acid-phosphatase and DNA-Virus-Infections

Iridovirus can cause a mass of death in grouper, leading to huge economic loss in recent years. At present, practical vaccine is still the best way to control the outbreak of this virus. Many researches had indicated that the major capsid protein (MCP) of grouper iridovirus of Taiwan (TGIV) is an effective antigen to induce a specific immune response in grouper. However, these traditional vaccines that based on large proteins or whole organisms are faced with challenges because of the unnecessary antigenic load. Thus, in this study, we screened the dominant linear epitope within the MCP of TGIV and then, a new peptide vaccine (P2) was developed via prokaryotic expression system. Furthermore, SWCNTs was used as a vaccine carrier to enhance the immunoprotective effect. To evaluate the immunoprotective effect of this vaccine, a total of 245 fish were vaccinated with P2 (5, 10, 20 mg L

Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Antigens, Viral; Capsid Proteins; DNA Virus Infections; Drug Carriers; Epitopes; Fish Diseases; Gene Expression; Iridoviridae; Nanotubes, Carbon; Perciformes; Superoxide Dismutase; Vaccines, Subunit; Viral Vaccines