acid-phosphatase and Diphtheria

The cytochemical study of lymphocytes and neutrophils isolated from fractionated blood of diphtheria patients and carriers has revealed that a decrease in the activity of lymphocyte succinic dehydrogenase and myeloperoxidase can be observed at all periods of the disease and in all its forms. A decrease in the activity of lymphocyte nonspecific esterase has been noted only in patients with toxic and subtoxic diphtheria and a decrease in the activity of neutrophil alkaline phosphatase, in carriers. The analysis of correlations between the parameters of five enzymes under study (lymphocyte succinic dehydrogenase, lymphocyte acid phosphatase, lymphocyte non-specific esterase, myeloperoxidase, neutrophil alkaline phosphatase) and enzymatic rosette parameters has been made. The analysis has revealed an essential increase in the number of correlations in comparison with donors, changes in the qualitative nature of these correlations and sometimes the reversion of the correlations. Carriers have shown the greatest number of correlations. By the end of the terms of observations no restoration of normal correlations has been observed.

Topics: Acid Phosphatase; Alkaline Phosphatase; Carrier State; Diphtheria; Esterases; Histocytochemistry; Humans; Lymphocytes; Neutrophils; Peroxidase; Succinate Dehydrogenase

Topics: Acid Phosphatase; Animals; Demyelinating Diseases; Diphtheria; Histocytochemistry; Lysosomes; Macrophages; Nerve Degeneration; Peripheral Nervous System Diseases; Poultry; Sciatic Nerve