acid-phosphatase and Dementia

Topics: Acid Phosphatase; Aged; Aging; Aluminum; Animals; Brain Diseases; Cerebral Cortex; Cholinesterases; Dementia; Esterases; Glutamate Dehydrogenase; Hippocampus; Histocytochemistry; Humans; Lysosomes; Male; Microscopy, Electron; Nervous System; Neurons; Nissl Bodies; Oxidoreductases; Phosphates; Pigments, Biological; Rabbits; Spinal Cord

In seven patients with cerebral atrophy due to pre-senile dementia and/or cerebrovascular disease, the activity of acid phosphatase in lumbar cerebrospinal fluid (CSF) was higher (p less than 0.05) than in six controls. The activity of arylsulphatase and beta-galactosidase in CSF was the same in the two groups. In the serum, the activities of acid phosphatase and arylsulphatase were the same in the two groups but the activity of beta-galactosidase was lower (p less than 0.02) in patients with cerebral atrophy.

Topics: Acid Phosphatase; Adult; Aged; Arylsulfatases; Cerebrovascular Disorders; Dementia; Female; Galactosidases; Humans; Lysosomes; Male; Middle Aged; Sulfatases

The water-soluble proteins of the cerebral gray matter and some enzyme systems (cholinesterase, acetylcholinesterase, lactate dehydrogenase, malate dehydrogenase, acid phosphatase) were studied in 9 autopsy cases of Alzheimer's presenile or senile dementia, 1 case of Pick's disease and 1 case of cerebral arteriosclerosis. The proteins and enzyme patterns were visualized on polyacrylamide gradient gels after electrophoresis. In all patients studied, the profiles of cerebral gray-matter proteins were normal. In the patients with advanced dementia, the enzyme patterns usually were abnormal. Particularly in Alzheimer's disease, the activity of malate dehydrogenase was markedly increased.

Topics: Acetylcholinesterase; Acid Phosphatase; Aged; Alzheimer Disease; Brain; Brain Chemistry; Cholinesterases; Dementia; Female; Humans; Intracranial Arteriosclerosis; L-Lactate Dehydrogenase; Malate Dehydrogenase; Male; Nerve Tissue Proteins

Topics: Acid Phosphatase; Cerebral Cortex; Child; Chorea; Dementia; Female; Histocytochemistry; Humans; Inclusion Bodies; Lipidoses; Male; Microscopy, Electron; Neurons; Pigments, Biological; Seizures; Speech Disorders; Syndrome

Topics: Acetylcholinesterase; Acid Phosphatase; Adenosine Triphosphate; Aged; Cerebral Cortex; Dementia; Humans; Neurofibrils

Topics: Acetylcholinesterase; Acid Phosphatase; Adenosine Triphosphatases; Aged; Alkaline Phosphatase; Brain; Cholinesterases; Dementia; Esterases; Histocytochemistry; Humans; Intracranial Arteriosclerosis; Middle Aged; Schizophrenia

Topics: Acid Phosphatase; Adenosine Triphosphatases; Aged; Autopsy; Brain; Brain Diseases; Cholinesterases; Dementia; Esterases; Histocytochemistry; Humans; Middle Aged

Topics: Acid Phosphatase; Adenosine Triphosphatases; Adult; Aged; Alkaline Phosphatase; Animals; Biopsy; Cerebral Cortex; Dementia; Disease Models, Animal; Female; Frontal Lobe; Histocytochemistry; Humans; Male; Middle Aged; Neurofibrils; Neurons; Oxidoreductases; Phosphoric Monoester Hydrolases; Rabbits; Succinate Dehydrogenase; Temporal Lobe

Topics: Acid Phosphatase; Aging; Amyloidosis; Animals; Axons; Brain; Brain Diseases; Cerebral Cortex; Dementia; Dog Diseases; Dogs; Histocytochemistry; Humans; Macrophages; Microscopy; Nerve Degeneration; Neuroglia

Topics: Acetylcholinesterase; Acid Phosphatase; Aged; Arteries; Capillaries; Cerebral Cortex; Dementia; Dihydrolipoamide Dehydrogenase; Female; Humans; Middle Aged; NAD

Topics: Acid Phosphatase; Adult; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Bilirubin; Blood Protein Electrophoresis; Creatinine; Dementia; Folic Acid; Fructose-Bisphosphate Aldolase; Gait; Humans; L-Lactate Dehydrogenase; Lipidoses; Male; Movement Disorders; Pedigree; Porphyrins; Thymol

Topics: Acid Phosphatase; Aged; Amyloid; Arteries; Brain; Capillaries; Dementia; Dihydrolipoamide Dehydrogenase; Female; Histocytochemistry; Humans; Microscopy, Electron; Middle Aged; Nerve Degeneration; Neuroglia; Paranoid Disorders

Topics: Acid Phosphatase; Aged; Basement Membrane; Biopsy; Capillaries; Cerebral Cortex; Dementia; Glycogen; Histocytochemistry; Humans; Lipid Metabolism; Male; Microscopy, Electron; Middle Aged; Neuroglia; Neurons; Pigments, Biological; Veins

Topics: Acid Phosphatase; Adenosine Triphosphatases; Alkaline Phosphatase; Cerebral Cortex; Dementia; Frontal Lobe; Humans; Male; Middle Aged; Neurofibrils; Phosphoric Monoester Hydrolases; Pyrophosphatases

Topics: Acid Phosphatase; Axons; Cerebral Cortex; Dementia; Dendrites; Histocytochemistry; Humans; Male; Microscopy, Electron; Middle Aged; Neurofibrils; Synapses

Topics: Acid Phosphatase; Axons; Cytoplasmic Granules; Dementia; Dendrites; Endoplasmic Reticulum; Frontal Lobe; Histocytochemistry; Humans; Lysosomes; Microscopy, Electron; Nerve Degeneration

Topics: Acid Phosphatase; Aphasia; Brain; Central Nervous System Diseases; Cerebral Cortex; Dementia; Deoxyribonucleases; Dihydrolipoamide Dehydrogenase; Frontal Lobe; Histocytochemistry; Humans; Lysosomes; Male; Microscopy, Electron; Middle Aged; Motor Neurons; NAD; Nerve Degeneration; Neuroglia; Oxidoreductases; Pigments, Biological; RNA; Spinal Cord

Topics: Acetylcholinesterase; Acid Phosphatase; Animals; Cats; Dementia; Dihydrolipoamide Dehydrogenase; Haplorhini; Hippocampus; Histocytochemistry; Humans; L-Lactate Dehydrogenase; Lipidoses; Rabbits; Rats; Zinc