acid-phosphatase and Hernia--Ventral

The present study was undertaken to evaluate a new prototype mesh that consists of a knitted polyester structure treated with a fluoropolymer and impregnated with gelatin. The Fluoropassiv mesh, as well as two controls, the Surgipro polypropylene mesh and the Gore-Tex expanded polytetrafluoroethylene patch, were used for the repair of experimentally induced abdominal hernias in piglets and followed for scheduled implantation periods of 4, 15, and 60 days. At the sacrifice the mesh and surrounding tissue were excised for histological assessment of the healing sequence, for the identification of changes in hematologic and immunological characteristics, and for the measurement of the mechanical properties. After cleaning to remove the encroaching tissue, the explanted devices were monitored for biostability by infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). The present study has demonstrated that the Fluoropassiv mesh provides adequate mechanical strength and compares favorably with the two controls. No exacerbated systemic or in situ hematologic or immunological reactions were observed with either the meshes of the patch material. Histological studies revealed that thick collagenous and vascularized tissue were well anchored to the three biomaterials as early as 15 days after implantation. The degree of tissue penetration differed depending on the device. Chemically, they proved stable over time.

Topics: Abdominal Muscles; Acid Phosphatase; Animals; Biocompatible Materials; Biomarkers; Calorimetry, Differential Scanning; Cross-Linking Reagents; Evaluation Studies as Topic; Exudates and Transudates; Female; Fluorine; Foreign-Body Reaction; Formaldehyde; Gelatin; Hernia, Ventral; Leukocyte Count; Microscopy, Electron, Scanning; Polyesters; Polypropylenes; Polytetrafluoroethylene; Spectroscopy, Fourier Transform Infrared; Stress, Mechanical; Surgical Mesh; Swine; Tensile Strength; Wound Healing