acid-phosphatase and Acne-Vulgaris

Propionibacterium acnes was grown in continuous culture in the presence of propylene phenoxetol. At sub-lethal concentrations of this antimicrobial agent (0.025-0.1% w/v) steady-state growth conditions were achieved. In comparison with the control, cell biomass, maximum specific growth rates and levels of the extracellular lipase and hyaluronate-lyase, decreased with increasing concentrations of propylene phenoxetol. Levels of protease activity remained approximately constant whilst production of acid phosphatase was significantly increased with increasing propylene phenoxetol concentrations. At the highest concentration of the antimicrobial agent (0.2% w/v) growth was completely inhibited.

Topics: Acid Phosphatase; Acne Vulgaris; Cell Division; Ethylene Glycols; Humans; Lipase; Peptide Hydrolases; Polysaccharide-Lyases; Propionibacterium acnes; Skin Diseases, Infectious

Topics: Acid Phosphatase; Acne Vulgaris; Humans; Hyaluronoglucosaminidase; Hydrogen-Ion Concentration; Lipase; Peptide Hydrolases; Propionibacterium acnes

Oral tetracycline eliminated the histochemical staining for nonspecific esterase in human sebaceous glands after two weeks of administration. This evidence offers further support for the hypothesis that the clinical benefits of tetracycline result from suppression of follicular esterase-lipases, probably those from C. acnes.

Topics: Acid Phosphatase; Acne Vulgaris; Esterases; Histocytochemistry; Humans; Male; Sebaceous Glands; Skin; Tetracycline