acid-phosphatase and Hematuria

Six cases of urinary bladder mucosa with prostate-type epithelium were studied clinically, morphologically, and immunohistochemically. All patients were male with an average age of fifty-three years; most presented with painless hematuria. Histologically, two types of lesions were observed, the polypoid located in various sites of the bladder wall and the flat lesion found in the bladder neck. Both lesions shared in common a prostatic-type and transitional surface epithelium while prostatic-type glands were prominent in the polypoid lesion. The prostatic-type epithelium was confirmed immunohistochemically by detection of prostatic specific antigen and prostatic acid phosphatase. Based on specific findings we considered the metaplasia as the most reliable histogenetic aspect.

Topics: Acid Phosphatase; Adult; Aged; Antigens, Neoplasm; Choristoma; Epithelium; Hematuria; Humans; Immunohistochemistry; Male; Metaplasia; Middle Aged; Prostate; Prostate-Specific Antigen; Urinary Bladder Neoplasms

We retrospectively reviewed records of 551 patients with clinical Stage C prostatic adenocarcinoma treated with 60 to 70 Gy external beam radiation. Elective pelvic node irradiation was given to 247 patients (45%). Follow-up for all surviving patients ranged from 16 to 201 months (median, 6.5 years; mean, 7 years). The 5-, 10-, and 15-year uncorrected actuarial survival rates were 72%, 47%, and 27%, respectively. Disease-free survival rates were 59%, 46%, and 40% at the corresponding times. Actuarial local control rates were 88%, 81%, and 75% at 5, 10, and 15 years, respectively. Disease-free survival was adversely affected by high pathologic grade, disease fixed to the pelvic sidewall, invasion of the bladder, prior transurethral resection, hydronephrosis, and elevated serum levels of prostatic acid phosphatase and creatinine. Elective pelvic node irradiation did not improve the outcome. Complications of treatment were acceptable: minor anorectal and/or urinary symptoms, 11%; mild to moderate complications, 19%; serious problems requiring surgery, 3%. It is concluded that localized, high-energy external beam irradiation provides excellent local control of disease, low morbidity, and 5-, 10-, and 15-year survival rates that have not been rivaled by other treatment.

Topics: Acid Phosphatase; Adenocarcinoma; Aged; Creatinine; Cystitis; Hematuria; Humans; Male; Middle Aged; Neoplasm Metastasis; Pelvic Neoplasms; Proctitis; Prognosis; Prostatic Neoplasms; Radiotherapy, High-Energy; Retrospective Studies; Urination

Topics: Acid Phosphatase; Adolescent; Alkaline Phosphatase; beta-Galactosidase; Child; Child, Preschool; gamma-Glutamyltransferase; Hematuria; Humans; L-Lactate Dehydrogenase; Nephritis

Topics: Acid Phosphatase; alpha-Fetoproteins; Carcinoembryonic Antigen; Female; Hematuria; Humans; Kidney Neoplasms; Male; Palpation; Prostatic Neoplasms; Testicular Neoplasms; Time Factors; Urinary Bladder Neoplasms; Urogenital Neoplasms

Topics: Acid Phosphatase; Biopsy; Hematuria; Humans; Male; Middle Aged; Palpation; Prostatic Neoplasms; Urination Disorders

Acute promyelocytic leukaemia (A.P.L.) is a rare but important type of acute myeloid leukaemia characterized by major bleeding in association with thrombocytopenia, a specific peripheral blood and bone marrow picture, low plasma fibrinogen, and the presence in the serum of fibrin degradation products. These last abnormalities are related to the disseminated intravascular consumption of coagulation factors with secondary fibrinolysis. A.P.L. requires early recognition and urgent treatment. With optimal management up to half of the patients may achieve complete remission of two years or more. Undoubtedly patients with A.P.L. do especially well when treated in special centres and some patients with A.P.L. now die before the nature of their disease is recognized. Increased familiarity with the problem, which has been known for nearly 20 years, should yield great dividends for those few patients who have this disease.

Topics: Acid Phosphatase; Binding Sites; Bone Marrow Cells; Erythrocytes; Factor V; Factor VIII; Fibrinogen; Hematuria; Hemorrhage; Heparin; Humans; Leukemia, Myeloid; Leukocyte Count; Peroxidases; Platelet Transfusion; Prognosis; Prothrombin; Purpura; Remission, Spontaneous; Thrombocytopenia; Vitamin B 12

Topics: Acid Phosphatase; Animals; Citrates; Citric Acid Cycle; Endoplasmic Reticulum; Female; Fluorine; Glycosuria; Hematuria; Injections, Intraperitoneal; Ketone Bodies; Kidney; Kidney Tubules; Kidney Tubules, Proximal; Male; Microscopy, Electron; Mitochondria; Proteinuria; Rats

Topics: 17-Ketosteroids; Acetates; Acid Phosphatase; Adenocarcinoma; Adenoma, Islet Cell; Adult; Aged; Biopsy; Blood Sedimentation; Estrogens; Hematuria; Humans; Male; Middle Aged; Neoplasm Metastasis; Prostatectomy; Prostatic Neoplasms; Radionuclide Imaging; Rectum; Urinary Incontinence

Topics: Acid Phosphatase; Adult; Azo Compounds; Hematuria; Humans; Male; Prostate; Proteinuria; Urinary Bladder; Urinary Bladder Diseases