acid-phosphatase and Dysentery

To assess functional activity of leukocytes, lipid peroxidation and enzymes indicating the severity of organ lesion in food poisoning and acute dysentery, the investigators employed the techniques of luminol- and biacridine-activated chemiluminescence of pure granulocyte population and whole blood, plasma chemiluminescence, assays of AAT, AsAT, AP, LDG. A relationship was established between chemiluminescence of leukocytes and whole blood, between leukocytic functional activity and the disease duration and severity. Indomethacin treatment of the patients reduced intoxication, did not affect leukocytic function, diminished plasma chemiluminescence. Functional activity of leukocytes and the enzymes levels were prognostically significant. Low response of leukocytes to the stimulus, i.e. a small rise of functional activity, served an unfavourable prognostic sign. A role of active oxygen forms produced by leukocytes is suggested in pathogenesis of alimentary toxo-infection.

Topics: Acid Phosphatase; Acute Disease; Adolescent; Adult; Alanine Transaminase; Aspartate Aminotransferases; Clinical Enzyme Tests; Dysentery; Foodborne Diseases; Humans; Indomethacin; L-Lactate Dehydrogenase; Leukocytes; Lipid Peroxidation; Luminescent Measurements; Middle Aged

Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Castor Oil; Dysentery; Fasting; Histocytochemistry; Intestinal Mucosa; Oxytetracycline