acetylcysteine has been researched along with Malignant Melanoma in 46 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (8.70) | 18.2507 |
| 2000's | 16 (34.78) | 29.6817 |
| 2010's | 20 (43.48) | 24.3611 |
| 2020's | 6 (13.04) | 2.80 |
| Authors | Studies |
|---|---|
| Arabnezhad, MR; Davani-Davari, D; Ghaffarian-Bahraman, A; Jamshidzadeh, A; Keshavarzi, M; Mohammadi-Bardbori, A | 1 |
| Bergo, MO; Chen, X; Kashif, M; Liu, Y; Schmidt, S; Truong, M; Tüksammel, E; Yao, H | 1 |
| Farhat, A; Guo, KL; Kovacs, B; Liu, J; Liu-Smith, F; Schomberg, J; Wang, Z; Xie, J; Zhou, Z | 1 |
| Baetz, T; Flemming, JA; Grin, A; Motomura, D | 1 |
| Chang, SN; Choi, DK; Hwang, BS; Kang, SC; Khan, I; Kim, CG; Lee, H; Park, JG; Park, SM | 1 |
| Awasthi, S; Horne, D; Mirzapoiazova, T; Salgia, R; Singhal, SS; Srivastava, S | 1 |
| Ding, Y; Liao, W; Wang, FF; Wang, R; Xiang, W | 1 |
| Jeong, YJ; Lee, JY; Park, J; Park, SN | 1 |
| Garrett-Mayer, E; Nishimura, MI; Paulos, CM; Scheffel, MJ; Scurti, G; Voelkel-Johnson, C; Wyatt, MM | 1 |
| Bento, AC; Burgeiro, A; Gajate, C; Mollinedo, F; Oliveira, PJ | 1 |
| Guo, YL; Ji, J; Yu, T | 1 |
| Chen, S; Goydos, JS; Haffty, B; Khan, A; Schiff, D; Shin, SS; Sierra, J; Wall, BA; Wangari-Talbot, J; Yu, LJ | 1 |
| Calderon-Aparicio, A; Rieber, M; Strasberg-Rieber, M | 1 |
| Bartozzi, B; Bernardini, G; Pierpaoli, E; Provinciali, M | 1 |
| Akula, MK; Akyürek, LM; Bergo, MO; Dalin, MG; Ibrahim, MX; Karlsson, C; Le Gal, K; Lindahl, P; Nilsson, J; Sayin, VI; Wiel, C | 1 |
| Brilot, F; Fonteneau, JF; Gannagé, M; Münz, C | 1 |
| Arva, NC; Gilgur, A; Gosain, AK; Hendrix, MJ; Margaryan, NV; Purnell, C; Seftor, EA; Strizzi, L | 1 |
| Liang, L; Zhang, Z | 1 |
| Chavez, V; Orue, A; Rieber, M; Strasberg-Rieber, M | 1 |
| Boucher, KM; Cassidy, PB; Florell, SR; Grossman, D; Honeggar, M; Leachman, SA; Liu, T | 1 |
| Green, MR; Santra, MK; Wajapeyee, N | 1 |
| Boucher, KM; Cassidy, P; Cotter, MA; Florell, SR; Goodson, AG; Grossman, D; Liu, T; Wade, M | 1 |
| Czyz, M; Düchler, M; Koprowska, K; Lesiak, K; Nejc, D; Zalesna, I | 1 |
| Jiang, H; Jin, J; Liu, H; Lu, L; Zhang, Y; Zhu, X | 1 |
| Nickoloff, BJ; Qin, JZ; Xin, H | 1 |
| Codogno, P; De Milito, A; Della Mina, P; Djavaheri-Mergny, M; Fais, S; Lozupone, F; Marino, ML; Meschini, S; Pattingre, S; Rivoltini, L; Venturi, G; Villa, A | 1 |
| Ando, T; Blank, C; Dürr, C; Gadiot, J; Ichikawa, J; Johansson, CC; Kiessling, R; Mougiakakos, D; Okita, R; Zeiser, R | 1 |
| Arruda, DC; Farias, CF; Favero, OA; Ferreira, MJ; Figueiredo, CR; Girola, N; Lago, JH; Massaoka, MH; Matsuo, AL; Romoff, P; Scutti, JA; Travassos, LR | 1 |
| Chang, C; Chapman, PB; Fleisher, M; Hwu, WJ; Krown, SE; Livingston, PO; Pinto, JT; Williams, L; Wolchok, JD | 1 |
| Rieber, M; Rieber, MS | 1 |
| Cho, D; Hahm, E; Hur, D; Hwang, YI; Kang, JS; Kim, D; Kim, S; Kim, YI; Kim, YS; Lee, WJ; Pang, S; Park, H; Park, JH; Yang, Y | 1 |
| Hasegawa, K; Inoue, S; Ito, S; Olivares, C; Otake, H; Solano, F; Wakamatsu, K; Yukitake, J | 1 |
| Friedlander, M; Kurtovic, J; Riordan, SM; Singh-Grewal, I; Webster, GJ | 1 |
| Ameri, K; Culmsee, C; Davis, RJ; Denko, N; Hai, T; Hammond, EM; Harris, AL; Katschinski, DM; Raida, M; Wagner, E; Wenger, RH | 1 |
| Richmond, A; Su, Y; Yang, J | 1 |
| Cassidy, P; Cotter, MA; Florell, SR; Grossman, D; Jenkins, N; Leachman, S; Robinette, K; Samlowski, WE; Thomas, J | 1 |
| Haikel, Y; Hassan, M; Hengge, UR; Selimovic, D | 1 |
| Albini, A; Balansky, R; D'Agostini, F; De Flora, S; Giunciuglio, D; Paglieri, I | 1 |
| Arstrand, K; Dizdar, N; Kågedal, B; Kullman, A | 1 |
| Benbow, U; Brinckerhoff, CE; Hamilton, JW; Maitra, R | 1 |
| Dizdar, N; Kågedal, B; Kullman, A | 1 |
| Bandrés, E; García-Foncillas, J; Okroujnov, I; Redondo, P; Solano, T | 1 |
| Burri, L; Heberer, M; Lévy, F; Lüscher, U; Noppen, C; Remmel, E; Schaefer, C; Spagnoli, GC; Zajac, P | 1 |
| Bartolazzi, A; Brodin, B; Dricu, A; Girnita, A; Girnita, L; Larsson, O; Lundeberg, J; Nilsson, G; Wejde, J; Wiman, KG; Xie, Y | 1 |
| Demary, K; Faller, DV; Liou, JS; Spanjaard, RA; Wong, L | 1 |
| Brötell, H; Hallberg, A; Karg, E; Rorsman, H; Rosengren, E; Tunek, A | 1 |
1 review(s) available for acetylcysteine and Malignant Melanoma
| Article | Year |
|---|---|
Targeting the mercapturic acid pathway for the treatment of melanoma.
Topics: Acetylcysteine; Animals; Apoptosis; ATP-Binding Cassette Transporters; Endocytosis; Humans; Melanoma | 2021 |
2 trial(s) available for acetylcysteine and Malignant Melanoma
| Article | Year |
|---|---|
A Phase II Randomized Placebo-Controlled Trial of Oral N-acetylcysteine for Protection of Melanocytic Nevi against UV-Induced Oxidative Stress In Vivo.
Topics: Acetylcysteine; Administration, Oral; Antioxidants; Biomarkers; Double-Blind Method; Glutamate-Cysteine Ligase; Guanine; Humans; Melanoma; Mutation; Nevus, Pigmented; Oxidative Stress; Pilot Projects; Receptor, Melanocortin, Type 1; Skin Neoplasms; Sunlight; Thioredoxin Reductase 1; Ultraviolet Rays | 2017 |
Phase I trial of high dose paracetamol and carmustine in patients with metastatic melanoma.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antineoplastic Agents, Alkylating; Carmustine; Cohort Studies; Dose-Response Relationship, Drug; Female; Free Radical Scavengers; Glutathione; Glutathione Reductase; Humans; Leukocytes, Mononuclear; Liver Neoplasms; Lymphatic Metastasis; Male; Maximum Tolerated Dose; Melanoma; Neoplasm Metastasis; Skin Neoplasms; Time Factors | 2003 |
43 other study(ies) available for acetylcysteine and Malignant Melanoma
| Article | Year |
|---|---|
Influence of cellular redox environment on aryl hydrocarbon receptor ligands induced melanogenesis.
Topics: Acetylcysteine; Animals; Benzo(a)pyrene; Carbazoles; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Ligands; Melanins; Melanoma; Mice; Onium Compounds; Oxidation-Reduction; Oxidative Stress; Receptors, Aryl Hydrocarbon | 2022 |
ROS-lowering doses of vitamins C and A accelerate malignant melanoma metastasis.
Topics: Acetylcysteine; Animals; Antioxidants; Ascorbic Acid; Humans; Melanoma; Melanoma, Cutaneous Malignant; Mice; Reactive Oxygen Species; Vitamin A; Vitamins | 2023 |
Luteolin inhibits melanoma growth in vitro and in vivo via regulating ECM and oncogenic pathways but not ROS.
Topics: Acetylcysteine; Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Cell Line, Tumor; Cell Proliferation; Extracellular Matrix; Gene Expression Regulation, Neoplastic; Humans; Luteolin; Melanoma; Metabolic Networks and Pathways; Mice, Nude; Oncogenes; Oxidative Stress; Reactive Oxygen Species; Xenograft Model Antitumor Assays | 2020 |
Severe Refractory Checkpoint Inhibitor-Related Hepatitis Reversed With Anti-Thymocyte Globulin and n-Acetylcysteine.
Topics: Acetylcysteine; Antilymphocyte Serum; Chemotherapy, Adjuvant; Drug Resistance; Drug Therapy, Combination; Female; Glucocorticoids; Hepatitis; Humans; Immune Checkpoint Inhibitors; Immunosuppressive Agents; Melanoma; Middle Aged; Severity of Illness Index; Skin Neoplasms; Treatment Outcome | 2020 |
Decursinol Angelate Arrest Melanoma Cell Proliferation by Initiating Cell Death and Tumor Shrinkage via Induction of Apoptosis.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Apoptosis; Autophagosomes; Benzopyrans; Butyrates; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Humans; Male; Melanoma; Melanoma, Experimental; Mice, Inbred BALB C; Mice, Nude; Mitochondria; Mitochondrial Membranes; Models, Biological; Reactive Oxygen Species; Skin Neoplasms | 2021 |
Curcumin inhibited growth of human melanoma A375 cells via inciting oxidative stress.
Topics: Acetylcysteine; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; Curcumin; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Melanoma; Membrane Potential, Mitochondrial; Oxidative Stress; Time Factors; Up-Regulation | 2017 |
An inhibitory mechanism of action of a novel syringic-acid derivative on α-melanocyte-stimulating hormone (α-MSH)-induced melanogenesis.
Topics: Acetylcysteine; alpha-MSH; Animals; Biosynthetic Pathways; Cell Line; Cell Line, Tumor; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Gallic Acid; Humans; MAP Kinase Signaling System; Melanins; Melanocytes; Melanoma; Mice; Microphthalmia-Associated Transcription Factor; Monophenol Monooxygenase; Oxidoreductases | 2017 |
N-acetyl cysteine protects anti-melanoma cytotoxic T cells from exhaustion induced by rapid expansion via the downmodulation of Foxo1 in an Akt-dependent manner.
Topics: Acetylcysteine; Animals; Cells, Cultured; Forkhead Box Protein O1; Free Radical Scavengers; Gene Expression Regulation, Neoplastic; Humans; Immunotherapy, Adoptive; Lymphocyte Activation; Melanoma; Mice; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; T-Lymphocytes, Cytotoxic | 2018 |
Rapid human melanoma cell death induced by sanguinarine through oxidative stress.
Topics: Acetylcysteine; Antineoplastic Agents; bcl-X Protein; Benzophenanthridines; Calcium; Caspase 3; Caspase 7; Cell Death; Cell Line, Tumor; Cell Survival; Glutathione; Humans; Isoquinolines; Melanoma; Membrane Potential, Mitochondrial; Membrane Proteins; Mitochondria; Oxidative Stress; Reactive Oxygen Species | 2013 |
MST1 activation by curcumin mediates JNK activation, Foxo3a nuclear translocation and apoptosis in melanoma cells.
Topics: Acetylcysteine; Animals; Apoptosis; Cell Line, Tumor; Cell Nucleus; Curcumin; Enzyme Activation; Forkhead Box Protein O3; Forkhead Transcription Factors; Hepatocyte Growth Factor; JNK Mitogen-Activated Protein Kinases; Melanoma; Melanoma, Experimental; Mice; Protein Transport; Proto-Oncogene Proteins; Reactive Oxygen Species | 2013 |
Disruption of GRM1-mediated signalling using riluzole results in DNA damage in melanoma cells.
Topics: Acetylcysteine; Apoptosis; Biopsy; Cell Line, Tumor; DNA Breaks, Double-Stranded; DNA Damage; Gene Knockdown Techniques; Glutamic Acid; Glutathione; Histones; Humans; Intracellular Space; Melanoma; Oxidative Stress; Reactive Oxygen Species; Receptors, Metabotropic Glutamate; Riluzole; Signal Transduction | 2014 |
Disulfiram anti-cancer efficacy without copper overload is enhanced by extracellular H2O2 generation: antagonism by tetrathiomolybdate.
Topics: Acetylcysteine; Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Chelating Agents; Copper; Disulfiram; Free Radical Scavengers; Humans; Hydrogen Peroxide; MAP Kinase Signaling System; Melanoma; Molybdenum; Mutation, Missense; Proto-Oncogene Proteins B-raf; Reactive Oxygen Species; Receptor, ErbB-2; Superoxide Dismutase | 2015 |
Zinc Induces Apoptosis of Human Melanoma Cells, Increasing Reactive Oxygen Species, p53 and FAS Ligand.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Fas Ligand Protein; Gene Expression Regulation, Neoplastic; Humans; Melanoma; Reactive Oxygen Species; Skin Neoplasms; Tumor Suppressor Protein p53; Zinc | 2015 |
Antioxidants can increase melanoma metastasis in mice.
Topics: Acetylcysteine; Animals; Antioxidants; Cell Line, Tumor; Chromans; Dietary Supplements; Disease Models, Animal; Glutathione; Humans; Male; Melanoma; Mice; Neoplasm Metastasis | 2015 |
The Tumor Antigen NY-ESO-1 Mediates Direct Recognition of Melanoma Cells by CD4+ T Cells after Intercellular Antigen Transfer.
Topics: Acetylcysteine; Antigen Presentation; Antigens, Neoplasm; Autophagy; Autophagy-Related Protein 12; CD4-Positive T-Lymphocytes; Cell Line, Tumor; Chloroquine; Dendritic Cells; Endocytosis; Epitopes, T-Lymphocyte; Histocompatibility Antigens Class II; Humans; Immunotherapy, Adoptive; Leupeptins; Lymphocyte Activation; Lysosomal-Associated Membrane Protein 2; Melanoma; Membrane Proteins; RNA Interference; RNA, Small Interfering; Small Ubiquitin-Related Modifier Proteins | 2016 |
Melanocytes Affect Nodal Expression and Signaling in Melanoma Cells: A Lesson from Pediatric Large Congenital Melanocytic Nevi.
Topics: Acetylcysteine; Animals; Cell Line; Cell Line, Tumor; Child; Female; Humans; Melanins; Melanocytes; Melanoma; Mice; Mice, Nude; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nodal Protein; Signal Transduction; Smad2 Protein | 2016 |
Gambogic Acid Inhibits Malignant Melanoma Cell Proliferation Through Mitochondrial p66shc/ROS-p53/Bax-Mediated Apoptosis.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Cell Line, Tumor; Cell Proliferation; Humans; Male; Melanoma; Membrane Potential, Mitochondrial; Mice; Mice, Nude; Mitochondria; Reactive Oxygen Species; RNA, Small Interfering; Src Homology 2 Domain-Containing, Transforming Protein 1; Toluene; Transplantation, Heterologous; Tumor Suppressor Protein p53; Xanthones | 2016 |
Hypoxic resistance of KRAS mutant tumor cells to 3-Bromopyruvate is counteracted by Prima-1 and reversed by N-acetylcysteine.
Topics: A549 Cells; Acetylcysteine; Aza Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Cyclin-Dependent Kinase Inhibitor p21; Drug Resistance, Neoplasm; Free Radical Scavengers; Gene Expression Regulation, Neoplastic; Glucose Transporter Type 1; GTP Phosphohydrolases; Humans; Lung Neoplasms; Melanoma; Membrane Proteins; Mutation; Proto-Oncogene Proteins p21(ras); Pyruvates; Reverse Transcriptase Polymerase Chain Reaction; Tumor Suppressor Protein p53 | 2016 |
F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage.
Topics: Acetylcysteine; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line, Tumor; Cyclin D1; Cysteine Proteinase Inhibitors; DNA Damage; DNA-Binding Proteins; F-Box Proteins; G1 Phase; Humans; Melanoma; Proteasome Endopeptidase Complex; Protein Serine-Threonine Kinases; Transcriptional Activation; Tumor Suppressor Proteins; Ubiquitination | 2009 |
Use of oral N-acetylcysteine for protection of melanocytic nevi against UV-induced oxidative stress: towards a novel paradigm for melanoma chemoprevention.
Topics: Acetylcysteine; Administration, Oral; Adult; Aged; Anticarcinogenic Agents; Antioxidants; Cysteine; Female; Glutathione; Humans; Male; Melanoma; Middle Aged; Nevus, Pigmented; Oxidative Stress; Risk; Skin Neoplasms; Time Factors; Ultraviolet Rays | 2009 |
Parthenolide, a sesquiterpene lactone from the medical herb feverfew, shows anticancer activity against human melanoma cells in vitro.
Topics: Acetylcysteine; Adult; Animals; Antineoplastic Agents; Apoptosis; Caspase 3; Cell Adhesion; Cell Growth Processes; Cell Line, Tumor; Drug Interactions; Female; Flow Cytometry; Humans; Male; Melanoma; Membrane Potential, Mitochondrial; Mice; Middle Aged; Reactive Oxygen Species; Sesquiterpenes; Skin Neoplasms; Tanacetum parthenium | 2010 |
The role of endogenous reactive oxygen species in oxymatrine-induced caspase-3-dependent apoptosis in human melanoma A375 cells.
Topics: Acetylcysteine; Alkaloids; Antineoplastic Agents; Apoptosis; Caspase 3; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Melanoma; Oxidative Stress; Quinolizines; Reactive Oxygen Species | 2010 |
3-Bromopyruvate induces necrotic cell death in sensitive melanoma cell lines.
Topics: Acetylcysteine; Adenosine Triphosphate; Apoptosis; Cell Line, Tumor; Glutathione; Humans; Melanoma; Membrane Potential, Mitochondrial; Necrosis; Pyruvates; Skin Neoplasms; Superoxides | 2010 |
Proton pump inhibition induces autophagy as a survival mechanism following oxidative stress in human melanoma cells.
Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 5; Beclin-1; Cell Cycle Proteins; Cell Line, Tumor; Esomeprazole; Humans; Hydrogen-Ion Concentration; Melanoma; Membrane Proteins; Microtubule-Associated Proteins; NADPH Oxidases; Oxidative Stress; Phosphoproteins; Phosphorylation; Proton Pump Inhibitors; Reactive Oxygen Species; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; TOR Serine-Threonine Kinases | 2010 |
High expression of GCLC is associated with malignant melanoma of low oxidative phenotype and predicts a better prognosis.
Topics: Acetylcysteine; Adult; Aged; Aged, 80 and over; Animals; Cell Line, Tumor; Cell Proliferation; Female; Flow Cytometry; Gene Expression Regulation, Neoplastic; Glutamate-Cysteine Ligase; Humans; Immunohistochemistry; In Vitro Techniques; Male; Melanoma; Mice; Mice, Knockout; Middle Aged; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Young Adult | 2012 |
Jacaranone induces apoptosis in melanoma cells via ROS-mediated downregulation of Akt and p38 MAPK activation and displays antitumor activity in vivo.
Topics: Acetylcysteine; Animals; Annexin A5; Antineoplastic Agents; Apoptosis; Asteraceae; Benzoquinones; Blotting, Western; Cell Line, Tumor; Chromatin; Colorimetry; Down-Regulation; Humans; In Situ Nick-End Labeling; In Vitro Techniques; Male; Melanoma; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Nuclear Magnetic Resonance, Biomolecular; p38 Mitogen-Activated Protein Kinases; Phytotherapy; Plant Extracts; Propidium; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; Superoxides | 2012 |
N-Acetylcysteine enhances UV-mediated caspase-3 activation, fragmentation of E2F-4, and apoptosis in human C8161 melanoma: inhibition by ectopic Bcl-2 expression.
Topics: Acetylcysteine; Apoptosis; Caspase 3; Caspases; DNA; DNA-Binding Proteins; E2F4 Transcription Factor; Enzyme Activation; Humans; JNK Mitogen-Activated Protein Kinases; Melanoma; Mitogen-Activated Protein Kinases; Phosphorylation; Proteins; Proto-Oncogene Proteins c-bcl-2; Transcription Factors; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Ultraviolet Rays | 2003 |
Vitamin C downregulates interleukin-18 production by increasing reactive oxygen intermediate and mitogen-activated protein kinase signalling in B16F10 murine melanoma cells.
Topics: Acetylcysteine; Animals; Antioxidants; Ascorbic Acid; Blotting, Western; Cell Line, Tumor; Densitometry; Down-Regulation; Enzyme Inhibitors; Flow Cytometry; Imidazoles; Immunoprecipitation; Interleukin-18; MAP Kinase Signaling System; Melanoma; Mice; p38 Mitogen-Activated Protein Kinases; Pyridines; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Skin Neoplasms; Time Factors | 2003 |
Synthesis and selective in vitro anti-melanoma effect of enantiomeric alpha-methyl- and alpha-ethyl-4-S-cysteaminylphenol.
Topics: 3T3 Cells; Acetylcysteine; Animals; Antineoplastic Agents; Cell Line, Tumor; Cysteamine; Glutathione; Inhibitory Concentration 50; Kinetics; Magnetic Resonance Spectroscopy; Melanoma; Melanoma, Experimental; Mice; Models, Chemical; Monophenol Monooxygenase; Phenols; Stereoisomerism; Time Factors; Tyrosine | 2003 |
Prevention of hepatotoxicity but loss of antimelanoma effect with combined fotemustine and anti-oxidant treatment.
Topics: Acetylcysteine; Adult; Antineoplastic Agents; Antioxidants; Brain Neoplasms; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Lung Neoplasms; Melanoma; Nitrosourea Compounds; Organophosphorus Compounds; Treatment Outcome | 2004 |
Induction of activating transcription factor 3 by anoxia is independent of p53 and the hypoxic HIF signalling pathway.
Topics: Acetylcysteine; Activating Transcription Factor 3; Amino Acids, Dicarboxylic; Basic Helix-Loop-Helix Transcription Factors; Breast Neoplasms; Cells, Cultured; Cyanides; Deferoxamine; Enzyme Activation; Free Radical Scavengers; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Melanoma; Mixed Function Oxygenases; Neurons; Oxygen; Proto-Oncogene Proteins c-jun; Siderophores; Signal Transduction; Transcription Factors; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Von Hippel-Lindau Tumor Suppressor Protein | 2007 |
Antioxidants tiron and N-acetyl-L-cysteine differentially mediate apoptosis in melanoma cells via a reactive oxygen species-independent NF-kappaB pathway.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Acetylcysteine; Antioxidants; Apoptosis; Cell Line, Tumor; Humans; Melanoma; Membrane Potentials; Mitochondria; Necrosis; NF-kappa B; Reactive Oxygen Species | 2007 |
N-acetylcysteine protects melanocytes against oxidative stress/damage and delays onset of ultraviolet-induced melanoma in mice.
Topics: Acetylcysteine; Animals; Anticarcinogenic Agents; Humans; Male; Melanocytes; Melanoma; Mice; Mice, Inbred C57BL; Neoplasms, Radiation-Induced; Oxidative Stress; Pyrimidine Dimers; Reactive Oxygen Species; Skin; Ultraviolet Rays | 2007 |
Taxol-induced mitochondrial stress in melanoma cells is mediated by activation of c-Jun N-terminal kinase (JNK) and p38 pathways via uncoupling protein 2.
Topics: Acetylcysteine; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Down-Regulation; Enzyme Activation; Free Radical Scavengers; Humans; Ion Channels; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase Kinase 5; MAP Kinase Signaling System; Melanoma; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Proteins; Models, Biological; p38 Mitogen-Activated Protein Kinases; Paclitaxel; Reactive Oxygen Species; Uncoupling Protein 2 | 2008 |
Inhibition of invasion, gelatinase activity, tumor take and metastasis of malignant cells by N-acetylcysteine.
Topics: 3T3 Cells; Acetylcysteine; Animals; Carcinoma, Lewis Lung; Cell Movement; Gelatinases; Glutathione; Glutathione Disulfide; Humans; Lung Neoplasms; Melanoma; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Mice, Nude; Neoplasm Invasiveness; Sarcoma, Experimental; Tumor Cells, Cultured | 1995 |
Effects on interstitial glutathione, cysteine and 5-S-cysteinyldopa of buthionine sulphoximine in human melanoma transplants.
Topics: Acetylcysteine; Animals; Antimetabolites, Antineoplastic; Buthionine Sulfoximine; Cysteine; Cysteinyldopa; Drug Interactions; Enzyme Inhibitors; Glutathione; Humans; Melanoma; Mice; Mice, Inbred BALB C; Mice, Nude; Microdialysis; Neoplasm Transplantation; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1997 |
Selective inhibition of collagenase-1, gelatinase A, and gelatinase B by chemotherapeutic agents.
Topics: Acetylcysteine; Antineoplastic Agents; Carboplatin; Cisplatin; Doxorubicin; Gelatinases; Humans; Matrix Metalloproteinase 1; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Melanoma; Metalloendopeptidases; Mitomycin; Neoplasm Invasiveness; Protease Inhibitors; Tumor Cells, Cultured | 1999 |
Comparison of N-acetylcysteine and l-2-oxothiazolidine-4-carboxylate as cysteine deliverers and glutathione precursors in human malignant melanoma transplants in mice.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Cysteine; Cysteinyldopa; Enzyme Inhibitors; Glutathione; Humans; Melanoma; Melanoma, Experimental; Mice; Mice, Nude; Microdialysis; Neoplasm Transplantation; Protein Precursors; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Transplantation, Heterologous; Tumor Cells, Cultured | 2000 |
Vascular endothelial growth factor (VEGF) and melanoma. N-acetylcysteine downregulates VEGF production in vitro.
Topics: Acetylcysteine; Adult; Antioxidants; Cells, Cultured; Down-Regulation; Endothelial Growth Factors; Female; Humans; Lymphokines; Male; Melanocytes; Melanoma; Middle Aged; Neoplasm Recurrence, Local; Skin Neoplasms; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2000 |
Naturally processed and concealed HLA-A2.1-restricted epitopes from tumor-associated antigen tyrosinase-related protein-2.
Topics: Acetylcysteine; Antigens, Neoplasm; CD8-Positive T-Lymphocytes; Cell Line, Transformed; Coculture Techniques; Cysteine Proteinase Inhibitors; DNA Mutational Analysis; Enzyme-Linked Immunosorbent Assay; Epitopes; HIV Protease Inhibitors; HLA-A2 Antigen; Humans; Intramolecular Oxidoreductases; Leukocytes, Mononuclear; Melanoma; Peptides; Reverse Transcriptase Polymerase Chain Reaction; Ritonavir; T-Lymphocytes, Cytotoxic; Tumor Cells, Cultured | 2000 |
Increased expression of insulin-like growth factor I receptor in malignant cells expressing aberrant p53: functional impact.
Topics: Acetylcysteine; Cell Division; Cell Survival; Cysteine Proteinase Inhibitors; Humans; Melanoma; Oligonucleotides, Antisense; Receptor, IGF Type 1; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2000 |
Redox control of retinoic acid receptor activity: a novel mechanism for retinoic acid resistance in melanoma cells.
Topics: Acetylcysteine; Antioxidants; Blotting, Northern; Blotting, Western; Cell Hypoxia; Dimerization; DNA; Drug Resistance, Neoplasm; Gene Expression; Hydrogen Peroxide; Luciferases; Melanoma; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Receptors, Retinoic Acid; Recombinant Fusion Proteins; Retinoid X Receptors; Signal Transduction; Transcription Factors; Transfection; Tretinoin; Tumor Cells, Cultured | 2001 |
Glutathione in human melanoma cells. Effects of cysteine, cysteine esters and glutathione isopropyl ester.
Topics: Acetylcysteine; Cysteine; Expectorants; Glutathione; Humans; Melanoma; Skin Neoplasms; Tumor Cells, Cultured | 1990 |