acid-phosphatase and Bone-Marrow-Diseases

Topics: Acid Phosphatase; Alkaline Phosphatase; Bone Marrow Diseases; Bone Neoplasms; Esterases; Glucosyltransferases; Glycogen; Histocytochemistry; Leukemia; Lipid Metabolism; Myeloproliferative Disorders; Peroxidases; Succinate Dehydrogenase

Bone marrow macrophages were found to express tartrate-resistant acid phosphatase (TRAP) under pathological conditions. In chronic granulocytic leukemia and metastatic carcinoma in the bone marrow this phenomenon was striking, all or almost all of the marrow macrophages being reactive. In other conditions, such as hypertransfusion or chemotherapy-induced marrow aplasia, the phenomenon did occur but was clearly a minor one. These observations indicate that tissue macrophages may become TRAP positive under the effect of unknown stimuli operating in certain pathological conditions. The results further suggest that the synthesis of the isoenzyme of acid phosphatase resistant to tartrate inhibition is a marker of macrophage activation rather than of differentiation towards particular subsets of the mononuclear phagocyte system.

Topics: Acid Phosphatase; Bone Marrow; Bone Marrow Cells; Bone Marrow Diseases; Bone Neoplasms; Carcinoma; Histocytochemistry; Humans; Leukemia, Myeloid; Macrophages; Tartrates

Topics: Acid Phosphatase; Agammaglobulinemia; Aged; Anemia, Myelophthisic; Blood Platelet Disorders; Bone Marrow Diseases; Diethylstilbestrol; Erythrocytes; Erythropoiesis; Half-Life; Humans; Iron; Iron Isotopes; L-Lactate Dehydrogenase; Leukocytes; Male; Neoplasm Metastasis; Osmotic Fragility; Prostatic Neoplasms; Remission, Spontaneous; Time Factors

Topics: Acid Phosphatase; Animals; Bone Marrow Diseases; Canaries; Cell Membrane

Topics: Acid Phosphatase; Bone Marrow Diseases; Cardiovascular Diseases; Clinical Enzyme Tests; Heart Diseases; Histocytochemistry; Humans; Leukocytes; Neoplasm Metastasis; Neoplasms; Thyroid Diseases

Topics: Acid Phosphatase; Bone Marrow; Bone Marrow Diseases; Humans; Leukemia; Leukemia, Myeloid; Myeloproliferative Disorders; Phosphoric Monoester Hydrolases