acid-phosphatase and Heart-Failure

Topics: Acid Phosphatase; Adrenal Cortex Hormones; Animals; Cardiomegaly; Cathepsins; Centrifugation, Density Gradient; Coronary Disease; Fasting; Heart Diseases; Heart Failure; Hormones; Humans; Hyperthyroidism; In Vitro Techniques; Liver; Lysosomes; Myocardial Infarction; Myocardium; Thyroxine

Topics: Acid Phosphatase; Aged; Carcinoma; Cardiovascular Diseases; Cerebrovascular Disorders; Clinical Trials as Topic; Diethylstilbestrol; Electrocardiography; Heart Failure; Humans; Ischemia; Male; Myocardial Infarction; Neoplasm Metastasis; Placebos; Plasminogen; Prognosis; Prostate; Prostatic Neoplasms; Pulmonary Embolism

This study of trimetasidine effects on plasmic hemostasis and blood biochemistry in patients with chronic heart failure (CCF) of NYHA functional class II-III.. This study enrolled 30 patients (24 males and 6 females) aged 40-72 years with class II-III CCF, postinfarction cardiosclerosis and ejection fraction under 40%. Previously the patients received perindopril (the inhibitor of angiotensin converting enzyme) in daily dose 2-4 mg, on-demand digoxin and diuretics. Trimetasidine was given in a daily dose 60 mg for 6 months. Before and after the treatment the patients' blood was examined for: levels of factors VII and X of antithrombin III coagulation, soluble fibrinomonomeric complexes (SFMC), fibrinogen, glucose, uric acid, creatinines, total cholesterol, high density lipoprotein, triglycerides, AST, ALT, LDH, acid phosphotase, gamma-GT, sodium, potassium, activated partial thrombin time.. Initially, the patients had a 23.9% increase in the levels of factors VII and X, a 14.3% decrease of antithrombin III, 29.8 and 227.6% rise in concentrations of fibrinogen and SFMC, respectively, compared to controls. Aftertreatment values of fibrinogen, factors VII and X, SFMC fell by 21.1, 17 and 35.5%, respectively. The thrombin time arose by 17.9% (p > 0.05). Insignificant inhibition was registered in the activity of acid phosphotase and gamma-GT. Glucose, AST, ALT, LDH levels remained unchanged. Plasma creatinine tended to lowering. Total cholesterol insignificantly increased at high levels of HDL cholesterol (p > 0.05) and reduced levels of triglycerides (p > 0.05).. Trimetasidine therapy, given after conventional treatment with diuretics, digoxin, inhibitor of angiotensin-converting enzyme, aspirin has a beneficial effect in patients with circulatory deficiency through improving hemostatic and biochemical parameters.

Topics: Acid Phosphatase; Adult; Aged; Biomarkers; Blood Coagulation Factors; Cholesterol, HDL; Chronic Disease; Creatinine; Female; Follow-Up Studies; Heart Failure; Hemostasis; Humans; Male; Middle Aged; Plasma; Treatment Outcome; Triglycerides; Trimetazidine; Vasodilator Agents

We have examined muscle strength, mitochondrial enzyme activity, histochemistry and fibre size in the quadriceps muscle of 9 patients with severe chronic heart failure. A needle biopsy of the quadriceps muscle was taken with patients at rest. Maximum oxygen uptake was measured during treadmill exercise. Mean maximal oxygen consumption was 11.7 ml.kg-1.min-1. Isometric maximum voluntary contraction was reduced to 55% of the predicted value for weight. Eight biopsies were abnormal. Findings included increased acid phosphatase, increased interstitial cellularity, excess intracellular lipid accumulation, atrophy of both type I and II fibres and variation in size with hypertrophy and atrophy of fibers. Muscle fibre capillary density and the activity of mitochondrial enzymes were normal. Changes in skeletal muscle strength may play a role in the limitation of exercise capacity seen in patients with congestive heart failure.

Topics: Acid Phosphatase; Aged; Biopsy; Electron Transport Complex IV; Heart Failure; Humans; Lipid Metabolism; Male; Middle Aged; Mitochondria, Muscle; Muscle Contraction; Muscles; Muscular Atrophy; Oxidoreductases; Oxygen Consumption; Succinate Cytochrome c Oxidoreductase

An 81-year-old male with congestive heart failure and prostatic hypertrophy was found to have markedly elevated serum acid phosphatase (EC 3.1.3.2) and moderately elevated serum alkaline phosphatase (EC 3.1.3.1). Alkaline phosphatase isoenzyme analysis was performed to determine the organ source of the enzyme. There was an unsual slow-migrating alkaline phosphatase isoenzyme band in the serum of this patient suggestive of hepatic origin by a variety of biochemical tests.

Topics: Acid Phosphatase; Aged; Alkaline Phosphatase; Heart Failure; Homoarginine; Humans; Isoenzymes; Liver; Male; Phenylalanine; Prostatic Hyperplasia

In exsudate cells separated from serous body cavities of 29 tumour patients and 30 patients with inflammatory and congestive effusion in cardiac failure or liver cirrhosis respectively the activities of acid and alkaline phosphatase were determined. In addition to sudanophilia the cell content of glycogen and that of ribonucleinic acid were evaluated. By means of cytochemical findings it could be found that an increase of unspecific esterase, acid phosphatase and ribonucleic acid in atypical cells points to a malignous ethiology of the exudate.

Topics: Acid Phosphatase; Alkaline Phosphatase; Ascitic Fluid; Esterases; Exudates and Transudates; Glycogen; Heart Failure; Histocytochemistry; Hodgkin Disease; Humans; Leukemia; Liver Cirrhosis; Lymphoma, Large B-Cell, Diffuse; Neoplasms; Peritonitis; Pleural Effusion; Pleurisy; RNA

Topics: Acid Phosphatase; Adenocarcinoma; Aged; Anorexia Nervosa; Barium Sulfate; Biopsy, Needle; Blood Urea Nitrogen; Castration; Colitis; Diarrhea; Heart Failure; Humans; Intestinal Mucosa; Lumbar Vertebrae; Male; Prostatic Neoplasms; Radiotherapy Dosage; Radiotherapy, High-Energy; Spinal Diseases; Uric Acid

Topics: Acid Phosphatase; Administration, Oral; Antineoplastic Agents; Carbamates; Carcinoembryonic Antigen; Estranes; Heart Diseases; Heart Failure; Humans; Male; Nausea; Neoplasm Metastasis; Nitrogen Mustard Compounds; Organophosphorus Compounds; Prostate; Prostatic Neoplasms; Vomiting

Topics: Acid Phosphatase; Animals; Cardiomegaly; Cathepsins; Dogs; Heart Failure; Lysosomes; Myocardium; Pulmonary Valve Stenosis; Ribonucleases

Topics: Acid Phosphatase; Animals; Deoxyribonucleases; Heart Failure; Lung; Lysosomes; Myocardium; Organ Size; Rabbits; Ribonucleases; Subcellular Fractions

Topics: Acid Phosphatase; Adolescent; Adult; Aged; Alkaline Phosphatase; Cell Count; Cell Nucleus; Child; Child, Preschool; Cytoplasm; Cytoplasmic Granules; Esterases; Heart Failure; Histiocytes; Histocytochemistry; Humans; Inclusion Bodies; Infant; Karyometry; Lymphocytes; Methods; Middle Aged; Pericardium

Topics: Acid Phosphatase; Adenosine Triphosphatases; Alkaline Phosphatase; Animals; Calcium; Cardiomegaly; Dihydrolipoamide Dehydrogenase; Electron Transport Complex IV; Esterases; Heart Failure; Histocytochemistry; Histological Techniques; Leucyl Aminopeptidase; Malate Dehydrogenase; Male; Myocardium; Nucleotidases; Oxidoreductases; Potassium; Rats; Sodium; Succinate Dehydrogenase

Topics: Acid Phosphatase; Blood Platelets; Breast Neoplasms; Buffers; Citrates; Cystic Fibrosis; Female; Heart Failure; Humans; Hydrogen-Ion Concentration; Kidney Failure, Chronic; Male; Phosphates; Prostate; Prostatic Diseases; Prostatic Neoplasms; Spectrophotometry; Stomach Neoplasms

Topics: Acid Phosphatase; Adenosine Triphosphatases; Adult; Alkaline Phosphatase; Angina Pectoris; Animals; Aortic Diseases; Blood Proteins; Chromatography; Chromatography, Gel; Diabetes Mellitus; Dogs; Electrocardiography; Electrophoresis; Female; Heart Failure; Humans; Hypertension; Isoenzymes; Kidney; Kidney Diseases; Liver; Liver Diseases; Lysosomes; Male; Mesenteric Arteries; Middle Aged; Mitochondria; Muscles; Myocardium; Potassium; Radionuclide Imaging; Rats; Sodium; Transaminases

Topics: Acid Phosphatase; Adenosine Triphosphatases; Adenosine Triphosphate; Adult; Aged; Alkaline Phosphatase; Bilirubin; Female; Heart Failure; Humans; Hydrogen-Ion Concentration; Hypertension; Liver Diseases; Male; Middle Aged; Phenolphthaleins; Phosphoric Monoester Hydrolases; Temperature; Transaminases

Topics: Acid Phosphatase; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Carbohydrate Metabolism; Cholinesterases; Clinical Enzyme Tests; D-Alanine Transaminase; Edema; Fructose-Bisphosphate Aldolase; Glucose-6-Phosphatase; Heart Failure; Humans; Isomerases; L-Lactate Dehydrogenase; Liver Circulation; Liver Diseases; Liver Function Tests; Pericarditis; Pleural Effusion; Proteins; Rabbits