acid-phosphatase and Jaundice--Neonatal

A series of genetic, developmental and environmental variables have been analyzed in a prospective sample of full-term newborn babies, compatible with their mothers in the major blood group systems, in order to attempt an evaluation of the effect of these variables on serum bilirubin level during the first few days of life. Three genetic factors (PGM1, ACP1 and ADA) and three non-genetic variables (rise of bilirubin level during the first day of life, a mother with a history of previous abortion, and use of alcoholic beverages by the mother) have a significant predictive value for the separation of newborns with clinically relevant jaundice from other infants.

Topics: Acid Phosphatase; Adenosine Deaminase; Adenylate Kinase; Blood Group Antigens; Genetic Variation; Humans; Infant, Newborn; Jaundice, Neonatal; Polymorphism, Genetic; Prospective Studies; Regression Analysis; Risk Factors

The effects of ACP1 phenotype on birth weight, neonatal jaundice, and obesity in children are dependent on ADA genotype. These phenomena may represent a clinical counterpart of the in vitro biochemical interactions between the two systems recently observed by our group.

Topics: Acid Phosphatase; Adenosine Deaminase; Erythrocytes; Genotype; Humans; Infant, Newborn; Jaundice, Neonatal; Nucleoside Deaminases; Obesity; Polymorphism, Genetic; Risk Factors

A sample of children treated by phototherapy during the neonatal period has been studied in the population of Penne (South Eastern Italy) in order to confirm the association previously reported in newborns from the population of Rome between neonatal jaundice and phenotypes of adenosine deaminase (ADA) and acid phosphatase (ACP1). The present data confirm that the incidence of clinically relevant jaundice is much greater in newborns of phenotype ACP1 BA carrying ADA2 allele than in other infants. Since ACP1 probably acts as flavin mononucleotide phosphatase and is modulated by purine nucleotides, it is likely that enzymes of purine nucleotide metabolism (including ADA), ACP1 and flavoenzymes (including gluthatione reductase and enzymes of Krebs cycle), may represent a polygenic complex influencing bilirubin levels in the first few days of life.

Topics: Acid Phosphatase; Adenosine Deaminase; Female; Humans; Infant, Newborn; Italy; Jaundice, Neonatal; Male; Nucleoside Deaminases; Phenotype; Phototherapy; Polymorphism, Genetic

Topics: Acid Phosphatase; Birth Weight; Body Height; Erythrocytes; Female; Fetal Blood; Fetus; Humans; Infant, Newborn; Jaundice, Neonatal; Male; Polymorphism, Genetic; Pregnancy

Topics: Acid Phosphatase; Alleles; Bilirubin; Birth Weight; Erythrocytes; Humans; Infant, Newborn; Jaundice, Neonatal; Phenotype; Prospective Studies

Topics: ABO Blood-Group System; Acid Phosphatase; Electrophoresis, Starch Gel; Erythroblastosis, Fetal; Erythrocytes; Exchange Transfusion, Whole Blood; Female; Humans; Infant, Newborn; Jaundice, Neonatal; Polymorphism, Genetic; Pregnancy; Rh-Hr Blood-Group System

Topics: Acid Phosphatase; Erythrocytes; Favism; Hemolysis; Humans; Infant, Newborn; Jaundice, Neonatal; Phenotype; Polymorphism, Genetic

In a Chinese population 1,000 full-term male neonates and a further 117 jaundiced neonates of both sexes were studied in an investigation of the frequency of deficiency of erythrocyte glucose-6-phosphate dehydrogenase (G6PD). This enzyme was found to be deficient in 3.6% of male neonates. Correlation of the results with the birthplace of the 602 mothers who were known to come from Kwangtung province showed no significant differences in the frequency of the deficiency between certain parts of the province.The deficiency of G6PD in hemizygous males is profound but it is not associated with erythrocyte acid monophosphoesterase deficiency in Chinese in Hong Kong. The G6PD deficiency accounts for 15.4% of all the 117 cases of neonatal jaundice. The relative importance of G6PD deficiency as a cause of neonatal jaundice does not differ materially in male and female mutants. Neonatal jaundice can occur in all genotypes of G6PD mutation in Chinese.

Topics: Acid Phosphatase; Adult; Asian People; Erythrocytes; Female; Glucosephosphate Dehydrogenase Deficiency; Hong Kong; Humans; Infant, Newborn; Jaundice, Neonatal; Kernicterus; Male; Metabolic Diseases

Topics: Acid Phosphatase; Asian People; Erythrocytes; Female; Glucosephosphate Dehydrogenase Deficiency; Humans; Infant, Newborn; Jaundice, Neonatal; Male; Taiwan