acid-phosphatase and Brain-Neoplasms

Topics: Acid Phosphatase; Animals; Brain Neoplasms; Glioma; Glucuronidase; Humans; Lysosomes; Meningioma; Neoplasms, Experimental; Neuroma; Rats

Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Brain Neoplasms; Breast Neoplasms; Carcinoma, Hepatocellular; Catalase; DNA Nucleotidyltransferases; Fructose-Bisphosphate Aldolase; Glycine Hydroxymethyltransferase; Hexokinase; Hodgkin Disease; Intestinal Neoplasms; Isoenzymes; L-Lactate Dehydrogenase; Leukemia; Liver; Liver Neoplasms; Lung Neoplasms; Neoplasms; Pyruvate Kinase; Ribonucleotides; Sarcoma, Experimental; Stomach Neoplasms; Uridine Kinase

Glioblastoma multiforme is one of the most malignant types of cancer. This is mainly due to a cell subpopulation with an extremely aggressive potential, called glioblastoma stem-like cells (GSCs). These cells produce high levels of extracellular adenosine which has been associated with increased chemoresistance, migration, and invasion in glioblastoma. In this study, we attempted to elucidate the mechanisms that control extracellular adenosine levels in GSC subtypes. By using primary and U87MG-derived GSCs, we associated increased extracellular adenosine with the mesenchymal phenotype. [

Topics: 5'-Nucleotidase; Acid Phosphatase; Adenosine; Biological Transport; Brain Neoplasms; Cell Line, Tumor; Equilibrative Nucleoside Transporter 1; Extracellular Space; Glioblastoma; GPI-Linked Proteins; Humans; Neoplastic Stem Cells

Prostatic Acid Phosphatase (PAP) is an enzyme that is produced primarily in the prostate and functions as a cell growth regulator and potential tumor suppressor. Understanding the genetic regulation of this enzyme is important because PAP plays an important role in prostate cancer and is expressed in other tissues such as the brain.. We tested association between 5.8 M SNPs and PAP levels in cerebrospinal fluid across 543 individuals in two datasets using linear regression. We then performed meta-analyses using METAL =with a significance threshold of p < 5 × 10(-8) and removed SNPs where the direction of the effect was different between the two datasets, identifying 289 candidate SNPs that affect PAP cerebrospinal fluid levels. We analyzed each of these SNPs individually and prioritized SNPs that had biologically meaningful functional annotations in wANNOVAR (e.g. non-synonymous, stop gain, 3' UTR, etc.) or had a RegulomeDB score less than 3.. Thirteen SNPs met our criteria, suggesting they are candidate causal alleles that underlie ACPP regulation and expression.. Given PAP's expression in the brain and its role as a cell-growth regulator and tumor suppressor, our results have important implications in brain health such as cancer and other brain diseases including neurodegenerative diseases (e.g., Alzheimer's disease and Parkinson's disease) and mental health (e.g., anxiety, depression, and schizophrenia).

Topics: Acid Phosphatase; Aged; Aged, 80 and over; Alleles; Alzheimer Disease; Brain; Brain Neoplasms; Gene Expression Regulation, Enzymologic; Gene Frequency; Genome-Wide Association Study; Genotype; Humans; Linear Models; Meta-Analysis as Topic; Middle Aged; Neurodegenerative Diseases; Polymorphism, Single Nucleotide; Risk Factors

Somatic cells do not have telomerase activity but immortalized cell lines and more than 85 % of the cancer cells show telomerase activation to prevent the telomere from progressive shortening. The activation of this enzyme has been found in a variety of human tumors and tumor-derived cell lines, but only few studies on telomerase activity in human brain tumors have been reported. Here, we evaluated telomerase activity in different grades of human astrocytoma and meningioma brain tumors. In this study, assay for telomerase activity performed on 50 eligible cases consisted of 26 meningioma, 24 astrocytoma according to the standard protocols. In the brain tissues, telomerase activity was positive in 39 (65 %) of 50 patients. One sample t test showed that the telomerase activity in meningioma and astrocytoma tumors was significantly positive entirely (P < 0.001). Also, grade I of meningioma and low grades of astrocytoma (grades I and II) significantly showed telomerase activity. According to our results, we suggest that activation of telomerase is an event that starts mostly at low grades of brain including meningioma and astrocytoma tumors.

Topics: Acid Phosphatase; Adult; Aged; Astrocytoma; Brain Neoplasms; Enzyme-Linked Immunosorbent Assay; Female; Humans; Isoenzymes; Male; Meningioma; Middle Aged; Neoplasm Grading; Tartrate-Resistant Acid Phosphatase; Telomerase

Aberrations of genes/proteins regulating cell cycle and growth, increased proliferation and telomerase activity (TA) are documentable in glioblastoma multiforme. TA is more frequently detectable in secondary glioblastoma, which is also characterized by p53 mutation/overexpression. Discordant telomere (Te) length values have been reported in glioblastomas with and without TA. In 31 glioblastomas, in which pre-existing astrocytoma was not documented, we compared cases with and without TA for the expression of p53, EGFR, c-Myc, MIB-1 and Topoisomerase IIalpha; p53 mutations were also investigated by SSCP-PCR. Correlations were made with Te parameters [TePs: number (TeNo), length and area] as evaluated by image analysis in interphase nuclei of fluorescence in situ hybridization (FISH)-processed sections. We found no differences in the expression of the proteins evaluated and in TePs, except Te/nuclear area %, which was significantly lower in TA+ cases (p=0.02). TePs were, instead, inversely correlated with TA (p=0.0001). TA was positively correlated with MIB1 staining index in the TA+ cases (p=0.033), which also showed a positive correlation between TeNo and EGFR expression (p=0.042), and a trend towards a negative correlation between TeNo and p53 expression (p=0.05). Tumors overexpressing EGFR had a significantly shorter lifetime (p=0.0001). TeNo seems to be inversely correlated to tumor proliferation and lifetime in glioblastoma multiforme.

Topics: Acid Phosphatase; Adolescent; Adult; Antigens, Neoplasm; Brain Neoplasms; Cell Division; Child; DNA Topoisomerases, Type II; DNA-Binding Proteins; ErbB Receptors; Glioblastoma; Humans; Image Processing, Computer-Assisted; In Situ Hybridization, Fluorescence; Isoenzymes; Ki-67 Antigen; Middle Aged; Polymorphism, Single-Stranded Conformational; Proto-Oncogene Proteins c-myc; Tartrate-Resistant Acid Phosphatase; Telomerase; Telomere; Tumor Suppressor Protein p53

The authors report a patient who was admitted to the hospital with neurologic symptoms and signs that were thought to be caused by a primary intracranial tumor.. Craniotomy resulted in successful resection of an occipital lobe tumor reported histologically as a papillary adenocarcinoma, probably metastatic from the kidney. However, a complete diagnostic study failed to demonstrate the primary focus.. Thirteen months later, the patient was readmitted to the hospital and found to have metastatic prostatic carcinoma. Immunoperoxidase staining for prostatic acid phosphatase of the prostatic tissue and of the previously resected brain tumor tissue indicated that the brain lesion was metastatic from the prostate.

Topics: Acid Phosphatase; Adenocarcinoma, Papillary; Aged; Brain Neoplasms; Carcinoembryonic Antigen; Humans; Lumbar Vertebrae; Male; Prostatic Neoplasms; Spinal Neoplasms; Tomography, X-Ray Computed

This study is a quantitative analysis of acid and alkaline phosphatase activity in human brain tumor homogenates and subcellular fractions, in parallel with normal brain tissue. Glioblastoma multiforme, meningioma, astrocytoma and normal tissue samples were separated by ultracentrifugation into five subcellular fractions: nuclei (N), mitochondria (M), microsomes (P), ribosomes (R) and supernatant (S). These two phosphatases showed significant increase in astrocytoma and meningioma tissue homogenates, compared with normal brain tissue. Alkaline phosphatase levels were determined to increase significantly in glioblastoma multiforme tissue homogenates as compared with normals, while those of acid phosphatase were observed to decrease. The results of this investigation also indicate that the subcellular distributions of acid and alkaline phosphatase show differences in the different tumor types. This observation is evidence against metabolic uniformity in tumoral tissue.

Topics: Acid Phosphatase; Alkaline Phosphatase; Brain Neoplasms; Humans; Subcellular Fractions

Topics: Acid Phosphatase; Brain Neoplasms; Clinical Enzyme Tests; Glucuronidase; Hexosaminidases; Humans; Lysosomes

Topics: Acid Phosphatase; Brain; Brain Neoplasms; Culture Techniques; Glucuronidase; Humans; Neurons

We have presented a case of typical alveolar soft part sarcoma probably originating from the soft tissues of the retroperitoneum with metastasis to the brain. An ultrastructural study including histochemical observation of the metastatic lesion was performed to clarify the nature of the crystals characteristic to the tumor cells of this disease. The crystalline structures have acid phosphatase activity at a histological and ultrastructural level. Our results suggested that they might be derived from coalescence of primary lysosomes or by digestive disintegration of some protein.

Topics: Acid Phosphatase; Adult; Brain Neoplasms; Crystallization; Humans; Inclusion Bodies; Male; Microscopy, Electron; Occipital Lobe; Retroperitoneal Neoplasms; Sarcoma

The clinical application of an immunohistochemical technique for prostatic acid phosphatase allowed the accurate diagnosis of metastatic prostatic carcinoma in 17 patients whose condition was not recognized by either clinical or histologic observations. The cardinal manifestations in these 17 patients included supraclavicular lymphadenopathy in 7, hilar lymphadenopathy in 1, pulmonary infiltration in 2, simulating carcinoma of the rectum in 4, fracture of femur in 1, orbital tumor in 1, and brain tumor in 1. A retrospective analysis of the radiologic features of these patients showed that the unusual manifestations were due to the route of metastasis, that is, direct invasion, lymphatic, and hematogenous. Radiologic studies, even in these unusual cases, are both useful in establishing the diagnosis and helpful in delineating the mode of metastasis of prostatic carcinoma.

Topics: Acid Phosphatase; Adenocarcinoma; Aged; Bone Neoplasms; Brain Neoplasms; Histocytochemistry; Humans; Immunoenzyme Techniques; Lymphatic Metastasis; Male; Middle Aged; Paranasal Sinus Neoplasms; Prostatic Neoplasms; Rectal Neoplasms; Retroperitoneal Neoplasms; Tomography, X-Ray Computed

Isozyme patterns for five acid hydrolases, acid phosphatase (AP), aryl-sulfate (AS), beta-glucuronidase (beta-Glu), N-acetylglucosaminidase (NAG) and beta-galactosidase (beta-Gal), were studied in isolated lysosomes from ethylnitrosourea (ENU)-induced gliomas and compared with normal and newborn rat brains. With polyacrylamide gel electrophoresis (PAGE), AP was separated into three bands, acidic (A), intermediate (B) and basic (C). In tumors and newborn brains there was a decrease in A and C but a significant increase in B. For NAG the acidic form was elevated by 9-19% in tumors, while newborn brains showed a 19% decrease. Even though the band intensities of beta-Glu in tumors and newborn brains were increased, the relative distribution remained similar to normal brain. With isoelectric focusing, five hydrolases were separated into four to five distinct forms. In ENU-induced gliomas the intensities of all peaks were considerably increased, but in most cases the number of isozymes remained the same. In tumors the isoelectric points were shifted towards the acidic side and smaller peaks in the basic regions merged into more acidic peaks. This effect was especially evident for AP and Gal. In the cases of AS, beta-Glu and NAG, consistently more activity was associated with acidic peaks than with the basic ones. Our data indicates that there is a significant increase in acidic forms of some of the lysosomal hydrolases studied in ENU-induced brain tumors.

Topics: Acetylglucosaminidase; Acid Phosphatase; Animals; Arylsulfatases; beta-Galactosidase; Brain; Brain Neoplasms; Ethylnitrosourea; Glucuronidase; Isoelectric Focusing; Isoenzymes; Lysosomes; Neoplasms, Experimental; Rats; Rats, Inbred Strains

The stability of lysosomes is a function of osmotic pressure, temperature and time. Detailed studies have shown that the release and availability of lysosomal enzymes changes according to the degree of membrane permeability. This paper describes a modification of the controlled temperature and osmotic freezing-sectioning technique for characterization of lysosomal stability in brain tumors. The method is based on the enzyme measurements of released acid phosphatase from sections of unfixed tissue under appropriate physical conditions. The results suggest the possibility of a relation between lysosomal stages of activation, enzyme latency and brain tumor malignancy.

Topics: Acid Phosphatase; Brain Neoplasms; Cell Membrane Permeability; Humans; Lysosomes; Neoplasm Staging

Topics: Acid Phosphatase; Asparaginase; Brain Neoplasms; Child; Child, Preschool; Cytarabine; Humans; Infant; Leukemia, Lymphoid; Lymphadenitis; Prognosis; Risk; T-Lymphocytes

Topics: Acid Phosphatase; Animals; Brain Injuries; Brain Neoplasms; Enzyme Activation; Glucuronidase; Humans; Lysosomes; Neoplasms, Experimental; Rats

Topics: Acid Phosphatase; Animals; Astrocytoma; Brain Neoplasms; Bucladesine; Cell Division; Glucuronidase; Humans; Neoplasms, Experimental; Rats

Topics: Acid Phosphatase; Brain Neoplasms; Cerebrospinal Fluid; Female; Glioma; Glucuronidase; Humans; Lysosomes; Middle Aged

A long-term tissue culture cell line has been derived from a human prostate adenocarcinoma metastatic to the brain. The cell line, DU 145, has been passaged 90 times in vitro over a period of 2 years. The cells are epithelial, grow in isolated islands on plastic Petri dishes, and form colonies in soft agar suspension culture. Karyotypic analysis demonstrates an aneuploid human karyotype with a modal chromosome number of 64. Distinctive marker chromosomes (a translocation Y chromosome, metacentric minute chromosomes and three large acrocentic chromosomes) have been identified. Electron microscopy of the original tumor tissue and of the tissue culture cell line show a remarkable similarity in cell organelle structure.

Topics: Acid Phosphatase; Adenocarcinoma; Aged; Aneuploidy; Brain; Brain Neoplasms; Cell Line; Chromosome Aberrations; Culture Techniques; Humans; Male; Neoplasm Metastasis; Prostatic Neoplasms

Topics: Acid Phosphatase; Animals; Astrocytes; Brain Chemistry; Brain Neoplasms; Bucladesine; Glioma; Glucuronidase; Humans; Lysosomes; Neuroglia; Rats

The tartrat resistant zinc activated acid phosphatase (ZT-AP) was investigated in 17 glial microtumours of the rat brain. The tumours were induced by N-ethyl-N-nitrosourea injected to newborn rats subcutaneously (85 mg/kg body weight). The morphology of these microtumours corresponds to the statements in the literature. In regard to their behaviour of the investigated enzyme the microtumours may be divided in 2 groups: 1) Microtumours with an activity of acid phosphatases but without any histochemically demonstrable activity of ZT-AP. Histologically they correspond to oligodendric microgliomas. 2) Microtumours with a high activity of acid phosphatases and a remarkable activity of ZT-AP especially in the perivascular cell proliferations. This type corresponds histologically to the astrocytic and mixed glial proliferations including glioblastomas. According to our present findings the ZT-AP was found in astrocytes and especially in mesenchymal cells. In some cases a focal increased activity of ZT-AP could also be observed before histological alterations appeared. We regard it as an early stage of the development of tumours.

Topics: Acid Phosphatase; Animals; Astrocytoma; Brain Neoplasms; Ethylnitrosourea; Female; Histocytochemistry; Male; Oligodendroglioma; Rats; Rats, Inbred Strains; Stimulation, Chemical; Tartrates; Zinc

Topics: Acid Phosphatase; Animals; Astrocytoma; Brain Neoplasms; Female; Glioma; Golgi Apparatus; Lysosomes; Macrophages; Maternal-Fetal Exchange; Neoplasms, Experimental; Neurilemmoma; Nitrosourea Compounds; Oligodendroglioma; Pregnancy; Rats; Rats, Inbred Strains

Topics: Acid Phosphatase; Animals; Brain; Brain Neoplasms; Ethylnitrosourea; Female; Glioma; Glucuronidase; Hexosaminidases; Lysosomes; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Oligodendroglioma; Pregnancy; Rats; Sulfatases

Topics: Acid Phosphatase; Adolescent; Adult; Brain; Brain Neoplasms; Dihydrolipoamide Dehydrogenase; Esterases; Female; Glucosephosphate Dehydrogenase; Glycerolphosphate Dehydrogenase; Hemangiopericytoma; Histocytochemistry; Humans; L-Lactate Dehydrogenase; Male; Middle Aged; Oxidoreductases; Staining and Labeling

A patient with ectopic pinealoma first presented with apparent anorexia nervosa and hypernatraemic coma. A history of diabetes insipidus two months previously was not known on admission to hospital. The diabetes insipidus was unmasked by the administration of steroids. Neuroendocrinal and neuropathological aspects of the case are discussed with reference to the march of symptoms due to the growth of the tumour. Histochemical evidence is presented supporting the similarity between ectopic pinealoma and seminoma which suggests that they may more properly be referred to as atypical teratomas.

Topics: Acid Phosphatase; Adult; Alkaline Phosphatase; Anorexia Nervosa; Brain Neoplasms; Coma; Diabetes Insipidus; Dihydrolipoamide Dehydrogenase; Dysgerminoma; Electron Transport Complex IV; Esterases; Female; Humans; Hydrocortisone; Hypernatremia; Hypothalamus; Male; Osmolar Concentration; Oxidoreductases; Pinealoma; Sodium; Testicular Neoplasms; Thyroxine; Tuberculosis; Vasopressins

Topics: Acid Phosphatase; Adult; Brain Neoplasms; Central Nervous System Diseases; Cerebrospinal Fluid; Child, Preschool; Epilepsy; Female; Glioblastoma; Humans; Hypersensitivity; Inflammation; Lymphoma, Large B-Cell, Diffuse; Lysosomes; Male; Mental Disorders; Neurotic Disorders; Peptide Hydrolases; Psychotic Disorders; Vascular Diseases

Topics: Acid Phosphatase; Adenosine Triphosphatases; Animals; Animals, Newborn; Brain Neoplasms; Demyelinating Diseases; Encephalomyelitis, Autoimmune, Experimental; Esterases; Fetus; Guinea Pigs; Humans; Mice; Multiple Sclerosis; Myelin Sheath; Neuroglia; Oligodendroglioma; Phosphoric Monoester Hydrolases; Rabbits

Topics: Acid Phosphatase; Animals; Astrocytoma; Brain Neoplasms; Cells, Cultured; Culture Techniques; Ependymoma; Glioblastoma; Glioma; Glucosephosphate Dehydrogenase; L-Lactate Dehydrogenase; Mice; Mice, Inbred C3H; Neoplasms, Experimental; Succinate Dehydrogenase

Topics: Acid Phosphatase; Adenosine Triphosphatases; Alkaline Phosphatase; Animals; Brain Neoplasms; Electron Transport Complex IV; Ependymoma; Esterases; Female; Glioma; Glucosephosphate Dehydrogenase; Glucuronidase; Hydrolases; L-Lactate Dehydrogenase; Maternal-Fetal Exchange; Neoplasms, Experimental; Nitrosourea Compounds; Pregnancy; Rats

Topics: Acid Phosphatase; Adenosine Triphosphate; Adult; Alkaline Phosphatase; Brain; Brain Neoplasms; Esterases; Female; Fructose-Bisphosphate Aldolase; Glucosephosphate Dehydrogenase; Glucuronidase; Glutamates; Glycerophosphates; Glycogen; Histocytochemistry; Humans; Lactates; Lipid Metabolism; Malates; Neoplasm Metastasis; Neuroectodermal Tumors, Primitive, Peripheral; Succinate Dehydrogenase

Topics: Acid Phosphatase; Adolescent; Adult; Aged; Alcohol Oxidoreductases; Alkaline Phosphatase; Astrocytoma; Brain Neoplasms; Female; Glioma; Glutamate Dehydrogenase; Glycerolphosphate Dehydrogenase; Histocytochemistry; Humans; L-Lactate Dehydrogenase; Male; Middle Aged; Oligodendroglioma; Succinate Dehydrogenase

Topics: Acid Phosphatase; Autolysis; Brain Neoplasms; Culture Techniques; Glioma; Histocytochemistry; Humans; L-Lactate Dehydrogenase; Succinate Dehydrogenase; Time Factors

Topics: Acid Phosphatase; Brain Neoplasms; Histocytochemistry; Humans

Topics: Acid Phosphatase; Animals; Brain Neoplasms; Glioma; Glucuronidase; Hexosaminidases; Humans; Hydrolases; Lysosomes; Neoplasms, Experimental; Neurilemmoma; Nitrosourea Compounds; Rats

Topics: Acid Phosphatase; Adenoma, Chromophobe; Astrocytoma; Biopsy; Brain Neoplasms; Choroid Plexus; Ependymoma; Glioblastoma; Hemangiosarcoma; Histocytochemistry; Humans; Medulloblastoma; Meningioma; Neurilemmoma; Oligodendroglioma; Papilloma; Pituitary Neoplasms; Rosaniline Dyes; Sarcoma; Staining and Labeling

Topics: Acid Phosphatase; Animals; Brain Neoplasms; Culture Techniques; Fibrosarcoma; Glucosephosphate Dehydrogenase; Glucosephosphates; Histocytochemistry; Histological Techniques; L-Lactate Dehydrogenase; Methylcholanthrene; Mice; Oxidoreductases; Sarcoma, Experimental; Staining and Labeling; Succinate Dehydrogenase

Topics: Acid Phosphatase; Animals; Brain Neoplasms; Cell Transformation, Neoplastic; Central Nervous System; Chromosomes; Culture Media; Cytogenetics; DNA; Esterases; Histocytochemistry; Karyotyping; Male; Morphogenesis; NAD; Neoplasm Transplantation; Oxidoreductases; Rats; Sarcoma, Experimental; Tetrazolium Salts

Topics: Acid Phosphatase; Adenoma, Chromophobe; Ameloblastoma; Astrocytoma; Biopsy; Brain; Brain Neoplasms; Cell Differentiation; Cerebellar Neoplasms; Cerebellum; Choroid Neoplasms; Choroid Plexus; Ependyma; Ependymoma; Esterases; Ganglia; Ganglioneuroma; Hemangiosarcoma; Histocytochemistry; Humans; Medulla Oblongata; Medulloblastoma; Meninges; Meningioma; Neuroectodermal Tumors, Primitive, Peripheral; Neuroma; Neurons; Oligodendroglioma; Pituitary Gland; Pituitary Neoplasms; Sarcoma

Topics: Acid Phosphatase; Adult; Aged; Alkaline Phosphatase; Brain Neoplasms; Female; Histocytochemistry; Humans; Male; Meningioma; Middle Aged

Topics: Acid Phosphatase; Animals; Brain Neoplasms; Cell Differentiation; Esterases; Glucuronidase; Histocytochemistry; Neoplasms, Experimental; Neurons; Rats

Topics: Acid Phosphatase; Adenoma, Chromophobe; Adenosine Triphosphatases; Alkaline Phosphatase; Brain Neoplasms; Glioblastoma; Histocytochemistry; Humans; Meningioma; Neurilemmoma; Peripheral Nervous System Neoplasms; Pituitary Neoplasms; Succinate Dehydrogenase; Vestibulocochlear Nerve

Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Brain Neoplasms; Disease Models, Animal; Enzymes; Esterases; Glioma; Glucuronidase; Histocytochemistry; Neoplasms, Experimental; Neurilemmoma; Nitroso Compounds; Oligodendroglioma; Rats

Topics: Acid Phosphatase; Alkaline Phosphatase; Aminopeptidases; Animals; Astrocytoma; Brain Neoplasms; Ependymoma; Esterases; Glioma; Histocytochemistry; Methylcholanthrene; Mice; Oligodendroglioma

Topics: Acid Phosphatase; Animals; Brain; Brain Chemistry; Brain Neoplasms; Carcinoma, Ehrlich Tumor; Glucuronidase; Histocytochemistry; Hyaluronoglucosaminidase; L-Lactate Dehydrogenase; Mice; Microscopy, Electron; Neoplasm Transplantation; Nucleosides; Oxidoreductases; Phosphotransferases; Thymidine; Transferases; Uracil; Uridine; Xanthine Oxidase

Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Brain Neoplasms; Chromium Isotopes; Ependymoma; Glycerophosphates; Injections, Intravenous; Kidney; Mice; Neoplasms, Experimental; Radiometry; Time Factors

Topics: Acid Phosphatase; Alkaline Phosphatase; Aminopeptidases; Animals; Brain Neoplasms; Histocytochemistry; Mice; Sarcoma, Experimental

Topics: Acid Phosphatase; Animals; Benz(a)Anthracenes; Benzopyrenes; Brain Neoplasms; Carcinogens; Cell Membrane; Cytoplasm; Endoplasmic Reticulum; Histocytochemistry; Hydrocarbons; Mice; Microscopy, Electron; Neoplasms, Experimental; Neoplasms, Muscle Tissue; Oncogenic Viruses; Staining and Labeling

Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Brain Neoplasms; Electron Transport Complex IV; Esterases; Histocytochemistry; L-Lactate Dehydrogenase; Leucyl Aminopeptidase; Neoplasms, Experimental; Oxidoreductases; Rats; Spinal Cord Neoplasms; Succinate Dehydrogenase

Topics: Acid Phosphatase; Astrocytoma; Brain Chemistry; Brain Neoplasms; Cytoplasm; Ependymoma; Esterases; Glioblastoma; Histocytochemistry; Humans; Lymphoma, Large B-Cell, Diffuse; Medulloblastoma; Neoplasm Metastasis; Neurilemmoma; Phosphates; Physostigmine

Topics: Acid Phosphatase; Age Factors; Bone Neoplasms; Brain Neoplasms; Humans; Male; Neoplasm Metastasis; Prognosis; Prostatic Neoplasms

Topics: Acid Phosphatase; Brain Neoplasms; Culture Techniques; Fibroblasts; Glioma; Histocytochemistry; Humans; Neuroglia

Topics: Acid Phosphatase; Adenosine Triphosphate; Animals; Brain; Brain Chemistry; Brain Neoplasms; Carbon Isotopes; Cathepsins; Cytoplasm; Injections, Intraperitoneal; Leucine; Liver; Lysosomes; Mechlorethamine; Methods; Perfusion; Protein Biosynthesis; Rats; RNA

Topics: Acid Phosphatase; Brain Abscess; Brain Edema; Brain Neoplasms; Cerebellum; Cerebral Cortex; Cerebral Hemorrhage; Esterases; Histocytochemistry; Humans; Neuroglia; Staining and Labeling

Topics: Acid Phosphatase; Alkaline Phosphatase; Brain Neoplasms; Cytoplasm; Cytoplasmic Granules; Electron Transport Complex IV; Esterases; Humans; L-Lactate Dehydrogenase; Leucyl Aminopeptidase; Meningioma; NAD; Spinal Cord Neoplasms; Succinate Dehydrogenase

Topics: Acid Phosphatase; Adenosine Triphosphatases; Alkaline Phosphatase; Astrocytoma; Brain Neoplasms; Carcinoma; Ependymoma; Esterases; Glioma; Glucosyltransferases; Histocytochemistry; Humans; Meningioma; Neurilemmoma; Oligodendroglioma; Sarcoma

Topics: Acid Phosphatase; Brain Edema; Brain Neoplasms; Histocytochemistry; Humans; In Vitro Techniques; Neuroglia; Pyrophosphatases; Thiamine

Topics: Acid Phosphatase; Alanine Transaminase; Aspartate Aminotransferases; Blood-Brain Barrier; Brain Neoplasms; Cerebrospinal Fluid; Cerebrovascular Disorders; Fructose-Bisphosphate Aldolase; Humans

Topics: Acid Phosphatase; Animals; Brain Neoplasms; Breast Neoplasms; Esterases; Female; Granulation Tissue; Granuloma, Giant Cell; Histocytochemistry; Hodgkin Disease; Humans; Hydrolases; Leucyl Aminopeptidase; Neoplasms; Ovarian Neoplasms; Oxidoreductases; Rats

Topics: Acid Phosphatase; Alkaline Phosphatase; Brain; Brain Neoplasms; Carcinoma; Cerebrospinal Fluid; Clinical Enzyme Tests; Cyst Fluid; Geriatrics; Glioma; Glucose; Glucose-6-Phosphate Isomerase; Humans; L-Lactate Dehydrogenase; Neoplasm Metastasis; Neoplasms; Phosphates

Topics: Acid Phosphatase; Adenoma; Brain Abscess; Brain Neoplasms; Cerebral Cortex; Ependymoma; Glioma; Histocytochemistry; Humans; Lymphoma, Large B-Cell, Diffuse; Medulloblastoma; Meningioma; Microscopy, Fluorescence; Pituitary Neoplasms; Staining and Labeling

Topics: Acid Phosphatase; Brain Neoplasms; Histocytochemistry; Humans

Topics: Acid Phosphatase; Adenosine Triphosphate; Alkaline Phosphatase; Astrocytoma; Brain; Brain Neoplasms; Cerebellar Neoplasms; Dihydrolipoamide Dehydrogenase; Electron Transport Complex II; Ependyma; Esterases; Glioblastoma; Glucose-6-Phosphatase; Hemangiosarcoma; Histocytochemistry; Intracranial Arteriosclerosis; L-Lactate Dehydrogenase; NAD; NADP; Oligodendroglioma; Succinate Dehydrogenase

Topics: Acid Phosphatase; Alkaline Phosphatase; Brain; Brain Neoplasms; Carbohydrates; Electrophoresis; Esterases; Histocytochemistry; Humans; L-Lactate Dehydrogenase; Multiple Sclerosis; Proteins

Topics: Acid Phosphatase; Alkaline Phosphatase; Astrocytoma; Brain; Brain Neoplasms; Esterases; Glioblastoma; Glioma; NAD; NADP; Neurochemistry; Oligodendroglioma; Oxidoreductases

Topics: Acid Phosphatase; Brain Neoplasms; Clinical Enzyme Tests; Esterases; Humans; Isoenzymes; L-Lactate Dehydrogenase; Nerve Tissue Proteins

Topics: Acid Phosphatase; Alkaline Phosphatase; Aminopeptidases; Brain Neoplasms; Esterases; Glioma; Glycosaminoglycans; Histocytochemistry; Hydrolases; Pathology