acetylcysteine has been researched along with Neuroblastoma in 91 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (13.19) | 18.2507 |
| 2000's | 45 (49.45) | 29.6817 |
| 2010's | 30 (32.97) | 24.3611 |
| 2020's | 4 (4.40) | 2.80 |
| Authors | Studies |
|---|---|
| Chang, J; Liu, XH; Que, ZL; Sun, X; Yu, JM; Zhou, WJ | 1 |
| Fu, Y; Hu, JF; Li, M; Ma, GL; Tang, Y; Wei, BG; Xiong, J; Yang, GX; Zhang, HY; Zhao, Y | 1 |
| Huang, Y; Li, J; Ma, L; Su, L; Wang, R; Wu, Y; Yang, GX; Zhang, C | 1 |
| Boga, C; Calonghi, N; Di Foggia, M; Esposito, E; Farruggia, G; Fiori, J; Micheletti, G; Rizzardi, N; Taddei, P; Zalambani, C | 1 |
| Baik, TK; Kim, YJ; Lee, JH; Lee, MJ; Lee, YJ; Woo, RS; Yoo, JY | 1 |
| Deng, YN; He, XL; Li, YF; Wang, LJ; Wang, T; Zhang, YH | 1 |
| Kommalapati, VK; Kumar, D; Tangutur, AD | 1 |
| Liu, Q; Qin, P; Shi, L; Wang, Q; Zhang, J | 1 |
| Chi, GF; Ding, Y; Feng, CS; Ge, PF; Luo, YN; Piao, MH; Wang, HF; Wang, ZQ | 1 |
| Chen, X; Davidoff, AM; Lian, G; Liu, L; Shah, N; Shen, Y; Wang, R; Wang, T; Yang, J | 1 |
| Abdal Dayem, A; Cho, SG; Choi, HY; Lee, SB | 1 |
| Jurkowska, H; Wróbel, M | 1 |
| Alboni, S; Benatti, C; Benatti, S; Brunello, N; Cossarizza, A; Gibellini, L; Montanari, C; Pariante, CM; Tascedda, F | 1 |
| Czarnecka, A; Domin, H; Jantas, D; Konieczny, J; Kuter, K; Lasoń, W; Lenda, T; Lorenc-Koci, E; Śmiałowska, M | 1 |
| Muldoon, LL; Neuwelt, EA; Pagel, MA; Wu, YJ | 1 |
| Ercal, N; Maddirala, Y; Tobwala, S | 1 |
| Chung, DH; Craig, BT; Gius, DR; Lee, S; Paul, P; Qiao, J; Rellinger, EJ; Zhu, Y | 1 |
| de Bittencourt Pasquali, MA; de Miranda Ramos, V; Dunkley, P; Gasparotto, J; Gelain, DP; Klafke, K; Moreira, JCF; Zanotto-Filho, A | 1 |
| Hwang, GW; Ishida, Y; Lee, JY; Naganuma, A; Takahashi, T | 1 |
| Butini, S; Campiani, G; Lennon, JC; O'Meara, A; Williams, DC; Zisterer, DM | 1 |
| Colla, R; De Ciucis, C; Domenicotti, C; Fenoglio, D; Furfaro, AL; Izzotti, A; Marengo, B; Passalacqua, M; Pronzato, MA; Pulliero, A; Ravera, S; Ricciarelli, R; Speciale, A; Traverso, N | 1 |
| Hirota, K; Kusunoki, M; Matsuo, Y; Nishi, K; Okamoto, A; Oku, K; Shingu, K; Sumi, C; Takenaga, K; Tanaka, M | 1 |
| Deng, H; Jankovic, J; Le, W; Pan, T; Xie, W; Zhao, H; Zhu, W | 1 |
| Caccamo, D; Condello, S; Currò, M; Ferlazzo, N; Ientile, R; Parisi, G | 1 |
| Chang, LS; Chen, KC; Lin, SR | 1 |
| Chen, X; Gao, P; Guo, L; He, P; Niu, Q; Wang, A; Xia, T; Xu, B; Xu, Z | 1 |
| Becker, A; Soliman, KF | 1 |
| Basu, A; Duseja, R; Ghosh, D; Mishra, MK | 1 |
| Galindo, MF; Jordán, J; Manzanares, J; Perez-Alvarez, S; Solesio, ME | 1 |
| Bamba, H; Hisa, Y; Sato, T; Tooyama, I; Urushitani, M | 1 |
| Aykin-Burns, N; O'Dorisio, MS; Shutt, DC; Spitz, DR | 1 |
| Chen, S; Ding, J; Ma, J; Sheng, C; Tan, Y; Wang, H; Wang, Z | 1 |
| Satayavivad, J; Suntararuks, S; Thiantanawat, A; Visitnonthachai, D; Watcharasit, P | 1 |
| Agrawal, K; George, W; Mondal, D; Petroni, D; Tsai, J | 1 |
| Chen, N; Hanly, L; Koren, G; Rieder, M; Yeger, H | 1 |
| Benbow, JH; DeGray, B; Ehrlich, BE | 1 |
| Chen, JH; Lin, CY; Lin, HH; Tsai, CW | 1 |
| Jiang, C; Liu, H; Ruan, J; Xiong, C | 1 |
| Ki, YW; Koh, HC; Lee, JE; Park, JH; Shin, IC | 1 |
| Cho, DH; Hong, J; Jo, YK; Kim, ES; Park, SJ; Shin, JH | 1 |
| Arsikin, K; Bumbasirevic, V; Harhaji-Trajkovic, L; Jovanovic, M; Kravic-Stevovic, T; Ristic, B; Tovilovic, G; Trajkovic, V; Zogovic, N | 1 |
| Maccioni, RB; Muñoz, P; Núñez, MT; Núñez-Millacura, C; Tapia, V | 1 |
| Hashimoto, K; Iyo, M; Komatsu, N; Shimizu, E | 1 |
| David, DC; Goedert, M; Layfield, R; Narain, Y; Serpell, L; Spillantini, MG | 1 |
| Junn, E; Kim, YM; Lee, G; Mouradian, MM; Tanaka, M | 1 |
| Bardini, P; Danni, O; Guglielmotto, M; Marra, L; Parola, M; Santoro, G; Tabaton, M; Tamagno, E | 1 |
| Benedi, J; Molina-Jimenez, MF; Sanchez-Reus, MI | 1 |
| Beretta, S; Carrì, MT; Casciati, A; Ceresa, C; Ferrarese, C; Ferri, A; Mattavelli, L; Sala, G | 1 |
| Hanson, AJ; Kumar, B; Prasad, KN | 1 |
| Andres, D; Benedi, J; Cascales, M; Molina-Jiménez, MF; Sánchez-Reus, MI | 2 |
| Conn, KJ; Eisenhauer, PB; Fine, RE; Gao, W; Lan, MS; McKee, A; Ullman, MD; Wells, JM | 1 |
| Cowburn, RF; Flood, F; Johnston, JA; Lannfelt, L; Murphy, S; Walker, B | 1 |
| Carreras, I; Conn, KJ; Eisenhauer, PB; Fine, RE; Garrett-Young, R; Ullman, MD; Wells, JM | 1 |
| Ahmad, R; Blackinton, J; Canet-Avilés, RM; Cookson, MR; Hague, SM; Kaleem, M; Miller, DW; van der Brug, MP | 1 |
| Kawatani, Y; Minegishi, N; Shimizu, R; Suzuki, N; Yamamoto, M | 1 |
| Graves, M; Ortiz, D; Rogers, E; Shea, TB; Tchantchou, F | 1 |
| Akaike, A; Izumi, Y; Katsuki, H; Kume, T; Sawada, H; Shimohama, S; Yamamoto, N | 1 |
| Aimo, L; Erlejman, AG; Keen, CL; Mackenzie, GG; Oteiza, PI; Zago, MP | 1 |
| Maeda, S; Ogita, K; Yamamuro, A; Yoshioka, Y | 1 |
| Inomata, M; Nakamura, M; Ohno, H; Shintani-Ishida, K; Uemura, K; Yoshida, K | 1 |
| Ceña, V; Posadas, I; Prieto-Lloret, J; Santos, P; Vellecco, V | 1 |
| Cai, F; He, G; Ishiura, S; Qing, H; Song, W; Tong, Y | 1 |
| Chi, ZQ; Ju, YW; Li, Q; Lin, X; Liu, JG; Wang, MW; Wang, YJ | 1 |
| Balakrishnan, S; Carrì, MT; Ebert, S; Goos, M; Jaiswal, MK; Keller, BU; Mitchell, T; Nau, R; Zech, WD | 1 |
| Chung, HY; Chung, JH; Kim, JH; Kim, JR; Kim, KS; Kim, MK; Kim, MS; Kim, SJ; Lee, J; Yu, BP | 1 |
| Sens, DA; Shavali, S | 1 |
| Chock, PB; Kwak, HS; Yim, HS; Yim, MB | 1 |
| Hayashi, M; Katagiri, M; Matsuzaki, K; Omura, S; Tanaka, H | 1 |
| Corey, EJ; Fenteany, G; Reichard, GA; Schreiber, SL; Standaert, RF | 1 |
| Osda, H | 1 |
| Baraban, JM; Hardwick, JM; Lee, SH; Lin, KI; Narayanan, R; Ratan, RR | 1 |
| Fenteany, G; Schreiber, SL | 2 |
| Bonvini, P; Neckers, LM; Nguyen, P; Trepel, J | 1 |
| Bercovich, B; Ciechanover, A; Gross-Mesilaty, S; Kahana, C; Reinstein, E; Schwartz, AL; Tobias, KE | 1 |
| Honda, T; Mercken, M; Murayama, M; Murayama, O; Nihonmatsu, N; Omori, A; Saido, TC; Sato, K; Takahashi, H; Takashima, A; Tsubuki, S; Yasutake, K | 1 |
| Huang, FF; Keller, JN; Markesbery, WR | 1 |
| Bang, JH; Choi, KS; Huh, K; Kim, SU; Park, SA | 1 |
| Omura, S; Tomoda, H | 1 |
| Baysang, G; Brack, C; Brockhaus, M; Meier, F; Müller-Spahn, F; Olivieri, G; Stähelin, HB | 1 |
| AbdulKarim, B; Bourhis, J; Deutsch, E; Dugray, A; Eschwege, F; M'Kacher, R; Maggiorella, L; Marangoni, E; Rasy, SD; Turhan, AG; Vaganay, S; Vainchenker, W | 1 |
| Ashline, D; Collins, SC; Dhitavat, S; Ho, PI; Ortiz, D; Rogers, E; Shea, TB | 1 |
| Junn, E; Mouradian, MM | 1 |
| Chong, YH; Montelaro, RC; Park, HK; Shin, SA; Sung, JH | 1 |
| Baysang, G; Brack, C; Studer, R | 1 |
| Gafni, M; Keren, O; Sarne, Y; Shapira, M | 1 |
| Andreatta, C; Nahreini, P; Prasad, KN | 1 |
| De Busser, HM; Lagrou, AR; Van Dessel, GA | 1 |
| Fujimoto, T; Matsuzaki, K; Moriguchi, R; Omura, S; Otoguro, K; Sasaki, Y; Tanaka, H | 1 |
| Fujimoto, T; Fujita, S; Furuya, T; Kosuge, K; Matsuzaki, K; Nakagawa, A; Omura, S | 1 |
3 review(s) available for acetylcysteine and Neuroblastoma
| Article | Year |
|---|---|
[Differentiation inducing compounds].
Topics: Acetylcysteine; Alkaloids; Animals; Anthraquinones; Blood Cells; Cell Differentiation; Cells, Cultured; Humans; Leukemia, Experimental; Neuroblastoma; Purine Nucleosides; Ribonucleosides; Sesquiterpenes; Staurosporine | 1993 |
Lactacystin, proteasome function, and cell fate.
Topics: Acetylcysteine; Animals; Apoptosis; Cell Cycle; Cell Line; Cell Physiological Phenomena; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Mice; Multienzyme Complexes; Neurites; Neuroblastoma; Proteasome Endopeptidase Complex | 1998 |
Lactacystin, a proteasome inhibitor: discovery and its application in cell biology.
Topics: Acetylcysteine; Animals; Antigen Presentation; Cell Cycle Proteins; Cell Differentiation; Cell Physiological Phenomena; Circadian Rhythm; Cysteine Endopeptidases; Endoplasmic Reticulum; Lactones; Multienzyme Complexes; Neuroblastoma; Proteasome Endopeptidase Complex; Structure-Activity Relationship; Ubiquitins | 2000 |
88 other study(ies) available for acetylcysteine and Neuroblastoma
| Article | Year |
|---|---|
Neuroprotective effects of mercaptoethylleonurine and mercaptoethylguanidine analogs on hydrogen peroxide-induced apoptosis in human neuronal SH-SY5Y cells.
Topics: Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Guanidines; Humans; Hydrogen Peroxide; Neuroblastoma; Neuroprotective Agents; Proto-Oncogene Proteins c-bcl-2 | 2013 |
Casuarinines A-J, lycodine-type alkaloids from Lycopodiastrum casuarinoides.
Topics: Acetylcholinesterase; Alkaloids; Cholinesterase Inhibitors; Humans; Hydrogen Peroxide; Lycopodiaceae; Molecular Structure; Neuroblastoma; Neuroprotective Agents; Nuclear Magnetic Resonance, Biomolecular; Piperidines | 2013 |
Synthesis and biological evaluation of 3-carbamate smilagenin derivatives as potential neuroprotective agents.
Topics: Animals; Glucose; Humans; Hydrogen Peroxide; Mice; Molecular Structure; Neuroblastoma; Neuroprotective Agents; Nitric Oxide; Oxidants; Oxidative Stress; Oxygen; RAW 264.7 Cells; Spirostans | 2019 |
Synthesis of thia-Michael-Type Adducts between Naphthoquinones and
Topics: Acetylcysteine; Cell Line, Tumor; HeLa Cells; Humans; Naphthoquinones; Neuroblastoma; Reactive Oxygen Species | 2022 |
Multiple low-dose radiation-induced neuronal cysteine transporter expression and oxidative stress are rescued by N-acetylcysteine in neuronal SH-SY5Y cells.
Topics: Acetylcysteine; Apoptosis; Cell Line, Tumor; Cell Survival; Humans; Neuroblastoma; Oxidative Stress; Reactive Oxygen Species; Tumor Suppressor Protein p53 | 2023 |
N-acetylcysteine improves autism-like behavior by recovering autophagic deficiency and decreasing Notch-1/Hes-1 pathway activity.
Topics: Acetylcysteine; Animals; Autistic Disorder; Behavior, Animal; Disease Models, Animal; Female; Humans; Neuroblastoma; Prenatal Exposure Delayed Effects; Rats; Valproic Acid | 2023 |
Inhibition of JNJ-26481585-mediated autophagy induces apoptosis via ROS activation and mitochondrial membrane potential disruption in neuroblastoma cells.
Topics: Acetylcysteine; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chloroquine; Drug Synergism; Free Radical Scavengers; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Membrane Potential, Mitochondrial; Mitochondria; Neuroblastoma; Peripheral Nervous System Neoplasms; Reactive Oxygen Species | 2020 |
Honokiol triggers receptor‑interacting protein kinase 3‑mediated cell death of neuroblastoma cells by upregulating reactive oxygen species.
Topics: Acetylcysteine; Apoptosis; Biphenyl Compounds; Cell Line, Tumor; Cell Proliferation; Cell Survival; Gene Silencing; Humans; Lignans; Neuroblastoma; Reactive Oxygen Species; Receptor-Interacting Protein Serine-Threonine Kinases; RNA, Small Interfering; Time Factors; Up-Regulation | 2017 |
Endoplasmic reticulum stress regulates oxygen-glucose deprivation-induced parthanatos in human SH-SY5Y cells via improvement of intracellular ROS.
Topics: Acetylcysteine; Apoptosis; Cell Line, Tumor; Endoplasmic Reticulum Stress; Free Radical Scavengers; Glucose; Glutathione; Humans; Hypoxia; L-Lactate Dehydrogenase; Lipid Peroxidation; Membrane Potential, Mitochondrial; Neuroblastoma; Phenylbutyrates; Reactive Oxygen Species; RNA, Small Interfering; Time Factors; Transfection | 2018 |
MYCN drives glutaminolysis in neuroblastoma and confers sensitivity to an ROS augmenting agent.
Topics: Acetylcysteine; Allografts; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Child; Dimethyl Fumarate; Drug Screening Assays, Antitumor; Free Radical Scavengers; Gene Expression Regulation, Neoplastic; Glutamine; Glycolysis; Humans; Mice; N-Myc Proto-Oncogene Protein; Neural Crest; Neuroblastoma; Neurons; Reactive Oxygen Species; RNA, Small Interfering; Signal Transduction | 2018 |
Silver Nanoparticles: Two-Faced Neuronal Differentiation-Inducing Material in Neuroblastoma (SH-SY5Y) Cells.
Topics: Acetylcysteine; Cell Line, Tumor; Humans; Membrane Potential, Mitochondrial; Metal Nanoparticles; Mitogen-Activated Protein Kinase 3; Neuroblastoma; Neurogenesis; Neurons; Reactive Oxygen Species; Silver; Tretinoin | 2018 |
Inhibition of Human Neuroblastoma Cell Proliferation by N-acetyl-L-cysteine as a Result of Increased Sulfane Sulfur Level.
Topics: Acetylcysteine; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Neuroblastoma; Sulfur Compounds; Sulfurtransferases; Up-Regulation | 2018 |
N-acetyl-cysteine prevents toxic oxidative effects induced by IFN-α in human neurons.
Topics: Acetylcysteine; Analysis of Variance; Apoptosis; bcl-2-Associated X Protein; Brain-Derived Neurotrophic Factor; Bromodeoxyuridine; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Flow Cytometry; Gene Expression Regulation; Humans; In Situ Nick-End Labeling; Neuroblastoma; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; RNA, Messenger; Time Factors; Tretinoin; Tumor Necrosis Factor-alpha | 2013 |
Lack of neuroprotective effect of celastrol under conditions of proteasome inhibition by lactacystin in in vitro and in vivo studies: implications for Parkinson's disease.
Topics: Acetylcysteine; Animals; Cell Line, Tumor; Cell Survival; Cells, Cultured; Cerebral Cortex; Corpus Striatum; Dopamine; Humans; Male; Mice; Neuroblastoma; Neurons; Neuroprotective Agents; Parkinson Disease; Pentacyclic Triterpenes; Proteasome Inhibitors; Rats; Rats, Wistar; Substantia Nigra; Triterpenes | 2014 |
N-acetylcysteine chemoprotection without decreased cisplatin antitumor efficacy in pediatric tumor models.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Antioxidants; Brain Neoplasms; Cells, Cultured; Child; Cisplatin; Disease Models, Animal; Female; Humans; Male; Medulloblastoma; Neoplasm Transplantation; Neoplasms, Experimental; Neuroblastoma; Oxidative Stress; Rats; Rats, Nude | 2015 |
N-acetylcysteineamide protects against manganese-induced toxicity in SHSY5Y cell line.
Topics: Acetylcysteine; Adenosine Triphosphate; Antioxidants; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Interactions; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Humans; Lipid Peroxidation; Malondialdehyde; Manganese; Neuroblastoma; Oxidative Stress; Reactive Oxygen Species; Time Factors | 2015 |
Antioxidant inhibition of steady-state reactive oxygen species and cell growth in neuroblastoma.
Topics: Acetylcysteine; Antioxidants; Biomarkers, Tumor; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Humans; Immunohistochemistry; Neuroblastoma; Reactive Oxygen Species | 2015 |
NRF2 Mediates Neuroblastoma Proliferation and Resistance to Retinoic Acid Cytotoxicity in a Model of In Vitro Neuronal Differentiation.
Topics: Acetylcysteine; Cell Death; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cell Survival; Extracellular Signal-Regulated MAP Kinases; Humans; Models, Biological; Neuroblastoma; NF-E2-Related Factor 2; Phosphorylation; Proto-Oncogene Proteins c-akt; Tretinoin | 2016 |
Transport of pyruvate into mitochondria is involved in methylmercury toxicity.
Topics: Acetyl Coenzyme A; Acetylcysteine; Antioxidants; Cytoplasm; Humans; Lactate Dehydrogenases; Methylmercury Compounds; Mitochondria; Neuroblastoma; Phosphopyruvate Hydratase; Pyruvic Acid; Reactive Oxygen Species; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2016 |
Involvement of AMP-activated protein kinase in mediating pyrrolo-1,5-benzoxazepine-induced apoptosis in neuroblastoma cells.
Topics: Acetyl-CoA Carboxylase; Acetylcysteine; AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Antioxidants; Apoptosis; Carboplatin; Cell Line, Tumor; Female; Humans; Mechanistic Target of Rapamycin Complex 1; Mice, Inbred BALB C; Mice, Nude; Myeloid Cell Leukemia Sequence 1 Protein; Neuroblastoma; Oxazepines; Phosphorylation; Pyrroles; Reactive Oxygen Species; Tubulin Modulators; Tumor Burden | 2016 |
Glutathione-mediated antioxidant response and aerobic metabolism: two crucial factors involved in determining the multi-drug resistance of high-risk neuroblastoma.
Topics: Acetylcysteine; Antioxidants; Apoptosis; Buthionine Sulfoximine; Catalase; Cell Line, Tumor; Cell Membrane; Cell Proliferation; Cell Survival; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Enzyme Inhibitors; Etoposide; Glutathione; Humans; Hydrogen Peroxide; Lipid Peroxidation; Neuroblastoma; Topoisomerase II Inhibitors; Up-Regulation | 2016 |
The antioxidant N-acetyl cysteine suppresses lidocaine-induced intracellular reactive oxygen species production and cell death in neuronal SH-SY5Y cells.
Topics: Acetylcysteine; Anesthetics, Local; Antioxidants; Apoptosis; Bupivacaine; Cell Death; Cell Line, Tumor; Cell Survival; Chromans; Dose-Response Relationship, Drug; HeLa Cells; Humans; Lidocaine; Membrane Potential, Mitochondrial; Mepivacaine; Mitochondria; Neuroblastoma; Reactive Oxygen Species; Time Factors | 2016 |
Nurr1 deficiency predisposes to lactacystin-induced dopaminergic neuron injury in vitro and in vivo.
Topics: Acetylcysteine; Analysis of Variance; Animals; Apoptosis; Brain Injuries; Causality; Cell Line, Tumor; DNA-Binding Proteins; Dopamine; Gene Expression Regulation; Humans; Male; Mice; Mice, Knockout; Neuroblastoma; Neurons; Nuclear Receptor Subfamily 4, Group A, Member 2; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-bcl-2; RNA, Small Interfering; Transcription Factors; Transfection; Tyrosine 3-Monooxygenase | 2008 |
NF-kappaB activation is associated with homocysteine-induced injury in Neuro2a cells.
Topics: Acetylcysteine; alpha-Tocopherol; Animals; Apoptosis; bcl-2-Associated X Protein; Benzofurans; Blotting, Western; Caspase 3; Cell Differentiation; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Electrophoretic Mobility Shift Assay; Free Radical Scavengers; Homocysteine; Mitochondria; Neuroblastoma; NF-kappa B; Peptides; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Tumor Suppressor Protein p53; Vitamin E | 2008 |
Involvement of mitochondrial alteration and reactive oxygen species generation in Taiwan cobra cardiotoxin-induced apoptotic death of human neuroblastoma SK-N-SH cells.
Topics: Acetylcysteine; Apoptosis; Caspases; Cell Line, Tumor; Cobra Cardiotoxin Proteins; Cyclosporine; Cytochromes c; Elapid Venoms; Enzyme Activation; Free Radical Scavengers; Humans; Membrane Potential, Mitochondrial; Mitochondria; Neuroblastoma; Reactive Oxygen Species; Rotenone; Uncoupling Agents | 2008 |
Influence of PCB153 on oxidative DNA damage and DNA repair-related gene expression induced by PBDE-47 in human neuroblastoma cells in vitro.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetylcysteine; Cell Line, Tumor; Deoxyguanosine; DNA Breaks; DNA Damage; DNA Repair; DNA-Binding Proteins; Gene Expression; Halogenated Diphenyl Ethers; Humans; Neuroblastoma; Oxidative Stress; Polychlorinated Biphenyls; Reactive Oxygen Species; X-ray Repair Cross Complementing Protein 1 | 2009 |
The role of intracellular glutathione in inorganic mercury-induced toxicity in neuroblastoma cells.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Cell Line, Tumor; Cell Survival; Cytoprotection; Glutamate-Cysteine Ligase; Glutathione; Mercuric Chloride; Mercury Poisoning; Mice; Neuroblastoma; Sulfhydryl Compounds | 2009 |
Antioxidant potential of Minocycline in Japanese Encephalitis Virus infection in murine neuroblastoma cells: correlation with membrane fluidity and cell death.
Topics: Acetylcysteine; Animals; Anisotropy; Anti-Bacterial Agents; Antioxidants; Blotting, Western; Brain Neoplasms; Cell Death; Cell Line, Tumor; Encephalitis, Japanese; Enzyme Inhibitors; Free Radicals; In Situ Nick-End Labeling; L-Lactate Dehydrogenase; Membrane Fluidity; Membrane Potentials; Mice; Mice, Inbred BALB C; Minocycline; Mitochondrial Membranes; Neuroblastoma; Onium Compounds; Reactive Oxygen Species | 2009 |
Lactacystin requires reactive oxygen species and Bax redistribution to induce mitochondria-mediated cell death.
Topics: Acetylcysteine; Apoptosis; bcl-2-Associated X Protein; Cell Death; Cell Line, Tumor; Cell Survival; Coloring Agents; Cytochromes c; Cytosol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Green Fluorescent Proteins; Humans; Membrane Potential, Mitochondrial; Mitochondria, Liver; Neuroblastoma; Reactive Oxygen Species; Recombinant Fusion Proteins; Tetrazolium Salts; Thiazoles | 2009 |
Synergistic effect between proteasome and autophagosome in the clearance of polyubiquitinated TDP-43.
Topics: Acetylcysteine; Adenine; Analysis of Variance; Autophagy; Cell Line, Tumor; Cell Nucleus; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Synergism; Green Fluorescent Proteins; Humans; Mutation; Neuroblastoma; Proteasome Endopeptidase Complex; Protein Transport; Subcellular Fractions; Transfection; Ubiquitin-Protein Ligases; Ubiquitination | 2010 |
2-deoxy-D-glucose induces oxidative stress and cell killing in human neuroblastoma cells.
Topics: AC133 Antigen; Acetylcysteine; Antigens, CD; Antimetabolites; Antioxidants; Catalase; Cell Line; Cell Line, Tumor; Cell Survival; Deoxyglucose; Dose-Response Relationship, Drug; Free Radical Scavengers; Glycoproteins; GTP-Binding Proteins; Humans; Immunohistochemistry; Neuroblastoma; Neurons; Oxidative Stress; Peptides; Polyethylene Glycols; Protein Glutamine gamma Glutamyltransferase 2; Stem Cells; Superoxide Dismutase; Time Factors; Transglutaminases; Tubulin | 2010 |
Amyloid-beta1-42 induces reactive oxygen species-mediated autophagic cell death in U87 and SH-SY5Y cells.
Topics: Acetylcysteine; Adenine; Amyloid beta-Peptides; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Division; Cell Line, Tumor; Drug Interactions; Glioma; Humans; Membrane Proteins; Mice; Mice, Mutant Strains; Neuroblastoma; Neurons; Oligopeptides; Peptide Fragments; Reactive Oxygen Species; RNA, Small Interfering | 2010 |
Acrylonitrile induced apoptosis via oxidative stress in neuroblastoma SH-SY5Y cell.
Topics: Acetylcysteine; Acrylonitrile; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Death; Cell Line, Tumor; Cell Survival; Enzyme Activation; Humans; Neuroblastoma; Oxidative Stress; Poly(ADP-ribose) Polymerases | 2010 |
Low-dose methylmercury-induced oxidative stress, cytotoxicity, and tau-hyperphosphorylation in human neuroblastoma (SH-SY5Y) cells.
Topics: Acetylcysteine; Antioxidants; Buthionine Sulfoximine; Cell Line, Tumor; Cell Survival; Dipeptides; Glutathione; Humans; Methylmercury Compounds; Mitochondria; Neuroblastoma; Oxidative Stress; Phosphorylation; Reactive Oxygen Species; tau Proteins | 2012 |
The effect of N-acetylcysteine on the antitumor activity of ifosfamide.
Topics: Acetylcysteine; Antineoplastic Agents, Alkylating; Cell Line, Tumor; Cell Survival; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Humans; Ifosfamide; Mesna; Neuroblastoma; Phosphoramide Mustards; Rhabdomyosarcoma | 2011 |
Protection of neuronal calcium sensor 1 protein in cells treated with paclitaxel.
Topics: Acetylcysteine; Calcium Signaling; Calpain; Cell Line, Tumor; Humans; Mutation; Neuroblastoma; Neuronal Calcium-Sensor Proteins; Neurons; Neuropeptides; Paclitaxel; Point Mutation; Protease Inhibitors; Protein Isoforms; Signal Transduction; Thermodynamics | 2011 |
Carnosic acid, a rosemary phenolic compound, induces apoptosis through reactive oxygen species-mediated p38 activation in human neuroblastoma IMR-32 cells.
Topics: Abietanes; Acetylcysteine; Apoptosis; Caspase 3; Cell Line, Tumor; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Humans; JNK Mitogen-Activated Protein Kinases; Neuroblastoma; p38 Mitogen-Activated Protein Kinases; Plant Extracts; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species | 2011 |
DEDC, a new flavonoid induces apoptosis via a ROS-dependent mechanism in human neuroblastoma SH-SY5Y cells.
Topics: Acetylcysteine; Antioxidants; Apoptosis; Cell Line, Tumor; Cell Survival; Cyclohexanones; Flavones; Humans; Neuroblastoma; NF-kappa B; Pyrrolidines; Reactive Oxygen Species; Signal Transduction; STAT3 Transcription Factor; Thiocarbamates; Tumor Suppressor Protein p53 | 2012 |
Reactive oxygen species and mitogen-activated protein kinase induce apoptotic death of SH-SY5Y cells in response to fipronil.
Topics: Acetylcysteine; Antioxidants; Apoptosis; Caspase 3; Caspase 9; Cell Line, Tumor; Humans; Insecticides; Mitogen-Activated Protein Kinases; Neuroblastoma; Oxidative Stress; Pyrazoles; Reactive Oxygen Species | 2012 |
Sertindole, a potent antagonist at dopamine D₂ receptors, induces autophagy by increasing reactive oxygen species in SH-SY5Y neuroblastoma cells.
Topics: Acetylcysteine; Antioxidants; Antipsychotic Agents; Autophagy; Cell Line, Tumor; Chromans; Dopamine D2 Receptor Antagonists; Humans; Imidazoles; Indoles; Neuroblastoma; Reactive Oxygen Species; Receptors, Dopamine D2 | 2012 |
Autophagy-dependent and -independent involvement of AMP-activated protein kinase in 6-hydroxydopamine toxicity to SH-SY5Y neuroblastoma cells.
Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; AMP-Activated Protein Kinases; Apoptosis; Autophagy; Cell Line; Gene Expression Regulation; Humans; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; Neuroblastoma; Oxidopamine; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Ribosomal Protein S6 Kinases, 70-kDa; RNA, Small Interfering; Sequestosome-1 Protein; Sirolimus; TOR Serine-Threonine Kinases | 2012 |
An oxidative stress-mediated positive-feedback iron uptake loop in neuronal cells.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetylcysteine; Animals; Antioxidants; Cell Line; Cell Survival; Cells, Cultured; Deoxyguanosine; DNA; DNA Damage; Feedback, Physiological; Iron; Iron Regulatory Protein 1; Iron Regulatory Protein 2; Iron-Regulatory Proteins; Iron-Sulfur Proteins; Mice; Neuroblastoma; Neurons; Oxidative Stress; RNA-Binding Proteins; Time Factors | 2002 |
Roles of endogenous glutathione levels on 6-hydroxydopamine-induced apoptotic neuronal cell death in human neuroblastoma SK-N-SH cells.
Topics: Acetylcysteine; Apoptosis; Benzimidazoles; Brain Neoplasms; Buthionine Sulfoximine; Cystine; DNA Fragmentation; Fluorescent Dyes; Free Radical Scavengers; Glutathione; Humans; Neuroblastoma; Neurons; Oxidopamine; Sympatholytics; Tumor Cells, Cultured | 2002 |
Proteasomal degradation of tau protein.
Topics: Acetylcysteine; Blotting, Western; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Humans; Multienzyme Complexes; Neuroblastoma; Proteasome Endopeptidase Complex; Protein Folding; Protein Isoforms; tau Proteins; Transfection; Tumor Cells, Cultured; Ubiquitin | 2002 |
Synphilin-1 degradation by the ubiquitin-proteasome pathway and effects on cell survival.
Topics: Acetylcysteine; alpha-Synuclein; Animals; Blotting, Western; Carrier Proteins; Cell Line; Cell Survival; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dimethyl Sulfoxide; Humans; Inclusion Bodies; Intracellular Signaling Peptides and Proteins; Kidney; Leupeptins; Macromolecular Substances; Mice; Multienzyme Complexes; Nerve Tissue Proteins; Neuroblastoma; Precipitin Tests; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Synucleins; Transfection; Ubiquitin | 2002 |
Multiple signaling events in amyloid beta-induced, oxidative stress-dependent neuronal apoptosis.
Topics: Acetylcysteine; alpha-Tocopherol; Amyloid beta-Peptides; Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Caspase 3; Caspases; Cell Differentiation; Cytochromes c; Enzyme Activation; Enzyme Inhibitors; Humans; Hydrogen Peroxide; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mitochondria; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neuroblastoma; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Peptide Fragments; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Thiazoles; Toluene; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2003 |
Effect of fraxetin and myricetin on rotenone-induced cytotoxicity in SH-SY5Y cells: comparison with N-acetylcysteine.
Topics: Acetylcysteine; Apoptosis; Caspase 3; Caspases; Cell Line, Tumor; Cell Survival; Coumarins; Flavonoids; Humans; L-Lactate Dehydrogenase; Neuroblastoma; Neuroprotective Agents; Reactive Oxygen Species; Rotenone | 2003 |
Mitochondrial dysfunction due to mutant copper/zinc superoxide dismutase associated with amyotrophic lateral sclerosis is reversed by N-acetylcysteine.
Topics: Acetylcysteine; Adenosine Triphosphate; Amyotrophic Lateral Sclerosis; Blotting, Western; Caspase 3; Caspases; Cell Death; DNA Fragmentation; Fluorescent Antibody Technique; Free Radical Scavengers; Humans; L-Lactate Dehydrogenase; Mitochondria; Mutation; Neuroblastoma; Reactive Oxygen Species; Superoxide Dismutase; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 2003 |
Sensitivity of proteasome to its inhibitors increases during cAMP-induced differentiation of neuroblastoma cells in culture and causes decreased viability.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Acetylcysteine; Adenylyl Cyclase Inhibitors; Animals; Cell Differentiation; Cell Survival; Cyclic AMP; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Fibroblasts; Leupeptins; Mice; Multienzyme Complexes; Neuroblastoma; Phosphodiesterase Inhibitors; Proteasome Endopeptidase Complex; Tumor Cells, Cultured | 2004 |
Neuroprotective effect of fraxetin and myricetin against rotenone-induced apoptosis in neuroblastoma cells.
Topics: Acetylcysteine; Analysis of Variance; Apoptosis; Blotting, Southern; Cell Line, Tumor; Cell Survival; Coumarins; DNA; Dose-Response Relationship, Drug; Ethidium; Flavonoids; Fluoresceins; Glutathione; Humans; Lipid Peroxidation; Microscopy, Confocal; Neuroblastoma; Neuroprotective Agents; Reactive Oxygen Species; Rotenone; Time Factors | 2004 |
Identification of the protein disulfide isomerase family member PDIp in experimental Parkinson's disease and Lewy body pathology.
Topics: 1-Methyl-4-phenylpyridinium; Acetylcysteine; Aged; Aged, 80 and over; Analysis of Variance; Animals; Blotting, Northern; Blotting, Western; Cell Differentiation; Cell Line, Tumor; Dopamine; Female; Gene Expression Regulation; Humans; Immunohistochemistry; Lewy Bodies; Male; Middle Aged; Neuroblastoma; Nuclear Proteins; Parkinsonian Disorders; Postmortem Changes; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Tretinoin | 2004 |
Proteasome-mediated effects on amyloid precursor protein processing at the gamma-secretase site.
Topics: Acetylcysteine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Caspase Inhibitors; Caspases; Cell Line, Tumor; Cell Survival; Culture Media; Endopeptidases; Humans; Multienzyme Complexes; Neuroblastoma; Peptide Hydrolases; Proteasome Endopeptidase Complex; Proteasome Inhibitors | 2005 |
Upregulation of clusterin/apolipoprotein J in lactacystin-treated SH-SY5Y cells.
Topics: Acetylcysteine; Analysis of Variance; Blotting, Western; Cell Differentiation; Cell Line, Tumor; Cell Survival; Clusterin; Cysteine Proteinase Inhibitors; Gene Expression Regulation; Glycoproteins; Humans; Microarray Analysis; Models, Biological; Molecular Chaperones; Neuroblastoma; Proteasome Endopeptidase Complex; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Subcellular Fractions; Time Factors; Up-Regulation | 2005 |
Effects of DJ-1 mutations and polymorphisms on protein stability and subcellular localization.
Topics: Acetylcysteine; Ammonium Chloride; Analysis of Variance; Animals; Blotting, Western; Cell Line, Tumor; Cycloheximide; Cysteine Proteinase Inhibitors; Dimerization; Fluorescent Antibody Technique; Gene Expression Regulation; Green Fluorescent Proteins; Humans; Immunoprecipitation; Intracellular Signaling Peptides and Proteins; Mice; Models, Molecular; Neuroblastoma; Oncogene Proteins; Point Mutation; Polymorphism, Genetic; Protein Deglycase DJ-1; Protein Synthesis Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Subcellular Fractions; Time Factors; Transfection | 2005 |
Effect of fraxetin on antioxidant defense and stress proteins in human neuroblastoma cell model of rotenone neurotoxicity. Comparative study with myricetin and N-acetylcysteine.
Topics: Acetylcysteine; Antioxidants; Blotting, Northern; Blotting, Western; Catalase; Coumarins; Cytosol; Dose-Response Relationship, Drug; Flavonoids; Flow Cytometry; Fluorescence; Glutathione Peroxidase; Glutathione Reductase; HSP70 Heat-Shock Proteins; Humans; Immunoblotting; Luminescent Measurements; Mitochondria; Neuroblastoma; Reactive Oxygen Species; Rotenone; Superoxide Dismutase; Tumor Cells, Cultured | 2005 |
Rapid turnover of GATA-2 via ubiquitin-proteasome protein degradation pathway.
Topics: Acetylcysteine; Animals; Cells, Cultured; Cycloheximide; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; GATA2 Transcription Factor; Gene Deletion; Gene Expression Regulation; Half-Life; Humans; Leukemia, Experimental; Leupeptins; Mice; Mutation; Neuroblastoma; Proteasome Endopeptidase Complex; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription Factors; Transcriptional Activation; Ubiquitins; Ultraviolet Rays | 2005 |
Dietary supplementation with 3-deaza adenosine, N-acetyl cysteine, and S-adenosyl methionine provide neuroprotection against multiple consequences of vitamin deficiency and oxidative challenge: relevance to age-related neurodegeneration.
Topics: Acetylcysteine; Animals; Apolipoproteins E; Cell Line, Tumor; Dietary Supplements; Disease Models, Animal; Folic Acid Deficiency; Glutathione; Glutathione Synthase; Maze Learning; Mice; Mice, Knockout; Neuroblastoma; Neuroprotective Agents; Oxidative Stress; S-Adenosylmethionine; Thiobarbituric Acid Reactive Substances; Tubercidin; Vitamin E Deficiency | 2004 |
Iron accelerates the conversion of dopamine-oxidized intermediates into melanin and provides protection in SH-SY5Y cells.
Topics: Acetylcysteine; Analysis of Variance; Area Under Curve; Buthionine Sulfoximine; Catalase; Cell Death; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; Cystine; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Electrochemistry; Enzyme Inhibitors; Humans; Hydrogen Peroxide; Indolequinones; Iron; Melanins; Models, Biological; Neuroblastoma; Superoxide Dismutase; Tetrazolium Salts; Thiazoles; Time Factors | 2005 |
alpha-Lipoic acid and N-acetyl cysteine prevent zinc deficiency-induced activation of NF-kappaB and AP-1 transcription factors in human neuroblastoma IMR-32 cells.
Topics: Acetylcysteine; Cell Line, Tumor; Enzyme Activation; Glutathione; Humans; Hydrogen Peroxide; Mitogen-Activated Protein Kinases; Neuroblastoma; NF-kappa B; Oxidants; Oxidative Stress; Phosphorylation; Thioctic Acid; Transcription Factor AP-1; Zinc | 2006 |
Involvement of endoplasmic reticulum stress on the cell death induced by 6-hydroxydopamine in human neuroblastoma SH-SY5Y cells.
Topics: Acetylcysteine; Activating Transcription Factor 6; Adrenergic Agents; Animals; Cell Death; Cell Line, Tumor; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Free Radical Scavengers; Heat-Shock Proteins; Humans; Molecular Chaperones; Neoplasm Proteins; Neuroblastoma; Oxidopamine; Parkinson Disease; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Transcription Factor CHOP; Tunicamycin; Ubiquitin | 2006 |
Ischemia promotes calpain-mediated degradation of p120-catenin in SH-SY5Y cells.
Topics: Acetylcysteine; Calpain; Catenins; Cell Adhesion Molecules; Cell Aggregation; Cell Death; Cell Line, Tumor; Delta Catenin; Dipeptides; Humans; Ischemia; Leupeptins; Neuroblastoma; Phosphoproteins | 2007 |
Acetaminophen potentiates staurosporine-induced death in a human neuroblastoma cell line.
Topics: Acetaminophen; Acetylcysteine; Antineoplastic Agents; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Survival; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochromes c; Dinoprostone; Disulfiram; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Free Radical Scavengers; Glutathione; Humans; Metalloporphyrins; Neuroblastoma; Prostaglandin-Endoperoxide Synthases; Staurosporine; Time Factors | 2007 |
Degradation of nicastrin involves both proteasome and lysosome.
Topics: Acetylcysteine; Amyloid Precursor Protein Secretases; Cell Line; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Gene Expression; Humans; Lysosomes; Membrane Glycoproteins; Mutation; Neuroblastoma; Proteasome Endopeptidase Complex; Transfection | 2007 |
Morphine inhibits doxorubicin-induced reactive oxygen species generation and nuclear factor kappaB transcriptional activation in neuroblastoma SH-SY5Y cells.
Topics: Acetylcysteine; Apoptosis; Caspase 3; Cell Line, Tumor; Cytochromes c; Cytoprotection; Doxorubicin; Enzyme Activation; Humans; I-kappa B Kinase; Morphine; Neuroblastoma; NF-kappa B; Protein Transport; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Signal Transduction; Transcriptional Activation | 2007 |
Expression of a Cu,Zn superoxide dismutase typical for familial amyotrophic lateral sclerosis increases the vulnerability of neuroblastoma cells to infectious injury.
Topics: Acetylcysteine; Amyotrophic Lateral Sclerosis; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antioxidants; Apoptosis; Bacterial Proteins; Calcium; Caspase 3; Cell Line, Tumor; Cell Survival; Cells, Cultured; Coculture Techniques; Humans; Immunohistochemistry; Lipopeptides; Macrophages; Monocytes; Mutation; Neuroblastoma; Peptides; Streptolysins; Superoxide Dismutase; Toll-Like Receptor 2; Transfection | 2007 |
Cytotoxicity of 1,2-diacetylbenzene in human neuroblastoma SHSY5Y cells is mediated by oxidative stress.
Topics: Acetophenones; Acetylcysteine; Antioxidants; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Survival; Environmental Pollutants; Flow Cytometry; Glutathione; Humans; Microscopy, Electron, Scanning; Microscopy, Fluorescence; Neuroblastoma; Oxidative Stress; Reactive Oxygen Species | 2008 |
Synergistic neurotoxic effects of arsenic and dopamine in human dopaminergic neuroblastoma SH-SY5Y cells.
Topics: Acetylcysteine; Anticarcinogenic Agents; Antioxidants; Arsenites; Cell Line, Tumor; Cell Survival; Dopamine; Dose-Response Relationship, Drug; Drug Antagonism; Drug Combinations; Drug Synergism; Humans; Isothiocyanates; Necrosis; Neuroblastoma; Neurons; Parkinson Disease; Sulfoxides; Thiocyanates | 2008 |
Endogenous intracellular glutathionyl radicals are generated in neuroblastoma cells under hydrogen peroxide oxidative stress.
Topics: Acetylcysteine; Cell Line; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Free Radicals; Glucose; Glucose Oxidase; Glutathione; Horseradish Peroxidase; Humans; Hydrogen Peroxide; Kinetics; Neuroblastoma; NF-kappa B; Oxidative Stress; Spin Labels; Superoxide Dismutase; Tumor Cells, Cultured | 1995 |
The neuritogenesis inducer lactacystin arrests cell cycle at both G0/G1 and G2 phases in neuro 2a cells.
Topics: Acetylcysteine; Animals; Cysteine Proteinase Inhibitors; G1 Phase; G2 Phase; Kinetics; Mice; Neuroblastoma; Resting Phase, Cell Cycle; Tumor Cells, Cultured | 1995 |
A beta-lactone related to lactacystin induces neurite outgrowth in a neuroblastoma cell line and inhibits cell cycle progression in an osteosarcoma cell line.
Topics: Acetylcysteine; Anti-Bacterial Agents; Cell Cycle; Cytoskeleton; Humans; In Vitro Techniques; Lactones; Neurites; Neuroblastoma; Osteosarcoma; Structure-Activity Relationship; Tumor Cells, Cultured | 1994 |
Thiol agents and Bcl-2 identify an alphavirus-induced apoptotic pathway that requires activation of the transcription factor NF-kappa B.
Topics: Acetylcysteine; Animals; Apoptosis; Base Sequence; Cell Nucleus; Chelating Agents; Dithiothreitol; DNA; Iron; Lipid Peroxidation; Male; Mercaptoethanol; Mice; Molecular Sequence Data; Neuroblastoma; NF-kappa B; Prostatic Neoplasms; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrrolidines; Rats; Sindbis Virus; Sulfhydryl Reagents; Thiocarbamates; Tumor Cells, Cultured | 1995 |
Specific inhibition of the chymotrypsin-like activity of the proteasome induces a bipolar morphology in neuroblastoma cells.
Topics: Acetylcysteine; Chymotrypsin; Cysteine Endopeptidases; Enzyme Inhibitors; Multienzyme Complexes; Neuroblastoma; Proteasome Endopeptidase Complex; Protein Binding; Substrate Specificity; Tumor Cells, Cultured | 1996 |
In vivo degradation of N-myc in neuroblastoma cells is mediated by the 26S proteasome.
Topics: Acetylcysteine; Calpain; Cysteine Proteinase Inhibitors; Humans; Lysosomes; Neuroblastoma; Peptide Hydrolases; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-myc; Substrate Specificity; Tumor Cells, Cultured; Ubiquitins | 1998 |
Basal and human papillomavirus E6 oncoprotein-induced degradation of Myc proteins by the ubiquitin pathway.
Topics: Acetylcysteine; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Humans; Leupeptins; Neuroblastoma; Oncogene Proteins, Viral; Papillomaviridae; Papillomavirus Infections; Proto-Oncogene Proteins c-myc; Signal Transduction; Tumor Cells, Cultured; Tumor Virus Infections; Ubiquitins | 1998 |
Dual roles of proteasome in the metabolism of presenilin 1.
Topics: Acetylcysteine; Alzheimer Disease; Amino Acid Sequence; Brain Chemistry; Coumarins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Glycoproteins; Humans; Isocoumarins; Kidney; Membrane Proteins; Molecular Sequence Data; Multienzyme Complexes; Mutation; Neuroblastoma; Peptide Fragments; Precipitin Tests; Presenilin-1; Proteasome Endopeptidase Complex; Serine Proteinase Inhibitors; Sulfones; Trypsin Inhibitors; Tumor Cells, Cultured | 1999 |
Decreased levels of proteasome activity and proteasome expression in aging spinal cord.
Topics: Acetylcysteine; Aging; Aldehydes; Amino Acid Chloromethyl Ketones; Animals; Cell Death; Cell Survival; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Glutathione; Iron; Lipid Peroxidation; Lysosomes; Mice; Motor Neurons; Multienzyme Complexes; Neuroblastoma; Oligopeptides; Oxidative Stress; Proteasome Endopeptidase Complex; Rats; Rats, Inbred F344; Reactive Oxygen Species; Spinal Cord; Tumor Cells, Cultured | 2000 |
Cisplatin-induced apoptotic cell death in mouse hybrid neurons is blocked by antioxidants through suppression of cisplatin-mediated accumulation of p53 but not of Fas/Fas ligand.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Cell Nucleus; Cell Survival; Chromans; Cisplatin; DNA Fragmentation; Fas Ligand Protein; fas Receptor; Ganglia, Spinal; Hybrid Cells; Kinetics; Membrane Glycoproteins; Mice; Neuroblastoma; Neurons, Afferent; Tumor Suppressor Protein p53 | 2000 |
N-acetyl-L-cysteine protects SHSY5Y neuroblastoma cells from oxidative stress and cell cytotoxicity: effects on beta-amyloid secretion and tau phosphorylation.
Topics: Acetylcysteine; Amyloid beta-Peptides; Blotting, Western; Cell Survival; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Glutathione; Glutathione Reductase; Humans; Hydrogen Peroxide; Neuroblastoma; Oxidative Stress; Peptide Fragments; Phosphorylation; tau Proteins; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured; Ultraviolet Rays | 2001 |
BCR-ABL down-regulates the DNA repair protein DNA-PKcs.
Topics: Acetylcysteine; Animals; Apoptosis; Blast Crisis; Child; Cysteine Endopeptidases; DNA Repair; DNA-Activated Protein Kinase; DNA-Binding Proteins; DNA, Neoplasm; Enzyme Induction; Enzyme Inhibitors; Fusion Proteins, bcr-abl; Gene Expression Regulation, Leukemic; Humans; In Situ Hybridization, Fluorescence; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Multienzyme Complexes; Neuroblastoma; Nuclear Proteins; Oligopeptides; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Serine-Threonine Kinases; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; Transfection; Tumor Cells, Cultured; Tumor Stem Cell Assay; Tyrphostins | 2001 |
Homocysteine potentiates beta-amyloid neurotoxicity: role of oxidative stress.
Topics: Acetylcysteine; Amyloid beta-Peptides; Apoptosis; Calcium; Cell Differentiation; Cytosol; Drug Synergism; Free Radical Scavengers; Homocysteine; Humans; Neuroblastoma; Neurotoxins; Oxidative Stress; Peptide Fragments; Phosphatidylserines; Reactive Oxygen Species; Tumor Cells, Cultured; Vitamin E | 2001 |
Apoptotic signaling in dopamine-induced cell death: the role of oxidative stress, p38 mitogen-activated protein kinase, cytochrome c and caspases.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Apoptosis; Biological Transport; Caspase 3; Caspase 9; Caspases; Cell Death; Cysteine Proteinase Inhibitors; Cytochrome c Group; Dopamine; Humans; Kinetics; Mitogen-Activated Protein Kinases; Neuroblastoma; Nomifensine; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Signal Transduction; Tumor Cells, Cultured | 2001 |
Protective effect of glutathione in HIV-1 lytic peptide 1-induced cell death in human neuronal cells.
Topics: Acetylcysteine; AIDS Dementia Complex; Amino Acid Sequence; Amino Acid Substitution; Antioxidants; Apoptosis; Cell Death; Cells, Cultured; Glutathione; HIV Envelope Protein gp41; HIV-1; Humans; Intracellular Membranes; Membrane Potentials; Mitochondria; Molecular Sequence Data; Nerve Degeneration; Neuroblastoma; Neurons; Neuroprotective Agents; Oxidation-Reduction; Peptide Fragments; Prodrugs; Tumor Cells, Cultured | 2001 |
N-Acetyl-L-Cystein downregulates beta-amyloid precursor protein gene transcription in human neuroblastoma cells.
Topics: Acetylcysteine; Amyloid beta-Protein Precursor; Antioxidants; Down-Regulation; Humans; Neuroblastoma; Oxidative Stress; Transcription, Genetic; Tumor Cells, Cultured | 2001 |
Divers pathways mediate delta-opioid receptor down regulation within the same cell.
Topics: Acetylcysteine; Analgesics, Opioid; Animals; Antirheumatic Agents; Chloroquine; Cysteine Proteinase Inhibitors; Diprenorphine; Down-Regulation; Etorphine; Flavonoids; Genistein; GTP-Binding Proteins; Humans; Kidney; MAP Kinase Signaling System; Narcotic Antagonists; Neuroblastoma; Phosphorylation; Radioligand Assay; Receptors, Opioid, delta; Staurosporine; Teprotide; Transfection; Tritium; Tumor Cells, Cultured | 2001 |
Proteasome activity is critical for the cAMP-induced differentiation of neuroblastoma cells.
Topics: Acetylcysteine; Animals; Cell Differentiation; Cyclic AMP; Cyclin B; Cyclin B1; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Flow Cytometry; Gene Expression Regulation, Neoplastic; Genes, myc; Green Fluorescent Proteins; Humans; Leupeptins; Luminescent Proteins; Mice; Multienzyme Complexes; Neuroblastoma; Proteasome Endopeptidase Complex; Retroviridae; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 2001 |
Prenylcysteine carboxymethyltransferase type III activity is decreased in retinoic acid-treated SH-SY5Y neuroblastoma cells.
Topics: Acetylcysteine; Antineoplastic Agents; Cell Differentiation; Genes, ras; Humans; Membrane Proteins; Methylation; Neuroblastoma; Norepinephrine; Nuclear Envelope; Protein Isoforms; Protein Methyltransferases; rab3A GTP-Binding Protein; rhoA GTP-Binding Protein; S-Adenosylhomocysteine; Tretinoin; Tumor Cells, Cultured | 2002 |
Lactacystin, a novel microbial metabolite, induces neuritogenesis of neuroblastoma cells.
Topics: Acetylcysteine; Animals; Anti-Bacterial Agents; Cyclic AMP; Microscopy, Electron; Molecular Conformation; Molecular Structure; Neuroblastoma; Neurons; Streptomyces; Tumor Cells, Cultured | 1991 |
Structure of lactacystin, a new microbial metabolite which induces differentiation of neuroblastoma cells.
Topics: Acetylcysteine; Anti-Bacterial Agents; Cell Differentiation; Magnetic Resonance Spectroscopy; Molecular Conformation; Molecular Structure; Neuroblastoma; Neurons; Streptomyces; Tumor Cells, Cultured; X-Ray Diffraction | 1991 |