acid-phosphatase and Cerebrovascular-Disorders

Topics: Acid Phosphatase; Aged; Carcinoma; Cardiovascular Diseases; Cerebrovascular Disorders; Clinical Trials as Topic; Diethylstilbestrol; Electrocardiography; Heart Failure; Humans; Ischemia; Male; Myocardial Infarction; Neoplasm Metastasis; Placebos; Plasminogen; Prognosis; Prostate; Prostatic Neoplasms; Pulmonary Embolism

In order to clarify the role of lysosomal enzymes in the developmental mechanisms of cerebral lesions under chronic hypertensive conditions, we histochemically and biochemically investigated acid phosphatase, N-acetyl-beta-glucosaminidase, and cathepsin B in the cerebral cortex and subcortical white matter in stroke-prone spontaneously hypertensive rats (SHRSP). Histochemical investigation showed that SHRSP had an increased number of cells with positive reaction to these enzymes in the edematous cortex and degenerated subcortical white matter. The cells with positive reaction were made up of reactive astrocytes and microglias. The activities of all enzymes in the aged SHRSP were higher than those in normotensive rats, the differences being significant at 24 weeks of age. The present study suggests that chronic hypertension or chronic edema causes increased activities of lysosomal enzymes in the cerebral cortex and subcortical white matter, and that the activated lysosomal enzymes take part in the developmental mechanisms of cystic formation as well as the diffuse degeneration of the white matter.

Topics: Acetylglucosaminidase; Acid Phosphatase; Animals; Astrocytes; Brain; Brain Edema; Cathepsin B; Cerebral Cortex; Cerebrovascular Disorders; Enzyme Activation; Hypertension; Male; Nerve Degeneration; Neurons; Rats; Rats, Inbred SHR; Rats, Inbred WKY

Changes in aortic lipolytic enzyme activities (cholesterol esterase and lipoprotein lipase) and acid phosphatase activity during aging were investigated in three strains of rats with different blood pressures; stroke prone spontaneously hypertensive rats (SHRSP), spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto (WKR). The blood pressures of male, 7 month old animals, was 234 (SHRSP), 173 (SHR) and 128 (WKR) mmHg. The cholesterol esterase activity markedly decreased with age in the aortas of SHRSP, SHR and normotensive WKR rats, while acid phosphatase activity decreased only slightly, if at all, and lipoprotein lipase activity remained unchanged. This effect was enhanced by increasing blood pressure in SHRSP, SHR and WKR. The total aortic cholesterol content increased significantly with hypertension in a inverse relation with cholesterol esterase activity. These results suggest that cholesterol deposition in aged arteries is, at least partialy, ascribable to an age-related decrease in cholesterol esterase, and that hypertension aggravates the deposition of arterial cholesterol by accelerating the age-related decrease in aortic cholesterol esterase activity.

Topics: Acid Phosphatase; Aging; Animals; Aorta; Blood Pressure; Body Weight; Carboxylic Ester Hydrolases; Cerebrovascular Disorders; Cholesterol; Female; Hypertension; Male; Phospholipids; Rats; Sterol Esterase; Triglycerides

Topics: 4-Nitrophenylphosphatase; Acid Phosphatase; Alkaline Phosphatase; Animals; Cerebrovascular Disorders; Hypertension; Kidney; L-Lactate Dehydrogenase; Male; Rats; Succinate Dehydrogenase

Topics: Acid Phosphatase; Adult; Aged; Alkaline Phosphatase; Brain; Brain Chemistry; Cerebrovascular Disorders; DNA; Female; Glycosaminoglycans; Humans; Hypertension; Intracranial Arteriosclerosis; Male; Middle Aged; RNA

Topics: Acid Phosphatase; Adult; Aged; Alkaline Phosphatase; Brain; Cerebral Hemorrhage; Cerebrovascular Disorders; Electron Transport Complex IV; Female; Glycogen; Histocytochemistry; Humans; Ischemia; Ischemic Attack, Transient; Leukocytes; Male; Middle Aged; Peroxidases

In seven patients with cerebral atrophy due to pre-senile dementia and/or cerebrovascular disease, the activity of acid phosphatase in lumbar cerebrospinal fluid (CSF) was higher (p less than 0.05) than in six controls. The activity of arylsulphatase and beta-galactosidase in CSF was the same in the two groups. In the serum, the activities of acid phosphatase and arylsulphatase were the same in the two groups but the activity of beta-galactosidase was lower (p less than 0.02) in patients with cerebral atrophy.

Topics: Acid Phosphatase; Adult; Aged; Arylsulfatases; Cerebrovascular Disorders; Dementia; Female; Galactosidases; Humans; Lysosomes; Male; Middle Aged; Sulfatases

Topics: Acid Phosphatase; Adenosine Triphosphatases; Alkaline Phosphatase; Animals; Brain; Cats; Cerebral Arteries; Cerebrovascular Disorders; Dihydrolipoamide Dehydrogenase; Electron Transport Complex IV; Esterases; Female; Glucosyltransferases; Ischemic Attack, Transient; L-Lactate Dehydrogenase; Male; Oxidoreductases; Phosphoric Monoester Hydrolases; Staining and Labeling; Succinate Dehydrogenase

Topics: Acid Phosphatase; Animals; Brain; Cerebral Cortex; Cerebrovascular Disorders; Disease Models, Animal; Glucuronidase; Glycogen; Hemiplegia; Hydrolases; Hypoxia; Hypoxia, Brain; Ischemic Attack, Transient; Lysosomes; Male; Mitochondria; Rats

Topics: Acid Phosphatase; Adolescent; Adult; Alkaline Phosphatase; Anemia; Animals; Bacterial Infections; Blood Cell Count; Cerebrovascular Disorders; Female; Gastroenteritis; Histocytochemistry; Humans; Male; Middle Aged; Myocardial Infarction; Neoplasms; Neutrophils; Rabbits; Virus Diseases

Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Axons; Brain Edema; Cerebrovascular Disorders; Dendrites; Female; Histocytochemistry; Hypoxia, Brain; In Vitro Techniques; Ischemia; Lysosomes; Male; Neuroglia; Neurons; Oxidoreductases; Rats; Succinate Dehydrogenase

Topics: Acid Phosphatase; Alanine Transaminase; Aspartate Aminotransferases; Blood-Brain Barrier; Brain Neoplasms; Cerebrospinal Fluid; Cerebrovascular Disorders; Fructose-Bisphosphate Aldolase; Humans