acid-phosphatase and Carcinoma--Basal-Cell

Adenoid basal cell carcinoma (ABC) is considered a rare cervical neoplasm which when present in 'pure' form, uniquely amongst apparently malignant cervical tumours, has never been reported to metastasise or lead to fatal patient outcome. We recently encountered a case of ABC that was morphologically reminiscent of prostatic differentiation, more specifically basal cell hyperplasia of the prostate. Immunohistochemistry was strongly positive for the prostate related marker NKX3.1 in the glandular cells, but there was no expression of prostate specific antigen (PSA) or prostatic acid phosphatase (PAP). However, subsequent review of five additional cervical ABCs demonstrated focal PAP expression in two of four tested cases, and all were NKX3.1 positive. NKX3.1 expression was also demonstrated in the glandular epithelium of 10 additional gynaecological lesions considered to show prostatic differentiation including five cases of cervical ectopic prostatic tissue, three ovarian teratomas with prostatic differentiation, and two vaginal tubulosquamous polyps. We suggest that some lesions traditionally classified as ABC may in fact represent a variant of prostatic differentiation within the cervix, possibly analogous to basal cell hyperplasia of the prostate.

Topics: Acid Phosphatase; Aged; Biomarkers, Tumor; Carcinoma, Basal Cell; Cell Differentiation; Cervix Uteri; Female; Homeodomain Proteins; Humans; Hyperplasia; Immunohistochemistry; Male; Middle Aged; Prostate; Prostate-Specific Antigen; Prostatic Neoplasms; Transcription Factors; Uterine Cervical Neoplasms

Topics: Acid Phosphatase; Adenocarcinoma; Carcinoma in Situ; Carcinoma, Adenoid Cystic; Carcinoma, Basal Cell; Cervix Uteri; Choristoma; Diagnosis, Differential; Female; Humans; Male; Middle Aged; Prostate; Prostate-Specific Antigen; Protein Tyrosine Phosphatases; Uterine Cervical Diseases; Uterine Cervical Neoplasms

Basal cell hyperplasia (BCH) is an uncommon proliferative lesion of the prostate gland. We studied ten cases of BCH, one case of an unusual adenoid basal cell tumor (ABT), and one case of a prostatic adenoid cystic carcinoma (ACC), using a panel of antibodies to define the histogenesis of these lesions. Monoclonal antibodies (MoAb) directed against a cytokeratin, which selectively stains basal cells (34 beta E12), and against muscle-specific actin, which stains myoepithelial cells (HHF35), were used. In addition, antibodies directed against prostatic acid phosphatase (PAP), prostate-specific antigen (PSA), S-100 protein, and vimentin were used. In the normal prostate, epithelial cells reacted positively with 34 beta E12, PAP, and PSA, and negatively with the actin, S-100 protein, and vimentin antibodies. In BCH, positive staining was seen for 34 beta E12, PSA, and PAP, with no reactivity for actin, S-100 protein, and vimentin. In ABT and ACC, positive reactivity was demonstrated for all antibodies except actin and vimentin. These findings indicate that the basaloid cells of BCH, ABT, and ACC are derived from basal cells of the normal prostate gland and suggest a continuum among the three lesions. The presence of S-100 protein in ABT and ACC may be related to the lack of this antigen's specificity for myoepithelial cells. The absence of reactivity with the HHF35 MoAb supports our belief that the S-100 positivity does not necessarily indicate myoepithelial cell differentiation.

Topics: Acid Phosphatase; Actins; Carcinoma, Adenoid Cystic; Carcinoma, Basal Cell; Humans; Immunoenzyme Techniques; Keratins; Male; Prostatic Hyperplasia; Prostatic Neoplasms; S100 Proteins; Vimentin

Topics: Acid Phosphatase; Carcinoma, Basal Cell; Clinical Enzyme Tests; Diagnosis, Differential; Fibrosarcoma; Histiocytoma, Benign Fibrous; Humans; Liposarcoma; Rhabdomyosarcoma; Soft Tissue Neoplasms; Tartrates

In 1969, Freeman and Winkelmann reported two cases of basal cell tumors with features of eccrine differentiation. On the basis of subsequent personal cases and isolated literature reports, we wish to emphasize the characteristics of this tumor. It is an infiltrating basaloid growth, usually on the scalp or head, that frequently recurs, apparently because of inadequate excision. Basaloid, alveolar, and cystic epithelial masses, which constitute the tumor, may be seen individually or together. Areas that appear to be morpheaform epithelioma or similar to syringoma can be observed. Enzyme studies reveal phosphorylase and focal lysosomal enzymes such as acid phosphatase. Acid mucopolysaccharides are present in foci. Electron microscopy shows epithelial masses with eccrine duct features. Eccrine epithelioma is a rare tumor that may be mistaken for syringoma, basal cell carcinoma, adenocystic carcinoma, sweat gland carcinoma, or metastatic tumor. Its differentiation toward eccrine structure and function predicts the chronic, recurrent, locally infiltrative clinical course observed in patients to date.

Topics: Acid Phosphatase; Carcinoma, Basal Cell; Female; Glycosaminoglycans; Histocytochemistry; Humans; Middle Aged; Phosphorylases; Scalp; Skin Neoplasms

Topics: Acid Phosphatase; Carcinoma, Basal Cell; Desmosomes; Humans; Inclusion Bodies; Lysosomes; Macrophages; Microscopy, Electron; Phagocytosis; Skin Neoplasms

Topics: Acid Phosphatase; Carcinoma, Basal Cell; Cell Membrane; Histocytochemistry; Humans; Macrophages; Microscopy, Electron; Phagocytosis; Radiation Effects; Skin Neoplasms

Topics: Acid Phosphatase; Alkaline Phosphatase; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Histocytochemistry; Humans; Skin Neoplasms

Topics: Acid Phosphatase; Alkaline Phosphatase; Blood Vessels; Carcinoma, Basal Cell; Carcinoma, Basosquamous; Carcinoma, Squamous Cell; Female; Histocytochemistry; Humans; Male; Phagocytosis; Radiotherapy Dosage; Skin Neoplasms

Topics: Acid Phosphatase; Aged; Carcinoma, Basal Cell; Female; Glucosyltransferases; Histocytochemistry; Humans; Male; Microscopy, Electron; Middle Aged; Neck; Scalp; Skin Neoplasms; Succinate Dehydrogenase

Topics: Acid Phosphatase; Adult; Aged; Alkaline Phosphatase; Aminopeptidases; Carcinoma, Basal Cell; Enzymes; Esterases; Female; Histocytochemistry; Humans; L-Lactate Dehydrogenase; Malate Dehydrogenase; Male; Oxidoreductases; Succinate Dehydrogenase

Topics: Acid Phosphatase; Adenosine Triphosphatases; Alkaline Phosphatase; Aminosalicylic Acids; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Deoxyribonucleases; Histocytochemistry; Humans; Keratoacanthoma