acid-phosphatase and AIDS-Related-Complex

In four series of experiments human peripheral blood neutrophils were found capable of synthetizing the active forms of such enzymes as myeloperoxidase and acid phosphatase after stimulation with opsonized zymosan, and the optimum conditions for testing the synthetizing activity of neutrophils were established. The examination of 39 practically healthy donors revealed an approximate equilibrium between the synthesis of the active forms of the enzyme and its excretion from the cell after this cell was activated. Considerable changes in the enzymatic activity of peripheral blood neutrophils were found in patients with yersiniosis, chronic herpes, chronic bronchitis and AIDS-associated complex. The possibility of a deficient enzymatic activity in some patients was suggested.

Topics: Acid Phosphatase; AIDS-Related Complex; Blood Donors; Bronchitis; Cells, Cultured; Dose-Response Relationship, Drug; Herpes Simplex; Humans; Lymphocyte Activation; Neutrophils; Peroxidase; Reference Values; Time Factors; Yersinia Infections