acid-phosphatase and Bronchial-Neoplasms

Endobronchial metastases can manifest clinical symptoms and x-ray findings mimicking a centrally located bronchogenic carcinoma. The authors recently encountered a case of endobronchial metastasis from a mucinous adenocarcinoma of the prostate that was originally diagnosed as a primary bronchogenic carcinoma. The correct diagnosis was made on the basis of the morphologic similarities between the primary prostatic lesion and the lung lesion and was corroborated by immunohistochemical analyses.

Topics: Acid Phosphatase; Adenocarcinoma, Mucinous; Aged; Bronchial Neoplasms; Carbazoles; Carcinoembryonic Antigen; Humans; Immunohistochemistry; Male; Prostatic Neoplasms; Staining and Labeling

Topics: Acid Phosphatase; Adult; Bronchial Neoplasms; Bronchitis; Chronic Disease; Female; Glucuronidase; Humans; Male; Ribonucleases; Sputum

The measurement of the activity of acid hydrolases and of alkaline phosphatase in bronchial aspirates obtained through bronchoscopic procedures from a series of 300 patients forms the basis for a screening program to diagnose bronchial malignant neoplasms more effectively. We define such a screening test as one permitting rapid measurements indicative of pathologic abnormalities and producing a preliminary diagnosis which, if in error, yields preferably a false-positive result. Using this approach, we demonstrated that an elevation of the activity of alkaline phosphatase or cathepsin D predicts a 50 percent likelihood of cancer, but elevation of both the concentrations of alkaline phosphatase and cathepsin D has an additive prediction of 71 percent. Data obtained in this study showed that the presence of a pulmonary tumor can cause increased levels of alkaline phosphatase or cathepsin D (or both) in bronchial aspirates before the presently accepted methods yield a diagnostic result. Furthermore, those patients with an elevated activity of alkaline phosphatase or cathepsin D (or both) but with no histologically demonstrable pulmonary carcinoma can be reexamined intermittently.

Topics: Acid Phosphatase; Alkaline Phosphatase; Bronchi; Bronchial Neoplasms; Cathepsins; Glucuronidase; Glycerophosphates; Humans; Hydrolases; Lysosomes; Middle Aged; Phosphoric Monoester Hydrolases; Suction

Topics: Acid Phosphatase; Bronchial Neoplasms; Carcinoma; Humans; Male; Middle Aged; Neoplasm Metastasis; Pancreas; Pancreatic Neoplasms; Tartrates

The measurement of acid and alkaline phosphatase and cathepsin activities in bronchial aspirates obtained through bronchoscopy from a series of 75 patients suggests a procedure that may have value as a routine diagnostic examination. Using this approach, seven patients with neoplasms in the lung showed elevated levels of alkaline phosphatase and cathepsin in bronchial aspirates without elevation in acid phosphatase activity.

Topics: Acid Phosphatase; Alkaline Phosphatase; Bronchi; Bronchial Neoplasms; Bronchitis; Bronchoscopy; Cathepsins; Humans; Isoenzymes; Lung Neoplasms

Topics: Acid Phosphatase; Adenocarcinoma; Adenosine Triphosphatases; Alkaline Phosphatase; Bronchi; Bronchial Neoplasms; Carcinoma, Squamous Cell; Esterases; Giant Cell Tumors; Glucosephosphate Dehydrogenase; Glutamate Dehydrogenase; Glycerolphosphate Dehydrogenase; Humans; Isocitrate Dehydrogenase; L-Lactate Dehydrogenase; Lung; Lung Neoplasms; Malate Dehydrogenase; NADH, NADPH Oxidoreductases; Neoplasm Metastasis; Oxidoreductases; Phosphogluconate Dehydrogenase; Phosphoric Monoester Hydrolases; Succinate Dehydrogenase

Topics: Acid Phosphatase; Adenoma; Adenosine Triphosphatases; Alkaline Phosphatase; Aminopeptidases; Bronchial Neoplasms; Carcinoma, Adenoid Cystic; Carcinoma, Bronchogenic; Clinical Enzyme Tests; Diagnosis, Differential; Dihydrolipoamide Dehydrogenase; Esterases; Glucosephosphate Dehydrogenase; Glutamate Dehydrogenase; Glycerolphosphate Dehydrogenase; Hamartoma; Histocytochemistry; Humans; Isocitrate Dehydrogenase; L-Lactate Dehydrogenase; Leiomyoma; Lung Neoplasms; Malate Dehydrogenase; Nucleotidases; Phosphogluconate Dehydrogenase; Succinate Dehydrogenase

Topics: Acid Phosphatase; Alkaline Phosphatase; Bone Neoplasms; Bronchial Neoplasms; Carcinoma; Esterases; Glycerolphosphate Dehydrogenase; Histocytochemistry; Humans; Kidney Neoplasms; L-Lactate Dehydrogenase; Leukocytes; Lymphoma, Non-Hodgkin; Male; Melanoma; Neoplasms; Peroxidases; Pharyngeal Neoplasms; Rectal Neoplasms; Sarcoma; Staining and Labeling; Succinate Dehydrogenase; Testicular Neoplasms