acetylcysteine has been researched along with Neurodegenerative Diseases in 37 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.70) | 18.2507 |
| 2000's | 12 (32.43) | 29.6817 |
| 2010's | 17 (45.95) | 24.3611 |
| 2020's | 7 (18.92) | 2.80 |
| Authors | Studies |
|---|---|
| Bravo-Díaz, C; Losada-Barreiro, S | 1 |
| Atlas, D | 1 |
| Cheng, J; Deng, H; Deng, S; Fan, K; Gong, L; Guo, Y; Kang, M; Li, H; Xu, H; Yang, H; Yang, Z; Yuan, L; Zheng, W | 1 |
| Elseady, WS; Ibrahim, MA; Keshk, WA; Shalaby, SM; Zalat, ZA | 1 |
| Pal, A; Pal, S; Rao, GN | 1 |
| Araújo Montoya, BO; Brum, PO; Campos Soares, M; Carazza Kessler, FG; Castro-Faria-Neto, HC; Dal-Pizzol, F; Fonseca Moreira, JC; Gasparotto, J; Gelain, DP; Góes Valente, WC; Ong, LK; Panzenhagen, AC; Peixoto, DO; Reis, PA; Schirato, GV; Senger, MR; Silva, FP; Telles de Sá Moreira, E | 1 |
| Alexis, A; Bergold, PJ; Nikulina, E; Rahman, SN; Whitney, K | 1 |
| Al Dulmani, SA; Al-Zahrani, FAM; Galal, MK; Hassanen, EI; Hussien, AM; Ibrahim, MA; Kamel, S; Morgan, AM; Ogaly, HA; Rashad, MM | 1 |
| Cai, Q; Cheng, W; Du, X; Ewert, DL; Floyd, RA; Kopke, RD; Li, W; West, MB | 1 |
| Ekimova, IV; Plaksina, DV | 1 |
| Bramanti, P; Mazzon, E; Tardiolo, G | 1 |
| Abe, A; Ariga, H; Iguchi-Ariga, SM; Kitaura, H; Maita, H; Shimizu, T; Takahashi-Niki, K; Takekoshi, Y | 1 |
| Krivitsky, A; Polyak, D; Satchi-Fainaro, R; Scomparin, A | 1 |
| Le, W; Xiao, Q; Yang, S | 1 |
| Beart, PM; Cater, MA; Cheung, NS; La Fontaine, S; Llanos, RM; Yap, YW | 1 |
| Heinemann, SD; Hutchison, DF; Leak, RK; Mason, DM; Posimo, JM | 1 |
| Chattipakorn, N; Chattipakorn, SC; Krintratun, W; Sripetchwandee, J; Wongjaikam, S | 1 |
| Das, D; Fox, PL; Mukhopadhyay, C; Mukhopadhyay, CK; Tapryal, N | 1 |
| Fu, X; Mei, J; Niu, C; Pan, Q | 1 |
| Chen, MJ; Cheung, NS; Chong, KW; Koay, ES; Lee, AY; Russo-Marie, F; Wong, BS | 1 |
| Bannai, S; Makino, N; Sagara, J; Shikano, N | 1 |
| Ebrahimi-Fakhari, D; Hyman, BT; McLean, PJ; Unni, VK; Vanderburg, CR | 1 |
| Chen, L; Chen, W; Han, X; Huang, S; Kontos, CD; Liu, L; Luo, Y; Shen, T; Xu, B; Zhou, H | 1 |
| Carlesi, C; Ienco, EC; LoGerfo, A; Mancuso, M; Orsucci, D; Ricci, G; Siciliano, G | 1 |
| Hota, KB; Hota, SK; Singh, SB; Srivastava, RB | 1 |
| Johnson, WM; Mieyal, JJ; Wilson-Delfosse, AL | 1 |
| Abu-Baker, A; Brais, B; Gaspar, C; Laganiere, J; Messaed, C; Rouleau, GA | 1 |
| Morrison, DC; Papasian, CJ; Qureshi, AA; Qureshi, N; Van Way, C; Vogel, SN | 1 |
| Fisher, PB; Sarkar, D | 1 |
| Kuo, YM; Wu, Z; Yang, Y; Zhou, B | 1 |
| Arakawa, M; Ishige, K; Ito, Y; Oda, T; Osada, N; Ushimaru, N | 1 |
| Berk, M; du Preez, JL; Harvey, BH; Joubert, C | 1 |
| Arakawa, M; Ito, Y | 1 |
| Kikuchi, S; Makita, Z; Miyata, T; Moriwaka, F; Shinpo, K; Tashiro, K | 1 |
| Banaclocha, MM | 1 |
| Butterfield, DA; Cardin, AL; Lauderback, CM; Pocernich, CB; Racine, CL | 1 |
| Amamath, V; Montine, TJ; Sidell, KR | 1 |
11 review(s) available for acetylcysteine and Neurodegenerative Diseases
| Article | Year |
|---|---|
Free radicals and polyphenols: The redox chemistry of neurodegenerative diseases.
Topics: Animals; Free Radicals; Humans; Neurodegenerative Diseases; Oxidation-Reduction; Oxidative Stress; Polyphenols; Reactive Oxygen Species | 2017 |
Emerging therapeutic opportunities of novel thiol-amides, NAC-amide (AD4/NACA) and thioredoxin mimetics (TXM-Peptides) for neurodegenerative-related disorders.
Topics: Acetylcysteine; Amides; Humans; Neurodegenerative Diseases; Peptides; Sulfhydryl Compounds; Thioredoxins | 2021 |
Overview on the Effects of
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents; Antioxidants; Clinical Trials as Topic; Humans; Neurodegenerative Diseases; Synaptic Transmission | 2018 |
Achieving successful delivery of oligonucleotides--From physico-chemical characterization to in vivo evaluation.
Topics: Acetylcysteine; Animals; Dendrimers; Drug Delivery Systems; Drug Evaluation, Preclinical; Hepatitis; HIV Infections; Humans; MicroRNAs; Microscopy; Neoplasms; Neurodegenerative Diseases; Oligonucleotides; RNA Interference; Static Electricity | 2015 |
Comparative Microarray Analysis Identifies Commonalities in Neuronal Injury: Evidence for Oxidative Stress, Dysfunction of Calcium Signalling, and Inhibition of Autophagy-Lysosomal Pathway.
Topics: Acetylcysteine; Animals; Autophagy; Calcium Signaling; Humans; Lysosomes; Microarray Analysis; Neurodegenerative Diseases; Neurons; Oxidative Stress; Pesticides; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Receptors, N-Methyl-D-Aspartate; Rotenone; Ubiquitin | 2016 |
Oxidative stress treatment for clinical trials in neurodegenerative diseases.
Topics: Acetylcysteine; Animals; Antioxidants; Clinical Trials as Topic; Humans; Mitochondria; Neurodegenerative Diseases; Oxidative Stress | 2011 |
Dysregulation of glutathione homeostasis in neurodegenerative diseases.
Topics: Acetylcysteine; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Brain; Friedreich Ataxia; Glutathione; Homeostasis; Humans; Huntington Disease; Neurodegenerative Diseases; Parkinson Disease | 2012 |
The proteasome: a central regulator of inflammation and macrophage function.
Topics: Acetylcysteine; Aging; Animals; Atherosclerosis; Cholesterol; Humans; Inflammation; Lipopolysaccharides; Macrophages; Mice; Neurodegenerative Diseases; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Shock, Hemorrhagic; Signal Transduction; Toll-Like Receptor 2 | 2005 |
Molecular mechanisms of aging-associated inflammation.
Topics: Acetylcysteine; Aging; Animals; Anti-Inflammatory Agents; Cell Line, Tumor; Cellular Senescence; Chemokines; Cytokines; Enzyme Inhibitors; Exoribonucleases; Free Radicals; Humans; Inflammation; Neurodegenerative Diseases; NF-kappa B; Reactive Oxygen Species | 2006 |
N-acetylcysteine and neurodegenerative diseases: basic and clinical pharmacology.
Topics: Acetylcysteine; Aldehydes; Central Nervous System Diseases; Cerebellum; Free Radical Scavengers; Humans; Neurodegenerative Diseases; Neurons; Reactive Oxygen Species | 2007 |
Dopamine thioethers in neurodegeneration.
Topics: Acetylcysteine; Animals; Corpus Striatum; Dopamine; Humans; Nerve Degeneration; Neurodegenerative Diseases; Sulfides | 2001 |
26 other study(ies) available for acetylcysteine and Neurodegenerative Diseases
| Article | Year |
|---|---|
Analysis of SOD1 variants in Chinese patients with familial amyotrophic lateral sclerosis.
Topics: Acetylcysteine; Amyotrophic Lateral Sclerosis; East Asian People; Humans; Mutation; Neurodegenerative Diseases; Reactive Oxygen Species; Superoxide Dismutase-1 | 2023 |
Redox status, inflammation, necroptosis and inflammasome as indispensable contributors to high fat diet (HFD)-induced neurodegeneration; Effect of N-acetylcysteine (NAC).
Topics: Acetylcysteine; Animals; Antioxidants; Diet, High-Fat; Inflammasomes; Inflammation; Male; Necroptosis; Neurodegenerative Diseases; Oxidation-Reduction; Oxidative Stress; Rats, Wistar | 2020 |
High glucose-induced ROS accumulation is a critical regulator of ERK1/2-Akt-tuberin-mTOR signalling in RGC-5 cells.
Topics: Acetylcysteine; Animals; DNA, Mitochondrial; Enzyme Inhibitors; Gene Expression Regulation; Glucose; Human Umbilical Vein Endothelial Cells; Humans; Hyperglycemia; Inflammation; Interferon Regulatory Factor-3; Membrane Potential, Mitochondrial; Mice; Mitochondria; Mitogen-Activated Protein Kinase 3; NADPH Oxidases; Neurodegenerative Diseases; Oxidative Stress; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Retinal Ganglion Cells; RNA, Small Interfering; Signal Transduction; TOR Serine-Threonine Kinases; Tuberous Sclerosis Complex 2 Protein | 2020 |
Neurological impairment caused by Schistosoma mansoni systemic infection exhibits early features of idiopathic neurodegenerative disease.
Topics: Acetylcysteine; Animals; Anthelmintics; Astrocytes; Deferoxamine; Disease Models, Animal; Free Radical Scavengers; Male; Mice; Microglia; Morris Water Maze Test; Neurodegenerative Diseases; Praziquantel; Schistosoma mansoni; Schistosomiasis mansoni; Siderophores | 2021 |
Delayed dosing of minocycline plus N-acetylcysteine reduces neurodegeneration in distal brain regions and restores spatial memory after experimental traumatic brain injury.
Topics: Acetylcysteine; Animals; Brain; Brain Injuries, Traumatic; Drug Administration Schedule; Drug Therapy, Combination; Free Radical Scavengers; Male; Memory Disorders; Mice; Mice, Inbred C57BL; Minocycline; Neurodegenerative Diseases; Neuroprotective Agents; Spatial Memory | 2021 |
The ameliorative effect of N-acetylcysteine against penconazole induced neurodegenerative and neuroinflammatory disorders in rats.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Behavior, Animal; Brain; Caspase 3; Elevated Plus Maze Test; Male; Malondialdehyde; Neurodegenerative Diseases; Neuroinflammatory Diseases; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Sprague-Dawley; Signal Transduction; Treatment Outcome; Triazoles | 2021 |
Antioxidants reduce neurodegeneration and accumulation of pathologic Tau proteins in the auditory system after blast exposure.
Topics: Acetylcysteine; Animals; Antioxidants; Auditory Cortex; Benzenesulfonates; Blast Injuries; Cell Death; Cells, Cultured; Hair Cells, Auditory; Male; Neurodegenerative Diseases; Neurons; Rats; Rats, Inbred Strains; Spiral Ganglion; tau Proteins; Unfolded Protein Response; Vestibulocochlear Nerve Diseases | 2017 |
[EFFECT OF QUERCETIN ON NEURODEGENERATIVE AND COMPENSATORY PROCESSES IN NIGROSTRIATAL SYSTEM IN A MODEL OF PRECLINICAL PARKINSON''S DISEASE STAGE IN RATS].
Topics: Acetylcysteine; Animals; Corpus Striatum; Dopaminergic Neurons; HSP70 Heat-Shock Proteins; Male; Neurodegenerative Diseases; Parkinson Disease, Secondary; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Quercetin; Rats; Rats, Wistar; Substantia Nigra | 2016 |
Prefoldin plays a role as a clearance factor in preventing proteasome inhibitor-induced protein aggregation.
Topics: Acetylcysteine; Animals; Antibodies, Monoclonal; Brain; Cell Death; Cell Line, Tumor; Cell Survival; Endoplasmic Reticulum; HeLa Cells; Humans; Male; Mice; Molecular Chaperones; Mutation, Missense; Neurodegenerative Diseases; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Binding; Protein Denaturation; Protein Structure, Tertiary; Thapsigargin; Ubiquitinated Proteins | 2013 |
G2019S LRRK2 and aging confer susceptibility to proteasome inhibitor-induced neurotoxicity in nigrostriatal dopaminergic system.
Topics: Acetylcysteine; Aging; Animals; Corpus Striatum; Cysteine Proteinase Inhibitors; Disease Models, Animal; Dopaminergic Neurons; Genetic Predisposition to Disease; Mice, Transgenic; Microglia; Motor Activity; Mutation; Neurodegenerative Diseases; Protein Serine-Threonine Kinases; Substantia Nigra; Tyrosine 3-Monooxygenase | 2015 |
Synergistic stress exacerbation in hippocampal neurons: Evidence favoring the dual-hit hypothesis of neurodegeneration.
Topics: Acetylcysteine; Animals; Cell Survival; Cells, Cultured; Glutathione; Hippocampus; HSP70 Heat-Shock Proteins; Leupeptins; Microtubule-Associated Proteins; Models, Neurological; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Oxidative Stress; Paraquat; Proteasome Endopeptidase Complex; Rats, Sprague-Dawley; Stress, Physiological | 2016 |
A combination of an iron chelator with an antioxidant effectively diminishes the dendritic loss, tau-hyperphosphorylation, amyloids-β accumulation and brain mitochondrial dynamic disruption in rats with chronic iron-overload.
Topics: Acetylcysteine; Amyloid beta-Peptides; Animals; Antioxidants; Apoptosis; Benzoates; Brain; Deferasirox; Deferoxamine; Dendrites; Diet; Disease Models, Animal; Drug Therapy, Combination; Iron; Iron Chelating Agents; Iron Overload; Male; Mitochondrial Dynamics; Neurodegenerative Diseases; Phosphorylation; Random Allocation; Rats, Wistar; tau Proteins; Triazoles | 2016 |
Reactive oxygen species regulate ceruloplasmin by a novel mRNA decay mechanism involving its 3'-untranslated region: implications in neurodegenerative diseases.
Topics: 3' Untranslated Regions; Acetylcysteine; Animals; Antifungal Agents; Antimycin A; Cell Line, Tumor; Ceruloplasmin; Free Radical Scavengers; Humans; Hydrogen Peroxide; Iron Overload; Mice; Mice, Knockout; Neurodegenerative Diseases; Organ Specificity; Oxidants; Oxidation-Reduction; Oxidative Stress; RNA Stability; RNA-Binding Proteins; Rotenone; Uncoupling Agents | 2009 |
Nigral degeneration with inclusion body formation and behavioral changes in rats after proteasomal inhibition.
Topics: Acetylcysteine; alpha-Synuclein; Animals; Behavior, Animal; Corpus Striatum; Cysteine Proteinase Inhibitors; Disease Models, Animal; Hypokinesia; Inclusion Bodies; Male; Microscopy, Electron, Transmission; Motor Activity; Neurodegenerative Diseases; Neurons; Proteasome Inhibitors; Rats; Rats, Sprague-Dawley; Substantia Nigra; Tyrosine 3-Monooxygenase | 2009 |
Annexin A3 is associated with cell death in lactacystin-mediated neuronal injury.
Topics: Acetylcysteine; Animals; Annexin A3; Cell Death; Cells, Cultured; Cerebral Cortex; Mice; Neurodegenerative Diseases; Neurons; Up-Regulation | 2010 |
Conflicting effects of N-acetylcysteine on purified neurons derived from rat cortical culture.
Topics: Acetylcysteine; Animals; Antioxidants; Cell Culture Techniques; Cell Death; Cell Survival; Cells, Cultured; Female; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Oxidative Stress; Rats | 2010 |
Studying protein degradation pathways in vivo using a cranial window-based approach.
Topics: Acetylcysteine; Animals; Blotting, Western; Craniotomy; Cysteine Proteinase Inhibitors; Disease Models, Animal; Humans; Mice; Microscopy, Confocal; Microtomy; Neurodegenerative Diseases; Proteasome Endopeptidase Complex; Ubiquitin | 2011 |
Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death.
Topics: Acetylcysteine; Androstadienes; Animals; Apoptosis; Cadmium; Carrier Proteins; Environmental Pollutants; Gene Expression Regulation; Humans; Intracellular Signaling Peptides and Proteins; NADPH Oxidases; Neurodegenerative Diseases; Neurons; PC12 Cells; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; rac1 GTP-Binding Protein; Rats; Reactive Oxygen Species; Receptors, Somatomedin; Ribosomal Protein S6 Kinases, 70-kDa; TOR Serine-Threonine Kinases; Wortmannin | 2011 |
Neuroglobin regulates hypoxic response of neuronal cells through Hif-1α- and Nrf2-mediated mechanism.
Topics: Acetylcysteine; Animals; Cell Hypoxia; Cell Survival; Cytochromes c; Free Radical Scavengers; Globins; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Nerve Tissue Proteins; Neurodegenerative Diseases; Neuroglobin; Neurons; NF-E2-Related Factor 2; Oxidation-Reduction; Proteolysis; Rats, Sprague-Dawley | 2012 |
Involvement of the ubiquitin-proteasome pathway and molecular chaperones in oculopharyngeal muscular dystrophy.
Topics: Acetylcysteine; Animals; Blotting, Western; Cell Survival; COS Cells; Cysteine Endopeptidases; Cytoplasm; Heat-Shock Proteins; HeLa Cells; HSP40 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Humans; Immunohistochemistry; Molecular Chaperones; Multienzyme Complexes; Muscular Dystrophy, Oculopharyngeal; Neurodegenerative Diseases; Peptides; Plasmids; Proteasome Endopeptidase Complex; Protein Conformation; Time Factors; Transfection; Ubiquitin | 2003 |
Dietary rescue of fumble--a Drosophila model for pantothenate-kinase-associated neurodegeneration.
Topics: Acetylcysteine; Adenosine Triphosphate; Animal Feed; Animals; Ascorbic Acid; Carnitine; Cloning, Molecular; Creatine; Diet; Disease Models, Animal; Drosophila; Drosophila melanogaster; Edetic Acid; Ginkgo biloba; Heterozygote; Humans; Inosine; Iron; Mutation; Neurodegenerative Diseases; Phenotype; Phosphotransferases (Alcohol Group Acceptor); Transgenes; Vitamin E | 2005 |
N-acetylcysteine selectively protects cerebellar granule cells from 4-hydroxynonenal-induced cell death.
Topics: Acetylcysteine; Aldehydes; Animals; Animals, Newborn; Antioxidants; Brain; Cell Death; Cells, Cultured; Cerebellum; Free Radical Scavengers; Glutathione; L-Lactate Dehydrogenase; Mitochondrial Membranes; Nerve Degeneration; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Neurotoxins; Oxidative Stress; Plant Extracts; Rats; Rats, Wistar | 2006 |
Effect of chronic N-acetyl cysteine administration on oxidative status in the presence and absence of induced oxidative stress in rat striatum.
Topics: Acetylcysteine; Animals; Antipsychotic Agents; Dose-Response Relationship, Drug; Free Radical Scavengers; Glutathione; Haloperidol; Lipid Peroxidation; Male; Neostriatum; Neurodegenerative Diseases; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Sprague-Dawley; Superoxides | 2008 |
Neurotoxicity of methylglyoxal and 3-deoxyglucosone on cultured cortical neurons: synergism between glycation and oxidative stress, possibly involved in neurodegenerative diseases.
Topics: Acetylcysteine; Animals; Apoptosis; Cell Survival; Cells, Cultured; Cerebral Cortex; Deoxyglucose; Dose-Response Relationship, Drug; Drug Synergism; Free Radical Scavengers; Glycation End Products, Advanced; Glycosylation; Neurodegenerative Diseases; Neurons; Oxidative Stress; Peroxides; Pyruvaldehyde; Rats; Rats, Sprague-Dawley | 1999 |
Therapeutic potential of N-acetylcysteine in age-related mitochondrial neurodegenerative diseases.
Topics: Acetylcysteine; Aging; Humans; Mitochondria; Neurodegenerative Diseases | 2001 |
Glutathione elevation and its protective role in acrolein-induced protein damage in synaptosomal membranes: relevance to brain lipid peroxidation in neurodegenerative disease.
Topics: Acetylcysteine; Acrolein; Animals; Brain; Cell Membrane; Electron Spin Resonance Spectroscopy; Female; Gerbillinae; Glutathione; Lipid Peroxidation; Nerve Tissue Proteins; Neurodegenerative Diseases; Synaptosomes | 2001 |