acid-phosphatase and Herpes-Simplex

The functional activity of peripheral phagocytes were comparatively studied in 14 HIV-infected patients and 28 patients with chronic Herpes simplex viral infection. The two groups exhibited lowered adhesive capacity of phagocytes, impaired production and excretion of active oxygen metabolites. In addition, the patients with chronic Herpes simplex infection showed much elevated levels of myeloperoxidase and acid phosphatase, which indicated its compensatory pattern. The HIV infected had no enhanced enzymatic activity. One cannot rule out that these differences in the functional activity of phagocytes are associated with different effects of viral peptides on the cellular wall of phagocytes.

Topics: Acid Phosphatase; Acquired Immunodeficiency Syndrome; Adult; Cell Adhesion; Chemotaxis, Leukocyte; Chronic Disease; Enzyme Activation; Female; Herpes Simplex; Humans; Male; Neutrophils; Peroxidase; Phagocytosis; Recurrence

In four series of experiments human peripheral blood neutrophils were found capable of synthetizing the active forms of such enzymes as myeloperoxidase and acid phosphatase after stimulation with opsonized zymosan, and the optimum conditions for testing the synthetizing activity of neutrophils were established. The examination of 39 practically healthy donors revealed an approximate equilibrium between the synthesis of the active forms of the enzyme and its excretion from the cell after this cell was activated. Considerable changes in the enzymatic activity of peripheral blood neutrophils were found in patients with yersiniosis, chronic herpes, chronic bronchitis and AIDS-associated complex. The possibility of a deficient enzymatic activity in some patients was suggested.

Topics: Acid Phosphatase; AIDS-Related Complex; Blood Donors; Bronchitis; Cells, Cultured; Dose-Response Relationship, Drug; Herpes Simplex; Humans; Lymphocyte Activation; Neutrophils; Peroxidase; Reference Values; Time Factors; Yersinia Infections

Herpes simplex virus (HSV) frequently infects human sensory ganglion neurons, and similar infections have been reported in experimental animals. Reported here is an investigation of in vivo neuronal function after HSV infection. It was observed that the proportion of fluoride resistant acid phosphatase (FRAP)-positive trigeminal ganglion neurons was decreased for several months after experimental infection of mice, and it is suggested that other neuronal functions may also be altered by HSV.

Topics: Acid Phosphatase; Animals; Fluorides; Herpes Simplex; Mice; Neurons; Sciatic Nerve; Trigeminal Ganglion

Acid phosphatase staining is performed on cerebrospinal fluid cells of 365 samples from 105 patients with various types of meningitis. This enzyme activity is strongly positive in the early samples of bacterial meningitis, as far as the patients had not received a pretreatment with antibiotics for more than 24 h. It allows monitoring the response to therapy in subsequent samples. Acid phosphatase activity is positive in 2 cases of cryptococcus meningitis. It is negative in all cases of aseptic and Mycoplasma pneumoniae meningitis. The results in herpes encephalitis are variable, depending on the clinical state and the degree of brain destruction. Acid phosphatase staining is a useful and rapid cytological technique for determination of the nature of the meningitis and for monitoring the therapeutical response.

Topics: Acid Phosphatase; Adolescent; Adult; Aged; Bacterial Infections; Cerebrospinal Fluid; Cytodiagnosis; Herpes Simplex; Humans; Macrophages; Meningitis; Middle Aged; Monocytes

Topics: Acid Phosphatase; Amino Acyl-tRNA Synthetases; Animals; Antibodies; Antibody Formation; Carbon Radioisotopes; Depression, Chemical; Fluorescent Antibody Technique; Gold; Gold Sodium Thiomalate; Herpes Simplex; Humans; In Vitro Techniques; Mercaptoethanol; Mixed Function Oxygenases; Pemphigus; Prostaglandins; Sheep; Skin; Tryptophan