acid-phosphatase and Adenocarcinoma--Papillary

Clinical and immunohistochemical studies were conducted to evaluate prostatic papillary adenocarcinoma and prostatic papillary hyperplasia. Subjects consisted of 5 cases of papillary adenocarcinoma and 2 cases of papillary hyperplasia. There is no conclusive clinical factor for preoperative diagnosis, but we attach importance to endoscopic findings. PSA, PAP, high molecular weight cytokeratin, and PCNA were evaluated immunohistochemically. PSA became positive in every instance but one--a case of papillary adenocarcinoma which became +/-. PAP was + in all cases, except for 1 case of papillary adenocarcinoma. Basal cells were positive for high molecular weight cytokeratin in 2 cases of papillary hyperplasia but were missing in papillary adenocarcinoma. Although PCNA was free from positive nuclei in papillary hyperplasia, positive nuclei were found in all cases of papillary adenocarcinoma. Considering these immunohistochemical results, papillary adenocarcinoma can be said to originate in the glandular epithelium of the prostate, as does ordinary prostatic carcinoma.

Topics: Acid Phosphatase; Adenocarcinoma, Papillary; Aged; Humans; Immunohistochemistry; Keratins; Male; Middle Aged; Proliferating Cell Nuclear Antigen; Prostate-Specific Antigen; Prostatic Neoplasms

The authors report a patient who was admitted to the hospital with neurologic symptoms and signs that were thought to be caused by a primary intracranial tumor.. Craniotomy resulted in successful resection of an occipital lobe tumor reported histologically as a papillary adenocarcinoma, probably metastatic from the kidney. However, a complete diagnostic study failed to demonstrate the primary focus.. Thirteen months later, the patient was readmitted to the hospital and found to have metastatic prostatic carcinoma. Immunoperoxidase staining for prostatic acid phosphatase of the prostatic tissue and of the previously resected brain tumor tissue indicated that the brain lesion was metastatic from the prostate.

Topics: Acid Phosphatase; Adenocarcinoma, Papillary; Aged; Brain Neoplasms; Carcinoembryonic Antigen; Humans; Lumbar Vertebrae; Male; Prostatic Neoplasms; Spinal Neoplasms; Tomography, X-Ray Computed

A case of papillary adenocarcinoma, developed on the urinary bladder neck is reported. This tumor is histologically identical to so called endometrial carcinoma of the prostate. Immunohistochemistry showed acid phosphatases and prostatic specific antigen (PSA) positive cells. Electron microscopy disclosed secretory vacuoles consistent with a prostatic origin. The histogenesis of endometrial carcinoma is briefly discussed likewise the precise site of origin of the reported case.

Topics: Acid Phosphatase; Adenocarcinoma, Papillary; Aged; Antigens, Neoplasm; Cytoplasm; Histocytochemistry; Humans; Immunologic Techniques; Male; Microscopy, Electron; Prostate; Prostatic Neoplasms; Urinary Bladder Neoplasms; Vacuoles

Five cases of papillary adenocarcinomas of the prostate were studied for prostate-specific acid phosphatase, using the immunoperoxidase method, to determine the origin and histogenesis of these uncommon tumors. All five cases were prostatic-acid-phosphatase positive, whereas four cases showed in situ carcinoma involving large periurethral ducts. Positive immunohistochemical localization of prostate-specific acid phosphatase is useful in identifying papillary carcinoma of true prostatic origin and distinguishing them from prostatic-acid-phosphatase-negative carcinomas which may include tumors arising from periurethral glands or metaplastic urethral mucosa.

Topics: Acid Phosphatase; Adenocarcinoma, Papillary; Histocytochemistry; Humans; Immunoenzyme Techniques; Male; Middle Aged; Prostatic Neoplasms; Staining and Labeling

Topics: Acid Phosphatase; Adenocarcinoma, Papillary; Aged; Biopsy; Humans; Male; Needles; Neoplasm Metastasis; Neoplasm Seeding; Neoplasms, Muscle Tissue; Perineum; Prostate; Prostatic Neoplasms

Topics: Acid Phosphatase; Adenocarcinoma, Papillary; Alanine; Alkaline Phosphatase; Amides; Amidohydrolases; Arginine; Brain; Carcinoma, Intraductal, Noninfiltrating; Cecal Neoplasms; Cobalt; Dipeptidases; Female; Glioma; Humans; Leucine; Manganese; Naphthalenes; Ovarian Neoplasms; Peptide Hydrolases; Phenylalanine