patients with different liver diseases, and the actvity of beta-glucuronidase in granulocytes and the rate of its release. Using the method for the releaseof beta-glucuronidase from the granulocytes they drew conclusions to thedegree of the membrane-damage occurring in the liver diseases. They provided that in the sera of patients with different liver diseases the increase in the activity of the acid phosphatase and the beta-glucuronidase is different. According to their in vitro studies the decrease in the beta-glucuronidase activity measured in the granulocytes, and the release of enzyme is in connection with the type of liver disease and with the different degree of lysosomal membrane alteration.

Topics: Acid Phosphatase; Adolescent; Adult; Aged; Chronic Disease; Female; Glucuronidase; Granulocytes; Hepatitis; Humans; Liver Cirrhosis; Liver Diseases; Lysosomes; Male; Middle Aged

High-performance liquid chromatography was used to assay serum acid and alkaline phosphatase. Samples were incubated with adenosine-5'-monophosphoric acid (AMP) in a buffer of required pH, 5'-nucleotidase was inhibited with Ni2+ ions, and the phosphatase activity was determined by measuring the concentration of the reaction product, adenosine. The analysis time, after the incubation is terminated, is short (7 min), and the assay is quantitative and reproducible. Complete separation of the reaction product from the substrate and the naturally occurring serum constituents and the high sensitivity of the ultraviolet detection system eliminate some of the problems commonly encountered in spectrophotometric assays.

Topics: Acid Phosphatase; Adenosine; Alkaline Phosphatase; Chromatography, High Pressure Liquid; Hepatitis; Humans; Liver Cirrhosis; Nucleotidases; Reference Values

In exsudate cells separated from serous body cavities of 29 tumour patients and 30 patients with inflammatory and congestive effusion in cardiac failure or liver cirrhosis respectively the activities of acid and alkaline phosphatase were determined. In addition to sudanophilia the cell content of glycogen and that of ribonucleinic acid were evaluated. By means of cytochemical findings it could be found that an increase of unspecific esterase, acid phosphatase and ribonucleic acid in atypical cells points to a malignous ethiology of the exudate.

Topics: Acid Phosphatase; Alkaline Phosphatase; Ascitic Fluid; Esterases; Exudates and Transudates; Glycogen; Heart Failure; Histocytochemistry; Hodgkin Disease; Humans; Leukemia; Liver Cirrhosis; Lymphoma, Large B-Cell, Diffuse; Neoplasms; Peritonitis; Pleural Effusion; Pleurisy; RNA

Topics: Acid Phosphatase; Adolescent; Child; Chronic Disease; Citric Acid Cycle; Female; Glutamate Dehydrogenase; Glycerolphosphate Dehydrogenase; Hepatitis; Humans; Liver Cirrhosis; Lymphocytes; Male; Prednisolone

Topics: Acid Phosphatase; Adult; Biopsy; Female; Hepatitis; Humans; Hyalin; Inclusion Bodies; Liver; Liver Cirrhosis; Male; Microscopy, Electron; Middle Aged

Topics: Acid Phosphatase; Alanine Transaminase; Alkaline Phosphatase; alpha 1-Antitrypsin Deficiency; Aspartate Aminotransferases; Blood Proteins; Carbon Radioisotopes; Ceruloplasmin; Child; Densitometry; Electrophoresis, Disc; Electrophoresis, Starch Gel; Female; Galactose; Galactosidases; Glucosidases; Glycoproteins; Humans; L-Lactate Dehydrogenase; Liver; Liver Cirrhosis; Metabolism, Inborn Errors; Microscopy, Electron; Sialic Acids; Transferases; Ultracentrifugation

Topics: Acid Phosphatase; Animals; Capillaries; Carbon Tetrachloride Poisoning; Female; Glucuronates; Glucuronidase; Glycosaminoglycans; Glycosides; Hexosaminidases; Liver; Liver Cirrhosis; Liver Cirrhosis, Experimental; Microcirculation; Phenylhydrazines; Rats

Topics: Acid Phosphatase; Adolescent; Adult; Aged; Aorta; Arteriosclerosis; Blood Vessels; Child; Chronic Disease; Coronary Disease; Coronary Vessels; Esterases; Female; Humans; Hyperthyroidism; Lipase; Lipid Metabolism; Liver Cirrhosis; Male; Middle Aged; Pneumonia; Tuberculosis, Pulmonary

Topics: Acid Phosphatase; Acute Disease; Adenosine Triphosphatases; Adult; Aged; Alcoholism; Alkaline Phosphatase; Biopsy; Chemical and Drug Induced Liver Injury; Cholestasis; Chronic Disease; Enzymes; Fatty Liver; Female; Hepatitis A; Histocytochemistry; Humans; Hydroxybutyrate Dehydrogenase; Liver; Liver Cirrhosis; Liver Diseases; Male; Middle Aged

Topics: Acid Phosphatase; Acute Kidney Injury; Alkaline Phosphatase; Animals; Chromates; Chromatography, Gel; Erythrocytes; Glomerulonephritis; Humans; Kidney; Kidney Failure, Chronic; Liver Cirrhosis; Nephrectomy; Nephrotic Syndrome; Rabbits; Renal Dialysis

Topics: Acid Phosphatase; Adolescent; Child; Child, Preschool; Chronic Disease; Esterases; Fatty Liver; Glycerolphosphate Dehydrogenase; Hepatitis; Histocytochemistry; Humans; Hypertension, Portal; Liver; Liver Cirrhosis; Liver Diseases; Malate Dehydrogenase; Succinate Dehydrogenase

Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Dihydrolipoamide Dehydrogenase; Disease Models, Animal; DNA; Electron Transport Complex IV; Esterases; Histocytochemistry; L-Lactate Dehydrogenase; Lipase; Liver; Liver Cirrhosis; Liver Glycogen; Methods; Proteins; Rabbits; RNA; Succinate Dehydrogenase

Topics: Acid Phosphatase; Adolescent; Adult; Alkaline Phosphatase; Blood Proteins; Chronic Disease; Depression, Chemical; Diet Therapy; Female; Hepatitis; Hepatolenticular Degeneration; Histocytochemistry; Humans; Iron; Lipase; Liver; Liver Cirrhosis; Liver Function Tests; Male; Penicillamine; Potassium; Pyridoxine; Radionuclide Imaging; Stimulation, Chemical; Sulfides; Vitamin B 12

Topics: ABO Blood-Group System; Acid Phosphatase; Adult; Alkaline Phosphatase; Blood Group Antigens; Brazil; Breast Neoplasms; Child; Diet; Electrophoresis; Female; Genetics, Medical; Hawaii; Humans; Intestines; Isoenzymes; Lewis Blood Group Antigens; Liver Cirrhosis; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Male; Phosphoric Monoester Hydrolases; Placenta; Pregnancy; Saliva; Stomach Neoplasms; Sweden; Tartrates

Topics: Acid Phosphatase; Aged; Alkaline Phosphatase; Bilirubin; Biopsy; Blood Cell Count; Blood Protein Disorders; Blood Protein Electrophoresis; Blood Sedimentation; Bone Marrow Examination; Carcinoma, Hepatocellular; Cholesterol; Hepatitis; Humans; Immunoelectrophoresis; Immunoglobulin G; Liver Cirrhosis; Liver Neoplasms; Male; Neoplasm Metastasis; Phosphates; Transaminases

Topics: Acid Phosphatase; Adult; Alkaline Phosphatase; Ascites; Creatine; Humans; Jaundice; Liver Cirrhosis; Male

Topics: Acid Phosphatase; Adenosine Triphosphatases; Alkaline Phosphatase; Biological Transport; Chronic Disease; Dihydrolipoamide Dehydrogenase; Electron Transport Complex IV; Glutamate Dehydrogenase; Glycerolphosphate Dehydrogenase; Glycogen; Hepatitis; Histocytochemistry; Humans; Liver; Liver Cirrhosis; Malate Dehydrogenase; Methods; Protein Biosynthesis; RNA; Succinate Dehydrogenase

Topics: Acid Phosphatase; Anabolic Agents; Chronic Disease; Electrophoresis; Humans; Liver Cirrhosis; Liver Function Tests; Methenolone; Sulfobromophthalein; Transaminases

Topics: Acid Phosphatase; Hepatitis A; Histocytochemistry; Humans; Hyperbilirubinemia; Jaundice; Liver; Liver Cirrhosis; Liver Diseases

Topics: Acid Phosphatase; Animals; Arteriosclerosis; Bronchiectasis; Celiac Plexus; Collagen Diseases; Dogs; Emphysema; Ganglia, Autonomic; Histocytochemistry; Humans; Infections; Liver Cirrhosis; Neoplasms; Synapses; Tuberculosis

Topics: Acid Phosphatase; Adenosine Triphosphatases; Alkaline Phosphatase; Bile Ducts, Intrahepatic; Biopsy; Clinical Enzyme Tests; Esterases; Histocytochemistry; Humans; Liver Cirrhosis; Liver Function Tests; Nucleotidases; Oxidoreductases; Succinate Dehydrogenase

Topics: Acid Phosphatase; Blood; Blood Chemical Analysis; Blood Coagulation Disorders; Blood Platelet Disorders; Blood Platelets; Hodgkin Disease; Humans; Leukemia; Leukemia, Myeloid; Liver Cirrhosis; Plasma; Platelet Count; Potassium; Primary Myelofibrosis; Thrombocythemia, Essential

Topics: Acid Phosphatase; Alkaline Phosphatase; Diagnosis, Differential; Glucosidases; Glycogen Storage Disease; Glycogen Storage Disease Type I; Humans; Liver; Liver Cirrhosis; Liver Glycogen; Phosphorylase Kinase

Topics: Acid Phosphatase; Alkaline Phosphatase; Hepatitis; Histocytochemistry; Humans; Liver; Liver Cirrhosis

Topics: Acid Phosphatase; Alkaline Phosphatase; Anabolic Agents; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Liver Cirrhosis; Rabbits

Topics: Acid Phosphatase; Alanine Transaminase; Biopsy; Biopsy, Needle; gamma-Globulins; Glucuronidase; Hepatitis; Humans; Liver; Liver Cirrhosis; Lysosomes; Research; Serum Albumin

Topics: Acid Phosphatase; Anemia; Anemia, Aplastic; Blood Cell Count; Blood Platelets; Bone Marrow Examination; Clinical Enzyme Tests; Diagnosis, Differential; Gaucher Disease; Geriatrics; Humans; Liver Cirrhosis; Pathology; Phosphates; Splenomegaly

Topics: Acid Phosphatase; Alkaline Phosphatase; Biopsy; Endoscopy; Humans; Liver; Liver Cirrhosis; Pathology

Topics: Acid Phosphatase; Alkaline Phosphatase; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Hepatitis; Kidney; Liver; Liver Cirrhosis; Phosphoric Monoester Hydrolases; Polysaccharides; Rats; Research; Toxicology

Topics: Acid Phosphatase; Animals; Carbon Tetrachloride; Liver Cirrhosis; Liver Cirrhosis, Experimental; Phosphoric Monoester Hydrolases; Rats