acid-phosphatase and Ancylostomiasis

Both infective larvae and pollutants disturb the homeostasis of female Swiss albino mice, causing ancylostomiasis and severe immunophysiological changes. In our experimental design, mice in group A were fed 0.01 mg of lead nitrate before infection with 500 larvae of Ancylostoma caninum, mice in group B were infected with larvae without previous lead treatment, and group C received lead nitrate treatment alone. Control animals in group D were neither treated with lead nitrate nor infected with larvae. While all three experimental groups showed disturbances in liver alkaline phosphatase (ALP) and acid phosphatase (ACP), group C receiving lead nitrate treatment alone and group A receiving lead nitrate with infection showed increased levels of ACP and decreased levels of ALP.

Topics: Acid Phosphatase; Alkaline Phosphatase; Ancylostomiasis; Animals; Female; Larva; Lead; Liver; Mice; Parasite Egg Count; Phosphoric Monoester Hydrolases

Administration of 0.01 and 0.1 mg of lead nitrate for 4 and 7 days and infection of Ancylostoma caninum larvae orally altered the activation of alkaline phosphatase and acid phosphatase in the hearts of mice when compared to infected animals and controls. Alkaline phosphatase activity increased significantly in all drug-treated + infected mice. The level of acid phosphatase decreased significantly in mice exposed to chronic doses of lead. The altered levels of alkaline phosphatase and acid phosphatase suggest that administration of lead could cause toxicity in the heart, disturbing the cellular metabolism; infection alone could not cause any significant changes in enzymes of heart.

Topics: Acid Phosphatase; Alkaline Phosphatase; Ancylostoma; Ancylostomiasis; Animals; Disease Models, Animal; Female; Lead Poisoning; Mice; Myocardium

Ancylostoma duodenale is still the dominant hookworm species in the Mediterranean area, India, China and Japan. In the present study, biopsied materials were taken from the small intestine of 30 patients infected only with A. duodenale and 12 cross matched controls. The results showed some pathological changes in severely infected cases. However, normal or insignificant changes were seen in the enzymatic activity of the intestinal mucosa.

Topics: Acid Phosphatase; Adolescent; Adult; Alkaline Phosphatase; Ancylostomiasis; Biopsy; Carboxylesterase; Carboxylic Ester Hydrolases; Histocytochemistry; Humans; Intestinal Diseases, Parasitic; Intestinal Mucosa; Intestine, Small; Male; Middle Aged; Succinate Dehydrogenase

Topics: Acid Phosphatase; Alkaline Phosphatase; Amyloid; Ancylostomiasis; Animals; Carbohydrates; Dog Diseases; Dogs; Female; Histocytochemistry; Hyaluronoglucosaminidase; Intestine, Small; Lipids; Male; Nucleic Acids; Pigments, Biological; Proteins; Skin