acid-phosphatase and Cardiomegaly

Topics: Acid Phosphatase; Adrenal Cortex Hormones; Animals; Cardiomegaly; Cathepsins; Centrifugation, Density Gradient; Coronary Disease; Fasting; Heart Diseases; Heart Failure; Hormones; Humans; Hyperthyroidism; In Vitro Techniques; Liver; Lysosomes; Myocardial Infarction; Myocardium; Thyroxine

Bones of cardiomyopathic hamsters (UM-X7.1 Syrian hamsters), at 5, 10 and 20 weeks of age, were compared chemically and histomorphologically with those of normal Syrian hamsters. Femurs of UM-X7.1 hamsters were significantly shorter than those of normal hamsters, and the mean dry weight, mean volume, mean ash weight per unit bone volume and mean ash as a percentage of dry weight of femurs were all significantly less in UM-X7.1 hamsters. The bone disorder preceded the myocardial calcium precipitation and myocardial hypertrophy in the cardiomyopathic hamsters. In addition, the percentage of cortical area measured on the cross-section of tibia and the appositional rate of bone minerals, determined by a tetracycline labelling technique, were also lower in the UM-X7.1 hamsters. These findings suggest that the bone disorder was associated with decreased bone formation in the UM-X7.1 Syrian hamsters.

Topics: Acid Phosphatase; Age Factors; Alkaline Phosphatase; Animals; Body Weight; Bone and Bones; Bone Density; Calcium; Cardiomegaly; Cardiomyopathies; Cricetinae; Female; Femur; Mesocricetus; Myocardium; Radiography; Tibia

Using electron microscopy and cytochemical techniques we investigated structures which are associated with long-term hypertension and ageing in the myocardial cell of the rat. Lysosomes, demonstrated by acid phosphatase and aryl sulfatase activities, were found mainly in the perinuclear region in young rats. With age these organelles appeared with increasing frequency in other regions of the cell. Spontaneously hypertensive rats (SHR) showed an earlier apparent migration of lysosomes than did normotensive rats (WKY). Our observations indicate that lysosomes were closely associated with autophagic vacuoles, membrane swirls , translucent mitochondria, myelin figures and other structures linked with degenerative events. In the oldest SHR lysosomes, autolysosomes (autophagic vacuoles with lysosomal activity), and degenerative structures were observed in various regions of the myocardial cell. Peroxisomes, as demonstrated by catalase activity, did not seem to be affected by hypertension or age. A number of dense osmophilic structures did not react for any of the enzymes studied; these included myelin figures, mitochondrial inclusions and diffuse dense bodies. Our observations implicate both ageing and hypertension in the enhancement of lysosomes and their end products.

Topics: Acid Phosphatase; Animals; Arylsulfatases; Autophagy; Cardiomegaly; Catalase; Histocytochemistry; Hypertension; Lysosomes; Microbodies; Microscopy, Electron; Myocardium; Rats; Rats, Inbred Strains; Sulfatases

Topics: Acetylglucosaminidase; Acid Phosphatase; Animals; Body Weight; Cardiomegaly; Cathepsins; Creatine Kinase; Desoxycorticosterone; Hexosaminidases; Hypertension; Lysosomes; Male; Myocardium; Organ Size; Rats; Sodium Chloride

Severe cardiac hypertrophy has been produced experimentally in rats by long-term, low-dose treatment with tri-iodothyroacetic acid. The dose used was insufficient to cause any apparent systemic or metabolic effect. It is suggested that similar iodinated substances in the blood in man, resulting from normal or abnormal thyroid hormone catabolism, may be causally related to some forms of cardiomyopathy.

Topics: Acetates; Acid Phosphatase; Alkaline Phosphatase; Animals; Cardiomegaly; Disease Models, Animal; Glycogen; Heart; Heart Ventricles; Mitochondria, Muscle; Myocardium; Organ Size; Rats; Succinate Dehydrogenase; Triiodothyronine

Topics: Acid Phosphatase; Animals; Body Weight; Cardiomegaly; Cathepsins; Creatine Kinase; Disease Models, Animal; Heart Ventricles; Hexosaminidases; Hyperthyroidism; Lysosomes; Male; Myocardium; Organ Size; Proteins; Rats; Remission, Spontaneous; Thyroxine

Topics: Acid Phosphatase; Cardiomegaly; Cardiomyopathies; Esterases; Glycogen; Humans; Lysosomes; Microscopy, Electron; Mitochondria, Muscle; Myocardial Contraction; Myocardium; NADH, NADPH Oxidoreductases

Topics: Acid Phosphatase; Animals; Cardiomegaly; Cathepsins; Dogs; Heart Failure; Lysosomes; Myocardium; Pulmonary Valve Stenosis; Ribonucleases

Topics: Acid Phosphatase; Adult; Amniocentesis; Cardiomegaly; Female; Fetal Diseases; Genes, Recessive; Glucose; Glucosidases; Glycogen Storage Disease; Heart Defects, Congenital; Heart Diseases; Heterozygote; Humans; Infant, Newborn; Lectins; Lymphocytes; Male; Myocardium; Pregnancy; Prenatal Diagnosis; Syndrome; Time Factors

Topics: Acid Phosphatase; Adenosine Triphosphatases; Alkaline Phosphatase; Animals; Calcium; Cardiomegaly; Dihydrolipoamide Dehydrogenase; Electron Transport Complex IV; Esterases; Heart Failure; Histocytochemistry; Histological Techniques; Leucyl Aminopeptidase; Malate Dehydrogenase; Male; Myocardium; Nucleotidases; Oxidoreductases; Potassium; Rats; Sodium; Succinate Dehydrogenase