acid-phosphatase and Disease

Topics: Acid Phosphatase; Alkaline Phosphatase; Aspartate Aminotransferases; Disease; Esterases; gamma-Glutamyltransferase; Humans; Isoenzymes

Topics: Acid Phosphatase; Alkaline Phosphatase; Anemia, Aplastic; Bone Marrow; Disease; Hemochromatosis; Histocytochemistry; Humans; Hypersplenism; Leukocyte Count; Lymphatic Diseases; Methods; Mononuclear Phagocyte System; Multiple Myeloma; Neutrophils; Staining and Labeling

Topics: Acid Phosphatase; Aerosols; Animals; Canaries; Chickens; Cilia; Common Cold; Disease; Environmental Exposure; Epithelium; Humans; Humidity; Lead Poisoning; Malaria; Mice; Mucous Membrane; Newcastle disease virus; Orthomyxoviridae; Parathion; Pneumonia; Rats; Respiratory Tract Infections; Skin Diseases; Temperature

Topics: Acid Phosphatase; Disease; Humans; Male; Phosphoric Monoester Hydrolases; Prostate; Prostatic Diseases; Urology

The paper reports a study of the distribution of phosphatases in the femora of three specimens of Humboldt's woolly monkey (Lagothrix humboldti) suffering from chronic hyperparathyroidism. Bone structure ranged from the apparently normal to extreme osteitis fibrosa. Most marked changes were found in the distribution of alkaline phosphatase, which reached at least 10 times the normal levels in the bone of the second monkey in the series, dropping to levels still well above normal in that of the most severely affected animal. Very high concentrations were found in the deeper layers of hypertrophied growth cartilage and in the osteoblasts lining poorly calcified trabeculae, and high concentrations in the fibre bone of the third animal. Lack of mineralization and the development of osteitis fibrosa are thus associated with a marked increase in alkaline phosphatase activity. Osteoclasts reacted strongly for acid phosphatase but were negative for alkaline phosphatase. Acid phosphatase levels were comparatively high in fibre bone, but overall levels ranged from 1/20 to less than 1/100 those of alkaline phosphatase. Some slow staining for acid phosphatase probably represents residual activity at acid pH of the markedly increased alkaline phosphatase. There may be some association between a failure of mineralization and the presence of acid phosphatase in osteoclasts and osteoid. The aetiology of the monkeys' condition is discussed. It seems likely that the parathyroid hypertrophy and rachitic changes were caused by low blood calcium dependent on a low calcium diet and lack of vitamin D, in which the requirements of New World monkeys are reputedly high.

Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Atelinae; Bone and Bones; Calcium; Disease; Haplorhini; Humans; Hyperparathyroidism; Monkey Diseases; Osteoclasts; Parathyroid Glands; Phosphoric Monoester Hydrolases

Topics: 5'-Nucleotidase; Acid Phosphatase; Alkaline Phosphatase; Biliary Tract; Biliary Tract Diseases; Bone Diseases; Disease; DNA; Leucyl Aminopeptidase; Liver Diseases; Pancreas; Pancreatic Diseases; Peptide Hydrolases; Phosphoric Monoester Hydrolases; Protein Tyrosine Phosphatases; RNA; Trees

Topics: Acid Phosphatase; Disease; Humans; Male; Phosphoric Monoester Hydrolases; Prostate; Prostatic Diseases

Topics: Acid Phosphatase; Disease; Gaucher Disease; Humans; Lipidoses; Male; Phosphoric Monoester Hydrolases; Prostate; Prostatic Diseases; Prostatism

Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Aorta; Aorta, Abdominal; Aortic Diseases; Constriction; Disease; Electron Transport Complex II; Hypertension; Kidney; Phosphoric Monoester Hydrolases; Rats; Succinate Dehydrogenase

Topics: Acid Phosphatase; Blood; Disease; Hematologic Diseases; Hematopoietic System; Phosphoric Monoester Hydrolases

Topics: Acid Phosphatase; Body Fluids; Chronic Disease; Disease; Humans; Male; Peptide Hydrolases; Prostate; Prostatic Diseases; Prostatitis