acid-phosphatase and Cystadenoma

Strumal carcinoids (SC) are ovarian tumors containing thyroid parenchyma admixed with carcinoid elements. Microscopically, the carcinoid component of SC usually presents a ribbon or trabecular pattern similar to the pattern exhibited by hindgut carcinoids. The authors designed an immunohistochemical study to ascertain further similarities of the carcinoid component of SC to rectal carcinoids.. Five cases of SC were examined by light microscopic study with hematoxylin and eosin and immunoperoxidase staining with a group of neurohormonal peptides, thyroglobulin, prostatic acid phosphatase, and prostate specific antigen.. All tumors were positive for thyroglobulin, chromogranin, prostatic acid phosphatase (PAP), and glucagon. They were consistently negative for prostate specific antigen and variably positive to the other antibodies.. The consistent positivity of the carcinoid component of SC to PAP immunostaining is a further similarity of these tumors to rectal carcinoids, in which positive immunostaining to PAP has been observed. The similarity is not well understood, however, as all evidence points to the origin of SC from germ cells in mature cystic teratomas without any embryologic relationship to the hindgut.

Topics: Acid Phosphatase; Adolescent; Adult; Carcinoid Tumor; Chromogranins; Cystadenoma; Dermoid Cyst; Female; Glucagon; Humans; Immunoenzyme Techniques; Male; Middle Aged; Ovarian Neoplasms; Pancreatic Polypeptide; Prostate; Serotonin; Struma Ovarii; Thyroglobulin

A slow-growing tumor on the dorsum of the right foot of a 25-year-old female had features that corresponded to papillary eccrine adenoma. The grouping of this entity under the term "tubular apocrine adenoma" in a recent edition of a textbook led to further study of this case in the form of enzyme histochemistry and electron microscopy. The tumor was positive for amylophosphorylase and negative for acid phosphatase, and on electron microscopy showed complex intercellular membrane interdigitation and a possible intercellular canaliculus. No features of apocrine differentiation were found, and we feel that this tumor is distinctly eccrine in its differentiation. The similarity of these two ostensibly separate entities, and the opinion of some authors that intermediate differentiation may be possible in adnexal tumors, would favor them being grouped under the single term of "tubulopapillary hidradenoma," with apocrine or eccrine differentiation as the case may be.

Topics: Acid Phosphatase; Adult; Cystadenoma; Female; Humans; Immunoenzyme Techniques; Periodic Acid-Schiff Reaction; Phosphorylases; Skin Neoplasms

Topics: Acid Phosphatase; Alkaline Phosphatase; Cystadenoma; Enzymes; Female; Humans; L-Lactate Dehydrogenase; Leucyl Aminopeptidase; Ovarian Cysts; Ovarian Follicle; Ovarian Neoplasms; Ovum

Topics: Acid Phosphatase; Adenocarcinoma, Mucinous; Adenoma; Adenoma, Pleomorphic; Adenosine Triphosphatases; Adult; Aged; Alkaline Phosphatase; Carcinoma, Adenoid Cystic; Cystadenoma; Dihydrolipoamide Dehydrogenase; Female; Glucosephosphate Dehydrogenase; Histocytochemistry; Humans; Leucyl Aminopeptidase; Male; Middle Aged; Monoamine Oxidase; Parotid Neoplasms; Salivary Gland Neoplasms; Succinate Dehydrogenase

Topics: Acid Phosphatase; Acute Kidney Injury; Animals; Bicarbonates; Cellulose; Chlorides; Chromatography, Ion Exchange; Cystadenoma; Dehydration; Electrophoresis; Female; Glycoproteins; Histocytochemistry; Humans; Hypotension; Middle Aged; Mucoproteins; Potassium; Potassium Isotopes; Rectal Neoplasms; Sodium; Sodium Isotopes; Tritium; Water-Electrolyte Balance

Topics: Acid Phosphatase; Adenolymphoma; Alkaline Phosphatase; Cystadenoma; Cystadenoma, Papillary; Electron Transport Complex II; Esterases; Galactosidases; Glycosaminoglycans; Hamartoma; Histocytochemistry; Humans; Leucyl Aminopeptidase; Pathology; Salivary Gland Neoplasms; Succinate Dehydrogenase