Compounds > acetylcysteine

acetylcysteine and Nerve Degeneration

acetylcysteine has been researched along with Nerve Degeneration in 50 studies

Research

Studies (50)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (4.00)18.2507
2000's30 (60.00)29.6817
2010's16 (32.00)24.3611
2020's2 (4.00)2.80

Authors

AuthorsStudies
Albertini, G; Bentea, E; Deneyer, L; Massie, A1
Alandes, S; Alcácer, J; Banacloche, S; Benlloch, M; Colomer, N; Coronado, JA; Drehmer, E; Estrela, JM; Jihad-Jebbar, A; López-Blanch, R; Marchio, P; Obrador, E; Rivera, P; Salvador, R; Vallés, SL1
Abramov, AY; Antoine, DJ; Aronica, E; Balosso, S; Del Giudice, E; Liang, LP; Pascente, R; Pastore, A; Patel, M; Pauletti, A; Ravizza, T; Rizzi, M; Salamone, A; Shekh-Ahmad, T; Terrone, G; van Vliet, EA; Vezzani, A; Villa, BR; Walker, MC1
Dexter, DT; Harrison, IF; Powell, NM1
Ding, K; Fang, J; Wang, HD; Zhou, XM; Zhou, Y; Zhu, L1
Goldstein, BJ; Goncalves, S1
Bian, ZC; Guan, JL; Liang, CC; Wang, C; Zhu, Y1
Bury, A; Dexter, DT; Elson, JL; Harrison, IF; Pienaar, IS; Simon, AK; Woll, P1
Angelatou, F; Antonopoulos, I; Botsakis, K; Georgiou, CD; Grintzalis, K; Margarity, M; Matsokis, NA; Panagopoulos, NT; Theodoritsi, S1
Han, J; Leak, RK; Mason, DM; Nouraei, N; Weilnau, JN; Zarger, L1
Jankovic, J; Kondo, S; Le, W; Pan, T; Xie, W; Zhu, W1
Du, Y; Fan, X; Le, W; Li, X; Luo, G; Yang, D1
Hashimoto, T; Ibuki, T; Iwanaga, T; Kishibuchi, R; Kitagawa, H; Mizuguchi, H; Momota, H; Nishihara, S; Onaka, Y; Sado, M; Wada, D; Watanabe, TK; Yamasaki, Y1
Du, Y; Fan, X; Le, W; Li, L; Li, T; Luo, G; Wang, Q; Wang, Y; Yang, D; Zhang, X1
Druse, MJ; Sheth, DS; Tajuddin, NF1
Castaño, A; Gavilán, E; Gavilán, MP; Jiménez, S; Pintado, C; Ríos, RM; Ruano, D; Vitorica, J1
Andersen, JK; Jankovic, J; Kaur, D; Le, W; Li, X; Luo, F; Xie, W; Zhu, W1
Jackson, T; Jengelley, TA; Jnobaptiste, R; McNaught, KS1
Jankovic, J; Le, W; Li, C; Li, X; Xie, W; Zhu, W1
Colakoglu, N; Karlidag, T; Kaygusuz, I; Sapmaz, E; Yalcin, S; Yildiz, M1
Hart, A; Terenghi, G; Wiberg, M1
Jankovic, J; Kansara, S; Le, WD; Li, XP; Xie, WJ; Zhang, Z1
Castaño, A; García-Cuervo, L; Gavilán, E; Gavilán, MP; Gutiérrez, A; Pintado, C; Ríos, RM; Ruano, D; Vitorica, J1
Jantas, D; Konieczny, J; Kuśmierczyk, J; Lasoń, W; Lenda, T; Lorenc-Koci, E; Roman, A1
Adams, J; Dave, JR; Elliott, PJ; Hale, SL; Moffett, JR; Tortella, FC; Williams, AJ1
Coleman, MP; Laser, H; Mack, TG; Wagner, D1
Hart, AM; Kellerth, JO; Terenghi, G; Wiberg, M1
Guerra, MJ; Labandeira-Garcia, JL; Muñoz, AM; Rey, P; Soto-Otero, R1
Barbosa, E; Paintlia, AS; Paintlia, MK; Singh, AK; Singh, I1
Le, W; Pan, T; Qu, S; Wang, X; Xie, W; Zhang, X1
Halliwell, B; Hyun, DH; Jenner, P; Lee, M1
Aoyama, K; Chan, WY; Chen, Y; Hamby, AM; Liu, J; Suh, SW; Swanson, RA1
Hazell, AS; Hoover, R; McIntosh, TK; Yi, JH1
Hausott, B; Ingorokva, S; Klimaschewski, L; Pfaller, K1
Arakawa, M; Ishige, K; Ito, Y; Oda, T; Osada, N; Ushimaru, N1
Grünblatt, E; Mandel, S; Youdim, MB1
Lim, HS; Lu, XY; Paz, J; Yao, H; Zhang, W1
Inayat-Hussain, SH; Ross, D; Zafar, KS1
Fukui, K; Kawataki, T; Koike, T; Yang, Y1
Fridkin, M; Jankovic, J; Le, W; Pan, T; Xie, W; Xu, P; Youdim, MB; Zheng, H; Zhu, W1
Le, W; Li, L; Li, X; Ming, M; Peng, C; Yang, D1
Burigo, M; Constantino, L; Dal-Pizzol, F; Di-Pietro, PB; Dias, ML; Machado, RA; Scaini, G; Streck, EL1
Jankovic, J; Le, W; Li, J; Pan, T; Xie, W; Youdim, MB; Zhu, W1
Ballard, C; Iravani, MM; Jenner, P; MacInnes, N; Perry, E; Perry, R; Piggott, M1
Chen, S; Du, Y; Huang, K; Le, W; Li, X; Yang, D; Zhang, X1
Bristol, LA; Brown, RH; Hosler, B; Kuncl, RW; Rothstein, JD1
Henderson, JT; Javaheri, M; Kopko, S; Roder, JC1
Chong, YH; Montelaro, RC; Park, HK; Shin, SA; Sung, JH1
Amarnath, V; Montine, TJ; Olson, SJ; Ou, JJ; Sidell, KR; Zhang, Y1
Amamath, V; Montine, TJ; Sidell, KR1

Reviews

2 review(s) available for acetylcysteine and Nerve Degeneration

ArticleYear
The nerve injury and the dying neurons: diagnosis and prevention.
    The Journal of hand surgery, European volume, 2011, Volume: 36, Issue:9

    Topics: Acetylcarnitine; Acetylcysteine; Animals; Axons; Cell Death; Cell Dedifferentiation; Humans; Nerve Degeneration; Nerve Growth Factors; Nerve Regeneration; Neurons; Neurons, Afferent; Neuroprotective Agents; Peripheral Nerve Injuries; Recovery of Function; Schwann Cells; Signal Transduction

2011
Dopamine thioethers in neurodegeneration.
    Current topics in medicinal chemistry, 2001, Volume: 1, Issue:6

    Topics: Acetylcysteine; Animals; Corpus Striatum; Dopamine; Humans; Nerve Degeneration; Neurodegenerative Diseases; Sulfides

2001

Other Studies

48 other study(ies) available for acetylcysteine and Nerve Degeneration

ArticleYear
Systemic LPS-induced neuroinflammation increases the susceptibility for proteasome inhibition-induced degeneration of the nigrostriatal pathway.
    Parkinsonism & related disorders, 2019, Volume: 68

    Topics: Acetylcysteine; Animals; Behavior, Animal; Corpus Striatum; Cysteine Proteinase Inhibitors; Disease Models, Animal; Illness Behavior; Inflammation; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Microglia; Nerve Degeneration; Neural Pathways; Proteasome Inhibitors; Substantia Nigra

2019
Nicotinamide Riboside and Pterostilbene Cooperatively Delay Motor Neuron Failure in ALS SOD1
    Molecular neurobiology, 2021, Volume: 58, Issue:4

    Topics: Acetylcysteine; Amyotrophic Lateral Sclerosis; Animals; Antioxidants; Apoptosis; Cytokines; Female; Male; Metabolome; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria; Motor Activity; Motor Neurons; Mutation; NAD; Nerve Degeneration; NF-E2-Related Factor 2; Niacinamide; Oxidation-Reduction; Pyridinium Compounds; Reactive Oxygen Species; Sirtuin 1; Sirtuin 3; Spinal Cord; Stilbenes; Superoxide Dismutase-1; Survival Analysis

2021
Targeting oxidative stress improves disease outcomes in a rat model of acquired epilepsy.
    Brain : a journal of neurology, 2017, Jul-01, Volume: 140, Issue:7

    Topics: Acetylcysteine; Animals; Astrocytes; Biomarkers; Cognitive Dysfunction; Disease Models, Animal; Drug Therapy, Combination; Epilepsy; Hippocampus; HMG-Box Domains; HMGB1 Protein; Isothiocyanates; Male; Nerve Degeneration; Neurons; Oxidative Stress; Rats; Sulfoxides

2017
The histone deacetylase inhibitor nicotinamide exacerbates neurodegeneration in the lactacystin rat model of Parkinson's disease.
    Journal of neurochemistry, 2019, Volume: 148, Issue:1

    Topics: Acetylation; Acetylcysteine; Animals; Cell Death; Disease Models, Animal; Dopaminergic Neurons; Histone Deacetylase Inhibitors; Male; Nerve Degeneration; Niacinamide; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley

2019
N-acetylcysteine amide provides neuroprotection via Nrf2-ARE pathway in a mouse model of traumatic brain injury.
    Drug design, development and therapy, 2018, Volume: 12

    Topics: Acetylcysteine; Animals; Antioxidant Response Elements; Antioxidants; Apoptosis; Behavior, Animal; Brain; Brain Injuries, Traumatic; Caspase 3; Disease Models, Animal; Heme Oxygenase-1; Male; Membrane Proteins; Mice, Inbred ICR; NAD(P)H Dehydrogenase (Quinone); Nerve Degeneration; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Signal Transduction; Time Factors

2018
Acute N-Acetylcysteine Administration Ameliorates Loss of Olfactory Neurons Following Experimental Injury In Vivo.
    Anatomical record (Hoboken, N.J. : 2007), 2020, Volume: 303, Issue:3

    Topics: Acetylcysteine; Animals; Cell Survival; Mice; Nerve Degeneration; Neuroprotective Agents; Olfactory Bulb; Olfactory Mucosa; Olfactory Receptor Neurons

2020
FIP200 is required for maintenance and differentiation of postnatal neural stem cells.
    Nature neuroscience, 2013, Volume: 16, Issue:5

    Topics: Acetylcysteine; Age Factors; Animals; Animals, Newborn; Apoptosis; Autophagy; Autophagy-Related Proteins; Bromodeoxyuridine; Cell Differentiation; Cerebral Ventricles; Chloroquine; Dentate Gyrus; Dicarbethoxydihydrocollidine; Embryo, Mammalian; Gene Expression Regulation, Developmental; Glial Fibrillary Acidic Protein; In Situ Nick-End Labeling; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; Mutation; Nerve Degeneration; Neural Cell Adhesion Molecule L1; Neural Stem Cells; Reactive Oxygen Species; Sialic Acids; SOXB1 Transcription Factors; Transcription Factor TFIIH; Transcription Factors; Tumor Suppressor Protein p53

2013
An animal model mimicking pedunculopontine nucleus cholinergic degeneration in Parkinson's disease.
    Brain structure & function, 2015, Volume: 220, Issue:1

    Topics: Acetylcysteine; Analysis of Variance; Animals; Antibodies, Monoclonal; Calcium-Binding Proteins; Cell Count; Choline O-Acetyltransferase; Cholinergic Neurons; Cysteine Proteinase Inhibitors; Disease Models, Animal; Forelimb; Functional Laterality; Image Processing, Computer-Assisted; Laser Capture Microdissection; Magnetic Resonance Imaging; Male; Membrane Proteins; Motor Activity; Muscle Proteins; Nerve Degeneration; Parkinson Disease; Pedunculopontine Tegmental Nucleus; Phosphopyruvate Hydratase; Rats; Rats, Sprague-Dawley; Tyrosine 3-Monooxygenase

2015
17β-Estradiol/N-acetylcysteine interaction enhances the neuroprotective effect on dopaminergic neurons in the weaver model of dopamine deficiency.
    Neuroscience, 2016, Apr-21, Volume: 320

    Topics: Acetylcysteine; Animals; Dopaminergic Neurons; Drug Synergism; Estradiol; Female; Immunohistochemistry; Male; Mice; Mice, Neurologic Mutants; Nerve Degeneration; Neuroprotective Agents; Parkinsonian Disorders

2016
Investigation of the therapeutic potential of N-acetyl cysteine and the tools used to define nigrostriatal degeneration in vivo.
    Toxicology and applied pharmacology, 2016, Apr-01, Volume: 296

    Topics: Acetylcysteine; Animals; Corpus Striatum; Male; Mice; Nerve Degeneration; Neuroprotective Agents; Oxidopamine; Substantia Nigra

2016
Neuroprotection of rapamycin in lactacystin-induced neurodegeneration via autophagy enhancement.
    Neurobiology of disease, 2008, Volume: 32, Issue:1

    Topics: Acetylcysteine; Animals; Autophagy; Cells, Cultured; Male; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neuroprotective Agents; Parkinson Disease; PC12 Cells; Protein Folding; Rats; Sirolimus

2008
c-Jun N-terminal kinase mediates lactacystin-induced dopamine neuron degeneration.
    Journal of neuropathology and experimental neurology, 2008, Volume: 67, Issue:10

    Topics: Acetylcysteine; Animals; Apoptosis; Blotting, Western; Caspase 3; Cell Line; Chromatography, High Pressure Liquid; Cysteine Proteinase Inhibitors; Cytochromes c; Dopamine; Immunohistochemistry; JNK Mitogen-Activated Protein Kinases; Male; Nerve Degeneration; Neurons; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Substantia Nigra; Tetrazolium Salts; Thiazoles

2008
Protective effect against Parkinson's disease-related insults through the activation of XBP1.
    Brain research, 2009, Feb-27, Volume: 1257

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Acetylcysteine; Animals; Cell Death; Cell Line; Cell Survival; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Dopamine; Endoplasmic Reticulum; Endoribonucleases; Humans; Leupeptins; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neurons; Parkinsonian Disorders; Protein Serine-Threonine Kinases; Regulatory Factor X Transcription Factors; RNA, Messenger; Signal Transduction; Stress, Physiological; Transcription Factors; X-Box Binding Protein 1

2009
An insight into the mechanistic role of p53-mediated autophagy induction in response to proteasomal inhibition-induced neurotoxicity.
    Autophagy, 2009, Volume: 5, Issue:5

    Topics: Acetylcysteine; Apoptosis; Autophagy; Cell Line, Tumor; Cytoprotection; Dopamine; Enzyme Inhibitors; Humans; Mitochondria; Nerve Degeneration; Neurons; Phagosomes; Phosphorylation; Proteasome Inhibitors; Protein Processing, Post-Translational; Sirolimus; Time Factors; Tumor Suppressor Protein p53

2009
Antioxidant neuroprotection against ethanol-induced apoptosis in HN2-5 cells.
    Brain research, 2009, Aug-18, Volume: 1285

    Topics: Acetylcysteine; Alcohol-Induced Disorders, Nervous System; Animals; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Cell Line; Central Nervous System Depressants; Cytoprotection; Ethanol; Female; Gene Expression Regulation; Hippocampus; Melatonin; Mice; Nerve Degeneration; Neuroprotective Agents; Oxidative Stress; Pregnancy; Prenatal Exposure Delayed Effects; Reactive Oxygen Species

2009
Dysfunction of the unfolded protein response increases neurodegeneration in aged rat hippocampus following proteasome inhibition.
    Aging cell, 2009, Volume: 8, Issue:6

    Topics: Acetylcysteine; Aging; Animals; Biomarkers; Caspase 3; Enzyme Inhibitors; Hippocampus; Male; Nerve Degeneration; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Signal Transduction; Unfolded Protein Response

2009
Genetic iron chelation protects against proteasome inhibition-induced dopamine neuron degeneration.
    Neurobiology of disease, 2010, Volume: 37, Issue:2

    Topics: Acetylcysteine; Animals; Apoferritins; Cation Transport Proteins; Chelation Therapy; Corpus Striatum; Cysteine Proteinase Inhibitors; Cytoprotection; Dopamine; Gene Expression Regulation; Genetic Therapy; Iron Metabolism Disorders; Mice; Mice, Transgenic; Nerve Degeneration; Neurons; Parkinson Disease; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Substantia Nigra

2010
The pattern of neuronal loss and survival may reflect differential expression of proteasome activators in Parkinson's disease.
    Synapse (New York, N.Y.), 2010, Volume: 64, Issue:3

    Topics: Acetylcysteine; Animals; Blotting, Western; Canavanine; Cell Survival; Cells, Cultured; Cysteine Proteinase Inhibitors; Dopamine; Immunohistochemistry; Locus Coeruleus; Male; Nerve Degeneration; Neurons; Oxidative Stress; Parkinson Disease; Proteasome Endopeptidase Complex; Protein Folding; Rats; Rats, Sprague-Dawley; Rotenone; Substantia Nigra; Ubiquitin-Activating Enzymes; Ubiquitin-Conjugating Enzymes; Uncoupling Agents

2010
Proteasome inhibition modeling nigral neuron degeneration in Parkinson's disease.
    Journal of neurochemistry, 2010, Volume: 115, Issue:1

    Topics: Acetylcysteine; Animals; Behavior, Animal; Blotting, Western; Cell Count; Chromatography, High Pressure Liquid; Dopamine; Fluorescent Antibody Technique; Immunohistochemistry; Iron; Male; Mice; Mice, Inbred C57BL; Microinjections; Microscopy, Electron; Nerve Degeneration; Neurons; Neuroprotective Agents; Parkinson Disease, Secondary; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Substantia Nigra; Ubiquitin

2010
Evaluation of the effect of methylprednisolone and N-acetylcystein on anastomotic degeneration and regeneraton of the facial nerve.
    Auris, nasus, larynx, 2012, Volume: 39, Issue:2

    Topics: Acetylcysteine; Anastomosis, Surgical; Animals; Anti-Inflammatory Agents; Cell Proliferation; Facial Nerve; Female; Free Radical Scavengers; Methylprednisolone; Microscopy, Electron; Nerve Degeneration; Nerve Regeneration; Neuroglia; Rabbits; Schwann Cells

2012
A mechanistic study of proteasome inhibition-induced iron misregulation in dopamine neuron degeneration.
    Neuro-Signals, 2012, Volume: 20, Issue:4

    Topics: Acetylcysteine; Antigens, CD; Blotting, Western; Cell Line; Cell Survival; Cysteine Proteinase Inhibitors; Dopaminergic Neurons; Ferritins; Genetic Vectors; Humans; Immunoprecipitation; Iron; Iron Metabolism Disorders; Iron-Regulatory Proteins; Lentivirus; Nerve Degeneration; Proteasome Endopeptidase Complex; Reactive Oxygen Species; Receptors, Transferrin; RNA, Small Interfering

2012
Lipopolysaccharide-induced neuroinflammation leads to the accumulation of ubiquitinated proteins and increases susceptibility to neurodegeneration induced by proteasome inhibition in rat hippocampus.
    Journal of neuroinflammation, 2012, May-04, Volume: 9

    Topics: Acetylcysteine; Aging; Animals; Drug Synergism; Hippocampus; Inflammation; Lipopolysaccharides; Male; Nerve Degeneration; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rats; Rats, Wistar; Ubiquitination

2012
The extent of neurodegeneration and neuroprotection in two chemical in vitro models related to Parkinson's disease is critically dependent on cell culture conditions.
    Neurotoxicity research, 2013, Volume: 24, Issue:1

    Topics: Acetylcysteine; Cell Death; Cell Differentiation; Cell Survival; Cells, Cultured; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Drug Interactions; Humans; Nerve Degeneration; Neuroprotective Agents; Parkinson Disease; Pentacyclic Triterpenes; Rotenone; Time Factors; Tretinoin; Triterpenes

2013
Delayed treatment with MLN519 reduces infarction and associated neurologic deficit caused by focal ischemic brain injury in rats via antiinflammatory mechanisms involving nuclear factor-kappaB activation, gliosis, and leukocyte infiltration.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2003, Volume: 23, Issue:1

    Topics: Acetylcysteine; Animals; Astrocytes; Brain Ischemia; Cell Movement; Cysteine Endopeptidases; Gliosis; Infarction, Middle Cerebral Artery; Inflammation Mediators; Leukocytes; Male; Multienzyme Complexes; Nerve Degeneration; Nervous System Diseases; NF-kappa B; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Recovery of Function

2003
Proteasome inhibition arrests neurite outgrowth and causes "dying-back" degeneration in primary culture.
    Journal of neuroscience research, 2003, Dec-15, Volume: 74, Issue:6

    Topics: Acetylcysteine; Animals; Cell Division; Cell Survival; Cells, Cultured; Cysteine Endopeptidases; Growth Inhibitors; Mice; Mice, Inbred C57BL; Multienzyme Complexes; Nerve Degeneration; Neural Inhibition; Neurites; PC12 Cells; Proteasome Endopeptidase Complex; Rats

2003
Sensory neuroprotection, mitochondrial preservation, and therapeutic potential of N-acetyl-cysteine after nerve injury.
    Neuroscience, 2004, Volume: 125, Issue:1

    Topics: Acetylcysteine; Animals; Axotomy; Dose-Response Relationship, Drug; Ganglia, Spinal; In Situ Nick-End Labeling; Lumbosacral Region; Male; Microscopy, Electron; Mitochondria; Nerve Degeneration; Neurons, Afferent; Neuroprotective Agents; Rats; Sciatic Nerve

2004
Systemic administration of N-acetylcysteine protects dopaminergic neurons against 6-hydroxydopamine-induced degeneration.
    Journal of neuroscience research, 2004, May-15, Volume: 76, Issue:4

    Topics: Acetylcysteine; Animals; Antigens, CD; Antigens, Neoplasm; Antigens, Surface; Ascorbic Acid; Avian Proteins; Basigin; Blood Proteins; Cell Count; Corpus Striatum; Cysteine; Dopamine; Drug Administration Routes; Female; Fluoresceins; Fluorescent Dyes; Free Radical Scavengers; Glial Fibrillary Acidic Protein; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hydroxydopamines; Immunohistochemistry; Membrane Glycoproteins; Nerve Degeneration; Neurons; Organic Chemicals; Phosphopyruvate Hydratase; Rats; Rats, Sprague-Dawley; Tyrosine 3-Monooxygenase

2004
N-acetylcysteine prevents endotoxin-induced degeneration of oligodendrocyte progenitors and hypomyelination in developing rat brain.
    Journal of neuroscience research, 2004, Nov-01, Volume: 78, Issue:3

    Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Acetylcysteine; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Antigens; CD11b Antigen; Cell Count; Cell Death; Cytokines; Demyelinating Diseases; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Female; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Infant, Newborn; Leukomalacia, Periventricular; Lipopolysaccharides; Male; Myelin Basic Protein; Nerve Degeneration; Neuroprotective Agents; O Antigens; Oligodendroglia; Pregnancy; Proteoglycans; Rats; Rats, Sprague-Dawley; Receptor, Platelet-Derived Growth Factor alpha; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stem Cells; Survival Rate; Time Factors; Transcription Factors

2004
Neuroprotection by iron chelator against proteasome inhibitor-induced nigral degeneration.
    Biochemical and biophysical research communications, 2005, Jul-29, Volume: 333, Issue:2

    Topics: Acetylcysteine; Animals; Deferoxamine; Iron Chelating Agents; Male; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neuroprotective Agents; Parkinsonian Disorders; Proteasome Inhibitors; Substantia Nigra; Treatment Outcome; Ubiquitin

2005
Effect of overexpression of wild-type or mutant parkin on the cellular response induced by toxic insults.
    Journal of neuroscience research, 2005, Oct-15, Volume: 82, Issue:2

    Topics: 1-Methyl-4-phenylpyridinium; Acetylcysteine; Aldehydes; Apoptosis; Cell Death; Cell Line, Tumor; Drug Resistance; Enzyme Inhibitors; Genetic Predisposition to Disease; Glutamic Acid; Guanine; Humans; Hydrogen Peroxide; Mutation; Nerve Degeneration; Neurons; Neurotoxins; Oxidative Stress; Parkinsonian Disorders; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Substantia Nigra; Tyrosine; Ubiquitin-Protein Ligases

2005
Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse.
    Nature neuroscience, 2006, Volume: 9, Issue:1

    Topics: Acetylcysteine; Aging; Animals; Behavior, Animal; Bicuculline; Blotting, Western; Brain; Cysteine; Excitatory Amino Acid Transporter 3; GABA Antagonists; Genotype; Glutathione; Immunohistochemistry; Mice; Mice, Knockout; Nerve Degeneration; Neurons; Oxidants; Oxidative Stress

2006
Early, transient increase in complexin I and complexin II in the cerebral cortex following traumatic brain injury is attenuated by N-acetylcysteine.
    Journal of neurotrauma, 2006, Volume: 23, Issue:1

    Topics: Acetylcysteine; Adaptor Proteins, Vesicular Transport; Animals; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Free Radical Scavengers; Glutamic Acid; Hippocampus; Male; Nerve Degeneration; Nerve Tissue Proteins; Neurotoxins; Oxidative Stress; Rats; Rats, Sprague-Dawley; SNARE Proteins; Synaptic Membranes; Synaptic Transmission; Time Factors; Up-Regulation

2006
Constitutively expressed catalytic proteasomal subunits are up-regulated during neuronal differentiation and required for axon initiation, elongation and maintenance.
    Journal of neurochemistry, 2006, Volume: 96, Issue:6

    Topics: Acetylcysteine; Animals; Animals, Newborn; Catalytic Domain; Cell Differentiation; Cell Survival; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Ganglia, Autonomic; Ganglia, Sensory; Growth Cones; Microscopy, Electron, Scanning; Nerve Degeneration; Nerve Growth Factor; Nerve Net; Nervous System; PC12 Cells; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rats; RNA, Messenger; Up-Regulation

2006
N-acetylcysteine selectively protects cerebellar granule cells from 4-hydroxynonenal-induced cell death.
    Neuroscience research, 2006, Volume: 55, Issue:3

    Topics: Acetylcysteine; Aldehydes; Animals; Animals, Newborn; Antioxidants; Brain; Cell Death; Cells, Cultured; Cerebellum; Free Radical Scavengers; Glutathione; L-Lactate Dehydrogenase; Mitochondrial Membranes; Nerve Degeneration; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Neurotoxins; Oxidative Stress; Plant Extracts; Rats; Rats, Wistar

2006
The copper chelator, D-penicillamine, does not attenuate MPTP induced dopamine depletion in mice.
    Journal of neural transmission (Vienna, Austria : 1996), 2007, Volume: 114, Issue:2

    Topics: Acetylcysteine; Animals; Chelating Agents; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Dopamine Agents; Iron; Male; Mice; Mice, Inbred C57BL; MPTP Poisoning; Nerve Degeneration; Neuroprotective Agents; Penicillamine; Salicylic Acid

2007
The neuroprotective role of attractin in neurodegeneration.
    Neurobiology of aging, 2007, Volume: 28, Issue:9

    Topics: 1-Methyl-4-phenylpyridinium; Acetylcysteine; Analysis of Variance; Apoptosis Inducing Factor; Cell Line, Tumor; Cell Survival; Cytochromes c; Gene Expression Regulation; Humans; In Situ Hybridization; Membrane Proteins; Nerve Degeneration; Neurotoxins; RNA, Small Interfering; Transfection; Tyrosine 3-Monooxygenase

2007
A comparative study of proteasomal inhibition and apoptosis induced in N27 mesencephalic cells by dopamine and MG132.
    Journal of neurochemistry, 2007, Volume: 102, Issue:3

    Topics: Acetylcysteine; Animals; Apoptosis; Caspases; Cell Line, Transformed; Cysteine Proteinase Inhibitors; Dopamine; Dose-Response Relationship, Drug; Enzyme Activation; Leupeptins; Mesencephalon; Nerve Degeneration; Neurons; Oxidative Stress; Parkinson Disease; Proteasome Endopeptidase Complex; Rats; Reactive Oxygen Species; Substantia Nigra

2007
Cellular Zn2+ chelators cause "dying-back" neurite degeneration associated with energy impairment.
    Journal of neuroscience research, 2007, Volume: 85, Issue:13

    Topics: Acetylcysteine; Adenosine Triphosphate; Animals; Chelating Agents; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Energy Metabolism; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neuritis; Organ Culture Techniques; Superior Cervical Ganglion; Time Factors

2007
Prevention and restoration of lactacystin-induced nigrostriatal dopamine neuron degeneration by novel brain-permeable iron chelators.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2007, Volume: 21, Issue:14

    Topics: Acetylcysteine; Animals; Blood-Brain Barrier; Dopamine; Goats; Hydroxyquinolines; Iron Chelating Agents; Male; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neurons; Rabbits; Substantia Nigra

2007
Glial cell-derived neurotrophic factor protects against proteasome inhibition-induced dopamine neuron degeneration by suppression of endoplasmic reticulum stress and caspase-3 activation.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2007, Volume: 62, Issue:9

    Topics: Acetylcysteine; Animals; Apoptosis; Caspase 3; Cells, Cultured; Dopamine; Endoplasmic Reticulum; Enzyme Activation; Glial Cell Line-Derived Neurotrophic Factor; Humans; Inclusion Bodies; Nerve Degeneration; Neurons; Parkinson Disease; Proteasome Inhibitors; Rats; Recombinant Proteins

2007
Inhibition of brain creatine kinase activity after renal ischemia is attenuated by N-acetylcysteine and deferoxamine administration.
    Neuroscience letters, 2008, Mar-21, Volume: 434, Issue:1

    Topics: Acetylcysteine; Animals; Antioxidants; Brain; Brain Diseases, Metabolic; Creatine Kinase; Deferoxamine; Down-Regulation; Ischemia; Kidney Diseases; Male; Nerve Degeneration; Oxidative Stress; Rats; Rats, Wistar; Subcellular Fractions; Time Factors; Treatment Outcome; Uremia

2008
Comparison of neuroprotective and neurorestorative capabilities of rasagiline and selegiline against lactacystin-induced nigrostriatal dopaminergic degeneration.
    Journal of neurochemistry, 2008, Volume: 105, Issue:5

    Topics: Acetylcysteine; Animals; Dopamine; Indans; Male; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neuroprotective Agents; Selegiline

2008
Proteasomal abnormalities in cortical Lewy body disease and the impact of proteasomal inhibition within cortical and cholinergic systems.
    Journal of neural transmission (Vienna, Austria : 1996), 2008, Volume: 115, Issue:6

    Topics: Acetylcholine; Acetylcysteine; Aged; Aged, 80 and over; alpha-Synuclein; Animals; Basal Nucleus of Meynert; Cell Death; Cells, Cultured; Cerebral Cortex; Cholinergic Fibers; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Humans; Lewy Bodies; Lewy Body Disease; Male; Nerve Degeneration; Nerve Tissue Proteins; Neural Pathways; Oligopeptides; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rats; Rats, Sprague-Dawley; Ubiquitin

2008
Multiple molecular pathways are involved in the neuroprotection of GDNF against proteasome inhibitor induced dopamine neuron degeneration in vivo.
    Experimental biology and medicine (Maywood, N.J.), 2008, Volume: 233, Issue:7

    Topics: Acetylcysteine; Animals; Cysteine Proteinase Inhibitors; Disease Models, Animal; Dopamine; Glial Cell Line-Derived Neurotrophic Factor; JNK Mitogen-Activated Protein Kinases; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase Kinases; Nerve Degeneration; p38 Mitogen-Activated Protein Kinases; Parkinson Disease; Phosphatidylinositol 3-Kinases; Proteasome Inhibitors; Proto-Oncogene Proteins c-akt; Random Allocation; Signal Transduction; Substantia Nigra

2008
Chronic inhibition of superoxide dismutase produces apoptotic death of spinal neurons.
    Proceedings of the National Academy of Sciences of the United States of America, 1994, May-10, Volume: 91, Issue:10

    Topics: Acetylcysteine; Amyotrophic Lateral Sclerosis; Animals; Animals, Newborn; Anti-Anxiety Agents; Antioxidants; Apoptosis; Base Sequence; Benzodiazepines; Biological Transport; Choline O-Acetyltransferase; Chromans; Ditiocarb; Glutamates; Glutamic Acid; Humans; Molecular Sequence Data; Motor Neurons; Nerve Degeneration; Neurotoxins; Oligonucleotides, Antisense; Organ Culture Techniques; Piperazines; Rats; Spinal Cord; Superoxide Dismutase

1994
Reduction of lower motor neuron degeneration in wobbler mice by N-acetyl-L-cysteine.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1996, Dec-01, Volume: 16, Issue:23

    Topics: Acetylcysteine; Animals; Facial Nerve; Forelimb; Free Radical Scavengers; Glutathione Peroxidase; Mice; Mice, Neurologic Mutants; Motor Neurons; Muscle, Skeletal; Neck; Nerve Degeneration; Spinal Cord

1996
Protective effect of glutathione in HIV-1 lytic peptide 1-induced cell death in human neuronal cells.
    Journal of neurovirology, 2001, Volume: 7, Issue:5

    Topics: Acetylcysteine; AIDS Dementia Complex; Amino Acid Sequence; Amino Acid Substitution; Antioxidants; Apoptosis; Cell Death; Cells, Cultured; Glutathione; HIV Envelope Protein gp41; HIV-1; Humans; Intracellular Membranes; Membrane Potentials; Mitochondria; Molecular Sequence Data; Nerve Degeneration; Neuroblastoma; Neurons; Neuroprotective Agents; Oxidation-Reduction; Peptide Fragments; Prodrugs; Tumor Cells, Cultured

2001
Cysteine and mercapturate conjugates of oxidized dopamine are in human striatum but only the cysteine conjugate impedes dopamine trafficking in vitro and in vivo.
    Journal of neurochemistry, 2001, Volume: 79, Issue:3

    Topics: Acetylcysteine; Aged; Aged, 80 and over; Animals; Brain; Cells, Cultured; Corpus Striatum; Cysteine; Dopamine; Esters; Female; Fetus; Humans; In Vitro Techniques; Male; Mesencephalon; Microdialysis; Nerve Degeneration; Oxidation-Reduction; Parkinson Disease; Rats; Rats, Sprague-Dawley; Synaptosomes

2001