acid-phosphatase and Carcinoma--Adenoid-Cystic

Adenoid cystic carcinoma is an unusual histological variant of prostatic carcinoma. Because of its rarity, the natural history of this tumor is not known. Here we report this rare entity in a 62-year-old man who presented with symptoms of urinary tract obstruction. Digital rectal examination and ultrasonography (USG) showed an enlarged hard nodular prostate. Serum prostate-specific antigen (PSA) and prostatic acid phosphate levels were found to be within the normal range. Transrectal ultrasound-guided 12 core biopsies of prostate showed morphological features of an adenoid cystic carcinoma in 8 cores (bilateral, mid and base) on histopathological examination. Immunohistochemistry performed for PSA on paraffin section was negative. After diagnosis, bilateral orchidectomy was performed, and hormonal therapy was started in the form of androgen receptor blocker. The patient was clinically stable during a limited follow up of six months.

Topics: Acid Phosphatase; Androgen Antagonists; Biomarkers; Biopsy; Carcinoma, Adenoid Cystic; Chemotherapy, Adjuvant; Digital Rectal Examination; Humans; Immunohistochemistry; Male; Middle Aged; Orchiectomy; Prostate-Specific Antigen; Prostatic Neoplasms; Protein Tyrosine Phosphatases; Treatment Outcome

Topics: Acid Phosphatase; Alkaline Phosphatase; Carcinoma, Adenoid Cystic; Glucosyltransferases; Histocytochemistry; Humans; Leucyl Aminopeptidase; Microscopy, Electron; Skin Neoplasms; Succinate Dehydrogenase; Sweat Gland Neoplasms

Topics: Acid Phosphatase; Adenocarcinoma; Carcinoma in Situ; Carcinoma, Adenoid Cystic; Carcinoma, Basal Cell; Cervix Uteri; Choristoma; Diagnosis, Differential; Female; Humans; Male; Middle Aged; Prostate; Prostate-Specific Antigen; Protein Tyrosine Phosphatases; Uterine Cervical Diseases; Uterine Cervical Neoplasms

Basal cell hyperplasia (BCH) is an uncommon proliferative lesion of the prostate gland. We studied ten cases of BCH, one case of an unusual adenoid basal cell tumor (ABT), and one case of a prostatic adenoid cystic carcinoma (ACC), using a panel of antibodies to define the histogenesis of these lesions. Monoclonal antibodies (MoAb) directed against a cytokeratin, which selectively stains basal cells (34 beta E12), and against muscle-specific actin, which stains myoepithelial cells (HHF35), were used. In addition, antibodies directed against prostatic acid phosphatase (PAP), prostate-specific antigen (PSA), S-100 protein, and vimentin were used. In the normal prostate, epithelial cells reacted positively with 34 beta E12, PAP, and PSA, and negatively with the actin, S-100 protein, and vimentin antibodies. In BCH, positive staining was seen for 34 beta E12, PSA, and PAP, with no reactivity for actin, S-100 protein, and vimentin. In ABT and ACC, positive reactivity was demonstrated for all antibodies except actin and vimentin. These findings indicate that the basaloid cells of BCH, ABT, and ACC are derived from basal cells of the normal prostate gland and suggest a continuum among the three lesions. The presence of S-100 protein in ABT and ACC may be related to the lack of this antigen's specificity for myoepithelial cells. The absence of reactivity with the HHF35 MoAb supports our belief that the S-100 positivity does not necessarily indicate myoepithelial cell differentiation.

Topics: Acid Phosphatase; Actins; Carcinoma, Adenoid Cystic; Carcinoma, Basal Cell; Humans; Immunoenzyme Techniques; Keratins; Male; Prostatic Hyperplasia; Prostatic Neoplasms; S100 Proteins; Vimentin

Adenoid cystic carcinoma occurs most commonly in the major and minor salivary glands, but also has been recognized in numerous other locations. Adenoid cystic carcinoma of the prostate gland is, however, extremely uncommon with only two other reported cases. The authors have studied a case of adenoid cystic carcinoma of the prostate with immunoperoxidase staining for both prostate-specific acid phosphatase and prostate-specific antigen, which have been shown to be specific for normal prostatic epithelium and prostatic carcinoma. The negative staining for these antigens in this tumor distinguishes adenoid cystic carcinoma from the usual acinic adenocarcinomas of the prostate, and suggests an origin from periurethral glands or metaplastic urethral mucosa.

Topics: Acid Phosphatase; Aged; Antigens, Neoplasm; Carcinoma, Adenoid Cystic; Humans; Male; Prostate; Prostate-Specific Antigen; Prostatic Neoplasms; Substrate Specificity

Topics: Acid Phosphatase; Age Factors; Alkaline Phosphatase; Carcinoma, Adenoid Cystic; Female; Humans; Leucyl Aminopeptidase; Male; Microscopy, Electron; Middle Aged; Ribosomes; Salivary Gland Neoplasms

Topics: Acid Phosphatase; Adenoma; Adenosine Triphosphatases; Alkaline Phosphatase; Aminopeptidases; Bronchial Neoplasms; Carcinoma, Adenoid Cystic; Carcinoma, Bronchogenic; Clinical Enzyme Tests; Diagnosis, Differential; Dihydrolipoamide Dehydrogenase; Esterases; Glucosephosphate Dehydrogenase; Glutamate Dehydrogenase; Glycerolphosphate Dehydrogenase; Hamartoma; Histocytochemistry; Humans; Isocitrate Dehydrogenase; L-Lactate Dehydrogenase; Leiomyoma; Lung Neoplasms; Malate Dehydrogenase; Nucleotidases; Phosphogluconate Dehydrogenase; Succinate Dehydrogenase

Topics: Acid Phosphatase; Adenocarcinoma, Mucinous; Adenoma; Adenoma, Pleomorphic; Adenosine Triphosphatases; Adult; Aged; Alkaline Phosphatase; Carcinoma, Adenoid Cystic; Cystadenoma; Dihydrolipoamide Dehydrogenase; Female; Glucosephosphate Dehydrogenase; Histocytochemistry; Humans; Leucyl Aminopeptidase; Male; Middle Aged; Monoamine Oxidase; Parotid Neoplasms; Salivary Gland Neoplasms; Succinate Dehydrogenase

Topics: Acid Phosphatase; Alkaline Phosphatase; Biopsy; Carcinoma, Adenoid Cystic; Ear Neoplasms; Ear, External; Esterases; Exocrine Glands; Glycogen; Histocytochemistry; Humans; Lipids; Microscopy, Electron; Salivary Gland Neoplasms; Succinate Dehydrogenase; Tracheal Neoplasms

Topics: Acid Phosphatase; Aged; Alkaline Phosphatase; Aminopeptidases; Carcinoma, Adenoid Cystic; Esterases; Female; Galactosidases; Humans; In Vitro Techniques; Male; Middle Aged; Salivary Gland Neoplasms; Salivary Glands; Succinate Dehydrogenase

Topics: Acid Phosphatase; Adenosine Triphosphatases; Aminopeptidases; Carcinoma, Adenoid Cystic; Esterases; Glucuronidase; Histocytochemistry; Humans; Nucleotidases; Phosphorylase Kinase; Skin Neoplasms; Succinate Dehydrogenase; Sweat Glands

Topics: Acid Phosphatase; Adenoma, Sweat Gland; Alkaline Phosphatase; Carcinoma, Adenoid Cystic; Carcinoma, Intraductal, Noninfiltrating; Cysts; Electron Transport Complex IV; Glucosyltransferases; Glucuronidase; Histocytochemistry; Humans; Leucyl Aminopeptidase; Nucleotidases; Oxidoreductases; Phosphoric Monoester Hydrolases; Skin Neoplasms; Succinate Dehydrogenase