acid-phosphatase and Deficiency-Diseases

Topics: Acid Phosphatase; Antibody Formation; Calcium; Child; Deficiency Diseases; Glucosephosphate Dehydrogenase; Humans; Immunity; Immunity, Cellular; Infections; Iron; Leukocytes; Lysosomes; NADH, NADPH Oxidoreductases; Nutrition Disorders; Peroxidases; Phagocytosis; Phosphogluconate Dehydrogenase; Protein-Energy Malnutrition

Zinc deficiency has become a global problem affecting the developed and developing countries due to inhibitors in the diet which prevents its absorption or due to a very low concentration of bioavailable zinc in the diet. Being present in high concentration in the prostate and having diverse biological function, we investigated the effects of dietary zinc deficiency for 2 and 4 weeks on dorso-lateral and ventral prostate. Sixty prepubertal rats were divided into three groups: zinc control (ZC), pair fed (PF) and zinc deficient (ZD) and fed on 100 μg/g (zinc control and pair fed groups) and 1 μg/g (zinc deficient) diet. Zinc deficiency was associated with degenerative changes in dorso-lateral and ventral prostate as made evident by karyolysis, karyorhexis, cytoplasmolysis, loss of cellularisation, decreased intraluminar secretion and degeneration of fibromuscular stroma. In response, protein carbonyl, nitric oxide, acid phosphatase, 3β-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase increased, exhibiting variable level of significance. Total protein and total zinc concentration in dorso-lateral and ventral prostate as well as in serum decreased (P < 0.001). Decrease (P < 0.001) was recorded in serum FSH and testosterone after 2 and 4 weeks of zinc deficiency. The changes were more prominent after 4 weeks of synthetic zinc deficient diet. The results indicate that zinc deficiency during prepubertal period affects the prostate structure, total protein concentration, enhanced protein carbonyl concentration, nitric oxide as well as acid phosphatase activities and impaired hydroxysteroid dehydrogenase activities. Evidently these changes could be attributed to dysfunction of dorso-lateral and ventral prostate after dietary zinc deficiency as well as impairment of metabolic and secretory activity, reduced gonadotropin levels by hypothalamus -hypophysial system which is indicative of a critical role of zinc in maintaining the prostate integrity.

Topics: 17-Hydroxysteroid Dehydrogenases; 3-Hydroxysteroid Dehydrogenases; Acid Phosphatase; Analysis of Variance; Animals; Deficiency Diseases; Diet; Follicle Stimulating Hormone; Male; Nitric Oxide; Prostate; Protein Carbonylation; Rats, Wistar; Testosterone; Time Factors; Trace Elements; Zinc

Topics: Acid Phosphatase; Alcohol Oxidoreductases; Alkaline Phosphatase; Animals; Cholinesterases; Deficiency Diseases; Ear, Inner; Electron Transport Complex IV; Female; Fetal Diseases; Glucosephosphate Dehydrogenase; Histocytochemistry; Manganese; Mice; Pregnancy; Sensory Receptor Cells; Skin

Topics: Acid Phosphatase; Animals; Cheek; Deficiency Diseases; Enzyme Activation; Epithelial Cells; Epithelium; Histocytochemistry; Keratosis; Male; Mouth Mucosa; Naphthols; Phosphates; Rats; Zinc

Topics: Acid Phosphatase; Animal Nutritional Physiological Phenomena; Animals; Cathepsins; Chickens; Deficiency Diseases; Enzyme Precursors; Female; Fibroblasts; Growth Disorders; Histocytochemistry; Liver; Lysosomes; Macrophages; Male; Muscle Development; Pancreas; Selenium; Species Specificity

Topics: Acid Phosphatase; Acyltransferases; Alkaline Phosphatase; Animals; Blood Cell Count; Bone Marrow; Bone Marrow Cells; Deficiency Diseases; Enzymes; Esterases; Glutamates; Leucyl Aminopeptidase; Leukocytes; Male; Naphthols; Neutrophils; Rats; Rats, Inbred Strains; Zinc

Topics: Acid Phosphatase; Animals; Anti-Inflammatory Agents; Deficiency Diseases; Dexamethasone; Drug Synergism; Glucuronidase; Hot Temperature; Liver; Lysosomes; Male; Membranes; Osmolar Concentration; Rats; Selenium; Sodium; Triamcinolone Acetonide; Vitamin E; Vitamin E Deficiency

Topics: Acid Phosphatase; Acyltransferases; Animals; Coenzyme A; Deficiency Diseases; Diet; Dietary Fats; Endoplasmic Reticulum; Fasting; Fatty Acids; Glucose-6-Phosphatase; Glycerophosphates; Hydrolases; Linoleic Acids; Liver; Male; Microsomes, Liver; Oleic Acids; Phenobarbital; Phosphatidylcholines; Phospholipases; Rats; RNA; Snakes; Succinate Dehydrogenase; Venoms

Topics: Acid Phosphatase; Animals; Brain; Brain Chemistry; Central Nervous System; Copper; Deficiency Diseases; Female; Hematocrit; Histocytochemistry; Liver; Male; Microscopy, Electron; Phosphotransferases; Spinal Cord; Swine; Swine Diseases; Thiamine Pyrophosphate

Topics: Acid Phosphatase; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Arginase; Deficiency Diseases; Dietary Proteins; Female; Glucosephosphate Dehydrogenase; Glucosyltransferases; Hydro-Lyases; Liver; Lyases; Malate Dehydrogenase; Male; Mixed Function Oxygenases; Oxidoreductases; Rats; Threonine

Topics: Acid Phosphatase; Age Factors; Alkaline Phosphatase; Animals; Deficiency Diseases; Glucuronidase; Kidney; Liver; Lysosomes; Muscular Diseases; Myocardium; Selenium; Sheep; Spleen; Sulfatases

Topics: Acid Phosphatase; Age Factors; Animals; Axons; Cholinesterases; Copper; Deficiency Diseases; Demyelinating Diseases; Electron Transport Complex IV; Histocytochemistry; Lysosomes; Muscles; Neuromuscular Junction; Sciatic Nerve; Sheep; Sheep Diseases; Species Specificity; Spinal Cord; Swayback

Topics: Acid Phosphatase; Animals; Animals, Newborn; Body Weight; Deficiency Diseases; Deoxyribonucleases; Diet; Female; Histocytochemistry; Lactation; Liver; Microscopy, Electron; Oxygenases; Phenylalanine; Pregnancy; Pregnancy Complications; Rats; Tyrosine

Topics: Acid Phosphatase; Animals; Body Weight; Cell Division; Deficiency Diseases; Dietary Fats; Electron Transport Complex IV; Fatty Acids; Female; Histocytochemistry; Linoleic Acids; Male; Mice; Skin; Succinate Dehydrogenase

Topics: Acid Phosphatase; Animals; Cathepsins; Chickens; Deficiency Diseases; Galactosidases; Glucuronidase; Linoleic Acid; Lysosomes; Methionine; Muscular Dystrophies; Oleic Acid; Oleic Acids; Pharmacology; Poultry Diseases; Research; Ribonucleases; Sulfatases; Vitamin E; Vitamin E Deficiency

Lysosomes appeared in the cytoplasm of cells of the renal papillae of rats fed on a potassium-deficient diet. The lysosomes were identified by their morphologic appearance when examined by electron microscopy, and by their acid phosphatase activity shown by both light and electron micro-scopic examination of Gomori-treated tissue.

Topics: Acid Phosphatase; Cell Biology; Cytoplasm; Deficiency Diseases; Diet; Kidney; Lysosomes; Microscopy, Electron; Potassium; Rats; Research