acid-phosphatase and Hematologic-Neoplasms

Acid phosphatase (ACP) is a hydrolytic lysosomal enzyme secreted by a number of cells including blood cells as well as by the prostate, bones, liver and other tissues. Several isozymes of ACP have tissue specificity. The isozymes can be fractionated by electrophoresis into six bands. Prostatic ACP (bands 2-4) is frequently measured for the diagnosis of prostatic disease. Band 5, tartrate resistant ACP (TRACP) consists of two isoforms, bands 5a and 5b. TRACP 5b is considered to be a marker of the osteoclasts and 5a is found in Gaucher's cells, or in the leukocytes of patients with hairy cell leukemia.

Topics: Acid Phosphatase; Biomarkers; Bone Diseases, Metabolic; Clinical Enzyme Tests; Female; Hematologic Neoplasms; Humans; Isoenzymes; Male; Organ Specificity; Prostatic Neoplasms; Sphingolipidoses; Tartrates