acid-phosphatase and Disseminated-Intravascular-Coagulation

The dependent of DIC development on lysosomal apparatus neutrophils activity was founded. The most severe changes in hemostasis system were registered in the period of maximum acid phosphatus activity.

Topics: Acid Phosphatase; Animals; Disease Models, Animal; Disseminated Intravascular Coagulation; Female; Hemostasis; Lysosomes; Male; Neutrophils; Rabbits; Time Factors

Development of experimental the syndrome of disseminated intravascular coagulation, DIC syndrome, in organism laboratory animals from affect preparation "EFA-2" by accompanied increase quantity of neutrophiles circulations, modifications of the lysosomal apparatus of neutrophiles the activity of the serum acid phosphatase increased, characteristic damage on hemostasis system and typical alteration in some organs. As a result limitation of number of neutrophiles was achieved of suppression, of granulocytopoiesis by means "Myelosan" pharmacy, did not increase activity in blood serum solution lysosomal enzyme of neutrophils and not development in organism DIC syndrome. Made conclusion, the neutrophils have influence of promotion generalization DIC syndrome.

Topics: Acid Phosphatase; Animals; Biomarkers; Busulfan; Disease Models, Animal; Disseminated Intravascular Coagulation; Female; Hematopoiesis; Hemostasis; Lysosomes; Male; Neutrophils; Rabbits

Topics: Acid Phosphatase; Animals; Catalase; Cholesterol; Complement System Proteins; Disseminated Intravascular Coagulation; Female; Fibrin Fibrinogen Degradation Products; Free Radicals; Rats; Rats, Inbred Strains; Reference Values; Shock, Septic; Superoxide Dismutase; Vitamin E

Gastrointestinal bleeding was the presenting manifestation in four patients without readily apparent prostate cancer. Three of these patients had laboratory evidence of acute disseminated intravascular coagulation (DIC) and one patient had a friable rectal mass. The diagnosis of prostate cancer was made in three patients by employing an immunoperoxidase technique for prostatic acid phosphatase in metastatic foci. Dramatic resolution of DIC occurred in two patients following hormone therapy. Radiation therapy was effective in controlling bleeding in another patient. Two patients are alive with no further bleeding episodes at 8 and 18 months follow-up, respectively. In patients who present with a bleeding diathesis and adenocarcinoma of unknown primary, it is important to consider prostate cancer because of its frequent and prolonged responsiveness to hormonal therapy.

Topics: Acid Phosphatase; Aged; Disseminated Intravascular Coagulation; Gastrointestinal Hemorrhage; Humans; Immunoenzyme Techniques; Male; Middle Aged; Prostatic Neoplasms

Topics: Acid Phosphatase; Animals; Disseminated Intravascular Coagulation; Dogs; Female; Fibrinolysis; Glucuronidase; Lysosomes

Topics: Acid Phosphatase; Blood Cells; Cytoplasmic Granules; Disseminated Intravascular Coagulation; Female; Hematopoietic Stem Cells; Histocytochemistry; Humans; Inclusion Bodies; Indicators and Reagents; Leukemia, Myeloid, Acute; Lysosomes; Microscopy, Electron; Staining and Labeling