acid-phosphatase and Adenolymphoma

Parotid adenolymphoma is composed of two histologic components, epithelial and lymphoid. Although some theories regarding the histogenesis of this tumor have long been disputed, there have been no definite conclusions. The purpose of this study was to clarify the origin of the epithelial components of this tumor using histochemical and immunopathological techniques, electron microscopy and a survey of HE-stained tumor sections. The results obtained indicated that the functions of the epithelial components were similar to those of the striated duct of the normal parotid gland, and morphological studies showed that the origin of the epithelial components may arise from parotid ductal inclusion in the lymphnodes in or around the parotid gland.

Topics: 5'-Nucleotidase; Acid Phosphatase; Adenolymphoma; Adenosine Triphosphatases; Adult; Aged; Epithelium; Glucuronidase; Humans; Immunoglobulin A; Microscopy, Electron; Middle Aged; Naphthol AS D Esterase; Nucleotidases; Parotid Neoplasms; Staining and Labeling

Two types of salivary monomorphic adenomas, the so-called adenolymphoma and oncocytoma (75 cases in a series of 873 salivary gland tumors) were studied. These tumors were almost always located in major salivary glands (essentially in the parotid gland). They were much more common in men (85%) than in women. The oncocyte represented the characteristic cell in these two neoplasms. By electron microscopy, they were seen to contain numerous and abnormal mitochondriae and well-developed lysosomal systems. These findings were correlated with a high level of activity of oxidative enzymes and of acid phosphatases. The histogenesis of these tumors was discussed. They seemed to arise from aberrant striated ducts embedded in heterotopic lymph nodes. The tumoral oncocytes would suffer a primary disturbance of their oxidative metabolism followed by a compensative mitochondrial hypertrophy.

Topics: Acid Phosphatase; Adenolymphoma; Adenoma; Female; Humans; Male; Microscopy, Electron; Salivary Gland Neoplasms

Topics: Acid Phosphatase; Adenolymphoma; Aged; Epithelium; Histocytochemistry; Humans; Lysosomes; Male; Microscopy; Microscopy, Electron; Parotid Neoplasms

Topics: Acid Phosphatase; Adenolymphoma; Alkaline Phosphatase; Cystadenoma; Cystadenoma, Papillary; Electron Transport Complex II; Esterases; Galactosidases; Glycosaminoglycans; Hamartoma; Histocytochemistry; Humans; Leucyl Aminopeptidase; Pathology; Salivary Gland Neoplasms; Succinate Dehydrogenase