acid-phosphatase and Carcinogenesis

The inactivation of tumor suppressor genes (TSGs) plays a vital role in the progression of human cancers. Nevertheless, those ubiquitous TSGs have been shown with limited roles in various stages of diverse carcinogenesis. Investigation on identifying unique TSG, especially for early stage of carcinogenesis, is imperative. As such, the search for organ-specific TSGs has emerged as a major strategy in cancer research. Prostate cancer (PCa) has the highest incidence in solid tumors in US males. Cellular prostatic acid phosphatase (cPAcP) is a prostate-specific differentiation antigen. Despite intensive studies over the past several decades on PAcP as a PCa biomarker, the role of cPAcP as a PCa-specific tumor suppressor has only recently been emerged and validated. The mechanism underlying the pivotal role of cPAcP as a prostate-specific TSG is, in part, due to its function as a protein tyrosine phosphatase (PTP) as well as a phosphoinositide phosphatase (PIP), an apparent functional homologue to phosphatase and tensin homolog (PTEN) in PCa cells. This review is focused on discussing the function of this authentic prostate-specific tumor suppressor and the mechanism behind the loss of cPAcP expression leading to prostate carcinogenesis. We review other phosphatases' roles as TSGs which regulate oncogenic PI3K signaling in PCa and discuss the functional similarity between cPAcP and PTEN in prostate carcinogenesis.

Topics: Acid Phosphatase; Animals; Carcinogenesis; Epithelium; Genes, Tumor Suppressor; Humans; Male; Prostate; Prostatic Neoplasms; Protein Tyrosine Phosphatases; PTEN Phosphohydrolase; Sequence Homology

This study aimed to radiolabel finasteride, a novel 5α-reductase inhibitor, to evaluate its cancer targeting potential in experimental model of prostate carcinogenesis. Finasteride was effectively radiolabeled with

Topics: Acid Phosphatase; Animals; Carcinogenesis; Carcinogens; Disease Models, Animal; Electrophoresis; Finasteride; Hydrogen-Ion Concentration; Kinetics; Male; Methylnitrosourea; Prostate; Prostatic Neoplasms; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Technetium; Time Factors; Tissue Distribution

XB130 is a cytosolic adaptor protein involved in various physiological processes and oncogenesis of certain malignancies, but its role in the development of prostate cancer remains unclear. In current study, we examined XB130 expression in prostate cancer tissues and found that XB130 expression was remarkably increased in prostate cancer tissues and significantly correlated with increased prostate specific antigen (PSA), free PSA (f-PSA), prostatic acid phosphatase (PAP) and T classification. Patients with highly expressed XB130 had significantly decreased survival, which suggested XB130 as a possible prognostic indicator for prostate cancer. In vitro experiments showed that reduced XB130 expression restrained tumor growth both in vitro and in vivo. Furthermore, XB130 knockdown hindered transition of G1 to S phase in prostate cancer cell line DU145 and LNCap, which might contribute to the inhibition of cellular proliferation. Results from transwell assay demonstrated that downregulation of XB130 may attenuate invasion and metastasis of prostate cancer. Semiquantitative analysis of Western blot suggested that decreased XB130 expression was accompanied by diminished Akt signaling and EMT process. Thus, above observations suggest that XB130 may be a novel molecular marker and potent therapeutic target for prostate cancer.

Topics: Acid Phosphatase; Adaptor Proteins, Signal Transducing; Biopsy; Carcinogenesis; Cell Growth Processes; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Humans; Male; Neoplasm Metastasis; Oncogene Protein v-akt; Prostate-Specific Antigen; Prostatic Neoplasms; RNA, Small Interfering; Signal Transduction; Up-Regulation

Topics: Acid Phosphatase; Animals; Carcinogenesis; Carcinoma; Carcinoma, Squamous Cell; Cheek; Cricetinae; Epithelial Cells; Histocytochemistry; Humans; Lysosomes; Mouth Neoplasms; Neoplasms, Experimental; Papilloma; Research

Topics: Acid Phosphatase; Animals; Carcinogenesis; Esterases; Glycoside Hydrolases; Neoplasms, Experimental; Phosphoric Monoester Hydrolases; Skin Neoplasms; Sulfhydryl Compounds