acetylcysteine and Lung Neoplasms

acetylcysteine has been researched along with Lung Neoplasms in 163 studies

Research

Studies (163)

TimeframeStudies, this research(%)All Research%
pre-199013 (7.98)18.7374
1990's29 (17.79)18.2507
2000's36 (22.09)29.6817
2010's69 (42.33)24.3611
2020's16 (9.82)2.80

Authors

AuthorsStudies
Cao, S; Han, B; Ling, X; Wang, H; Xu, J; Zhang, B; Zhang, X; Zhong, H; Zhong, R1
Geng, Y; Liu, P; Liu, Y; Xie, Y; Zhang, L; Zhu, X1
Jensen, RT; Moody, TW; Ramos-Alvarez, I1
Cui, XY; Park, SH; Park, WH1
Chen, M; Guo, Q; Hu, C; Liang, Y; Wang, W; Yang, L1
Bodinier, B; Chadeau-Hyam, M; Dagnino, S; Edmands, WB; Fiorito, G; Grigoryan, H; Guida, F; Karimi, M; Krogh, V; Naccarati, A; Polidoro, S; Rappaport, SM; Sacerdote, C; Vermeulen, R; Vineis, P1
Abid, S; Adnot, S; Attwe, A; Beaulieu, D; Bernard, D; Born, E; Bourachot, B; Breau, M; Collin, G; Czibik, G; Flaman, JM; Houssaini, A; Lipskaia, L; Marcos, E; Mechta-Grigoriou, F; Palazzo, A; Tran Van Nhieu, J1
Chen, W; Chen, YH; Ruan, Q; Sun, H; Tang, A; Wan, X; Wang, J; Yan, D; Yang, X; Zamani, A; Zhang, H1
Chen, H; Hu, J; Li, J; Shi, M; Wang, XH; Zhang, L1
Adnot, S; Bernard, D; Breau, M; Mechta-Grigoriou, F1
Lakshminarayanan, A; Rajendran, S; Ramanathan, G; Subramanian Shanmugam, SK1
Li, F; Liu, YG; Wang, LQ; Wen, DH; Xia, YC; Yin, H; Yu, BT; Zha, JH1
Jin, CH; Li, TZ; Li, YN; Shen, GN; Xu, WT; Xue, H; Zhang, DJ; Zhang, T; Zhang, Y; Zuo, WB1
Baek, SH; Park, J1
Jin, W; Lu, S; Shi, H; Shu, Y; Wang, X1
Gurunathan, S; Jeyaraj, M; Kang, MH; Kim, JH1
Fan, F; Ge, X; Huang, F; Li, S; Li, X; Liu, H; Pang, J; Wu, Y; Zhang, Y1
Chen, H; Hu, J; Li, D; Li, J; Shi, M; Wang, X; Zhang, H; Zhang, L; Zhang, R1
Chung, MH; Hahm, KB; Han, YM; Jeong, M; Ko, KH; Kwon, CI; Park, JM1
Lee, SH; Lee, YJ1
Park, WH; You, BR3
Cai, H; Ge, G; Yan, Y1
Hu, Y; Johnson, PF; Karin, M; Ma, B; Nussinov, R; Schrump, DS; Song, NY; Su, L; Sun, Z; Wang, Z; Willette-Brown, J; Wu, X; Xi, S; Xia, X; Zhu, F1
Hu, Y; Li, J; Wang, Y; Wu, W; Yan, Y; Yang, G; Zheng, Z; Zhou, Y1
Li, Z; Liu, W; Yang, Y; Zhao, Z1
Azuma, A; Bando, M; Date, H; Ebina, M; Fukuoka, J; Gemma, A; Goto, Y; Hasegawa, Y; Hattori, N; Homma, S; Inase, N; Inoue, Y; Ishii, Y; Izumi, S; Johkoh, T; Kido, T; Kishaba, T; Kishi, K; Miyamoto, A; Mukae, H; Nakayama, T; Nishioka, Y; Ogura, T; Sakamoto, S; Sasaki, S; Suda, T; Sugino, K; Taguchi, Y; Takahashi, H; Takahashi, K; Taniguchi, H; Watanabe, K; Yokoyama, A; Yoshino, I1
Chen, W; Li, X; Wu, J; Zhang, X1
Chang, YJ; Chao, MW; Chen, YC; Erkekoglu, P; Lin, CH; Lin, PY; Tseng, CY1
Díaz-García, VM; Díaz-Valdivia, N; Guerrero, S; Kogan, M; Lobos-González, L; Pérez-Donoso, JM; Quest, AF1
Jiao, P; Ren, G; Wang, S; Ye, L; Zhao, W; Zhou, J1
Choi, CM; Han, DW; Ji, W; Lee, JC; Song, SY1
Feng, YC; Jin, CH; Li, JQ; Luo, YH; Piao, XJ; Shen, GN; Wang, CY; Wang, JR; Xu, WT; Zhang, T; Zhang, Y1
Chen, Z; Qin, X1
Andreu, AL; Barreiro, E; de Kier Joffé, ED; Fermoselle, C; García-Arumí, E; Puente-Maestu, L; Puig-Vilanova, E; Tejedor, A; Urtreger, AJ1
Burgos-Morón, E; Calderón-Montaño, JM; López-Lázaro, M; Mateos, S; Orta, ML1
Bowtell, DD; Chen, A; Liu, MC; Möller, A; Sceneay, J; Wong, CS1
Hann, SS; Zhao, S; Zheng, F1
Abe, I; Chanvorachote, P; Cheun-Arom, T; Chuanasa, T; Saito, N; Sirimangkalakitti, N; Suwanborirux, K1
Kaushik, G; Kaushik, T; Khanduja, KL; Pathak, CM; Ranawat, P; Sharma, SK; Yadav, SK1
Luo, H; Schulte, BA; Tang, S; Wang, GY; Wang, L; Yang, A1
Bergo, MO; Ibrahim, MX; Larsson, E; Lindahl, P; Nilsson, JA; Sayin, VI1
Kaiser, J1
Kim, BM; Park, JB; Yang, KM1
Cinatl, J; Michaelis, M; Sithisarn, P1
Cha, BK; Hwang, KE; Hwang, YR; Jeong, ET; Kim, BR; Kim, HR; Kim, YS; Kwon, SJ; Park, DS; Yoon, KH2
Kang, S1
Kotapati, S; Le Marchand, L; Murphy, SE; Park, SL; Tiirikainen, M; Tretyakova, N; Wilkens, LR1
Kim, SH; Park, WH; You, BR1
Cui, R; Hua, P; Li, X; Sun, M; Tian, X; Zhang, G; Zhang, X; Zhang, Y1
Carmella, SG; Chen, M; Hecht, SS; Koh, WP; Murphy, SE; Wang, R; Yuan, JM1
Jayasree, K; Sara George, P; Saraswathy Veena, V; Sujathan, K1
Cromie, MM; Gao, W1
Carmella, SG; Chen, M; Haiman, CA; Hecht, SS; Le Marchand, L; Park, SL; Patel, Y; Stram, DO1
Gu, S; Shao, GG; Sun, LK; Wu, Y; Xiang, XY; Xue, YN; Yan, XY; Yang, XC; Zhang, Y1
Almosnid, NM; Altman, E; Chippada-Venkata, UD; Farone, A; Gao, Y; Gong, Y; Hosain, NA; Huang, R; Park, HS; Vick, E; Wen, Q1
Hanyuda, M; Hosokawa, Y; Karnan, S; Konishi, H; Miura, Y; Numanami, H; Ota, A; Tanaka, M1
Jin, F; Liu, X; Ma, L; Wang, R; Weng, D; Yao, J1
Cao, SJ; Gao, XM; Huang, YY; Jian, JF; Kang, N; Mao, YW; Peng, YF; Qiu, F; Zhang, Q1
Chen, X; Leung, CH; Lu, J; Luo, W; Ma, DL; Ma, G; Wang, Y1
Hou, SG; Li, XB; Lin, SS; Shi, YR; Sun, Y; Zhang, SY1
Gao, W; Liu, J; Liu, Z; Man, S; Wang, Y; Yu, P; Zhang, L1
Chang, WT; Chen, JY; Chiu, CC; Chou, HL; Fong, Y; Huang, HW; Tsai, EM; Wei, CK; Wu, CY1
Hong, SE; Jang, YS; Jeong, W; Jo, YJ; Kim, H; Kim, J; Lee, GR; Lee, HI; Lee, HJ; Lee, J; Lee, JS; Oh, SH1
Chavez, V; Orue, A; Rieber, M; Strasberg-Rieber, M1
Boldry, EJ; Esades, A; Kotapati, S; Le Marchand, L; Park, SL; Patel, YM; Stram, DO; Tiirikainen, M; Tretyakova, N1
Hirayama, A; Inanami, O; Kobayashi, S; Kon, Y; Kuwabara, M; Meike, S; Ogura, A; Oowada, S; Yasui, H1
Balansky, R; De Flora, S; Ganchev, G; Iltcheva, M; Steele, VE3
Han, YH; Park, WH1
Cheng, PF; Ma, HX; Wang, CJ; Wang, JH; Xie, SQ; Zhao, J1
Baas, P; Beijnen, JH; Keizer, RJ1
Han, YH; Kim, SH; Kim, SZ; Moon, HJ; Park, WH; You, BR1
Adams, LD; George, MH; King, LC; Moore, T; Nelson, G; Nesnow, S; Padgett, WT; Ross, JA1
Chan, HW; Chen, HH; Chiu, LY; Hsin, IL; Hsu, CP; Ko, JL; Sheu, GT; Wang, HD1
Autrup, H; Dang, DA; Foldbjerg, R1
Li, Y; Liu, B; Wu, X; Xu, K; Yan, H; Zhou, Q; Zhu, Y1
Chen, GG; Hsin, MK; Leung, BC; Leung, KC; Li, MY; Mok, TS; Underwood, MJ1
Chanvorachote, P; Halim, H; Nimmannit, U; Rojanasakul, Y; Rungtabnapa, P1
Chen, J; Gao, AC; Li, Y; Liu, C; Liu, H; Wang, T; Wu, Z; Zhou, Q; Zhu, Y1
Li, Y; Liu, B; Wu, H; Wu, X; Xu, K; Yan, H; Zhou, Q; Zhu, Y1
Kashyap, MP; Lohani, M; Pant, AB; Rahman, Q; Srivastava, RK1
Fu, Z; Guan, L; Hu, Z; Huang, J; Li, X; Li, Z; Liu, H1
Brock, SE; Mitchell, RA; Rendon, BE; Yaddanapudi, K1
Attia, A; Isom, S; Kock, ND; McBride, JE; Miller, MS; Moore, JE; Munley, MT; Walb, MC1
Aqil, F; Bansal, SS; Gupta, RC; Kausar, H; Munagala, R; Vadhanam, MV1
Simkeviciene, V; Straukas, J; Uleckiene, S1
Pastorino, U; van Zandwijk, N1
Brent, GA; Dubinett, SM; Hershman, JM; Huang, M; Kogai, T; Sharma, S; Zhang, L; Zhu, LX1
Futakuchi, M; Ogawa, K; Shirai, T; Takahashi, S; Tamano, S1
Friedlander, M; Kurtovic, J; Riordan, SM; Singh-Grewal, I; Webster, GJ1
Henfling, ME; Ramaekers, FC; Schutte, B1
Witschi, H1
Kassie, F; Mersch-Sundermann, V; Wu, XJ1
Gallimore, PH; Grand, RJ; Hussain, R; Mymryk, JS; Turnell, AS; Zhang, X1
Chung, FL; Conaway, CC; Hecht, SS; McIntee, EJ; Pittman, B; Schwartz, JE; Tian, D; Wang, CX; Yang, YM1
Foth, H; Glahn, F; Stehfest, E; Torky, A1
Alexandre, J; Batteux, F; Chéreau, C; Goldwasser, F; Guillevin, L; Laurent, A; Nicco, C; Weill, B1
Shyamaladevi, CS; Vanisree, AJ1
Bosari, S; Carelli, S; Di Giulio, AM; Gorio, A; Paratore, S1
Dai, W; Darzynkiewicz, Z; Huang, X; Kurose, A; Tanaka, T; Traganos, F1
Duong, HQ; Han, SI; Joo, YM; Kang, HS; Kim, CH; Kim, YJ; Lee, SY; Lim, SC; Moon, JY; Park, HG; Park, MJ; Yoo, MA; Youk, HS1
Borges, FT; Dalboni, MA; Garofalo, AS; Pavão dos Santos, OF1
Hour, MJ; Lee, HZ; Leung, HW; Lin, CJ; Wang, MY; Yang, WH1
Bepler, G; Gray, J; Kelley, M; Kurie, J; Mao, JT; Szabo, E1
Aburatani, H; Fukayama, M; Goto, A; Ishikawa, S; Matsubara, D; Miyazawa, K; Nakamura, Y; Niki, T; Ota, S; Sachiko, O1
Lambert, JD; Sang, S; Yang, CS1
An, S; Choe, TB; Hong, SI; Jin, HO; Kim, ES; Kim, JI; Lee, HC; Lee, SJ; Park, IC; Rhee, CH; Seo, SK; Woo, SH; Yoo, DH1
Saiers, JH; Slavik, M2
Gillen, LE; Holdiness, MR; Morgan, LR1
Donley, PJ; Harrison, EF; Hunter, HL; Morgan, LR2
Baas, P; Stewart, FA; van Mansom, I; van Tinteren, H; van Zandwijk, N1
Albini, A; Balansky, R; D'Agostini, F; De Flora, S; Giunciuglio, D; Paglieri, I1
van Zandwijk, N2
Bridgeman, MM; MacNee, W; Marsden, M; Morrison, D; Selby, C1
Bistoni, F; Cociani, C; Dottorini, M; Eslami, A; Pietrella, D; Todisco, T; Vecchiarelli, A1
Giaccia, AJ; Hahn, GM; Koong, AC; Saad, AH1
Hallman, M; Kivisaari, L; Maasilta, P; Mattson, K; Taskinen, E1
De Flora, S; De Vries, N1
de Vries, N; Pastorino, U; van Zandwijk, N2
Feldstein, TJ; Hartfield, D; Horner, H; Kobrinsky, NL; Maksymiuk, A; Minuk, GY; White, DF1
Choi, CI; Chung, FL; Jiao, D; Kelloff, G; Pittman, B; Rigotty, J; Rivenson, A; Steele, V; Zang, E1
Albini, A; D'Agostini, F; De Flora, S; Giunciuglio, D; Masiello, L1
Ahmed, T; Kehrer, JP; Pakenham, G; Perry, CS; Ramu, K1
De Flora, S1
Bagnasco, M; Bennicelli, C; Camoirano, A; De Flora, S; Kensler, TW; Qian, GS; van Zandwijk, N; Wigbout, G; Zhu, YR1
Choi, AM; Jacoby, DB; Knobil, K; Weigand, GW1
Chung, FL; Conaway, CC; Jiao, D; Kelloff, GJ; Rivenson, A; Steele, VE1
Hunninghake, GW; Mastronarde, JG; Matsushima, K; Monick, MM; Mukaida, N1
Balansky, RM; De Flora, S1
Albini, A; Bagnasco, M; D'Agostini, F; De Flora, S; Giunciuglio, D1
Dubrovskaya, VA; Wetterhahn, KE1
Kobzik, L; Stringer, B1
Espiritu, I; Willits, NH; Witschi, H; Yu, M1
Han, JA; Park, SC1
Chi, CX; Jiang, Y; Rom, WN; Tchou-Wong, KM; Yie, TA1
Goldman, Y; Peled, A; Shinitzky, M1
Omenn, GS1
Dalesio, O; de Vries, N; Pastorino, U; van Tinteren, H; van Zandwijk, N1
Harani, N; Haslett, C; MacKinnon, AC; Rahman, I; Rintoul, R; Sethi, T; Waters, C1
Balansky, RM; Camoirano, A; D'Agostini, F; de Flora, S1
Balansky, RM; Bennicelli, C; D'Agostini, F; De Flora, S; Kelloff, GJ; Lubet, RA1
Deloughery, TG; Hasler, BP; Muldoon, LL; Neuwelt, EA; Pagel, MA1
Amin, S; Chiao, JW; Chung, FL; Conaway, CC; Dai, W; Reinhardt, J; Wang, CX; Whysner, J; Yang, YM1
Espiritu, I; Pinkerton, KE; Suffia, M; Witschi, H1
Carpenter, LR; Moy, JN; Roebuck, KA1
Blomqvist, P; Holsti, LR; Kivisaari, L; Maasilta, P; Mattson, K1
Baldewyns, P; Beauduin, M; Gourdin, P; Minette, P; Pluygers, E; Robinet, P1
Blank, LE; Haveman, J; Joenje, H; van Rijn, J; van Zandwijk, N; Wanamarta, AH1
Jepsen, S; Klaerke, A; Nielsen, PH; Nielsen, ST; Simonsen, O1
Birch, R; Einhorn, LH; Greco, FA; Kramer, BS; Loehrer, PJ1
Holoye, PY1
Astengo, M; Bennicelli, C; De Flora, S; Serra, D1
De Flora, A; De Flora, S; Rossi, GA1
Kline, I1
Mirra, AP1

Reviews

5 review(s) available for acetylcysteine and Lung Neoplasms

ArticleYear
Japanese guideline for the treatment of idiopathic pulmonary fibrosis.
    Respiratory investigation, 2018, Volume: 56, Issue:4

    Topics: Acetylcysteine; Administration, Inhalation; Adrenal Cortex Hormones; Antineoplastic Combined Chemotherapy Protocols; Comorbidity; Disease Progression; Drug Therapy, Combination; Evidence-Based Medicine; Glycine; Humans; Idiopathic Pulmonary Fibrosis; Immunosuppressive Agents; Indoles; Japan; Lung Neoplasms; Meta-Analysis as Topic; Practice Guidelines as Topic; Prognosis; Pyridones; Quality of Health Care; Sulfonamides; Survival Rate

2018
Chemoprevention of lung cancer: soon daily practice?
    Expert review of anticancer therapy, 2003, Volume: 3, Issue:1

    Topics: Acetylcysteine; Animals; Anticarcinogenic Agents; Antineoplastic Agents; Antioxidants; Carotenoids; Clinical Trials as Topic; Diet; Humans; Lung Neoplasms; Pyrazines; Retinoids; Selenium; Smoking; Vitamin E

2003
N-acetyl-l-cysteine.
    Journal of cellular biochemistry. Supplement, 1993, Volume: 17F

    Topics: Acetylcysteine; Animals; Anticarcinogenic Agents; Antioxidants; Humans; Laryngeal Neoplasms; Lung Neoplasms; Mouth Neoplasms

1993
N-acetylcysteine (NAC) and glutathione (GSH): antioxidant and chemopreventive properties, with special reference to lung cancer.
    Journal of cellular biochemistry. Supplement, 1995, Volume: 22

    Topics: Acetylcysteine; Anticarcinogenic Agents; Antidotes; Antioxidants; Expectorants; Glutathione; Humans; Lung Neoplasms; Smoking

1995
[Molecular epidemiology and prevention of bronchopulmonary carcinoma].
    Chirurgia italiana, 1995, Volume: 47, Issue:3

    Topics: Acetylcysteine; Air Pollution, Indoor; Carcinoma, Bronchogenic; Female; Free Radical Scavengers; Humans; Italy; Lung Neoplasms; Male; Risk Factors; Smoking; United States

1995

Trials

12 trial(s) available for acetylcysteine and Lung Neoplasms

ArticleYear
Safety and efficacy of dendritic cell-based immunotherapy (DCVAC/LuCa) combined with carboplatin/pemetrexed for patients with advanced non-squamous non-small-cell lung cancer without oncogenic drivers.
    ESMO open, 2022, Volume: 7, Issue:1

    Topics: Acetylcysteine; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Non-Small-Cell Lung; Dendritic Cells; Humans; Immunotherapy; Lung Neoplasms; Pemetrexed; Prospective Studies

2022
Protective effect of N-acetylcysteine on the urotoxicity produced by oxazaphosphorine without interference with anticancer activity.
    European journal of cancer & clinical oncology, 1982, Volume: 18, Issue:1

    Topics: Acetylcysteine; Antineoplastic Agents; Cyclophosphamide; Hematuria; Humans; Ifosfamide; Lung Neoplasms

1982
Effect of N-acetylcysteïne on Photofrin-induced skin photosensitivity in patients.
    Lasers in surgery and medicine, 1995, Volume: 16, Issue:4

    Topics: Acetylcysteine; Adult; Aged; Aged, 80 and over; Dihematoporphyrin Ether; Edema; Erythema; Esophageal Neoplasms; Female; Follow-Up Studies; Free Radicals; Glutathione; Humans; Lung Neoplasms; Male; Middle Aged; Photochemotherapy; Photosensitivity Disorders; Reactive Oxygen Species; Skin

1995
Macrophage activation by N-acetyl-cysteine in COPD patients.
    Chest, 1994, Volume: 105, Issue:3

    Topics: Acetylcysteine; Bronchoalveolar Lavage Fluid; Candida albicans; Female; Humans; In Vitro Techniques; Leukocytes, Mononuclear; Lung Diseases, Obstructive; Lung Neoplasms; Macrophage Activation; Macrophages, Alveolar; Male; Middle Aged; Neutrophils; Phagocytosis

1994
Chemoprevention of cancer.
    The European respiratory journal, 1993, Volume: 6, Issue:3

    Topics: Acetylcysteine; Animals; Antineoplastic Agents; Diet; Digestive System Neoplasms; Diterpenes; Head and Neck Neoplasms; Humans; Isotretinoin; Lung Neoplasms; Neoplasms, Second Primary; Retinyl Esters; Smoking Prevention; Vitamin A

1993
Treatment of advanced malignancies with high-dose acetaminophen and N-acetylcysteine rescue.
    Cancer investigation, 1996, Volume: 14, Issue:3

    Topics: Acetaminophen; Acetylcysteine; Adult; Aged; Antineoplastic Agents; Carcinoma, Small Cell; Drug Combinations; Female; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasms; Time Factors

1996
EUROSCAN, a randomized trial of vitamin A and N-acetylcysteine in patients with head and neck cancer or lung cancer. For the EUropean Organization for Research and Treatment of Cancer Head and Neck and Lung Cancer Cooperative Groups.
    Journal of the National Cancer Institute, 2000, Jun-21, Volume: 92, Issue:12

    Topics: Acetylcysteine; Adult; Aged; Aged, 80 and over; Anticarcinogenic Agents; Antineoplastic Combined Chemotherapy Protocols; Disease-Free Survival; Diterpenes; Drug Administration Schedule; Europe; Female; Head and Neck Neoplasms; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasms, Second Primary; Patient Compliance; Retinyl Esters; Risk Factors; Smoking; Survival Analysis; Treatment Failure; Vitamin A

2000
N-acetylcysteine in combination with radiotherapy in the treatment of non-small cell lung cancer: a feasibility study.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 1992, Volume: 25, Issue:3

    Topics: Acetylcysteine; Adult; Aged; Carcinoma, Non-Small-Cell Lung; Combined Modality Therapy; Feasibility Studies; Humans; Lung; Lung Neoplasms; Middle Aged; Radiation Injuries; Radiation-Protective Agents; Radiotherapy Dosage; Tomography, X-Ray Computed

1992
The EUROSCAN Study. EUROSCAN Steering Committee.
    British journal of cancer, 1991, Volume: 64, Issue:6

    Topics: Acetylcysteine; Head and Neck Neoplasms; Humans; Lung Neoplasms; Neoplasm Recurrence, Local; Neoplasms, Second Primary; Survival Analysis; Vitamin A

1991
Peroral N-acetylcysteine as prophylaxis against bronchopulmonary complications of pulmonary surgery.
    Scandinavian journal of thoracic and cardiovascular surgery, 1989, Volume: 23, Issue:2

    Topics: Acetylcysteine; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Lung; Lung Neoplasms; Male; Middle Aged; Postoperative Complications; Premedication; Pulmonary Atelectasis; Random Allocation

1989
Ifosfamide plus N-acetylcysteine in the treatment of small cell and non-small cell carcinoma of the lung: a Southeastern Cancer Study Group Trial.
    Cancer treatment reports, 1986, Volume: 70, Issue:7

    Topics: Acetylcysteine; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Bronchogenic; Carcinoma, Small Cell; Clinical Trials as Topic; Female; Humans; Ifosfamide; Lung Neoplasms; Male; Middle Aged

1986
"Ifosfamide plus N-acetylcysteine in the treatment of small cell and non-small cell carcinoma of the lung: a Southeastern Cancer Study Group Trial".
    Cancer treatment reports, 1987, Volume: 71, Issue:4

    Topics: Acetylcysteine; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Clinical Trials as Topic; Humans; Ifosfamide; Lung Neoplasms

1987

Other Studies

146 other study(ies) available for acetylcysteine and Lung Neoplasms

ArticleYear
Xanthatin inhibits non-small cell lung cancer proliferation by breaking the redox balance.
    Drug development research, 2022, Volume: 83, Issue:5

    Topics: Acetylcysteine; Antioxidants; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Furans; Humans; Lung Neoplasms; Oxidation-Reduction; Reactive Oxygen Species

2022
Adding of neurotensin to non-small cell lung cancer cells increases tyrosine phosphorylation of HER3.
    Peptides, 2022, Volume: 156

    Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Acetylcysteine; Antibodies, Monoclonal; Antioxidants; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; ErbB Receptors; Humans; Lung Neoplasms; Matrix Metalloproteinase Inhibitors; Neuregulins; Neurotensin; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptor, ErbB-3; Receptors, Neurotensin; Superoxides; Tyrosine

2022
Anti-Cancer Effects of Auranofin in Human Lung Cancer Cells by Increasing Intracellular ROS Levels and Depleting GSH Levels.
    Molecules (Basel, Switzerland), 2022, Aug-15, Volume: 27, Issue:16

    Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Auranofin; Buthionine Sulfoximine; Cell Line, Tumor; Cell Proliferation; Glutathione; Humans; Lung Neoplasms; Membrane Potential, Mitochondrial; Reactive Oxygen Species

2022
Saikosaponin-D induces the pyroptosis of lung cancer by increasing ROS and activating the NF-κB/NLRP3/caspase-1/GSDMD pathway.
    Journal of biochemical and molecular toxicology, 2023, Volume: 37, Issue:8

    Topics: Acetylcysteine; Carcinoma, Non-Small-Cell Lung; Caspase 1; Humans; Inflammasomes; Lung Neoplasms; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Phosphate-Binding Proteins; Pore Forming Cytotoxic Proteins; Pyroptosis; Reactive Oxygen Species; Tumor Microenvironment

2023
Agnostic Cys34-albumin adductomics and DNA methylation: Implication of N-acetylcysteine in lung carcinogenesis years before diagnosis.
    International journal of cancer, 2020, 06-15, Volume: 146, Issue:12

    Topics: Acetylcysteine; Biomarkers, Tumor; Carcinogenesis; Case-Control Studies; CpG Islands; DNA Adducts; DNA Methylation; Epigenomics; Female; Follow-Up Studies; Humans; Lung Neoplasms; Male; Middle Aged; Oxidation-Reduction; Prospective Studies; Risk Assessment; Smoking

2020
The antioxidant N-acetylcysteine protects from lung emphysema but induces lung adenocarcinoma in mice.
    JCI insight, 2019, 10-03, Volume: 4, Issue:19

    Topics: Acetylcysteine; Adenocarcinoma of Lung; Animals; Antioxidants; Disease Models, Animal; Female; Humans; Lung; Lung Diseases; Lung Neoplasms; Male; Mice; Mice, Knockout; Oxidative Stress; Proto-Oncogene Proteins c-jun; Pulmonary Emphysema; Reactive Oxygen Species

2019
TIPE2 specifies the functional polarization of myeloid-derived suppressor cells during tumorigenesis.
    The Journal of experimental medicine, 2020, 02-03, Volume: 217, Issue:2

    Topics: Acetylcysteine; Adoptive Transfer; Animals; Carcinogenesis; Cell Polarity; Cell Transformation, Neoplastic; Female; HEK293 Cells; Humans; Intracellular Signaling Peptides and Proteins; Lung Neoplasms; Lysine; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Myeloid Cells; Myeloid-Derived Suppressor Cells; Reactive Oxygen Species; Signal Transduction; Transfection

2020
Combined treatment with N-acetylcysteine and gefitinib overcomes drug resistance to gefitinib in NSCLC cell line.
    Cancer medicine, 2020, Volume: 9, Issue:4

    Topics: Acetylcysteine; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; ErbB Receptors; Gefitinib; Humans; Lung Neoplasms; Mutation; Protein Kinase Inhibitors

2020
[Antioxidant treatment promotes lung cancer while protecting against lung emphysema].
    Medecine sciences : M/S, 2020, Volume: 36, Issue:3

    Topics: Acetylcysteine; Animals; Antioxidants; Cell Transformation, Neoplastic; Cellular Senescence; Cytoprotection; Humans; Lung; Lung Neoplasms; Mice; Mice, Knockout; Oxidative Stress; Proto-Oncogene Proteins c-jun; Pulmonary Emphysema

2020
Antioxidant Antagonises Chemotherapeutic Drug Effect in Lung Cancer Cell Line A549.
    Asian Pacific journal of cancer prevention : APJCP, 2020, Apr-01, Volume: 21, Issue:4

    Topics: Acetylcysteine; Antimetabolites, Antineoplastic; Antioxidants; Apoptosis; Cell Proliferation; Drug Therapy, Combination; Free Radical Scavengers; Humans; Lung Neoplasms; Thioguanine; Tumor Cells, Cultured

2020
Resibufogenin suppresses growth and metastasis through inducing caspase-1-dependent pyroptosis via ROS-mediated NF-κB suppression in non-small cell lung cancer.
    Anatomical record (Hoboken, N.J. : 2007), 2021, Volume: 304, Issue:2

    Topics: Acetylcysteine; Antioxidants; Bufanolides; Carcinoma, Non-Small-Cell Lung; Caspase 1; Cell Line, Tumor; Cell Proliferation; Cell Survival; Humans; Lung Neoplasms; NF-kappa B; Pyroptosis; Reactive Oxygen Species

2021
Isoorientin induces the apoptosis and cell cycle arrest of A549 human lung cancer cells via the ROS‑regulated MAPK, STAT3 and NF‑κB signaling pathways.
    International journal of oncology, 2020, Volume: 57, Issue:2

    Topics: A549 Cells; Acetylcysteine; Apoptosis; Drug Screening Assays, Antitumor; G2 Phase Cell Cycle Checkpoints; Humans; Lung Neoplasms; Luteolin; MAP Kinase Signaling System; NF-kappa B; Reactive Oxygen Species; STAT3 Transcription Factor

2020
Combination Therapy with Cinnamaldehyde and Hyperthermia Induces Apoptosis of A549 Non-Small Cell Lung Carcinoma Cells via Regulation of Reactive Oxygen Species and Mitogen-Activated Protein Kinase Family.
    International journal of molecular sciences, 2020, Aug-28, Volume: 21, Issue:17

    Topics: A549 Cells; Acetylcysteine; Acrolein; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Proliferation; Cell Survival; Combined Modality Therapy; Drug Screening Assays, Antitumor; Gene Expression Regulation, Neoplastic; Humans; Hyperthermia, Induced; JNK Mitogen-Activated Protein Kinases; Lung Neoplasms; MAP Kinase Signaling System; Phosphorylation; Reactive Oxygen Species

2020
Raddeanin A suppresses lung cancer cell proliferation via induction of apoptosis and increased production of ROS.
    Cellular and molecular biology (Noisy-le-Grand, France), 2020, Oct-31, Volume: 66, Issue:7

    Topics: Acetylcysteine; Apoptosis; bcl-2-Associated X Protein; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Cytochromes c; Humans; Lung Neoplasms; Membrane Potential, Mitochondrial; Reactive Oxygen Species; Saponins

2020
Platinum Nanoparticles Enhance Exosome Release in Human Lung Epithelial Adenocarcinoma Cancer Cells (A549): Oxidative Stress and the Ceramide Pathway are Key Players.
    International journal of nanomedicine, 2021, Volume: 16

    Topics: A549 Cells; Acetylcholinesterase; Acetylcysteine; Adenocarcinoma of Lung; Aniline Compounds; Benzylidene Compounds; Cell Proliferation; Cell Survival; Ceramides; Enzyme Activation; Exosomes; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Lutein; Metal Nanoparticles; Neoplasm Proteins; Oxidative Stress; Particle Size; Platinum; RNA, Messenger; Serum; Sphingomyelin Phosphodiesterase; Static Electricity

2021
EGFR tyrosine kinase inhibitor Almonertinib induces apoptosis and autophagy mediated by reactive oxygen species in non-small cell lung cancer cells.
    Human & experimental toxicology, 2021, Volume: 40, Issue:12_suppl

    Topics: Acetylcysteine; Acrylamides; Antineoplastic Agents; Apoptosis; Autophagy; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; ErbB Receptors; Humans; Indoles; Lung Neoplasms; Protein Kinase Inhibitors; Pyrimidines; Reactive Oxygen Species

2021
Cigarette smoke extract induces EGFR-TKI resistance via promoting EGFR signaling pathway and ROS generation in NSCLC cell lines.
    Lung cancer (Amsterdam, Netherlands), 2017, Volume: 109

    Topics: A549 Cells; Acetylcysteine; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cigarette Smoking; Drug Resistance, Neoplasm; ErbB Receptors; Free Radical Scavengers; Gefitinib; Humans; Lung Neoplasms; Protein Kinase Inhibitors; Quinazolines; Reactive Oxygen Species; Signal Transduction

2017
Synthetic 8-hydroxydeoxyguanosine inhibited metastasis of pancreatic cancer through concerted inhibitions of ERM and Rho-GTPase.
    Free radical biology & medicine, 2017, Volume: 110

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Hydroxy-2'-Deoxyguanosine; Acetylcysteine; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Claudin-1; Deoxyguanosine; DNA-Binding Proteins; Epithelial-Mesenchymal Transition; Focal Adhesion Kinase 1; Gene Expression Regulation, Neoplastic; GTPase-Activating Proteins; Humans; Hyaluronan Receptors; Imidazoles; Lung Neoplasms; Matrix Metalloproteinases; Mice; Mice, Nude; NADPH Oxidases; Pancreatic Neoplasms; Pyrroles; rho-Associated Kinases; Signal Transduction; Transcription Factors; Vimentin; Xenograft Model Antitumor Assays; Zonula Occludens-1 Protein

2017
Pro-oxidant activity of sulforaphane and cisplatin potentiates apoptosis and simultaneously promotes autophagy in malignant mesothelioma cells.
    Molecular medicine reports, 2017, Volume: 16, Issue:2

    Topics: Acetylcysteine; Antioxidants; Apoptosis; Autophagy; bcl-2-Associated X Protein; Cell Cycle Checkpoints; Cell Line, Tumor; Cisplatin; Glutathione; Humans; Isothiocyanates; Lung Neoplasms; Membrane Potential, Mitochondrial; Mesothelioma; Mesothelioma, Malignant; Microtubule-Associated Proteins; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Sulfoxides; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53; Up-Regulation

2017
Suberoylanilide hydroxamic acid induces thioredoxin1-mediated apoptosis in lung cancer cells via up-regulation of miR-129-5p.
    Molecular carcinogenesis, 2017, Volume: 56, Issue:12

    Topics: 3' Untranslated Regions; A549 Cells; Acetylcysteine; Apoptosis; Blotting, Western; Buthionine Sulfoximine; Cell Line; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Glutathione; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Lung Neoplasms; MAP Kinase Kinase Kinase 5; MAP Kinase Signaling System; MicroRNAs; Reactive Oxygen Species; Thioredoxins; Up-Regulation; Vorinostat

2017
Ginsenoside Rh2 Inhibited Proliferation by Inducing ROS Mediated ER Stress Dependent Apoptosis in Lung Cancer Cells.
    Biological & pharmaceutical bulletin, 2017, Dec-01, Volume: 40, Issue:12

    Topics: Acetylcysteine; Activating Transcription Factor 4; Apoptosis; Caspases, Initiator; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Endoplasmic Reticulum Stress; Ginsenosides; Humans; Lung Neoplasms; Phenylbutyrates; Reactive Oxygen Species; Transcription Factor CHOP; Up-Regulation

2017
IKKα inactivation promotes Kras-initiated lung adenocarcinoma development through disrupting major redox regulatory pathways.
    Proceedings of the National Academy of Sciences of the United States of America, 2018, 01-23, Volume: 115, Issue:4

    Topics: Acetophenones; Acetylcysteine; Adenocarcinoma; Animals; Cell Proliferation; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p21; Epigenesis, Genetic; Humans; I-kappa B Kinase; Lung Neoplasms; Mice; NADPH Oxidase 2; NF-E2-Related Factor 2; Proto-Oncogene Proteins p21(ras); Reactive Oxygen Species; Tumor Suppressor Protein p53

2018
Sulforaphane-N-Acetyl-Cysteine inhibited autophagy leading to apoptosis via Hsp70-mediated microtubule disruption.
    Cancer letters, 2018, 09-01, Volume: 431

    Topics: Acetylcysteine; Aged; Anticarcinogenic Agents; Apoptosis; Autophagy; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Survival; Female; HSP70 Heat-Shock Proteins; Humans; Isothiocyanates; Lung Neoplasms; Macrolides; Male; Microtubules; Middle Aged; Phenotype; Stathmin; Sulfoxides; Tissue Array Analysis; Tubulin

2018
T59, a New Compound Reconstructed from Curcumin, Induces Cell Apoptosis through Reactive Oxygen Species Activation in Human Lung Cancer Cells.
    Molecules (Basel, Switzerland), 2018, May-24, Volume: 23, Issue:6

    Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Curcumin; Humans; Lung Neoplasms; Membrane Potential, Mitochondrial; Membrane Potentials; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; TOR Serine-Threonine Kinases

2018
Glutathione reductase-mediated thiol oxidative stress suppresses metastasis of murine melanoma cells.
    Free radical biology & medicine, 2018, Volume: 129

    Topics: Acetylcysteine; Actins; Animals; Antineoplastic Agents; Cadherins; Carcinogenesis; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; Glutathione Reductase; Isografts; Lung Neoplasms; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Oxidative Stress; Reactive Oxygen Species; Signal Transduction; Skin Neoplasms; Snail Family Transcription Factors; Thiocarbamates; Tumor Burden; Vimentin

2018
Anti-cancer effects of 3,5-dimethylaminophenol in A549 lung cancer cells.
    PloS one, 2018, Volume: 13, Issue:10

    Topics: A549 Cells; Acetylcysteine; Aminophenols; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinogenesis; Cell Proliferation; DNA Damage; Female; Fibroblasts; Free Radical Scavengers; Humans; Lung Neoplasms; Mice; Mice, Nude; Oxidative Stress; Reactive Oxygen Species; Xenograft Model Antitumor Assays

2018
Biomimetic quantum dot-labeled B16F10 murine melanoma cells as a tool to monitor early steps of lung metastasis by in vivo imaging.
    International journal of nanomedicine, 2018, Volume: 13

    Topics: Acetylcysteine; Animals; Biomimetic Materials; Cell Movement; Cell Proliferation; Cell Survival; Diagnostic Imaging; Glutathione; Humans; Hydrodynamics; Lung Neoplasms; Melanoma, Experimental; Mice, Inbred C57BL; Quantum Dots; Reactive Oxygen Species; Staining and Labeling; Static Electricity; Tissue Distribution

2018
Gambogic acid-induced autophagy in nonsmall cell lung cancer NCI-H441 cells through a reactive oxygen species pathway.
    Journal of cancer research and therapeutics, 2018, Volume: 14, Issue:Supplement

    Topics: Acetylcysteine; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Survival; Female; Garcinia; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Reactive Oxygen Species; Signal Transduction; Xanthones; Xenograft Model Antitumor Assays

2018
Efficacy of nebulized acetylcysteine for relieving symptoms and reducing usage of expectorants in patients with radiation pneumonitis.
    Thoracic cancer, 2019, Volume: 10, Issue:2

    Topics: Acetylcysteine; Adenocarcinoma; Administration, Inhalation; Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Case-Control Studies; Expectorants; Female; Follow-Up Studies; Humans; Lung Neoplasms; Male; Middle Aged; Prognosis; Prospective Studies; Radiation Pneumonitis; Radiotherapy; Retrospective Studies; Small Cell Lung Carcinoma

2019
The design of 1,4-naphthoquinone derivatives and mechanisms underlying apoptosis induction through ROS-dependent MAPK/Akt/STAT3 pathways in human lung cancer cells.
    Bioorganic & medicinal chemistry, 2019, 04-15, Volume: 27, Issue:8

    Topics: Acetylcysteine; Apoptosis; Cell Line, Tumor; Drug Design; G1 Phase Cell Cycle Checkpoints; Humans; Lung Neoplasms; Mitogen-Activated Protein Kinases; Naphthoquinones; Phosphorylation; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; STAT3 Transcription Factor

2019
Metabolic dependence of cyclosporine A on cell proliferation of human non‑small cell lung cancer A549 cells and its implication in post‑transplant malignancy.
    Oncology reports, 2019, Volume: 41, Issue:5

    Topics: A549 Cells; Acetylcysteine; Carcinogenesis; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Cyclosporine; Energy Metabolism; Free Radical Scavengers; Glucose; Graft Rejection; Humans; Immunosuppressive Agents; Lung Neoplasms; Organ Transplantation; Palmitic Acid; Reactive Oxygen Species; Signal Transduction

2019
Mitochondrial dysfunction and therapeutic approaches in respiratory and limb muscles of cancer cachectic mice.
    Experimental physiology, 2013, Volume: 98, Issue:9

    Topics: Acetylcysteine; Animals; Antioxidants; Boronic Acids; Bortezomib; Cachexia; Diaphragm; Electron Transport Chain Complex Proteins; Female; Lung Neoplasms; MAP Kinase Signaling System; Mice; Mitochondria; Mitochondrial Diseases; Mitogen-Activated Protein Kinases; Muscle Strength; Muscle, Skeletal; NF-kappa B; Oxidative Stress; Pyrazines

2013
Zebularine inhibits the growth of A549 lung cancer cells via cell cycle arrest and apoptosis.
    Molecular carcinogenesis, 2014, Volume: 53, Issue:11

    Topics: Acetylcysteine; Antioxidants; Apoptosis; Caspase 3; Caspase 8; Cell Line, Tumor; Cell Proliferation; Cytidine; DNA Modification Methylases; Down-Regulation; Fibroblasts; G1 Phase Cell Cycle Checkpoints; Glutathione; Humans; Lung Neoplasms; Membrane Potential, Mitochondrial; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; S Phase Cell Cycle Checkpoints; Thioredoxin Reductase 1; Tumor Suppressor Protein p53

2014
A hydroalcoholic extract from the leaves of Nerium oleander inhibits glycolysis and induces selective killing of lung cancer cells.
    Planta medica, 2013, Volume: 79, Issue:12

    Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; BRCA2 Protein; Cardenolides; Cell Line, Tumor; Cell Survival; Cisplatin; DNA Damage; Glycolysis; Humans; Lung Neoplasms; Nerium; Plant Extracts; Plant Leaves; Plants, Medicinal; Reactive Oxygen Species

2013
The antioxidant N-acetylcysteine prevents HIF-1 stabilization under hypoxia in vitro but does not affect tumorigenesis in multiple breast cancer models in vivo.
    PloS one, 2013, Volume: 8, Issue:6

    Topics: Acetylcysteine; Animals; Antineoplastic Agents; Antioxidants; Apoptosis; Carcinogenesis; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Epithelial-Mesenchymal Transition; Female; Glutathione; Hypoxia-Inducible Factor 1, alpha Subunit; Lung Neoplasms; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasm Transplantation; Neovascularization, Pathologic; Phenotype; Protein Stability; Tumor Burden; Vascular Endothelial Growth Factor A

2013
Targeting 3-phosphoinositide-dependent protein kinase 1 by N-acetyl-cysteine through activation of peroxisome proliferators activated receptor alpha in human lung cancer cells, the role of p53 and p65.
    Journal of experimental & clinical cancer research : CR, 2013, Jul-18, Volume: 32

    Topics: 3-Phosphoinositide-Dependent Protein Kinases; Acetylcysteine; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Enzyme Activation; Gene Silencing; Humans; Lung Neoplasms; PPAR alpha; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Transcription Factor RelA; Transcriptional Activation; Tumor Suppressor Protein p53

2013
Replacement of a quinone by a 5-O-acetylhydroquinone abolishes the accidental necrosis inducing effect while preserving the apoptosis-inducing effect of renieramycin M on lung cancer cells.
    Journal of natural products, 2013, Aug-23, Volume: 76, Issue:8

    Topics: Acetylcysteine; Alkaloids; Antineoplastic Agents; Apoptosis; Humans; Hydroquinones; Lung Neoplasms; Molecular Structure; Necrosis; Structure-Activity Relationship; Tetrahydroisoquinolines; Tumor Suppressor Protein p53

2013
Curcumin sensitizes lung adenocarcinoma cells to apoptosis via intracellular redox status mediated pathway.
    Indian journal of experimental biology, 2012, Volume: 50, Issue:12

    Topics: Acetylcysteine; Adenocarcinoma; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Buthionine Sulfoximine; Caspase 3; Cell Line, Tumor; Curcumin; Drug Screening Assays, Antitumor; Enzyme Activation; Enzyme Induction; Glutamate-Cysteine Ligase; Glutathione; Humans; Lipid Peroxidation; Lung Neoplasms; MAP Kinase Signaling System; Oxidants; Oxidation-Reduction; Phosphorylation; Protein Processing, Post-Translational; Reactive Oxygen Species; RNA, Messenger; RNA, Neoplasm; Superoxides

2012
Resveratrol enhances ionizing radiation-induced premature senescence in lung cancer cells.
    International journal of oncology, 2013, Volume: 43, Issue:6

    Topics: Acetylcysteine; Antioxidants; Apoptosis; beta-Galactosidase; Carcinoma, Non-Small-Cell Lung; Cell Cycle Checkpoints; Cell Line, Tumor; Cellular Senescence; DNA Breaks, Double-Stranded; Humans; Lung Neoplasms; Phosphorylation; Proto-Oncogene Proteins c-akt; Radiation Tolerance; Radiation-Sensitizing Agents; Reactive Oxygen Species; Resveratrol; Ribonucleotide Reductases; Stilbenes; TOR Serine-Threonine Kinases

2013
Antioxidants accelerate lung cancer progression in mice.
    Science translational medicine, 2014, Jan-29, Volume: 6, Issue:221

    Topics: Acetylcysteine; Animals; Antioxidants; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Disease Progression; DNA Damage; Fibroblasts; Humans; Lung Neoplasms; Mice; Reactive Oxygen Species; Solubility; Tumor Suppressor Protein p53; Vitamin E

2014
Biomedical research. Antioxidants could spur tumors by acting on cancer gene.
    Science (New York, N.Y.), 2014, Jan-31, Volume: 343, Issue:6170

    Topics: Acetylcysteine; Animals; Antioxidants; Carcinogens; Dietary Supplements; DNA Damage; Genes, Neoplasm; Humans; Lung Neoplasms; Mice; Smoking; Tumor Suppressor Protein p53; Vitamin E; Vitamins

2014
ω-Hydroxyundec-9-enoic acid induces apoptosis through ROS-mediated endoplasmic reticulum stress in non-small cell lung cancer cells.
    Biochemical and biophysical research communications, 2014, Jun-06, Volume: 448, Issue:3

    Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Caspase 6; Caspase 9; Cell Line, Tumor; Endoplasmic Reticulum Stress; Free Radical Scavengers; Gene Knockdown Techniques; Humans; Lung Neoplasms; Poly(ADP-ribose) Polymerases; Reactive Oxygen Species; Transcription Factor CHOP; Undecylenic Acids

2014
Effects of flavonoid-induced oxidative stress on anti-H5N1 influenza a virus activity exerted by baicalein and biochanin A.
    BMC research notes, 2014, Jun-23, Volume: 7

    Topics: Acetylcysteine; Anticarcinogenic Agents; Antioxidants; Antiviral Agents; Cell Line, Tumor; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Flavanones; Flavonoids; Genistein; Host-Pathogen Interactions; Humans; Influenza A Virus, H5N1 Subtype; Lung Neoplasms; Macrophages; Monocytes; Oxidative Stress; Reactive Oxygen Species; Virus Replication

2014
Enhanced apoptosis by pemetrexed and simvastatin in malignant mesothelioma and lung cancer cells by reactive oxygen species-dependent mitochondrial dysfunction and Bim induction.
    International journal of oncology, 2014, Volume: 45, Issue:4

    Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Cell Line, Tumor; Drug Synergism; Gene Expression Regulation, Neoplastic; Glutamates; Guanine; Humans; Lung Neoplasms; Membrane Potential, Mitochondrial; Membrane Proteins; Mesothelioma; Mesothelioma, Malignant; Pemetrexed; Proto-Oncogene Proteins; Reactive Oxygen Species; Simvastatin

2014
2014 American Thoracic Society International Conference.
    The Lancet. Respiratory medicine, 2014, Volume: 2, Issue:7

    Topics: Acetylcysteine; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal, Humanized; Asthma; Congresses as Topic; Eosinophilia; Expectorants; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Idiopathic Pulmonary Fibrosis; Indoles; Lung Neoplasms; Protein Kinase Inhibitors; Pulmonary Disease, Chronic Obstructive; Pyridones; Respiratory Distress Syndrome

2014
1,3-Butadiene exposure and metabolism among Japanese American, Native Hawaiian, and White smokers.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2014, Volume: 23, Issue:11

    Topics: Acetylcysteine; Asian; Butadienes; Female; Genotype; Glutathione Transferase; Hawaii; Humans; Japan; Lung Neoplasms; Male; Native Hawaiian or Other Pacific Islander; Sex Factors; Smoking; White People

2014
Reactive oxygen species, glutathione, and thioredoxin influence suberoyl bishydroxamic acid-induced apoptosis in A549 lung cancer cells.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2015, Volume: 36, Issue:5

    Topics: Acetylcysteine; Apoptosis; Cell Line, Tumor; Cell Proliferation; Glutathione; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Lung Neoplasms; Reactive Oxygen Species; Thioredoxins

2015
Pemetrexed induces apoptosis in malignant mesothelioma and lung cancer cells through activation of reactive oxygen species and inhibition of sirtuin 1.
    Oncology reports, 2015, Volume: 33, Issue:5

    Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cytochromes c; Down-Regulation; Free Radical Scavengers; Humans; Lung Neoplasms; Membrane Potential, Mitochondrial; Mesothelioma; Mesothelioma, Malignant; Mitochondria; Pemetrexed; Reactive Oxygen Species; Sirtuin 1

2015
Cepharanthine induces apoptosis through reactive oxygen species and mitochondrial dysfunction in human non-small-cell lung cancer cells.
    Biochemical and biophysical research communications, 2015, May-01, Volume: 460, Issue:2

    Topics: Acetylcysteine; Apoptosis; Benzylisoquinolines; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Humans; Lung Neoplasms; Membrane Potential, Mitochondrial; Reactive Oxygen Species

2015
Elevated levels of mercapturic acids of acrolein and crotonaldehyde in the urine of Chinese women in Singapore who regularly cook at home.
    PloS one, 2015, Volume: 10, Issue:3

    Topics: Acetylcysteine; Acrolein; Aged; Aldehydes; Asian People; Benzene; Biomarkers; Carcinogens; Cooking; Female; Humans; Lung Neoplasms; Middle Aged; Singapore; Smoking

2015
Comparative analysis of cell morphology in sputum samples homogenized with dithiothreitol, N-acetyl-L cysteine, Cytorich(®) red preservative and in cellblock preparations to enhance the sensitivity of sputum cytology for the diagnosis of lung cancer.
    Diagnostic cytopathology, 2015, Volume: 43, Issue:7

    Topics: Acetylcysteine; Cytodiagnosis; Dithiothreitol; DNA, Neoplasm; Early Detection of Cancer; Humans; Immunohistochemistry; Lung; Lung Neoplasms; Preservatives, Pharmaceutical; Sensitivity and Specificity; Sputum; Tumor Cells, Cultured

2015
Epigallocatechin-3-gallate enhances the therapeutic effects of leptomycin B on human lung cancer a549 cells.
    Oxidative medicine and cellular longevity, 2015, Volume: 2015

    Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Catechin; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Cytochrome P-450 CYP3A; Down-Regulation; Fatty Acids, Unsaturated; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Humans; Inhibitor of Apoptosis Proteins; Lung Neoplasms; Reactive Oxygen Species; Superoxide Dismutase; Survivin; Up-Regulation

2015
Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer.
    PloS one, 2015, Volume: 10, Issue:6

    Topics: Acetylcysteine; Acrolein; Aged; Aldehydes; Ethnicity; Female; Hawaii; Humans; Lung Neoplasms; Male; Middle Aged; Risk Factors; Smoking

2015
Sanguinarine-induced apoptosis in lung adenocarcinoma cells is dependent on reactive oxygen species production and endoplasmic reticulum stress.
    Oncology reports, 2015, Volume: 34, Issue:2

    Topics: Acetylcysteine; Adenocarcinoma; Adenocarcinoma of Lung; Apoptosis; Benzophenanthridines; Cell Line, Tumor; Cell Proliferation; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Gene Expression Regulation, Neoplastic; Humans; Isoquinolines; Lung Neoplasms; Reactive Oxygen Species

2015
The antidiabetic compound 2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione, isolated from Averrhoa carambola L., demonstrates significant antitumor potential against human breast cancer cells.
    Oncotarget, 2015, Sep-15, Volume: 6, Issue:27

    Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Apoptosis; Averrhoa; Bone Neoplasms; Breast Neoplasms; Caspases; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclohexenes; Cytochromes c; Drug Screening Assays, Antitumor; Enzyme-Linked Immunosorbent Assay; Female; Humans; Hypoglycemic Agents; Inhibitory Concentration 50; Lung Neoplasms; MCF-7 Cells; NF-kappa B; Oxidative Stress; Phosphorylation; Reactive Oxygen Species; Tumor Necrosis Factor-alpha

2015
Inhibition of NADPH oxidase 4 induces apoptosis in malignant mesothelioma: Role of reactive oxygen species.
    Oncology reports, 2015, Volume: 34, Issue:4

    Topics: Acetylcysteine; Apoptosis; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Mesothelioma; Mesothelioma, Malignant; NADPH Oxidase 4; NADPH Oxidases; Onium Compounds; Oxidative Stress; Reactive Oxygen Species; RNA, Messenger; Signal Transduction

2015
Gallic acid induces apoptosis and enhances the anticancer effects of cisplatin in human small cell lung cancer H446 cell line via the ROS-dependent mitochondrial apoptotic pathway.
    Oncology reports, 2016, Volume: 35, Issue:5

    Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Cell Line, Tumor; Cell Shape; Cell Survival; Cisplatin; Drug Screening Assays, Antitumor; Drug Synergism; Gallic Acid; Humans; Lung Neoplasms; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Membranes; Reactive Oxygen Species; Small Cell Lung Carcinoma

2016
Physalin A induces G2/M phase cell cycle arrest in human non-small cell lung cancer cells: involvement of the p38 MAPK/ROS pathway.
    Molecular and cellular biochemistry, 2016, Volume: 415, Issue:1-2

    Topics: Acetylcysteine; Carcinoma, Non-Small-Cell Lung; Cell Division; Cell Line, Tumor; G2 Phase; Humans; Lung Neoplasms; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Reactive Oxygen Species; Withanolides

2016
Cucurbitacin E induces caspase-dependent apoptosis and protective autophagy mediated by ROS in lung cancer cells.
    Chemico-biological interactions, 2016, Jun-25, Volume: 253

    Topics: Acetylcysteine; Apoptosis; Autophagy; Blotting, Western; Caspase 3; Caspase 7; Cell Line, Tumor; Cell Proliferation; Chloroquine; Drug Synergism; Humans; Lung Neoplasms; Macrolides; Membrane Potential, Mitochondrial; Microscopy, Fluorescence; Microtubule-Associated Proteins; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Triterpenes

2016
Cedrol induces autophagy and apoptotic cell death in A549 non-small cell lung carcinoma cells through the P13K/Akt signaling pathway, the loss of mitochondrial transmembrane potential and the generation of ROS.
    International journal of molecular medicine, 2016, Volume: 38, Issue:1

    Topics: A549 Cells; Acetylcysteine; Apoptosis; Autophagosomes; Autophagy; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Cell Shape; Humans; L-Lactate Dehydrogenase; Lung Neoplasms; Membrane Potential, Mitochondrial; Phosphatidylinositol 3-Kinase; Polycyclic Sesquiterpenes; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; Terpenes

2016
Paris Saponin II induced apoptosis via activation of autophagy in human lung cancer cells.
    Chemico-biological interactions, 2016, Jun-25, Volume: 253

    Topics: A549 Cells; Acetylcysteine; Apoptosis; Autophagy; Blotting, Western; Cell Line; Chloroquine; Glutathione; Humans; JNK Mitogen-Activated Protein Kinases; Lung Neoplasms; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Rhizome; Saponins; Signal Transduction

2016
A Quinone-Containing Compound Enhances Camptothecin-Induced Apoptosis of Lung Cancer Through Modulating Endogenous ROS and ERK Signaling.
    Archivum immunologiae et therapiae experimentalis, 2017, Volume: 65, Issue:3

    Topics: A549 Cells; Acetylcysteine; Antineoplastic Agents; Apoptosis; Benzoquinones; Camptothecin; Carcinoma, Non-Small-Cell Lung; Caspases; Cell Proliferation; Drug Resistance, Neoplasm; Drug Synergism; Drug Therapy, Combination; Humans; Lung Neoplasms; MAP Kinase Signaling System; Mitochondria; Putrescine; Reactive Oxygen Species

2017
Effective killing of cancer cells and regression of tumor growth by K27 targeting sulfiredoxin.
    Free radical biology & medicine, 2016, Volume: 101

    Topics: A549 Cells; Acetylcysteine; Adenocarcinoma, Bronchiolo-Alveolar; Animals; Antineoplastic Agents; Antioxidants; Apoptosis; beta-Alanine; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Epithelial Cells; Female; Gene Expression; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mitochondria; Molecular Targeted Therapy; Oxidative Stress; Oxidoreductases Acting on Sulfur Group Donors; Quinazolines; Reactive Oxygen Species; Xenograft Model Antitumor Assays

2016
Hypoxic resistance of KRAS mutant tumor cells to 3-Bromopyruvate is counteracted by Prima-1 and reversed by N-acetylcysteine.
    BMC cancer, 2016, 11-18, Volume: 16, Issue:1

    Topics: A549 Cells; Acetylcysteine; Aza Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Cyclin-Dependent Kinase Inhibitor p21; Drug Resistance, Neoplasm; Free Radical Scavengers; Gene Expression Regulation, Neoplastic; Glucose Transporter Type 1; GTP Phosphohydrolases; Humans; Lung Neoplasms; Melanoma; Membrane Proteins; Mutation; Proto-Oncogene Proteins p21(ras); Pyruvates; Reverse Transcriptase Polymerase Chain Reaction; Tumor Suppressor Protein p53

2016
Genetic Determinants of 1,3-Butadiene Metabolism and Detoxification in Three Populations of Smokers with Different Risks of Lung Cancer.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2017, Volume: 26, Issue:7

    Topics: Acetylcysteine; Aged; Asian; Biomarkers; Black or African American; Butadienes; Carcinogens; Female; Gene Deletion; Gene Dosage; Genome-Wide Association Study; Glutathione; Glutathione Transferase; Humans; Lung Neoplasms; Male; Middle Aged; Polymorphism, Single Nucleotide; Risk Factors; Smokers; Smoking; White People

2017
Redox regulation in radiation-induced cytochrome c release from mitochondria of human lung carcinoma A549 cells.
    Cancer letters, 2009, May-08, Volume: 277, Issue:1

    Topics: Acetylcysteine; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Caspases; Cell Line, Tumor; Cytochromes c; Electron Spin Resonance Spectroscopy; Humans; Lung Neoplasms; Membrane Potential, Mitochondrial; Mitochondria; Oxidation-Reduction; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Superoxides

2009
Prenatal N-acetylcysteine prevents cigarette smoke-induced lung cancer in neonatal mice.
    Carcinogenesis, 2009, Volume: 30, Issue:8

    Topics: Acetylcysteine; Adenocarcinoma, Bronchiolo-Alveolar; Animals; Animals, Newborn; Body Weight; Female; Free Radical Scavengers; Hyperplasia; Lung Neoplasms; Mice; Pregnancy; Prenatal Exposure Delayed Effects; Smoking

2009
The effects of N-acetyl cysteine, buthionine sulfoximine, diethyldithiocarbamate or 3-amino-1,2,4-triazole on antimycin A-treated Calu-6 lung cells in relation to cell growth, reactive oxygen species and glutathione.
    Oncology reports, 2009, Volume: 22, Issue:2

    Topics: Acetylcysteine; Adenocarcinoma; Amitrole; Antimycin A; Buthionine Sulfoximine; Cell Line, Tumor; Cell Proliferation; Ditiocarb; Glutathione; Humans; Lung Neoplasms; Membrane Potential, Mitochondrial; Reactive Oxygen Species

2009
Polyamine transporter recognization and antitumor effects of anthracenymethyl homospermidine.
    Toxicology, 2009, Sep-19, Volume: 263, Issue:2-3

    Topics: Acetylcysteine; Animals; Anthracenes; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspase 9; Cell Line, Tumor; Cytochrome c Group; Dose-Response Relationship, Drug; Enzyme Activation; Gene Expression Regulation, Enzymologic; Lung Neoplasms; Matrix Metalloproteinases; Melanoma, Experimental; Membrane Transport Proteins; Mice; Mitochondria; Neoplasm Metastasis; Oxidative Stress; Polyamines; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Spermidine; Xenograft Model Antitumor Assays

2009
Prevention of cigarette smoke-induced lung tumors in mice by budesonide, phenethyl isothiocyanate, and N-acetylcysteine.
    International journal of cancer, 2010, Mar-01, Volume: 126, Issue:5

    Topics: Acetylcysteine; Animals; Animals, Newborn; Anticarcinogenic Agents; Budesonide; Disease Models, Animal; Female; Isothiocyanates; Lung Neoplasms; Male; Mice; Tobacco Smoke Pollution

2010
'Flooding' of the lungs and severe dyspnea in a patient with bronchoalveolar carcinoma.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2011, Volume: 17, Issue:3

    Topics: Acetylcysteine; Adenocarcinoma, Bronchiolo-Alveolar; Administration, Inhalation; Administration, Oral; Dyspnea; Expectorants; Female; Humans; Hyperhomocysteinemia; Lung; Lung Diseases; Lung Neoplasms; Middle Aged; Nebulizers and Vaporizers; Risk Factors; Severity of Illness Index; Sputum

2011
The effects of N-acetyl cysteine on the MG132 proteasome inhibitor-treated lung cancer cells in relation to cell growth, reactive oxygen species and glutathione.
    International journal of molecular medicine, 2010, Volume: 25, Issue:4

    Topics: Acetylcysteine; Apoptosis; Buthionine Sulfoximine; Cell Line, Tumor; Cell Proliferation; Ditiocarb; Glutathione; Humans; Leupeptins; Lung Neoplasms; Membrane Potential, Mitochondrial; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Reactive Oxygen Species

2010
Lack of contribution of covalent benzo[a]pyrene-7,8-quinone-DNA adducts in benzo[a]pyrene-induced mouse lung tumorigenesis.
    Chemico-biological interactions, 2010, Jul-30, Volume: 186, Issue:2

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Acetylcysteine; Animals; Benzo(a)pyrene; Carcinogens; DNA Adducts; Free Radical Scavengers; Humans; Lung Neoplasms; Male; Mice; Mice, Inbred A; Models, Biological; Phosphorus Radioisotopes; Polycyclic Aromatic Hydrocarbons

2010
N-acetyl cysteine mitigates curcumin-mediated telomerase inhibition through rescuing of Sp1 reduction in A549 cells.
    Mutation research, 2010, Jun-01, Volume: 688, Issue:1-2

    Topics: Acetylcysteine; Adenocarcinoma; Cell Line, Tumor; Cell Shape; Cell Survival; Curcumin; Down-Regulation; Humans; Lung Neoplasms; Reactive Oxygen Species; Sp1 Transcription Factor; Telomerase

2010
Gallic acid-induced lung cancer cell death is related to glutathione depletion as well as reactive oxygen species increase.
    Toxicology in vitro : an international journal published in association with BIBRA, 2010, Volume: 24, Issue:5

    Topics: Acetylcysteine; Antineoplastic Agents; Ascorbic Acid; Buthionine Sulfoximine; Cell Death; Cell Line, Tumor; Cell Proliferation; Gallic Acid; Glutathione; Humans; Lung Neoplasms; Oxidative Stress; Reactive Oxygen Species

2010
Cytotoxicity and genotoxicity of silver nanoparticles in the human lung cancer cell line, A549.
    Archives of toxicology, 2011, Volume: 85, Issue:7

    Topics: Acetylcysteine; Antioxidants; Biological Transport; Carcinoma; Cell Death; Cell Line, Tumor; DNA Adducts; DNA Damage; Humans; Lung Neoplasms; Materials Testing; Metal Nanoparticles; Mitochondria; Mutagens; Oxidative Stress; Povidone; Pulmonary Alveoli; Reactive Oxygen Species; Silver; Silver Nitrate; Surface Properties

2011
Isothiocyanates induce oxidative stress and suppress the metastasis potential of human non-small cell lung cancer cells.
    BMC cancer, 2010, Jun-09, Volume: 10

    Topics: Acetylcysteine; Antineoplastic Agents, Phytogenic; Antioxidants; beta Catenin; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Flow Cytometry; Glutathione; Humans; Inhibitory Concentration 50; Isothiocyanates; Lung Neoplasms; Matrix Metalloproteinase 2; Neoplasm Invasiveness; NF-kappa B; Nuclear Proteins; Oxidative Stress; Proto-Oncogene Proteins c-akt; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Transfection; Twist-Related Protein 1

2010
Thromboxane synthase suppression induces lung cancer cell apoptosis via inhibiting NF-κB.
    Experimental cell research, 2010, Dec-10, Volume: 316, Issue:20

    Topics: Acetylcysteine; Active Transport, Cell Nucleus; Antioxidants; Apoptosis; Caspase 3; Caspase 9; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Cell Survival; Cytosol; Drug Synergism; Enzyme Inhibitors; Humans; I-kappa B Proteins; Imidazoles; Lung Neoplasms; Membrane Potential, Mitochondrial; NF-kappa B; NF-KappaB Inhibitor alpha; Nitriles; Phosphorylation; Poly(ADP-ribose) Polymerases; Reactive Oxygen Species; Sulfones; Thromboxane-A Synthase; Transcription Factor RelA; Tumor Necrosis Factor-alpha

2010
Hydrogen peroxide inhibits non-small cell lung cancer cell anoikis through the inhibition of caveolin-1 degradation.
    American journal of physiology. Cell physiology, 2011, Volume: 300, Issue:2

    Topics: Acetylcysteine; Anoikis; Carcinoma, Non-Small-Cell Lung; Catalase; Caveolin 1; Cell Line, Tumor; Down-Regulation; Free Radical Scavengers; Humans; Hydrogen Peroxide; Lung Neoplasms; Proteasome Endopeptidase Complex; Ubiquitination

2011
Intracellular glutathione content influences the sensitivity of lung cancer cell lines to methylseleninic acid.
    Molecular carcinogenesis, 2012, Volume: 51, Issue:4

    Topics: Acetylcysteine; Apoptosis; Buthionine Sulfoximine; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Flow Cytometry; Glutathione; Glutathione Transferase; Humans; Lung Neoplasms; Microscopy, Fluorescence; Organoselenium Compounds; Oxidative Stress; Reactive Oxygen Species

2012
Mitogen-activated protein kinase mediates the apoptosis of highly metastatic human non-small cell lung cancer cells induced by isothiocyanates.
    The British journal of nutrition, 2011, Volume: 106, Issue:12

    Topics: Acetylcysteine; Antioxidants; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Cycle Checkpoints; Cell Line, Tumor; Cyclin B1; Gene Expression; Humans; Isothiocyanates; Lung Neoplasms; MAP Kinase Signaling System; Neoplasm Metastasis; Transcription Factor AP-1

2011
Ameliorative effects of dimetylthiourea and N-acetylcysteine on nanoparticles induced cyto-genotoxicity in human lung cancer cells-A549.
    PloS one, 2011, Volume: 6, Issue:9

    Topics: Acetylcysteine; Cell Line, Tumor; Cell Survival; Cytochrome P-450 CYP2E1; Cytokinesis; Cytoprotection; Cytotoxins; Free Radical Scavengers; Humans; Lung Neoplasms; Micronucleus Tests; Mutagens; Nanoparticles; Nanotubes, Carbon; Reactive Oxygen Species; Thiourea; Titanium

2011
Transplacental antioxidants inhibit lung tumors in mice exposed to cigarette smoke after birth: a novel preventative strategy?
    Current cancer drug targets, 2012, Volume: 12, Issue:2

    Topics: Acetylcysteine; Animals; Animals, Newborn; Antioxidants; Ascorbic Acid; Body Weight; Female; Lung Neoplasms; Maternal-Fetal Exchange; Mice; Nicotiana; Placenta; Pregnancy; Reactive Oxygen Species; Smoke; Survival

2012
[Hypoxia upregulates the expression of annexin A1 in lung adenocarcinoma a549 cells].
    Zhongguo fei ai za zhi = Chinese journal of lung cancer, 2012, Volume: 15, Issue:5

    Topics: Acetylcysteine; Active Transport, Cell Nucleus; Adenocarcinoma; Annexin A1; Antioxidants; Blotting, Western; Cell Hypoxia; Cell Line, Tumor; Cell Nucleus; Free Radical Scavengers; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; NF-kappa B; Pyrrolidines; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Thiocarbamates; Up-Regulation

2012
Negative regulation of AMP-activated protein kinase (AMPK) activity by macrophage migration inhibitory factor (MIF) family members in non-small cell lung carcinomas.
    The Journal of biological chemistry, 2012, Nov-02, Volume: 287, Issue:45

    Topics: Acetylcysteine; AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Antigens, Differentiation, B-Lymphocyte; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Deoxyglucose; Enzyme Activation; Free Radical Scavengers; Glucose; Histocompatibility Antigens Class II; Humans; Immunoblotting; Intramolecular Oxidoreductases; Lung Neoplasms; Macrophage Migration-Inhibitory Factors; Mutation; Oxidation-Reduction; Phosphorylation; Protein Serine-Threonine Kinases; Reactive Oxygen Species; RNA Interference; Signal Transduction; TOR Serine-Threonine Kinases

2012
Chemoprevention by N-acetylcysteine of low-dose CT-induced murine lung tumorigenesis.
    Carcinogenesis, 2013, Volume: 34, Issue:2

    Topics: Acetylcysteine; Animals; Carcinogens; Cell Transformation, Neoplastic; Female; Free Radical Scavengers; Lung Neoplasms; Male; Mice; Mice, Inbred A; Neoplasms, Radiation-Induced; Nitrosamines; Tomography, X-Ray Computed

2013
Cucurbitacin B potently suppresses non-small-cell lung cancer growth: identification of intracellular thiols as critical targets.
    Cancer letters, 2013, May-10, Volume: 332, Issue:1

    Topics: Acetylcysteine; Actin Cytoskeleton; Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Shape; Cell Survival; Dose-Response Relationship, Drug; Female; G2 Phase Cell Cycle Checkpoints; Glutathione; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; Humans; Lung Neoplasms; Mass Spectrometry; Mice; Mice, Nude; Mitochondria; Molecular Chaperones; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Signal Transduction; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Sulfhydryl Compounds; Time Factors; Triterpenes; Tumor Burden; Xenograft Model Antitumor Assays

2013
N-acetil-l-cysteine and 2-amino-2-thiiazoline N-acetyl-l-cysteinate as a possible cancer chemopreventive agents in murine models.
    Acta biologica Hungarica, 2002, Volume: 53, Issue:3

    Topics: Acetylcysteine; Adenoma; Animals; Anticarcinogenic Agents; Dose-Response Relationship, Drug; Female; Lung Neoplasms; Mice; Mice, Inbred BALB C; Models, Animal; Thiazoles

2002
Nonradioactive iodide effectively induces apoptosis in genetically modified lung cancer cells.
    Cancer research, 2003, Aug-15, Volume: 63, Issue:16

    Topics: Acetylcysteine; Animals; Apoptosis; Down-Regulation; Female; Humans; Inhibitor of Apoptosis Proteins; Iodide Peroxidase; Iodides; Lung Neoplasms; Mice; Mice, SCID; Microtubule-Associated Proteins; Neoplasm Proteins; Neoplasm Transplantation; Survivin; Symporters; Transplantation, Heterologous; Tumor Cells, Cultured

2003
Suppression of metastasis by nuclear factor kappaB inhibitors in an in vivo lung metastasis model of chemically induced hepatocellular carcinoma.
    Cancer science, 2004, Volume: 95, Issue:1

    Topics: Acetylcysteine; Animals; Aspirin; Blotting, Western; Carcinogens; Diethylnitrosamine; E-Selectin; Enzyme Inhibitors; Free Radical Scavengers; Intercellular Adhesion Molecule-1; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Neoplasm Metastasis; NF-kappa B; Nitrosamines; Pentoxifylline; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Vascular Cell Adhesion Molecule-1

2004
Prevention of hepatotoxicity but loss of antimelanoma effect with combined fotemustine and anti-oxidant treatment.
    Internal medicine journal, 2004, Volume: 34, Issue:5

    Topics: Acetylcysteine; Adult; Antineoplastic Agents; Antioxidants; Brain Neoplasms; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Lung Neoplasms; Melanoma; Nitrosourea Compounds; Organophosphorus Compounds; Treatment Outcome

2004
Proteasomes act in the pre-mitochondrial signal transduction route towards roscovitine-induced apoptosis.
    International journal of oncology, 2004, Volume: 25, Issue:5

    Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cysteine Proteinase Inhibitors; Humans; Leupeptins; Lung Neoplasms; Membrane Potentials; Mitochondria; Proteasome Endopeptidase Complex; Purines; Roscovitine; Signal Transduction; Tumor Cells, Cultured

2004
Carcinogenic activity of cigarette smoke gas phase and its modulation by beta-carotene and N-acetylcysteine.
    Toxicological sciences : an official journal of the Society of Toxicology, 2005, Volume: 84, Issue:1

    Topics: Acetylcysteine; Animals; Atmosphere Exposure Chambers; beta Carotene; Carcinogens; Free Radical Scavengers; Lung Neoplasms; Male; Metals; Mice; Nicotiana; Nitrosamines; Polycyclic Aromatic Hydrocarbons; Smoke

2005
The role of reactive oxygen species (ROS) production on diallyl disulfide (DADS) induced apoptosis and cell cycle arrest in human A549 lung carcinoma cells.
    Mutation research, 2005, Nov-11, Volume: 579, Issue:1-2

    Topics: Acetylcysteine; Allyl Compounds; Antineoplastic Agents; Antioxidants; Apoptosis; Carcinoma; Cell Cycle; Cell Proliferation; Cell Survival; Disulfides; Dose-Response Relationship, Drug; Humans; Lung Neoplasms; Reactive Oxygen Species; Tumor Cells, Cultured

2005
Accumulation of p53 in response to adenovirus early region 1A sensitizes human cells to tumor necrosis factor alpha-induced apoptosis.
    Virology, 2005, Sep-30, Volume: 340, Issue:2

    Topics: Acetylcysteine; Adenovirus E1A Proteins; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Humans; Lung Neoplasms; Recombinant Proteins; Transfection; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53

2005
Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice.
    Cancer research, 2005, Sep-15, Volume: 65, Issue:18

    Topics: Acetylcysteine; Adenocarcinoma; Adenoma; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Body Weight; Carcinogens; Caspase 3; Caspases; Cell Growth Processes; Disease Progression; Female; In Situ Nick-End Labeling; Isothiocyanates; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Smoking; Sulfoxides; Thiocyanates

2005
Non-destructive micromethod for MRP1 functional assay in human lung tumor cells.
    Archives of toxicology, 2006, Volume: 80, Issue:3

    Topics: Acetylcysteine; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Buthionine Sulfoximine; Cell Culture Techniques; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Fluorometry; Glutathione; Humans; Immunohistochemistry; Lung Neoplasms; Multidrug Resistance-Associated Proteins; Propionates; Quinolines; Sensitivity and Specificity; Verapamil

2006
Accumulation of hydrogen peroxide is an early and crucial step for paclitaxel-induced cancer cell death both in vitro and in vivo.
    International journal of cancer, 2006, Jul-01, Volume: 119, Issue:1

    Topics: Acetylcysteine; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Free Radical Scavengers; Glutathione; Humans; Hydrogen Peroxide; Lung Neoplasms; Paclitaxel; Reactive Oxygen Species; Spectrometry, Fluorescence

2006
The effect of N-acetylcysteine in combination with vitamin C on the activity of ornithine decarboxylase of lung carcinoma cells--In vitro.
    Life sciences, 2006, Jul-10, Volume: 79, Issue:7

    Topics: Acetylcysteine; Ascorbic Acid; Cell Line, Tumor; Cell Proliferation; Cell Survival; DNA, Neoplasm; Dose-Response Relationship, Drug; Free Radical Scavengers; Humans; Lung Neoplasms; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; RNA, Neoplasm; Thymidine

2006
Degradation of insulin-like growth factor-I receptor occurs via ubiquitin-proteasome pathway in human lung cancer cells.
    Journal of cellular physiology, 2006, Volume: 208, Issue:2

    Topics: Acetylcysteine; Cell Line; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Down-Regulation; Humans; Kinetics; Lung Neoplasms; Phosphorylation; Proteasome Endopeptidase Complex; Receptor, IGF Type 1; Tyrosine; Ubiquitin

2006
Activation of ATM and histone H2AX phosphorylation induced by mitoxantrone but not by topotecan is prevented by the antioxidant N-acetyl-L-cysteine.
    Cancer biology & therapy, 2006, Volume: 5, Issue:8

    Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Cell Cycle; Cell Cycle Proteins; DNA Damage; DNA-Binding Proteins; Flow Cytometry; Fluorescent Antibody Technique; Histones; HL-60 Cells; Humans; Lung Neoplasms; Mitoxantrone; Phosphorylation; Protein Serine-Threonine Kinases; Topotecan; Tumor Cells, Cultured; Tumor Suppressor Proteins

2006
Protein kinase C-ERK1/2 signal pathway switches glucose depletion-induced necrosis to apoptosis by regulating superoxide dismutases and suppressing reactive oxygen species production in A549 lung cancer cells.
    Journal of cellular physiology, 2007, Volume: 211, Issue:2

    Topics: Acetylcysteine; Antioxidants; Apoptosis; Apoptosis Inducing Factor; Caspase 3; Caspase 9; Catalase; Cell Line, Tumor; Cell Survival; Endodeoxyribonucleases; Enzyme Activation; Enzyme Induction; Enzyme Stability; Extracellular Signal-Regulated MAP Kinases; Glucose; HMGB1 Protein; Humans; Lung Neoplasms; Mitochondria; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Necrosis; Protein Kinase C; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Time Factors

2007
Reactive oxygen species independent cytotoxicity induced by radiocontrast agents in tubular cells (LLC-PK1 and MDCK).
    Renal failure, 2007, Volume: 29, Issue:2

    Topics: Acetylcysteine; Animals; Antioxidants; Cell Hypoxia; Cell Line; Cell Line, Tumor; Cell Survival; Contrast Media; Dogs; Kidney; L-Lactate Dehydrogenase; Lung Neoplasms; Necrosis; Radioisotopes; Reactive Oxygen Species; Swine

2007
Kaempferol induces apoptosis in human lung non-small carcinoma cells accompanied by an induction of antioxidant enzymes.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2007, Volume: 45, Issue:10

    Topics: Acetylcysteine; Adenosine Triphosphate; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Apoptosis Inducing Factor; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Caspase 3; Cell Line, Tumor; Cell Survival; Enzyme Induction; Flow Cytometry; Free Radical Scavengers; Humans; Immunohistochemistry; Kaempferols; L-Lactate Dehydrogenase; Lung Neoplasms; Membrane Potentials; Mitochondria; Neoplasm Proteins; Reactive Oxygen Species

2007
Lung cancer chemoprevention: ACCP evidence-based clinical practice guidelines (2nd Edition).
    Chest, 2007, Volume: 132, Issue:3 Suppl

    Topics: Acetylcysteine; alpha-Tocopherol; Anticarcinogenic Agents; Aspirin; beta Carotene; Chemoprevention; Clinical Trials, Phase III as Topic; Evidence-Based Medicine; Humans; Isotretinoin; Lung Neoplasms; United States; Vitamin A

2007
Constitutive activation of c-Met is correlated with c-Met overexpression and dependent on cell-matrix adhesion in lung adenocarcinoma cell lines.
    Cancer science, 2008, Volume: 99, Issue:1

    Topics: Acetylcysteine; Adenocarcinoma; Animals; Antibodies; Blotting, Western; Cadherins; Cell Adhesion; Cell Line, Tumor; Culture Media, Conditioned; DNA, Neoplasm; Dogs; Down-Regulation; Extracellular Matrix; Hepatocyte Growth Factor; Humans; Lung Neoplasms; Oligonucleotide Array Sequence Analysis; Phosphorylation; Polymorphism, Single Nucleotide; Proto-Oncogene Proteins c-met; Tyrosine

2008
N-Acetylcysteine enhances the lung cancer inhibitory effect of epigallocatechin-3-gallate and forms a new adduct.
    Free radical biology & medicine, 2008, Mar-15, Volume: 44, Issue:6

    Topics: Acetylcysteine; Animals; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Apoptosis; Catechin; Cell Line, Tumor; Cell Proliferation; Chromatography, High Pressure Liquid; Flow Cytometry; Humans; Lung Neoplasms; Mice; Radiation-Protective Agents

2008
A combination of sulindac and arsenic trioxide synergistically induces apoptosis in human lung cancer H1299 cells via c-Jun NH2-terminal kinase-dependent Bcl-xL phosphorylation.
    Lung cancer (Amsterdam, Netherlands), 2008, Volume: 61, Issue:3

    Topics: Acetylcysteine; Apoptosis; Arsenic Trioxide; Arsenicals; bcl-X Protein; Carcinoma, Non-Small-Cell Lung; Caspases; Cell Line, Tumor; Drug Synergism; Humans; JNK Mitogen-Activated Protein Kinases; Lung Neoplasms; Membrane Potential, Mitochondrial; Mitochondria; Oxides; Phosphorylation; Reactive Oxygen Species; Signal Transduction; Sulindac

2008
Pilot study of intravenous ifosfamide plus oral acetylcysteine in the treatment of non-small cell lung cancer.
    Veterinary and human toxicology, 1981, Volume: 23, Issue:Suppl 1

    Topics: Acetylcysteine; Adenocarcinoma; Administration, Oral; Carcinoma; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Cyclophosphamide; Drug Therapy, Combination; Female; Humans; Ifosfamide; Infusions, Parenteral; Lung Neoplasms; Male; Pilot Projects

1981
N-acetylcysteine: its bioavailability and interaction with ifosfamide metabolites.
    Seminars in oncology, 1983, Volume: 10, Issue:1 Suppl 1

    Topics: Acetates; Acetylcysteine; Biological Availability; Carcinoma, Bronchogenic; Chemical Phenomena; Chemistry; Chromatography, Gas; Chromatography, Ion Exchange; Cyclophosphamide; Drug Interactions; Humans; Ifosfamide; Kinetics; Lung Neoplasms; Time Factors

1983
Phase I clinical study of acetylcysteine's preventing ifosfamide-induced hematuria.
    Seminars in oncology, 1983, Volume: 10, Issue:1 Suppl 1

    Topics: Acetylcysteine; Acrolein; Adenocarcinoma; Carcinoma, Squamous Cell; Cyclophosphamide; Cystitis; Dose-Response Relationship, Drug; Drug Evaluation; Drug Therapy, Combination; Hematuria; Humans; Ifosfamide; Lung Neoplasms

1983
The control of ifosfamide-induced hematuria with N-acetylcysteine in patients with advanced carcinoma of the lung.
    Seminars in oncology, 1982, Volume: 9, Issue:4 Suppl 1

    Topics: Acetylcysteine; Administration, Oral; Cyclophosphamide; Female; Hematuria; Humans; Ifosfamide; Lung Neoplasms; Male; Random Allocation

1982
Inhibition of invasion, gelatinase activity, tumor take and metastasis of malignant cells by N-acetylcysteine.
    International journal of cancer, 1995, Mar-29, Volume: 61, Issue:1

    Topics: 3T3 Cells; Acetylcysteine; Animals; Carcinoma, Lewis Lung; Cell Movement; Gelatinases; Glutathione; Glutathione Disulfide; Humans; Lung Neoplasms; Melanoma; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Mice, Nude; Neoplasm Invasiveness; Sarcoma, Experimental; Tumor Cells, Cultured

1995
N-acetylcysteine for lung cancer prevention.
    Chest, 1995, Volume: 107, Issue:5

    Topics: Acetylcysteine; Humans; Lung Neoplasms

1995
Effect of N-acetyl cysteine on the concentrations of thiols in plasma, bronchoalveolar lavage fluid, and lung tissue.
    Thorax, 1994, Volume: 49, Issue:7

    Topics: Acetylcysteine; Adult; Aged; Bronchoalveolar Lavage Fluid; Bronchoscopy; Carcinoma, Bronchogenic; Drug Administration Schedule; Female; Glutathione; Humans; Lung; Lung Diseases, Obstructive; Lung Neoplasms; Male; Middle Aged; Pneumonectomy

1994
Activation of potassium channels by hypoxia and reoxygenation in the human lung adenocarcinoma cell line A549.
    Journal of cellular physiology, 1993, Volume: 156, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcysteine; Adenocarcinoma; Alkaloids; Free Radical Scavengers; Humans; Hypoxia; Isoquinolines; Lung Neoplasms; Oxidation-Reduction; Oxygen; Piperazines; Potassium Channels; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Tetraethylammonium; Tetraethylammonium Compounds; Time Factors; Tumor Cells, Cultured

1993
Bronchoalveolar lavage fluid findings following radiotherapy for non-small cell lung cancer.
    International journal of radiation oncology, biology, physics, 1993, Apr-30, Volume: 26, Issue:1

    Topics: Acetylcysteine; Adult; Aged; Bronchoalveolar Lavage Fluid; Carcinoma, Non-Small-Cell Lung; Female; Humans; Interferon-alpha; Lung Neoplasms; Male; Middle Aged; Pneumonia; Radiation-Protective Agents; Radiation-Sensitizing Agents; Radiotherapy

1993
Chemopreventive efficacy of arylalkyl isothiocyanates and N-acetylcysteine for lung tumorigenesis in Fischer rats.
    Cancer research, 1996, Feb-15, Volume: 56, Issue:4

    Topics: Acetylcysteine; Analysis of Variance; Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Chi-Square Distribution; Diet; Free Radical Scavengers; Incidence; Isothiocyanates; Leukemia, Experimental; Leydig Cell Tumor; Lung Neoplasms; Lymphoma; Male; Nicotiana; Nitrosamines; Pancreatic Neoplasms; Plants, Toxic; Rats; Rats, Inbred F344; Survival Rate; Testicular Neoplasms

1996
Synergism between N-acetylcysteine and doxorubicin in the prevention of tumorigenicity and metastasis in murine models.
    International journal of cancer, 1996, Sep-17, Volume: 67, Issue:6

    Topics: Acetylcysteine; Animals; Antineoplastic Combined Chemotherapy Protocols; Disease Models, Animal; Doxorubicin; Drug Screening Assays, Antitumor; Drug Synergism; Female; Lung Neoplasms; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Mice, Nude; Survival Analysis

1996
Studies on the basis for the toxicity of acrolein mercapturates.
    Toxicology and applied pharmacology, 1996, Volume: 140, Issue:2

    Topics: Acetylcysteine; Acrolein; Adenocarcinoma; Cyclophosphamide; Growth Inhibitors; Humans; Lung Neoplasms; Tumor Cells, Cultured

1996
Smokers and urinary genotoxins: implications for selection of cohorts and modulation of endpoints in chemoprevention trials.
    Journal of cellular biochemistry. Supplement, 1996, Volume: 25

    Topics: Acetylcysteine; Adult; Anticarcinogenic Agents; Biomarkers, Tumor; Chemoprevention; China; Clinical Trials, Phase II as Topic; Cohort Studies; DNA Repair; Female; Humans; Lung Neoplasms; Male; Middle Aged; Mutagenicity Tests; Mutagens; Netherlands; Pyrazines; Research Design; Smoking; Thiones; Thiophenes

1996
Role of oxidants in influenza virus-induced gene expression.
    The American journal of physiology, 1998, Volume: 274, Issue:1

    Topics: Acetylcysteine; Animals; Base Sequence; Binding Sites; Chick Embryo; Epithelial Cells; Gene Expression Regulation; Humans; Influenza A virus; Interleukin-8; Lung Neoplasms; NF-kappa B; Nuclear Proteins; Oligodeoxyribonucleotides; Reactive Oxygen Species; RNA, Messenger; Sp1 Transcription Factor; Superoxide Dismutase; Transcription, Genetic; Tumor Cells, Cultured

1998
Chemopreventive potential of fumaric acid, N-acetylcysteine, N-(4-hydroxyphenyl) retinamide and beta-carotene for tobacco-nitrosamine-induced lung tumors in A/J mice.
    Cancer letters, 1998, Feb-13, Volume: 124, Issue:1

    Topics: Acetylcysteine; Animals; Anticarcinogenic Agents; beta Carotene; Carcinogens; Dose-Response Relationship, Drug; Female; Fenretinide; Fumarates; Lung Neoplasms; Mice; Mice, Inbred A; Nicotiana; Nitrosamines; Plants, Toxic

1998
Activator protein-1 is the preferred transcription factor for cooperative interaction with nuclear factor-kappaB in respiratory syncytial virus-induced interleukin-8 gene expression in airway epithelium.
    The Journal of infectious diseases, 1998, Volume: 177, Issue:5

    Topics: Acetylcysteine; Antioxidants; Cell Line; Cell Nucleus; Chloramphenicol O-Acetyltransferase; Cyclic N-Oxides; Dimethyl Sulfoxide; Epithelial Cells; Gene Expression Regulation, Neoplastic; Humans; Interleukin-8; Lung Neoplasms; NF-kappa B; Recombinant Proteins; Respiratory Syncytial Viruses; Transcription Factor AP-1; Transfection; Tumor Cells, Cultured

1998
Chemoprevention by N-acetylcysteine of urethane-induced clastogenicity and lung tumors in mice.
    International journal of cancer, 1998, Jul-17, Volume: 77, Issue:2

    Topics: Acetylcysteine; Administration, Oral; Animals; Anticarcinogenic Agents; Antimutagenic Agents; Body Weight; Carcinogens; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Micronuclei, Chromosome-Defective; Time Factors; Urethane

1998
Inhibition by oral N-acetylcysteine of doxorubicin-induced clastogenicity and alopecia, and prevention of primary tumors and lung micrometastases in mice.
    International journal of oncology, 1998, Volume: 13, Issue:2

    Topics: Acetylcysteine; Administration, Oral; Alopecia; Animals; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Doxorubicin; Drug Synergism; Erythrocytes; Female; Free Radical Scavengers; Lung Neoplasms; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Micronuclei, Chromosome-Defective; Mutagens; Neoplasm Transplantation

1998
Effects of Cr(VI) on the expression of the oxidative stress genes in human lung cells.
    Carcinogenesis, 1998, Volume: 19, Issue:8

    Topics: Acetylcysteine; Actins; Carcinogens, Environmental; Cell Line; Chromium; Glutathione; Heme Oxygenase (Decyclizing); Humans; Lung Neoplasms; Oxidative Stress; Polymerase Chain Reaction; RNA, Messenger; Superoxide Dismutase; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

1998
Environmental particulate-mediated cytokine production in lung epithelial cells (A549): role of preexisting inflammation and oxidant stress.
    Journal of toxicology and environmental health. Part A, 1998, Sep-11, Volume: 55, Issue:1

    Topics: Acetylcysteine; Adenocarcinoma, Bronchiolo-Alveolar; Air Pollution; Antioxidants; Carbon; Chromans; Coal Ash; Dose-Response Relationship, Drug; Epithelial Cells; Flow Cytometry; Fluoresceins; Free Radical Scavengers; Humans; Industrial Waste; Interleukin-8; Lung; Lung Neoplasms; Oxidative Stress; Particle Size; Particulate Matter; Petroleum; Piperazines; Pneumonia; Quartz; Titanium; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

1998
The effects of phenethyl isothiocyanate, N-acetylcysteine and green tea on tobacco smoke-induced lung tumors in strain A/J mice.
    Carcinogenesis, 1998, Volume: 19, Issue:10

    Topics: Acetylcysteine; Animals; Anticarcinogenic Agents; Female; Isothiocyanates; Lung Neoplasms; Male; Mice; Nicotiana; Plants, Toxic; Smoke; Tea

1998
Hydrogen peroxide mediates doxorubicin-induced transglutaminase 2 expression in PC-14 human lung cancer cell line.
    Experimental & molecular medicine, 1999, Jun-30, Volume: 31, Issue:2

    Topics: Acetylcysteine; Antineoplastic Agents; Doxorubicin; Enzyme Induction; Gene Expression Regulation, Enzymologic; Glutathione; Humans; Hydrogen Peroxide; Lung Neoplasms; Reactive Oxygen Species; Transglutaminases; Tumor Cells, Cultured

1999
Induction of tumor suppression and glandular differentiation of A549 lung carcinoma cells by dominant-negative IGF-I receptor.
    Oncogene, 1999, Oct-28, Volume: 18, Issue:44

    Topics: Acetylcysteine; Adenocarcinoma; Animals; Apoptosis; Carcinogenicity Tests; Cell Differentiation; Cell Division; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Genes, Dominant; Genes, Tumor Suppressor; Humans; Leupeptins; Lung Neoplasms; Mice; Mice, Nude; Multienzyme Complexes; Phosphorylation; Proteasome Endopeptidase Complex; Receptor, IGF Type 1; Tumor Cells, Cultured; Ultraviolet Rays

1999
Effective elimination of lung metastases induced by tumor cells treated with hydrostatic pressure and N-acetyl-L-cysteine.
    Cancer research, 2000, Jan-15, Volume: 60, Issue:2

    Topics: Acetylcysteine; Adenosine; Animals; CD4 Antigens; CD8 Antigens; Female; Humans; Hydrostatic Pressure; Hypersensitivity, Delayed; Lung; Lung Neoplasms; Lymphocyte Culture Test, Mixed; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasm Metastasis; Spleen

2000
Chemoprevention of lung cancer is proving difficult and frustrating, requiring new approaches.
    Journal of the National Cancer Institute, 2000, Jun-21, Volume: 92, Issue:12

    Topics: Acetylcysteine; Anticarcinogenic Agents; beta Carotene; Carcinogens; Diterpenes; Glucuronides; Glutathione; Humans; Lung Neoplasms; Randomized Controlled Trials as Topic; Retinyl Esters; Vitamin A

2000
[Arg(6), D-Trp(7,9), N(me)Phe(8)]-substance P (6-11) (antagonist G) induces AP-1 transcription and sensitizes cells to chemotherapy.
    British journal of cancer, 2000, Volume: 83, Issue:7

    Topics: Acetylcysteine; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Small Cell; Cell Division; CHO Cells; Cricetinae; Drug Synergism; Etoposide; Free Radical Scavengers; Glutathione; Growth Inhibitors; JNK Mitogen-Activated Protein Kinases; Lipid Peroxidation; Lung Neoplasms; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Oligopeptides; Oxidation-Reduction; Reactive Oxygen Species; Stimulation, Chemical; Transcription Factor AP-1; Transcription, Genetic; Tumor Cells, Cultured

2000
Interactions between N-acetylcysteine and ascorbic acid in modulating mutagenesis and carcinogenesis.
    International journal of cancer, 2000, Dec-01, Volume: 88, Issue:5

    Topics: Acetylcysteine; Animals; Ascorbic Acid; Carcinogenicity Tests; Cell Transformation, Neoplastic; Chromium; Drug Stability; Female; Lung Neoplasms; Mice; Mutagenesis; Urethane

2000
Pilot studies evaluating the lung tumor yield in cigarette smoke-exposed mice.
    International journal of oncology, 2001, Volume: 18, Issue:3

    Topics: Acetylcysteine; Adenoma; Animals; Body Weight; Butylated Hydroxytoluene; Chlorodiphenyl (54% Chlorine); Cytogenetic Analysis; DNA Damage; DNA, Neoplasm; Female; Incidence; Injections, Intraperitoneal; Lung Neoplasms; Mice; Mice, Hairless; Mice, Inbred C57BL; Pilot Projects; Smoking

2001
Therapeutic efficacy of aortic administration of N-acetylcysteine as a chemoprotectant against bone marrow toxicity after intracarotid administration of alkylators, with or without glutathione depletion in a rat model.
    Cancer research, 2001, Nov-01, Volume: 61, Issue:21

    Topics: Acetylcysteine; Animals; Antimetabolites; Antineoplastic Agents, Alkylating; Aorta, Thoracic; Blood-Brain Barrier; Bone Marrow Diseases; Brain; Brain Neoplasms; Buthionine Sulfoximine; Carcinoma, Small Cell; Dose-Response Relationship, Drug; Drug Interactions; Female; Glutathione; Infusions, Intra-Arterial; Lung Neoplasms; Rats; Rats, Long-Evans; Tissue Distribution; Xenograft Model Antitumor Assays

2001
Inhibition of benzo(a)pyrene-induced lung tumorigenesis in A/J mice by dietary N-acetylcysteine conjugates of benzyl and phenethyl isothiocyanates during the postinitiation phase is associated with activation of mitogen-activated protein kinases and p53 a
    Cancer research, 2002, Jan-01, Volume: 62, Issue:1

    Topics: Acetylcysteine; Animals; Anticarcinogenic Agents; Apoptosis; bcl-2-Associated X Protein; Benzo(a)pyrene; Carcinogens; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Enzyme Activation; Female; Gene Expression Regulation, Neoplastic; Isothiocyanates; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Mitogen-Activated Protein Kinases; NF-kappa B; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Transcription Factor AP-1; Tumor Suppressor Protein p53

2002
Expression of cyclin D1/2 in the lungs of strain A/J mice fed chemopreventive agents.
    Carcinogenesis, 2002, Volume: 23, Issue:2

    Topics: Acetylcysteine; Animals; Anticarcinogenic Agents; Aspirin; Blotting, Western; Cell Nucleus; Cyclin D1; Cyclin D2; Cyclins; Cyclohexenes; Dexamethasone; Free Radical Scavengers; Immunohistochemistry; Inositol; Isothiocyanates; Limonene; Lung; Lung Neoplasms; Male; Mice; Nicotiana; Organoselenium Compounds; Tea; Terpenes; Time Factors

2002
Respiratory syncytial virus and TNF alpha induction of chemokine gene expression involves differential activation of Rel A and NF-kappa B1.
    BMC infectious diseases, 2002, Mar-28, Volume: 2

    Topics: Acetylcysteine; Antiviral Agents; Chemokines; Dexamethasone; Free Radical Scavengers; Gene Expression Regulation, Neoplastic; Glucocorticoids; Humans; Lung Neoplasms; NF-kappa B; Oxidation-Reduction; Respiratory Syncytial Viruses; Signal Transduction; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

2002
Biomarker assessments in asbestos-exposed workers as indicators for selective prevention of mesothelioma or bronchogenic carcinoma: rationale and practical implementations.
    European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 1992, Volume: 1, Issue:2

    Topics: Acetylcysteine; Antigens, Neoplasm; Asbestos; Ascorbic Acid; beta Carotene; Biomarkers, Tumor; Carcinoembryonic Antigen; Carcinoma, Bronchogenic; Carotenoids; Cohort Studies; Ferritins; Humans; Hyaluronic Acid; Longitudinal Studies; Lung Neoplasms; Male; Mesothelioma; Middle Aged; Occupational Diseases; Occupational Exposure; Peptides; Riboflavin; Selenium; Tissue Polypeptide Antigen; Vitamin A; Vitamin E

1992
Effect of N-acetylcysteine on the antiproliferative action of X-rays or bleomycin in cultured human lung tumor cells.
    Journal of cancer research and clinical oncology, 1989, Volume: 115, Issue:4

    Topics: Acetylcysteine; Bleomycin; Cell Survival; Glutathione; Humans; Lung Neoplasms; Radiation Tolerance; Tumor Cells, Cultured

1989
Inhibition of urethan-induced lung tumors in mice by dietary N-acetylcysteine.
    Cancer letters, 1986, Volume: 32, Issue:3

    Topics: Acetylcysteine; Animals; Diet; Glutathione; Lung Neoplasms; Male; Mice; Urethane

1986
Metabolic, desmutagenic and anticarcinogenic effects of N-acetylcysteine.
    Respiration; international review of thoracic diseases, 1986, Volume: 50 Suppl 1

    Topics: Acetylcysteine; Animals; Biotransformation; Carcinogens; Glutathione; Humans; Lung Neoplasms; Mutagens; Mutation; Smoking

1986
Potentially useful combinations of chemotherapy detected in mouse tumor systems.
    Cancer chemotherapy reports. Part 2, 1974, Volume: 4, Issue:1

    Topics: Acetylcysteine; Animals; Antineoplastic Agents; Azauridine; Bleomycin; Camptothecin; Cyclic P-Oxides; Cyclophosphamide; Cytarabine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Ethylamines; Fluorouracil; Imidazoles; Leukemia L1210; Lung Neoplasms; Methotrexate; Mice; Neoplasms, Experimental; Oxazines; Piperazines; Procarbazine; Propane; Triazenes

1974
[Use of acetylcysteine combined with thiamphenicol by intramuscular route in the preparation of the tracheo-bronchial tree for oncological thoracic surgery].
    Revista brasileira de medicina, 1971, Volume: 28, Issue:4

    Topics: Acetylcysteine; Bronchial Neoplasms; Chloramphenicol; Esophageal Neoplasms; Humans; Injections, Intramuscular; Lung Neoplasms; Male; Preoperative Care; Thoracic Neoplasms; Tracheal Neoplasms

1971