acid-phosphatase and Hypothermia

The LD50 dose of endotoxin results in a considerable increase in the plasma level of acidic phosphatase and beta-glucuronidase. The endotoxin decreases the quantity of gamma-globulin fraction of sera as an effect of neutral lysosomal proteases. In hypothermic rabbits the activity of lysosomal enzymes is increased only slightly after administration of endotoxin and the change in the gamma-globulin level is also more less than in the normothermic animals. The importance of our results in the pathogenesis of inflammation induced by endotoxin is discussed.

Topics: Acid Phosphatase; Animals; Blood Proteins; Body Temperature; Endotoxins; Female; gamma-Globulins; Glucuronidase; Hematocrit; Hypothermia; Lethal Dose 50; Lysosomes; Male; Rabbits

Topics: Acid Phosphatase; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; D-Alanine Transaminase; Hypothermia; Hypothermia, Induced; Kidney; Rats; Research

Topics: Acid Phosphatase; Alkaline Phosphatase; Coloring Agents; Fructose-Bisphosphate Aldolase; Hypothermia; Hypothermia, Induced; Liver; Rats; Research

Topics: Acid Phosphatase; Adenosine Triphosphatases; Alkaline Phosphatase; Animals; Brain; Brain Chemistry; Central Nervous System; Cerebrovascular Circulation; Dihydrolipoamide Dehydrogenase; Dogs; Glucosephosphate Dehydrogenase; Hypothermia; Hypothermia, Induced; Metabolism; Nervous System; Pathology; Physiology; Research; Succinate Dehydrogenase

Topics: Acid Phosphatase; Animals; Brain; Death; Dogs; Hypothermia; Neurochemistry; Phosphoric Monoester Hydrolases