acid-phosphatase and Lichen-Planus

Topics: Acid Phosphatase; Adult; Epithelium; Female; Histocytochemistry; Humans; Lichen Planus; Lysosomes; Male; Microscopy, Electron; Middle Aged; Mouth Diseases; Mouth Mucosa

Lysosomal activity was demonstrated in the majority of the lymphocytes forming the mononuclear cell infiltrate in oral lichen planus. Staining for acid phosphatase, N-acetyl-beta-D-glucosaminidase, nonspecific esterase, and beta-glucuronidase was present in these cells in tissue sections, indicating their T cell origin. Small numbers of enzyme-negative lymphocytes were also present. Macrophages showing stronger staining were found scattered through the infiltrates in large numbers. These observations indicate roles for T cells and macrophages in the pathogenesis of lichen planus.

Topics: Acetylglucosaminidase; Acid Phosphatase; Esterases; Glucuronidase; Histocytochemistry; Humans; Lichen Planus; Macrophages; Mouth Diseases; Plasma Cells; Staining and Labeling; T-Lymphocytes

Untreated cases of lichen planus have been studied by histochemical techniques. The acid phosphatase reaction in the transitional zone has been quantitatively estimated and compared with the adjacent relatively normal epidermis. It was found that despite a thickened and accentuated granular layer as seen by routine histological methods there was a marked reduction in the intensity of the acid phosphatase reaction. The glucose-6-phosphate dehydrogenase reaction was marked in the upper layers of the epidermis in active lesions of lichen planus. This is similar to psoriasis, but different from normal human epidermis. The suggestion by other authors that lichen planus is an inborn error of metabolism is discussed. The dendritic cells of the epidermis as studied by the ATPase reaction are virtually absent in regions of active lichen planus and the possible significance of this is mentioned. The horny layer gives a dense reaction for phospholipids in lichen planus and this is similar to psoriatic keratin. The significance of this finding is considered.

Topics: Acid Phosphatase; Adenosine Triphosphatases; Dendrites; Glucosephosphate Dehydrogenase; Histocytochemistry; Humans; Keratins; Lichen Planus; Metabolism, Inborn Errors; Naphthols; Phospholipids; Skin

Topics: Acid Phosphatase; Cell Differentiation; Cell Membrane; Desmosomes; Eosinophils; Female; Histocytochemistry; Humans; Hypersensitivity, Delayed; Intercellular Junctions; Langerhans Cells; Lichen Planus; Lymphocytes; Macrophages; Male; Mast Cells; Microscopy, Electron; Monocytes; Neutrophils; Peroxidases; Plasma Cells

Topics: Acid Phosphatase; Acute Disease; Biopsy; Catechol Oxidase; Chronic Disease; Depression, Chemical; Dihydrolipoamide Dehydrogenase; Dihydroxyphenylalanine; Electron Transport Complex IV; Esterases; Histocytochemistry; Humans; Lichen Planus; Melanocytes; NAD; Necrosis; Oxygen Consumption; Skin; Succinate Dehydrogenase