acid-phosphatase and Behcet-Syndrome

The activities of the lysosomal enzymes of leukocytes were correlated with the types of ocular attacks of Behcet's disease, ie, the anterior or posterior types. No significant correlation was found between the types of attacks and the activities of acid phosphatase and beta-glucuronidase. Myeloperoxidase (MPO) activity in the neutrophils, however, was significantly lower in the posterior type than in the anterior type. In selected cases, the time-course of the MPO activity was studied: the activity decreased at attacks and showed a recovery as the symptoms subsided. The recovery after the attacks was faster in the anterior type than in the posterior type. The difference between the MPO activities in the two types of attacks was thought to be due to the fact that the posterior type attack shows more severe ocular inflammation than the anterior type attack. It is possible that the MPO is released from the neutrophils just before the onset of the ocular attacks.

Topics: Acid Phosphatase; Adult; Behcet Syndrome; Blood Proteins; Cell Separation; Enzymes, Immobilized; Female; Glucuronidase; Humans; Male; Neutrophils; Peroxidase; Prognosis

Topics: Acid Phosphatase; Adult; Behcet Syndrome; Female; Glucuronidase; Humans; Leukocytes; Lysosomes; Male; Middle Aged; Peroxidase

Samples of serum from patients with ocular manifestation of Behçet's disease of various types were analyzed using acid phosphatase and beta-glucuronidase as lysosomal marker enzymes, in comparison to those from control patients with myopia, retinal detachment, and uveitis of unknown etiology. The lysosomal enzyme activities in Behçet's disease, especially in the attack phase, were found to be higher than those of the controls. In the sera of two patients with Behçet's disease, the activities in the attack phase were slightly higher than in the remission phase. It was suggested that the ocular symptoms in Behçet's disease might represent exacerbation better than other symptoms, in view of the high lysosomal enzyme activities in the attack phase, as classified by ocular symptoms alone.

Topics: Acid Phosphatase; Adult; Behcet Syndrome; Eye Manifestations; Female; Glucuronidase; Humans; Lysosomes; Male

Topics: Acid Phosphatase; Alkaline Phosphatase; Arthritis, Reactive; Behcet Syndrome; Buffers; Chondrocalcinosis; Gout; Histocytochemistry; Humans; Hydrarthrosis; Joint Diseases; Methods; Synovial Fluid; Ultracentrifugation