acetylglucosamine has been researched along with Alzheimer Disease in 52 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (9.62) | 18.2507 |
| 2000's | 10 (19.23) | 29.6817 |
| 2010's | 31 (59.62) | 24.3611 |
| 2020's | 6 (11.54) | 2.80 |
| Authors | Studies |
|---|---|
| Duell, F; Fredolini, C; Grande, G; Jönsson, L; Laukka, EJ; Schedin-Weiss, S; Tjernberg, L; Vetrano, DL; Winblad, B; Zhou, RZ | 1 |
| Arumugam, TV; Jo, DG; Lai, MKP; Park, J | 1 |
| Ahmad, I; Ahmad, W; Shabbiri, K | 1 |
| Gaunitz, S; Schedin-Weiss, S; Tjernberg, LO | 1 |
| Cork, GK; Flax, J; Griffith, S; Miller, R; Qiang, A; Slawson, C; Swerdlow, RH; Thompson, J; Wilkins, HM | 1 |
| Balana, AT; Pratt, MR | 1 |
| Hao, J; He, Y; Li, H; Ma, X | 1 |
| Chun, YS; Chung, S; Kwon, OH | 1 |
| Aguilar, AL; Hou, X; Wang, PG; Wen, L; Wu, P | 1 |
| Cardoso, SM; Correia, SC; Moreira, PI; Pinho, TS; Verde, DM | 1 |
| Kizuka, Y; Taniguchi, N | 1 |
| Barone, E; Butterfield, DA; Cassano, T; Castagnola, M; Castellani, A; Di Domenico, F; Gaetani, S; Iavarone, F; Lanzillotta, C; Perluigi, M; Sharma, N; Tramutola, A; Vincenzoni, F | 1 |
| Ambrósio, AF; Correia, SC; Moreira, PI; Perry, G; Pinho, TS | 1 |
| Groves, JA; Lee, A; Yildirir, G; Zachara, NE | 1 |
| Diwu, Y; Shi, J; Tian, J | 1 |
| Suh, PG; Yang, YR | 1 |
| Cheung, AH; McIntosh, LP; Okon, M; Vocadlo, DJ; Yuzwa, SA | 1 |
| Bielska, AA; Brister, MA; Pandey, AK; Zondlo, NJ | 1 |
| Vocadlo, DJ; Yuzwa, SA | 1 |
| Butterfield, DA; Förster, S; Schmitz, B; Sultana, R; Triplett, JC; Welleford, AS | 1 |
| Shan, X; Vocadlo, DJ; Yuzwa, SA; Zhu, Y | 1 |
| Endo, T; Fujinawa, R; Hashimoto, Y; Hatsuta, H; Iwata, N; Kitazume, S; Kizuka, Y; Manya, H; Murayama, S; Nakano, M; Saido, TC; Saito, T; Staufenbiel, M; Taniguchi, N; Yamaguchi, Y | 1 |
| Angiari, S; Bistaffa, E; Bonetti, B; Busetto, G; Commisso, M; Farinazzo, A; Guzzo, F; Marconi, S; Musumeci, S; Sotgiu, S; Turano, E | 1 |
| Hanover, JA; Olivier-Van Stichelen, S | 1 |
| Cha, MY; Cho, HJ; Cho, JW; Choi, H; Choi, YJ; Dickson, DW; Hong, HS; Jin, SM; Jung, YO; Kang, MJ; Kim, C; Kim, DK; Kim, J; Mook-Jung, I; Murray, ME; Song, HK; Yi, EC | 1 |
| Cassano, T; dos Santos, M; Gaetani, S; Gatta, E; Lefebvre, T; Maccari, S; Mairesse, J; Marrocco, J; Mir, AM; Nicoletti, F | 1 |
| Chu, D; Dai, CL; Gong, CX; Gu, J; Gu, JH; Iqbal, K; Jin, N; Liu, F; Shi, J; Sun, J; Xie, S; Zhang, L | 1 |
| Despres, C; Hackenberger, CP; Reimann, O; Schwagerus, S; Smet-Nocca, C | 1 |
| Gong, CX; Iqbal, K; Liu, F | 1 |
| Chatham, JC; Darley-Usmar, V; McMahon, LL; Wani, WY; Zhang, J | 1 |
| Hsieh-Wilson, LC; Jensen, EH; Rexach, JE; Vinters, HV; Wang, AC | 1 |
| Du, JT; Hu, J; Li, YM; Si, T; Wu, WH; Yu, CH; Zhao, YF | 1 |
| Dehennaut, V; Drougat, L; Guinez, C; Lefebvre, T; Michalski, JC; Mir, AM; Mortuaire, M; Olivier, S; Vercoutter-Edouart, AS | 1 |
| Deng, Y; Gong, CX; Grundke-Iqbal, I; Iqbal, K; Li, B; Liu, Y | 1 |
| Fukuda, T; Matsumoto, E; Miura, Y; Onogi, S | 1 |
| Adolf-Bergfoyle, J; Adolf-Bryfogle, J; Deuso, J; Gong, Y; Lippa, CF; Nowak, MG; Skorobogatko, YV; Vosseller, K | 1 |
| Iverfeldt, K; Jacobsen, KT | 1 |
| Hart, GW; Vosseller, K; Zachara, NE | 1 |
| Clark, T; Macauley, MS; Shan, X; Skorobogatko, Y; Vocadlo, DJ; Vosseller, K; Yuzwa, SA | 1 |
| Ancsin, J; Bhat, S; Kisilevsky, R; Li, Z; Marone, S; Szarek, WA | 1 |
| Gong, CX; Grundke-Iqbal, I; Hart, GW; Iqbal, K; Liu, F | 1 |
| Ancsin, J; Kisilevsky, R; Li, Z; Marone, S; Szarek, WA; Vohra, R | 1 |
| Campo, P; Fernández, A; García-Segura, JM; Gil-Gregorio, P; Maestú, F; Montoya, J; Ortiz, T; Viaño, J | 1 |
| Hart, GW; Housley, MP; Slawson, C | 1 |
| Dias, WB; Hart, GW | 1 |
| Bonetti, B; Gini, B; Marconi, S; Musumeci, S; Sotgiu, S | 1 |
| Griffith, LS; Schmitz, B | 1 |
| Griffith, LS; Mathes, M; Schmitz, B | 1 |
| Coleman, PD; Yao, PJ | 2 |
| Gong, CX; Grundke-Iqbal, I; Iqbal, K; Liu, F; Merkle, RK; Zaidi, T | 1 |
| Hill, SJ; Sparkman, DR; White, CL | 1 |
13 review(s) available for acetylglucosamine and Alzheimer Disease
| Article | Year |
|---|---|
O-GlcNAcylation as a Therapeutic Target for Alzheimer's Disease.
Topics: Acetylglucosamine; Aged; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Antigens, Neoplasm; Brain; Diabetes Mellitus, Type 2; Disease Models, Animal; Glucose; Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing); Glycosylation; Hexosamines; Histone Acetyltransferases; Humans; Hyaluronoglucosaminidase; Insulin Resistance; Molecular Structure; Nerve Tissue Proteins; Neurodegenerative Diseases; Neuroprotective Agents; Phosphorylation; Protein Isoforms; Protein Processing, Post-Translational; Stroke; tau Proteins; Uridine Diphosphate; Uridine Diphosphate N-Acetylgalactosamine | 2020 |
Mechanistic roles for altered O-GlcNAcylation in neurodegenerative disorders.
Topics: Acetylglucosamine; alpha-Synuclein; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Glycosylation; Humans; N-Acetylglucosaminyltransferases; Parkinson Disease; Protein Processing, Post-Translational; tau Proteins | 2021 |
The emerging link between O-GlcNAcylation and neurological disorders.
Topics: Acetylglucosamine; Acetylglucosaminidase; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Brain; Humans; N-Acetylglucosaminyltransferases; Nervous System Diseases; Neurons; Parkinson Disease; Protein Processing, Post-Translational; Proteins | 2017 |
O-GlcNAcylation and neuronal energy status: Implications for Alzheimer's disease.
Topics: Acetylglucosamine; Alzheimer Disease; Animals; Brain; Energy Metabolism; Glucose; Humans; Neurons; Protein Processing, Post-Translational | 2018 |
Neural functions of bisecting GlcNAc.
Topics: Acetylglucosamine; Alzheimer Disease; Amyloid Precursor Protein Secretases; Animals; Brain; Humans; Models, Biological; Up-Regulation | 2018 |
O-GlcNAcylation in cellular functions and human diseases.
Topics: Acetylglucosamine; Alzheimer Disease; Animals; Cardiovascular Diseases; Glycosylation; Humans; Signal Transduction | 2014 |
O-GlcNAc and neurodegeneration: biochemical mechanisms and potential roles in Alzheimer's disease and beyond.
Topics: Acetylglucosamine; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antigens, Neoplasm; Histone Acetyltransferases; Humans; Hyaluronoglucosaminidase; N-Acetylglucosaminyltransferases; Neurodegenerative Diseases; tau Proteins | 2014 |
The emerging link between O-GlcNAc and Alzheimer disease.
Topics: Acetylglucosamine; Alzheimer Disease; Amyloid beta-Peptides; Animals; Glucose; Humans; Neurons; tau Proteins | 2014 |
You are what you eat: O-linked N-acetylglucosamine in disease, development and epigenetics.
Topics: Acetylglucosamine; Alzheimer Disease; Cardiovascular Diseases; Chromatin; Chronic Disease; Diabetes Mellitus, Type 2; Diet; Epigenesis, Genetic; Feeding Behavior; Female; Gene Expression Regulation; Genetic Loci; Genomic Imprinting; Homeostasis; Humans; Hypothalamo-Hypophyseal System; Lupus Erythematosus, Systemic; N-Acetylglucosaminyltransferases; Neoplasms; Neurogenesis; Obesity; Protein Processing, Post-Translational; X Chromosome Inactivation | 2015 |
O-GlcNAcylation and neurodegeneration.
Topics: Acetylglucosamine; Acylation; Alzheimer Disease; Animals; beta-N-Acetylhexosaminidases; Brain; Glycoside Hydrolases; Glycosylation; Humans; N-Acetylglucosaminyltransferases; Neurodegenerative Diseases; Protein Processing, Post-Translational; Proteins | 2017 |
Dysregulation of the nutrient/stress sensor O-GlcNAcylation is involved in the etiology of cardiovascular disorders, type-2 diabetes and Alzheimer's disease.
Topics: Acetylglucosamine; Alzheimer Disease; Animals; Basic Helix-Loop-Helix Transcription Factors; Brain; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Forkhead Box Protein O1; Forkhead Transcription Factors; Glucose; Homeodomain Proteins; HSP70 Heat-Shock Proteins; Humans; Insulin Resistance; Myocardial Reperfusion Injury; N-Acetylglucosaminyltransferases; Proteasome Endopeptidase Complex; Trans-Activators; Transcription Factors; Ubiquitins | 2010 |
Cycling of O-linked beta-N-acetylglucosamine on nucleocytoplasmic proteins.
Topics: Acetylglucosamine; Alzheimer Disease; Animals; Cytoplasm; Enzymes; Humans; Nuclear Proteins; Phosphates | 2007 |
O-GlcNAc modification in diabetes and Alzheimer's disease.
Topics: Acetylglucosamine; Acylation; Alzheimer Disease; Diabetes Mellitus; Humans; Models, Biological; Protein Processing, Post-Translational | 2007 |
39 other study(ies) available for acetylglucosamine and Alzheimer Disease
| Article | Year |
|---|---|
A glycan epitope correlates with tau in serum and predicts progression to Alzheimer's disease in combination with APOE4 allele status.
Topics: Acetylglucosamine; Alleles; Alzheimer Disease; Amyloid beta-Peptides; Apolipoprotein E4; Biomarkers; Cognitive Dysfunction; Genotype; Humans; Peptide Fragments; Retrospective Studies; tau Proteins | 2023 |
Prediction of human tau 3D structure, and interplay between O-β-GlcNAc and phosphorylation modifications in Alzheimer's disease: C. elegans as a suitable model to study these interactions in vivo.
Topics: Acetylglucosamine; Alzheimer Disease; Amino Acid Sequence; Animals; Animals, Genetically Modified; Binding Sites; Caenorhabditis elegans; Glycosylation; Humans; Models, Animal; Models, Molecular; Neurofibrillary Tangles; Phosphorylation; Protein Structure, Quaternary; Recombinant Proteins; Structural Homology, Protein; tau Proteins | 2020 |
The N-glycan profile in cortex and hippocampus is altered in Alzheimer disease.
Topics: Acetylglucosamine; Aged; Aged, 80 and over; Alzheimer Disease; Asparagine; Brain Chemistry; Cerebral Cortex; Chromatography, Gel; Chromatography, High Pressure Liquid; Epitopes; Female; Fucose; Galactose; Glycoproteins; Hippocampus; Humans; Male; N-Acetylneuraminic Acid; Polysaccharides; Tandem Mass Spectrometry | 2021 |
OGA Inhibition Alters Energetics and Nutrient Sensing in Alzheimer's Disease Cytoplasmic Hybrids.
Topics: Acetylation; Acetylglucosamine; Aged; Aged, 80 and over; Alzheimer Disease; beta-N-Acetylhexosaminidases; Cell Line, Tumor; Cell Respiration; Energy Metabolism; Enzyme Inhibitors; Female; Glycolysis; Humans; Hybrid Cells; In Vitro Techniques; Male; Mitochondria; Neurons; Pyrans; Sirtuin 3; Stress, Physiological; Thiazoles | 2020 |
O-GlcNAcylation of amyloid-β precursor protein at threonine 576 residue regulates trafficking and processing.
Topics: Acetylglucosamine; Acylation; Alzheimer Disease; Amyloid beta-Protein Precursor; Cell Membrane; Glycosylation; HeLa Cells; Humans; Point Mutation; Protein Processing, Post-Translational; Protein Transport; Threonine; trans-Golgi Network | 2017 |
A Chemoenzymatic Histology Method for O-GlcNAc Detection.
Topics: Acetylglucosamine; Alzheimer Disease; Animals; Brain; Brain Chemistry; Histological Techniques; Humans; Mice; Neoplasms; Organ Specificity; Tissue Distribution | 2017 |
Proteomic identification of altered protein O-GlcNAcylation in a triple transgenic mouse model of Alzheimer's disease.
Topics: Acetylglucosamine; Alzheimer Disease; Animals; beta-N-Acetylhexosaminidases; Brain; Disease Models, Animal; Female; Humans; Insulin Receptor Substrate Proteins; Male; Mice; Mice, Transgenic; N-Acetylglucosaminyltransferases; Phosphorylation; Proteins; Proteomics; Proto-Oncogene Proteins c-akt | 2018 |
Diminished O-GlcNAcylation in Alzheimer's disease is strongly correlated with mitochondrial anomalies.
Topics: Acetylglucosamine; Acylation; Aged; Aged, 80 and over; Alzheimer Disease; Animals; Brain; Cell Line; Humans; Male; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria; Protein Processing, Post-Translational | 2019 |
Dynamic O-GlcNAcylation and its roles in the cellular stress response and homeostasis.
Topics: Acetylglucosamine; Alzheimer Disease; Animals; beta-N-Acetylhexosaminidases; Calcium; Heat-Shock Proteins; Humans; Mitochondria; N-Acetylglucosaminyltransferases; Parkinson Disease; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction | 2013 |
Effect of xixin decoction on O-linked N-acetylglucosamine glycosylation of tau proteins in rat brain with sporadic Alzheimer disease.
Topics: Acetylglucosamine; Alzheimer Disease; Animals; Brain; Drugs, Chinese Herbal; Glycosylation; Humans; Male; Rats; Rats, Sprague-Dawley; tau Proteins | 2013 |
O-GlcNAc modification of tau directly inhibits its aggregation without perturbing the conformational properties of tau monomers.
Topics: Acetylglucosamine; Alzheimer Disease; Animals; Fluorescence Resonance Energy Transfer; Humans; Mice; Microtubules; Mutagenesis, Site-Directed; Nuclear Magnetic Resonance, Biomolecular; Protein Conformation; Protein Folding; Protein Multimerization; Protein Processing, Post-Translational; Protein Structure, Secondary; Recombinant Proteins; tau Proteins; Tubulin | 2014 |
OGlcNAcylation and phosphorylation have opposing structural effects in tau: phosphothreonine induces particular conformational order.
Topics: Acetylglucosamine; Acylation; Alzheimer Disease; Amino Acid Sequence; Humans; Models, Molecular; Molecular Sequence Data; N-Acetylglucosaminyltransferases; Phosphorylation; Phosphothreonine; Protein Processing, Post-Translational; Protein Stability; Protein Structure, Secondary; tau Proteins | 2014 |
Increased O-GlcNAc levels correlate with decreased O-GlcNAcase levels in Alzheimer disease brain.
Topics: Acetylglucosamine; Aged, 80 and over; Alzheimer Disease; beta-N-Acetylhexosaminidases; Brain; Case-Control Studies; Female; Humans; Immunoblotting; Male; N-Acetylglucosaminyltransferases; Protein Processing, Post-Translational | 2014 |
An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease.
Topics: Acetylglucosamine; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Female; Glycosylation; Humans; Lysosomes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Acetylglucosaminyltransferases; Protein Transport | 2015 |
Neurotoxicity and synaptic plasticity impairment of N-acetylglucosamine polymers: implications for Alzheimer's disease.
Topics: Acetylglucosamine; Aged; Aged, 80 and over; Alzheimer Disease; Animals; Cells, Cultured; Female; Hippocampus; Humans; Long-Term Potentiation; Male; Mice; Microglia; Middle Aged; Neuronal Plasticity; Neurons; Polymers; Qa-SNARE Proteins; Synaptophysin | 2015 |
Mitochondrial ATP synthase activity is impaired by suppressed O-GlcNAcylation in Alzheimer's disease.
Topics: Acetylglucosamine; Adenosine Triphosphate; Alzheimer Disease; Animals; beta-N-Acetylhexosaminidases; CHO Cells; Cricetulus; Disease Models, Animal; Glycosylation; HeLa Cells; Humans; Mice; Mice, Transgenic; Mitochondria; Mitochondrial Proton-Translocating ATPases; N-Acetylglucosaminyltransferases; Oxidative Phosphorylation Coupling Factors; Protein Processing, Post-Translational | 2015 |
Evidence for an imbalance between tau O-GlcNAcylation and phosphorylation in the hippocampus of a mouse model of Alzheimer's disease.
Topics: Acetylglucosamine; Acylation; Alzheimer Disease; Animals; Brain; Disease Models, Animal; Glycosylation; Hippocampus; Humans; Male; Mice; Mice, Transgenic; Phosphorylation; tau Proteins | 2016 |
O-GlcNAcylation of protein kinase A catalytic subunits enhances its activity: a mechanism linked to learning and memory deficits in Alzheimer's disease.
Topics: Acetylglucosamine; Alzheimer Disease; Animals; Brain; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinase Catalytic Subunits; Diazooxonorleucine; Down-Regulation; Glycosylation; HEK293 Cells; HeLa Cells; Humans; Learning; Male; Memory; Memory Disorders; Mice, Inbred C57BL; Phosphorylation; Protein Transport; Rats, Sprague-Dawley; Subcellular Fractions; tau Proteins | 2016 |
Semi-synthesis of a tag-free O-GlcNAcylated tau protein by sequential chemoselective ligation.
Topics: Acetylglucosamine; Alzheimer Disease; Chemistry Techniques, Synthetic; Humans; Molecular Structure; Peptides; Protein Processing, Post-Translational; Serine; tau Proteins | 2016 |
O-GlcNAcylation: A regulator of tau pathology and neurodegeneration.
Topics: Acetylglucosamine; Alzheimer Disease; Animals; Brain; Glucose; Glycosylation; Humans; Mice; Phosphorylation; tau Proteins; Tauopathies | 2016 |
Loss of O-GlcNAc glycosylation in forebrain excitatory neurons induces neurodegeneration.
Topics: Acetylglucosamine; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain Mapping; Crosses, Genetic; Female; Glycosylation; Hippocampus; Humans; Inflammation; Male; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Acetylglucosaminyltransferases; Neurodegenerative Diseases; Neuroglia; Neurons; Phosphorylation; Prosencephalon; Signal Transduction; tau Proteins | 2016 |
O-GlcNAcylation modulates the self-aggregation ability of the fourth microtubule-binding repeat of tau.
Topics: Acetylglucosamine; Acylation; Alzheimer Disease; Amino Acid Sequence; Humans; Microtubules; Molecular Sequence Data; Peptides; Protein Conformation; Repetitive Sequences, Amino Acid; Serine; tau Proteins | 2008 |
Dysregulation of insulin signaling, glucose transporters, O-GlcNAcylation, and phosphorylation of tau and neurofilaments in the brain: Implication for Alzheimer's disease.
Topics: Acetylglucosamine; Alzheimer Disease; Animals; Glucose; Glucose Transport Proteins, Facilitative; Humans; Insulin; Male; Microtubules; N-Acetylglucosaminyltransferases; Neurofilament Proteins; Phosphorylation; Rats; Rats, Wistar; Signal Transduction; Streptozocin; tau Proteins | 2009 |
Aggregation of Alzheimer amyloid beta peptide (1-42) on the multivalent sulfonated sugar interface.
Topics: Acetylglucosamine; Alzheimer Disease; Amyloid beta-Peptides; Amyloidosis; Cell Membrane; HeLa Cells; Humans; Microscopy, Atomic Force; Peptide Fragments; Protein Folding; Spectroscopy, Fourier Transform Infrared; Sulfonic Acids; Surface Plasmon Resonance | 2010 |
Human Alzheimer's disease synaptic O-GlcNAc site mapping and iTRAQ expression proteomics with ion trap mass spectrometry.
Topics: Acetylglucosamine; Alzheimer Disease; Amino Acid Sequence; Animals; Cerebral Cortex; Glycosylation; Humans; Mass Spectrometry; Mice; Molecular Sequence Data; Neuronal Plasticity; Peptide Mapping; Phosphorylation; Proteins; Proteomics; Sequence Alignment; Synapses | 2011 |
O-GlcNAcylation increases non-amyloidogenic processing of the amyloid-β precursor protein (APP).
Topics: Acetylglucosamine; Acylation; Alzheimer Disease; Amyloid beta-Protein Precursor; beta-N-Acetylhexosaminidases; Cell Line, Tumor; Gene Knockdown Techniques; Humans; N-Acetylglucosaminyltransferases; Oximes; Phenylcarbamates; RNA, Small Interfering | 2011 |
Detection and analysis of proteins modified by O-linked N-acetylglucosamine.
Topics: Acetylglucosamine; Alzheimer Disease; Antibodies; beta-N-Acetylhexosaminidases; Cell Nucleus; Cells, Cultured; Diabetes Mellitus, Type 2; Glycosylation; Humans; N-Acetylglucosaminyltransferases; Protein Processing, Post-Translational; Proteins | 2011 |
Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation.
Topics: Acetylglucosamine; Adaptor Proteins, Signal Transducing; Alzheimer Disease; Animals; Carbohydrate Conformation; Disease Models, Animal; Enzyme Inhibitors; Female; Humans; Mice; Mice, Transgenic; N-Acetylglucosaminyltransferases; Neurodegenerative Diseases; Neurons; Phosphorylation; Pyrans; tau Proteins; Thiazoles | 2012 |
Novel glycosaminoglycan precursors as anti-amyloid agents, part III.
Topics: Acetylglucosamine; Alzheimer Disease; Amyloid beta-Peptides; Animals; Basement Membrane; Brain; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Glycosaminoglycans; Golgi Apparatus; Heparan Sulfate Proteoglycans; Hepatocytes; Macrophages; Mice; Molecular Structure; Plaque, Amyloid | 2003 |
O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease.
Topics: Acetylglucosamine; Aged; Aged, 80 and over; Alzheimer Disease; Animals; Brain; Female; Glycosylation; Humans; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Middle Aged; PC12 Cells; Phosphorylation; Rats; Rats, Wistar; Starvation; tau Proteins | 2004 |
Novel glycosaminoglycan precursors as antiamyloid agents: Part IV.
Topics: Acetylglucosamine; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Basement Membrane; Cell Adhesion; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Drug Evaluation, Preclinical; Glycosaminoglycans; Heparan Sulfate Proteoglycans; Hepatocytes; Macrophages; Mice; Mice, Transgenic; Neuroprotective Agents; Protein Conformation | 2004 |
Proton magnetic resonance spectroscopy and magnetoencephalographic estimation of delta dipole density: a combination of techniques that may contribute to the diagnosis of Alzheimer's disease.
Topics: Acetylglucosamine; Aged; Alzheimer Disease; Brain Chemistry; Choline; Creatine; Female; Glutamic Acid; Humans; Inositol; Magnetic Resonance Imaging; Magnetoencephalography; Male; Middle Aged; Phosphocreatine; Regression Analysis | 2005 |
Different content of chitin-like polysaccharides in multiple sclerosis and Alzheimer's disease brains.
Topics: Acetylglucosamine; Aged; Alzheimer Disease; Brain Chemistry; Chitin; Frontal Lobe; Humans; Immunohistochemistry; Macrophages; Middle Aged; Multiple Sclerosis; Polysaccharides; Temporal Lobe | 2008 |
O-linked N-acetylglucosamine is upregulated in Alzheimer brains.
Topics: Acetylglucosamine; Aged; Aged, 80 and over; Alzheimer Disease; Brain; Carbohydrate Conformation; Cerebral Cortex; Cytoskeletal Proteins; Detergents; Hippocampus; Humans; Phosphorylation; Prosencephalon; Proteins; Solubility | 1995 |
Beta-amyloid precursor protein is modified with O-linked N-acetylglucosamine.
Topics: Acetylglucosamine; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Antibodies, Monoclonal; Carbohydrates; Cells, Cultured; Cerebellum; Galactose; Immunohistochemistry; Mice; Mice, Inbred Strains; Precipitin Tests | 1995 |
Reduction of O-linked N-acetylglucosamine-modified assembly protein-3 in Alzheimer's disease.
Topics: Acetylation; Acetylglucosamine; Adaptor Proteins, Vesicular Transport; Aged; Aged, 80 and over; Alzheimer Disease; Cerebellum; Enzyme Inhibitors; Female; Frontal Lobe; Galactose; Galactosyltransferases; Humans; Male; Middle Aged; Molecular Weight; Monomeric Clathrin Assembly Proteins; Nerve Tissue Proteins; Neurofibrillary Tangles; Oligosaccharides; Ovalbumin; Phosphoproteins; Phosphorylation; Tritium | 1998 |
Reduced O-glycosylated clathrin assembly protein AP180: implication for synaptic vesicle recycling dysfunction in Alzheimer's disease.
Topics: Acetylglucosamine; Adaptor Proteins, Vesicular Transport; Alzheimer Disease; Clathrin; Enzyme Inhibitors; Galactose; Glycosylation; Humans; Monomeric Clathrin Assembly Proteins; Nerve Tissue Proteins; Neurofibrillary Tangles; Neurofilament Proteins; Phosphoproteins; Precipitin Tests; Synapses; Synaptic Vesicles; Synaptophysin; Tritium | 1998 |
Role of glycosylation in hyperphosphorylation of tau in Alzheimer's disease.
Topics: Acetylglucosamine; Alzheimer Disease; Glycosylation; Hexoses; Humans; N-Acetylneuraminic Acid; Neurofibrillary Tangles; Nucleotidyltransferases; Phosphorylation; Protein Processing, Post-Translational; tau Proteins | 2002 |
Paired helical filaments are not the major binding sites for wheat germ and Dolichos biflorus agglutinins in the neurofibrillary tangles of Alzheimer's disease.
Topics: Acetylglucosamine; Alzheimer Disease; Cytoskeleton; Glucosamine; Humans; Immunohistochemistry; Intermediate Filaments; Lectins; Membrane Glycoproteins; Plant Lectins; Wheat Germ Agglutinins | 1990 |