acetylcysteine and Parkinsonian Disorders

Topics: Acetylcysteine; alpha-Synuclein; Animals; Chaperone-Mediated Autophagy; Histone Deacetylase 6; HSP90 Heat-Shock Proteins; Humans; Male; Mice; Mice, Inbred C57BL; Parkinsonian Disorders; Protein Aggregates

Topics: Acetylation; Acetylcysteine; Animals; Cell Death; Disease Models, Animal; Dopaminergic Neurons; Histone Deacetylase Inhibitors; Male; Nerve Degeneration; Niacinamide; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley

Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Acetylcysteine; Analysis of Variance; Animals; Calcium-Binding Proteins; Disease Models, Animal; Encephalitis; Glial Fibrillary Acidic Protein; Imaging, Three-Dimensional; Male; Mice; Mice, Inbred C57BL; Microfilament Proteins; Microscopy, Confocal; Neuroprostanes; Parkinsonian Disorders; Physical Conditioning, Animal; S100 Calcium Binding Protein beta Subunit; Substantia Nigra; Time Factors; Tyrosine 3-Monooxygenase

Topics: Acetylcysteine; Action Potentials; Animals; Dicarboxylic Acids; Disease Models, Animal; Exploratory Behavior; Forelimb; Free Radical Scavengers; Functional Laterality; Glutamate Decarboxylase; Glutamate Plasma Membrane Transport Proteins; In Vitro Techniques; Male; Motor Activity; Neuroglia; Neurotransmitter Uptake Inhibitors; Parkinsonian Disorders; Pyrrolidines; Rats; Rats, Wistar; Substantia Nigra; Thiobarbituric Acid Reactive Substances; Tyrosine 3-Monooxygenase

Topics: Acetylcysteine; Albumins; Apoptosis; Arginine; Aspartate Aminotransferases; Catalysis; Cell Survival; Cysteine; Escherichia coli; Fructose-Bisphosphate Aldolase; Glucose; Glycolates; Glyoxal; Humans; Intracellular Signaling Peptides and Proteins; Lactates; Lysine; Mass Spectrometry; Oncogene Proteins; Oxidative Stress; Parkinsonian Disorders; Protein Deglycase DJ-1; Pyruvaldehyde

Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcysteine; Animals; Cell Count; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; GABA-A Receptor Agonists; Homovanillic Acid; Locomotion; Male; Muscimol; Neurons; Oxidopamine; Parkinson Disease; Parkinsonian Disorders; Rats, Wistar; Receptors, GABA-A; Substantia Nigra

Topics: Acetylcysteine; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Drug Interactions; Dynamins; Male; Oxidative Stress; Parkinsonian Disorders; Protein Binding; Random Allocation; Rats; Rats, Wistar; Rotarod Performance Test; Rotenone; Substantia Nigra; Ubiquitin-Protein Ligases

Topics: Acetylcysteine; alpha-Synuclein; Animals; Cell Count; Choline O-Acetyltransferase; Cholinergic Neurons; Disease Models, Animal; Dopaminergic Neurons; Male; Microglia; Neurons; Parkinson Disease; Parkinsonian Disorders; Pars Compacta; Pedunculopontine Tegmental Nucleus; Protein Aggregation, Pathological; Rats; Rats, Sprague-Dawley; Tyrosine 3-Monooxygenase

Topics: Acetylcysteine; Animals; Dopaminergic Neurons; Male; Neuroprotective Agents; Parkinsonian Disorders; Proteasome Inhibitors; Rats, Sprague-Dawley; Substantia Nigra; Valproic Acid; Ventral Tegmental Area

Topics: Acetylcysteine; Animals; Dopaminergic Neurons; Drug Synergism; Estradiol; Female; Immunohistochemistry; Male; Mice; Mice, Neurologic Mutants; Nerve Degeneration; Neuroprotective Agents; Parkinsonian Disorders

Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcysteine; Amphetamine; Animals; Benzazepines; Central Nervous System Agents; Corpus Striatum; Dopamine; Dopamine Antagonists; Functional Laterality; Glutamic Acid; Haloperidol; Homovanillic Acid; Male; Movement; Parkinsonian Disorders; Rats, Wistar; Receptors, Dopamine; Rotation; Substantia Nigra

Topics: Acetylcysteine; Amphetamine; Animals; Apomorphine; Benzazepines; Central Nervous System Stimulants; Corpus Striatum; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Functional Laterality; Male; Motor Activity; Oxidopamine; Parkinsonian Disorders; Pars Compacta; Raclopride; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Rotation

Topics: Acetylcysteine; Artifacts; Culture Media; Cysteine; Escherichia coli; Glucose; Glycation End Products, Advanced; Glycosylation; Glyoxal; Humans; Intracellular Signaling Peptides and Proteins; Mutation; Oncogene Proteins; Parkinsonian Disorders; Protein Deglycase DJ-1; Pyruvaldehyde

Topics: Acetylcysteine; Animals; Behavior, Animal; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Male; Mice, Inbred C57BL; Motor Activity; Neural Pathways; Neuronal Plasticity; Parkinson Disease; Parkinsonian Disorders; Pars Compacta; Post-Synaptic Density; Rotarod Performance Test; Synapses

Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Acetylcysteine; Animals; Cell Death; Cell Line; Cell Survival; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Dopamine; Endoplasmic Reticulum; Endoribonucleases; Humans; Leupeptins; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neurons; Parkinsonian Disorders; Protein Serine-Threonine Kinases; Regulatory Factor X Transcription Factors; RNA, Messenger; Signal Transduction; Stress, Physiological; Transcription Factors; X-Box Binding Protein 1

Topics: Acetylcysteine; alpha-Synuclein; Animals; Apomorphine; Corpus Striatum; Cysteine Proteinase Inhibitors; Disease Models, Animal; Dopamine; Dopamine Agonists; Iron; Magnetic Resonance Imaging; Male; Mesencephalon; Motor Activity; Neurons; Parkinsonian Disorders; Random Allocation; Rats; Rats, Sprague-Dawley; Substantia Nigra

Topics: Acetylcysteine; Animals; Catalase; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Humans; Hydrogen Peroxide; Indans; Male; Neuroprotective Agents; Oxidopamine; Parkinsonian Disorders; PC12 Cells; Rats; Rats, Sprague-Dawley

Topics: Acetylcysteine; Ammonium Chloride; Animals; Disease Models, Animal; Dopamine; Nerve Tissue Proteins; Neurons; Neurotoxins; Oryzias; Parkinsonian Disorders; Phenotype; Substantia Nigra; Tunicamycin

Topics: Acetophenones; Acetylcysteine; Animals; Apoptosis; Caspases; CD11b Antigen; Corpus Striatum; Cytochromes c; Dopamine; Dopaminergic Neurons; Enzyme Inhibitors; Glutathione; Male; Membrane Glycoproteins; Mitochondria; Motor Activity; NADPH Oxidase 2; NADPH Oxidases; Oxidative Stress; Paraquat; Parkinsonian Disorders; Phosphoproteins; Rats; Rats, Wistar; Serotonin; Substantia Nigra; Tyrosine 3-Monooxygenase

Topics: Acetylcysteine; Animals; Cysteine Proteinase Inhibitors; Disease Models, Animal; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopaminergic Neurons; Mice; Mice, Inbred C57BL; Microglia; Motor Activity; Neostriatum; Nuclear Receptor Subfamily 4, Group A, Member 2; Parkinsonian Disorders; Proteasome Endopeptidase Complex; Real-Time Polymerase Chain Reaction; RNA, Messenger; Substantia Nigra; Transcriptional Activation; Vesicular Monoamine Transport Proteins

Topics: Acetylcysteine; Animals; Antioxidants; Cells, Cultured; Chromans; Disease Models, Animal; Dopamine; Drug Combinations; Female; Fetus; Glutathione; Graft Survival; Male; Neurons; Oxidopamine; Parkinsonian Disorders; Piperazines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Stem Cell Transplantation; Stem Cells; Substantia Nigra

Topics: Acetylcysteine; Adolescent; Adult; Age of Onset; Amino Acid Sequence; Animals; Cell Line; DNA Mutational Analysis; Female; Genes, Recessive; Humans; Intracellular Signaling Peptides and Proteins; Male; Middle Aged; Molecular Sequence Data; Mutation; Oncogene Proteins; Parkinsonian Disorders; Protein Deglycase DJ-1; RNA, Messenger

Topics: 1-Methyl-4-phenylpyridinium; Acetylcysteine; Aged; Aged, 80 and over; Analysis of Variance; Animals; Blotting, Northern; Blotting, Western; Cell Differentiation; Cell Line, Tumor; Dopamine; Female; Gene Expression Regulation; Humans; Immunohistochemistry; Lewy Bodies; Male; Middle Aged; Neuroblastoma; Nuclear Proteins; Parkinsonian Disorders; Postmortem Changes; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Tretinoin

Topics: Acetylcysteine; Animals; Deferoxamine; Iron Chelating Agents; Male; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neuroprotective Agents; Parkinsonian Disorders; Proteasome Inhibitors; Substantia Nigra; Treatment Outcome; Ubiquitin

Topics: 1-Methyl-4-phenylpyridinium; Acetylcysteine; Aldehydes; Apoptosis; Cell Death; Cell Line, Tumor; Drug Resistance; Enzyme Inhibitors; Genetic Predisposition to Disease; Glutamic Acid; Guanine; Humans; Hydrogen Peroxide; Mutation; Nerve Degeneration; Neurons; Neurotoxins; Oxidative Stress; Parkinsonian Disorders; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Substantia Nigra; Tyrosine; Ubiquitin-Protein Ligases

Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Acetylcysteine; Alkynes; Animals; Antioxidants; Antiparkinson Agents; Biotransformation; Carrier Proteins; Cell Nucleus; Co-Repressor Proteins; Cystathionine gamma-Lyase; Cytosol; Dopamine; Drug Evaluation, Preclinical; Electron Transport Complex I; Enzyme Activation; Glutathione; Glycine; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Kinase 4; MAP Kinase Kinase Kinase 5; MAP Kinase Signaling System; Mesencephalon; Mice; Mice, Inbred C57BL; Molecular Chaperones; MPTP Poisoning; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Nuclear Proteins; Oncogene Proteins; Parkinsonian Disorders; Peroxiredoxins; Phosphorylation; Protein Deglycase DJ-1; Protein Processing, Post-Translational; Protein Transport; Substantia Nigra; Thioctic Acid

Topics: Acetylcysteine; Brain; Cell Death; Cells, Cultured; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum; Humans; Ligases; Microscopy, Fluorescence; Parkinsonian Disorders; Precipitin Tests; Protein Binding; Protein Folding; Receptors, Cell Surface; Recombinant Fusion Proteins; Two-Hybrid System Techniques; Ubiquitin-Conjugating Enzymes; Ubiquitin-Protein Ligases; Ubiquitins

Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Acetylcysteine; Animals; Apoptosis; Brain; Cell Division; Cell Survival; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Free Radical Scavengers; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nerve Growth Factor; Neurons; p38 Mitogen-Activated Protein Kinases; Parkinsonian Disorders; PC12 Cells; Protein Serine-Threonine Kinases; Rats; Reactive Oxygen Species