acid-phosphatase and Drug-Hypersensitivity

Topics: Acid Phosphatase; Aged; Clinical Trials as Topic; Drug Hypersensitivity; Humans; Injections, Intramuscular; Male; Middle Aged; Organ Size; Placebos; Pregnanes; Progestins; Prostate; Prostatic Hyperplasia; Pyuria; Thyroid Gland; Urinary Catheterization; Urography

Activities of angiotensin-converting enzyme and acid phosphatase were markedly elevated in the lesions of metal-induced hypersensitivity and foreign body types of granulomas. We biochemically studied these enzymes by means of gel filtration and electrophoresis and compared them with the same enzymes of normal dermis. Two forms of angiotensin-converting enzyme found in normal dermis were increased proportionally. Catalytic properties and heat stability of the enzyme in the lesions and normal dermis were the same. On the other hand, acid phosphatase in the lesions showed a different isozyme pattern from that seen in normal dermis. The enzyme from normal dermis had apparent molecular weight of 150000 and 90000, whereas an additional enzyme with a molecular weight of 230000 was detected in granulomatous lesions. Three isozymes were demonstrable in normal dermis but two additional isoenzymes appeared in granulomatous lesions: the isozyme patterns between the foreign body and hypersensitivity granulomas are different.

Topics: Acid Phosphatase; Drug Hypersensitivity; Granuloma; Humans; Kinetics; Molecular Weight; Peptidyl-Dipeptidase A; Reference Values; Skin; Skin Diseases

Topics: Acid Phosphatase; Animals; Antibodies; Antigen-Antibody Complex; Cytoplasmic Granules; Drug Hypersensitivity; Erythrocytes; Fibroblasts; Freund's Adjuvant; gamma-Globulins; Histocytochemistry; Hypersensitivity, Delayed; Lymphocytes; Macrophages; Ovalbumin; Peroxidases; Plants; Rabbits; Rats; Sheep; Skin; Staining and Labeling; Time Factors

Topics: Acid Phosphatase; Animals; Deoxyribonucleases; Drug Hypersensitivity; Guinea Pigs; Lymph Nodes; Spleen; Streptomycin

Topics: Acid Phosphatase; Adult; Antibodies; Antigens; Blood Coagulation Factors; Blood Coagulation Tests; Blood Platelets; Clot Retraction; Drug Hypersensitivity; Female; Humans; Male; Prednisone; Quinine

Topics: Acid Phosphatase; Adult; Bromides; Drug Hypersensitivity; Erythema; Female; Humans; Infusions, Parenteral; Skin Diseases; Sodium; Solutions; Thyroid Gland