acid-phosphatase and African-Swine-Fever

acid-phosphatase has been researched along with African-Swine-Fever* in 2 studies

Other Studies

2 other study(ies) available for acid-phosphatase and African-Swine-Fever

ArticleYear
Modulation of monocytic cell activity and virus susceptibility during differentiation into macrophages.
    Journal of immunology (Baltimore, Md. : 1950), 1999, Apr-01, Volume: 162, Issue:7

    A major component of innate immune responses relies on monocytes and macrophages, virus infection of which will pose a particular problem for immunological defense. Consequently, the monocytic cell differentiation pathway was analyzed in terms of cellular modulations therein and their relation to monocytotropic virus infection. Differentiation was characterized by down-regulation of CD14, MHC Ags, the monocytic SWC1 marker, and p53; concomitant up-regulation of the SWC9 macrophage marker, a putative porcine CD80 (detected with anti-human CD80 Ab), and acid phosphatase secretion were also characteristic. Elevated phagocytic and endocytic activities as well as endosomal/lysosomal acidification were identified as being important to the macrophage. In contrast, monocytes possessed high accessory activity. This was multifactorial, concomitantly requiring 1) high MHC Ag expression; 2) enzyme activity of esterase, peroxidase, myeloperoxidase, and 5' nucleotidase in preference to glucosidase, galactosidase, and glucuronidase; and 3) elevated capacity for spontaneous IL-1 production. Only with all parameters was efficient stimulation of Ag-specific lymphocytes possible. These results point to a continuous process during differentiation, involving inter-related characteristics linking the more accessory monocyte to the scavenger macrophage, both in vitro and in vivo. Of particular interest was how these characteristics related to monocytotropic virus infection, and how a particular virus could show a clear preference for the differentiating macrophages. Such results not only further our understanding of porcine immunology, but also provide evidence and a potential model for the determination and characterization of monocytotropic virus-host cell interactions.

    Topics: Acid Phosphatase; African Swine Fever; African Swine Fever Virus; Animals; Antigen-Presenting Cells; Antigens, Surface; Cell Differentiation; Cells, Cultured; Disease Susceptibility; Endocytosis; Hydrogen-Ion Concentration; Interleukin-1; Intracellular Fluid; Macrophages; Monocytes; Phagocytosis; Swine; Tartrates

1999
Lymphocyte function and cell-mediated immunity in pigs with experimentally induced African swine fever.
    American journal of veterinary research, 1981, Volume: 42, Issue:8

    Twenty-five pigs inoculated with African Swine fever virus were studied for the development of changes in lymphocyte numbers and function. The results indicated that lymphopenia and decreased percentage of circulating T-lymphocytes occurred as early as 7 days after the pigs were inoculated. These were accompanied by depressed lymphocyte function, as measured by mitogen- or antigen-induced blastogenesis. There were proportionately greater decreases in T-lymphocyte numbers and function than were found for B-lymphocytes. Studies of phagocytic cell function revealed decreased phagocytic function for peripheral blood monocytes and unchanged (normal) neutrophil function. Depressed T-lymphocyte function occurred in pigs with acute and subacute infections, indicating depression of cellular immune function.

    Topics: Acid Phosphatase; African Swine Fever; African Swine Fever Virus; Animals; Antibodies, Viral; B-Lymphocytes; Immunity, Cellular; Leukocyte Count; Lymphocyte Activation; Lymphocytes; Phagocytosis; Swine; T-Lymphocytes

1981