acetylcysteine has been researched along with Lung Neoplasms in 163 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (7.98) | 18.7374 |
| 1990's | 29 (17.79) | 18.2507 |
| 2000's | 36 (22.09) | 29.6817 |
| 2010's | 69 (42.33) | 24.3611 |
| 2020's | 16 (9.82) | 2.80 |
| Authors | Studies |
|---|---|
| Cao, S; Han, B; Ling, X; Wang, H; Xu, J; Zhang, B; Zhang, X; Zhong, H; Zhong, R | 1 |
| Geng, Y; Liu, P; Liu, Y; Xie, Y; Zhang, L; Zhu, X | 1 |
| Jensen, RT; Moody, TW; Ramos-Alvarez, I | 1 |
| Cui, XY; Park, SH; Park, WH | 1 |
| Chen, M; Guo, Q; Hu, C; Liang, Y; Wang, W; Yang, L | 1 |
| Bodinier, B; Chadeau-Hyam, M; Dagnino, S; Edmands, WB; Fiorito, G; Grigoryan, H; Guida, F; Karimi, M; Krogh, V; Naccarati, A; Polidoro, S; Rappaport, SM; Sacerdote, C; Vermeulen, R; Vineis, P | 1 |
| Abid, S; Adnot, S; Attwe, A; Beaulieu, D; Bernard, D; Born, E; Bourachot, B; Breau, M; Collin, G; Czibik, G; Flaman, JM; Houssaini, A; Lipskaia, L; Marcos, E; Mechta-Grigoriou, F; Palazzo, A; Tran Van Nhieu, J | 1 |
| Chen, W; Chen, YH; Ruan, Q; Sun, H; Tang, A; Wan, X; Wang, J; Yan, D; Yang, X; Zamani, A; Zhang, H | 1 |
| Chen, H; Hu, J; Li, J; Shi, M; Wang, XH; Zhang, L | 1 |
| Adnot, S; Bernard, D; Breau, M; Mechta-Grigoriou, F | 1 |
| Lakshminarayanan, A; Rajendran, S; Ramanathan, G; Subramanian Shanmugam, SK | 1 |
| Li, F; Liu, YG; Wang, LQ; Wen, DH; Xia, YC; Yin, H; Yu, BT; Zha, JH | 1 |
| Jin, CH; Li, TZ; Li, YN; Shen, GN; Xu, WT; Xue, H; Zhang, DJ; Zhang, T; Zhang, Y; Zuo, WB | 1 |
| Baek, SH; Park, J | 1 |
| Jin, W; Lu, S; Shi, H; Shu, Y; Wang, X | 1 |
| Gurunathan, S; Jeyaraj, M; Kang, MH; Kim, JH | 1 |
| Fan, F; Ge, X; Huang, F; Li, S; Li, X; Liu, H; Pang, J; Wu, Y; Zhang, Y | 1 |
| Chen, H; Hu, J; Li, D; Li, J; Shi, M; Wang, X; Zhang, H; Zhang, L; Zhang, R | 1 |
| Chung, MH; Hahm, KB; Han, YM; Jeong, M; Ko, KH; Kwon, CI; Park, JM | 1 |
| Lee, SH; Lee, YJ | 1 |
| Park, WH; You, BR | 3 |
| Cai, H; Ge, G; Yan, Y | 1 |
| Hu, Y; Johnson, PF; Karin, M; Ma, B; Nussinov, R; Schrump, DS; Song, NY; Su, L; Sun, Z; Wang, Z; Willette-Brown, J; Wu, X; Xi, S; Xia, X; Zhu, F | 1 |
| Hu, Y; Li, J; Wang, Y; Wu, W; Yan, Y; Yang, G; Zheng, Z; Zhou, Y | 1 |
| Li, Z; Liu, W; Yang, Y; Zhao, Z | 1 |
| Azuma, A; Bando, M; Date, H; Ebina, M; Fukuoka, J; Gemma, A; Goto, Y; Hasegawa, Y; Hattori, N; Homma, S; Inase, N; Inoue, Y; Ishii, Y; Izumi, S; Johkoh, T; Kido, T; Kishaba, T; Kishi, K; Miyamoto, A; Mukae, H; Nakayama, T; Nishioka, Y; Ogura, T; Sakamoto, S; Sasaki, S; Suda, T; Sugino, K; Taguchi, Y; Takahashi, H; Takahashi, K; Taniguchi, H; Watanabe, K; Yokoyama, A; Yoshino, I | 1 |
| Chen, W; Li, X; Wu, J; Zhang, X | 1 |
| Chang, YJ; Chao, MW; Chen, YC; Erkekoglu, P; Lin, CH; Lin, PY; Tseng, CY | 1 |
| Díaz-García, VM; Díaz-Valdivia, N; Guerrero, S; Kogan, M; Lobos-González, L; Pérez-Donoso, JM; Quest, AF | 1 |
| Jiao, P; Ren, G; Wang, S; Ye, L; Zhao, W; Zhou, J | 1 |
| Choi, CM; Han, DW; Ji, W; Lee, JC; Song, SY | 1 |
| Feng, YC; Jin, CH; Li, JQ; Luo, YH; Piao, XJ; Shen, GN; Wang, CY; Wang, JR; Xu, WT; Zhang, T; Zhang, Y | 1 |
| Chen, Z; Qin, X | 1 |
| Andreu, AL; Barreiro, E; de Kier Joffé, ED; Fermoselle, C; García-Arumí, E; Puente-Maestu, L; Puig-Vilanova, E; Tejedor, A; Urtreger, AJ | 1 |
| Burgos-Morón, E; Calderón-Montaño, JM; López-Lázaro, M; Mateos, S; Orta, ML | 1 |
| Bowtell, DD; Chen, A; Liu, MC; Möller, A; Sceneay, J; Wong, CS | 1 |
| Hann, SS; Zhao, S; Zheng, F | 1 |
| Abe, I; Chanvorachote, P; Cheun-Arom, T; Chuanasa, T; Saito, N; Sirimangkalakitti, N; Suwanborirux, K | 1 |
| Kaushik, G; Kaushik, T; Khanduja, KL; Pathak, CM; Ranawat, P; Sharma, SK; Yadav, SK | 1 |
| Luo, H; Schulte, BA; Tang, S; Wang, GY; Wang, L; Yang, A | 1 |
| Bergo, MO; Ibrahim, MX; Larsson, E; Lindahl, P; Nilsson, JA; Sayin, VI | 1 |
| Kaiser, J | 1 |
| Kim, BM; Park, JB; Yang, KM | 1 |
| Cinatl, J; Michaelis, M; Sithisarn, P | 1 |
| Cha, BK; Hwang, KE; Hwang, YR; Jeong, ET; Kim, BR; Kim, HR; Kim, YS; Kwon, SJ; Park, DS; Yoon, KH | 2 |
| Kang, S | 1 |
| Kotapati, S; Le Marchand, L; Murphy, SE; Park, SL; Tiirikainen, M; Tretyakova, N; Wilkens, LR | 1 |
| Kim, SH; Park, WH; You, BR | 1 |
| Cui, R; Hua, P; Li, X; Sun, M; Tian, X; Zhang, G; Zhang, X; Zhang, Y | 1 |
| Carmella, SG; Chen, M; Hecht, SS; Koh, WP; Murphy, SE; Wang, R; Yuan, JM | 1 |
| Jayasree, K; Sara George, P; Saraswathy Veena, V; Sujathan, K | 1 |
| Cromie, MM; Gao, W | 1 |
| Carmella, SG; Chen, M; Haiman, CA; Hecht, SS; Le Marchand, L; Park, SL; Patel, Y; Stram, DO | 1 |
| Gu, S; Shao, GG; Sun, LK; Wu, Y; Xiang, XY; Xue, YN; Yan, XY; Yang, XC; Zhang, Y | 1 |
| Almosnid, NM; Altman, E; Chippada-Venkata, UD; Farone, A; Gao, Y; Gong, Y; Hosain, NA; Huang, R; Park, HS; Vick, E; Wen, Q | 1 |
| Hanyuda, M; Hosokawa, Y; Karnan, S; Konishi, H; Miura, Y; Numanami, H; Ota, A; Tanaka, M | 1 |
| Jin, F; Liu, X; Ma, L; Wang, R; Weng, D; Yao, J | 1 |
| Cao, SJ; Gao, XM; Huang, YY; Jian, JF; Kang, N; Mao, YW; Peng, YF; Qiu, F; Zhang, Q | 1 |
| Chen, X; Leung, CH; Lu, J; Luo, W; Ma, DL; Ma, G; Wang, Y | 1 |
| Hou, SG; Li, XB; Lin, SS; Shi, YR; Sun, Y; Zhang, SY | 1 |
| Gao, W; Liu, J; Liu, Z; Man, S; Wang, Y; Yu, P; Zhang, L | 1 |
| Chang, WT; Chen, JY; Chiu, CC; Chou, HL; Fong, Y; Huang, HW; Tsai, EM; Wei, CK; Wu, CY | 1 |
| Hong, SE; Jang, YS; Jeong, W; Jo, YJ; Kim, H; Kim, J; Lee, GR; Lee, HI; Lee, HJ; Lee, J; Lee, JS; Oh, SH | 1 |
| Chavez, V; Orue, A; Rieber, M; Strasberg-Rieber, M | 1 |
| Boldry, EJ; Esades, A; Kotapati, S; Le Marchand, L; Park, SL; Patel, YM; Stram, DO; Tiirikainen, M; Tretyakova, N | 1 |
| Hirayama, A; Inanami, O; Kobayashi, S; Kon, Y; Kuwabara, M; Meike, S; Ogura, A; Oowada, S; Yasui, H | 1 |
| Balansky, R; De Flora, S; Ganchev, G; Iltcheva, M; Steele, VE | 3 |
| Han, YH; Park, WH | 1 |
| Cheng, PF; Ma, HX; Wang, CJ; Wang, JH; Xie, SQ; Zhao, J | 1 |
| Baas, P; Beijnen, JH; Keizer, RJ | 1 |
| Han, YH; Kim, SH; Kim, SZ; Moon, HJ; Park, WH; You, BR | 1 |
| Adams, LD; George, MH; King, LC; Moore, T; Nelson, G; Nesnow, S; Padgett, WT; Ross, JA | 1 |
| Chan, HW; Chen, HH; Chiu, LY; Hsin, IL; Hsu, CP; Ko, JL; Sheu, GT; Wang, HD | 1 |
| Autrup, H; Dang, DA; Foldbjerg, R | 1 |
| Li, Y; Liu, B; Wu, X; Xu, K; Yan, H; Zhou, Q; Zhu, Y | 1 |
| Chen, GG; Hsin, MK; Leung, BC; Leung, KC; Li, MY; Mok, TS; Underwood, MJ | 1 |
| Chanvorachote, P; Halim, H; Nimmannit, U; Rojanasakul, Y; Rungtabnapa, P | 1 |
| Chen, J; Gao, AC; Li, Y; Liu, C; Liu, H; Wang, T; Wu, Z; Zhou, Q; Zhu, Y | 1 |
| Li, Y; Liu, B; Wu, H; Wu, X; Xu, K; Yan, H; Zhou, Q; Zhu, Y | 1 |
| Kashyap, MP; Lohani, M; Pant, AB; Rahman, Q; Srivastava, RK | 1 |
| Fu, Z; Guan, L; Hu, Z; Huang, J; Li, X; Li, Z; Liu, H | 1 |
| Brock, SE; Mitchell, RA; Rendon, BE; Yaddanapudi, K | 1 |
| Attia, A; Isom, S; Kock, ND; McBride, JE; Miller, MS; Moore, JE; Munley, MT; Walb, MC | 1 |
| Aqil, F; Bansal, SS; Gupta, RC; Kausar, H; Munagala, R; Vadhanam, MV | 1 |
| Simkeviciene, V; Straukas, J; Uleckiene, S | 1 |
| Pastorino, U; van Zandwijk, N | 1 |
| Brent, GA; Dubinett, SM; Hershman, JM; Huang, M; Kogai, T; Sharma, S; Zhang, L; Zhu, LX | 1 |
| Futakuchi, M; Ogawa, K; Shirai, T; Takahashi, S; Tamano, S | 1 |
| Friedlander, M; Kurtovic, J; Riordan, SM; Singh-Grewal, I; Webster, GJ | 1 |
| Henfling, ME; Ramaekers, FC; Schutte, B | 1 |
| Witschi, H | 1 |
| Kassie, F; Mersch-Sundermann, V; Wu, XJ | 1 |
| Gallimore, PH; Grand, RJ; Hussain, R; Mymryk, JS; Turnell, AS; Zhang, X | 1 |
| Chung, FL; Conaway, CC; Hecht, SS; McIntee, EJ; Pittman, B; Schwartz, JE; Tian, D; Wang, CX; Yang, YM | 1 |
| Foth, H; Glahn, F; Stehfest, E; Torky, A | 1 |
| Alexandre, J; Batteux, F; Chéreau, C; Goldwasser, F; Guillevin, L; Laurent, A; Nicco, C; Weill, B | 1 |
| Shyamaladevi, CS; Vanisree, AJ | 1 |
| Bosari, S; Carelli, S; Di Giulio, AM; Gorio, A; Paratore, S | 1 |
| Dai, W; Darzynkiewicz, Z; Huang, X; Kurose, A; Tanaka, T; Traganos, F | 1 |
| Duong, HQ; Han, SI; Joo, YM; Kang, HS; Kim, CH; Kim, YJ; Lee, SY; Lim, SC; Moon, JY; Park, HG; Park, MJ; Yoo, MA; Youk, HS | 1 |
| Borges, FT; Dalboni, MA; Garofalo, AS; Pavão dos Santos, OF | 1 |
| Hour, MJ; Lee, HZ; Leung, HW; Lin, CJ; Wang, MY; Yang, WH | 1 |
| Bepler, G; Gray, J; Kelley, M; Kurie, J; Mao, JT; Szabo, E | 1 |
| Aburatani, H; Fukayama, M; Goto, A; Ishikawa, S; Matsubara, D; Miyazawa, K; Nakamura, Y; Niki, T; Ota, S; Sachiko, O | 1 |
| Lambert, JD; Sang, S; Yang, CS | 1 |
| An, S; Choe, TB; Hong, SI; Jin, HO; Kim, ES; Kim, JI; Lee, HC; Lee, SJ; Park, IC; Rhee, CH; Seo, SK; Woo, SH; Yoo, DH | 1 |
| Saiers, JH; Slavik, M | 2 |
| Gillen, LE; Holdiness, MR; Morgan, LR | 1 |
| Donley, PJ; Harrison, EF; Hunter, HL; Morgan, LR | 2 |
| Baas, P; Stewart, FA; van Mansom, I; van Tinteren, H; van Zandwijk, N | 1 |
| Albini, A; Balansky, R; D'Agostini, F; De Flora, S; Giunciuglio, D; Paglieri, I | 1 |
| van Zandwijk, N | 2 |
| Bridgeman, MM; MacNee, W; Marsden, M; Morrison, D; Selby, C | 1 |
| Bistoni, F; Cociani, C; Dottorini, M; Eslami, A; Pietrella, D; Todisco, T; Vecchiarelli, A | 1 |
| Giaccia, AJ; Hahn, GM; Koong, AC; Saad, AH | 1 |
| Hallman, M; Kivisaari, L; Maasilta, P; Mattson, K; Taskinen, E | 1 |
| De Flora, S; De Vries, N | 1 |
| de Vries, N; Pastorino, U; van Zandwijk, N | 2 |
| Feldstein, TJ; Hartfield, D; Horner, H; Kobrinsky, NL; Maksymiuk, A; Minuk, GY; White, DF | 1 |
| Choi, CI; Chung, FL; Jiao, D; Kelloff, G; Pittman, B; Rigotty, J; Rivenson, A; Steele, V; Zang, E | 1 |
| Albini, A; D'Agostini, F; De Flora, S; Giunciuglio, D; Masiello, L | 1 |
| Ahmed, T; Kehrer, JP; Pakenham, G; Perry, CS; Ramu, K | 1 |
| De Flora, S | 1 |
| Bagnasco, M; Bennicelli, C; Camoirano, A; De Flora, S; Kensler, TW; Qian, GS; van Zandwijk, N; Wigbout, G; Zhu, YR | 1 |
| Choi, AM; Jacoby, DB; Knobil, K; Weigand, GW | 1 |
| Chung, FL; Conaway, CC; Jiao, D; Kelloff, GJ; Rivenson, A; Steele, VE | 1 |
| Hunninghake, GW; Mastronarde, JG; Matsushima, K; Monick, MM; Mukaida, N | 1 |
| Balansky, RM; De Flora, S | 1 |
| Albini, A; Bagnasco, M; D'Agostini, F; De Flora, S; Giunciuglio, D | 1 |
| Dubrovskaya, VA; Wetterhahn, KE | 1 |
| Kobzik, L; Stringer, B | 1 |
| Espiritu, I; Willits, NH; Witschi, H; Yu, M | 1 |
| Han, JA; Park, SC | 1 |
| Chi, CX; Jiang, Y; Rom, WN; Tchou-Wong, KM; Yie, TA | 1 |
| Goldman, Y; Peled, A; Shinitzky, M | 1 |
| Omenn, GS | 1 |
| Dalesio, O; de Vries, N; Pastorino, U; van Tinteren, H; van Zandwijk, N | 1 |
| Harani, N; Haslett, C; MacKinnon, AC; Rahman, I; Rintoul, R; Sethi, T; Waters, C | 1 |
| Balansky, RM; Camoirano, A; D'Agostini, F; de Flora, S | 1 |
| Balansky, RM; Bennicelli, C; D'Agostini, F; De Flora, S; Kelloff, GJ; Lubet, RA | 1 |
| Deloughery, TG; Hasler, BP; Muldoon, LL; Neuwelt, EA; Pagel, MA | 1 |
| Amin, S; Chiao, JW; Chung, FL; Conaway, CC; Dai, W; Reinhardt, J; Wang, CX; Whysner, J; Yang, YM | 1 |
| Espiritu, I; Pinkerton, KE; Suffia, M; Witschi, H | 1 |
| Carpenter, LR; Moy, JN; Roebuck, KA | 1 |
| Blomqvist, P; Holsti, LR; Kivisaari, L; Maasilta, P; Mattson, K | 1 |
| Baldewyns, P; Beauduin, M; Gourdin, P; Minette, P; Pluygers, E; Robinet, P | 1 |
| Blank, LE; Haveman, J; Joenje, H; van Rijn, J; van Zandwijk, N; Wanamarta, AH | 1 |
| Jepsen, S; Klaerke, A; Nielsen, PH; Nielsen, ST; Simonsen, O | 1 |
| Birch, R; Einhorn, LH; Greco, FA; Kramer, BS; Loehrer, PJ | 1 |
| Holoye, PY | 1 |
| Astengo, M; Bennicelli, C; De Flora, S; Serra, D | 1 |
| De Flora, A; De Flora, S; Rossi, GA | 1 |
| Kline, I | 1 |
| Mirra, AP | 1 |
5 review(s) available for acetylcysteine and Lung Neoplasms
| Article | Year |
|---|---|
Japanese guideline for the treatment of idiopathic pulmonary fibrosis.
Topics: Acetylcysteine; Administration, Inhalation; Adrenal Cortex Hormones; Antineoplastic Combined Chemotherapy Protocols; Comorbidity; Disease Progression; Drug Therapy, Combination; Evidence-Based Medicine; Glycine; Humans; Idiopathic Pulmonary Fibrosis; Immunosuppressive Agents; Indoles; Japan; Lung Neoplasms; Meta-Analysis as Topic; Practice Guidelines as Topic; Prognosis; Pyridones; Quality of Health Care; Sulfonamides; Survival Rate | 2018 |
Chemoprevention of lung cancer: soon daily practice?
Topics: Acetylcysteine; Animals; Anticarcinogenic Agents; Antineoplastic Agents; Antioxidants; Carotenoids; Clinical Trials as Topic; Diet; Humans; Lung Neoplasms; Pyrazines; Retinoids; Selenium; Smoking; Vitamin E | 2003 |
N-acetyl-l-cysteine.
Topics: Acetylcysteine; Animals; Anticarcinogenic Agents; Antioxidants; Humans; Laryngeal Neoplasms; Lung Neoplasms; Mouth Neoplasms | 1993 |
N-acetylcysteine (NAC) and glutathione (GSH): antioxidant and chemopreventive properties, with special reference to lung cancer.
Topics: Acetylcysteine; Anticarcinogenic Agents; Antidotes; Antioxidants; Expectorants; Glutathione; Humans; Lung Neoplasms; Smoking | 1995 |
[Molecular epidemiology and prevention of bronchopulmonary carcinoma].
Topics: Acetylcysteine; Air Pollution, Indoor; Carcinoma, Bronchogenic; Female; Free Radical Scavengers; Humans; Italy; Lung Neoplasms; Male; Risk Factors; Smoking; United States | 1995 |
12 trial(s) available for acetylcysteine and Lung Neoplasms
| Article | Year |
|---|---|
Safety and efficacy of dendritic cell-based immunotherapy (DCVAC/LuCa) combined with carboplatin/pemetrexed for patients with advanced non-squamous non-small-cell lung cancer without oncogenic drivers.
Topics: Acetylcysteine; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Non-Small-Cell Lung; Dendritic Cells; Humans; Immunotherapy; Lung Neoplasms; Pemetrexed; Prospective Studies | 2022 |
Protective effect of N-acetylcysteine on the urotoxicity produced by oxazaphosphorine without interference with anticancer activity.
Topics: Acetylcysteine; Antineoplastic Agents; Cyclophosphamide; Hematuria; Humans; Ifosfamide; Lung Neoplasms | 1982 |
Effect of N-acetylcysteïne on Photofrin-induced skin photosensitivity in patients.
Topics: Acetylcysteine; Adult; Aged; Aged, 80 and over; Dihematoporphyrin Ether; Edema; Erythema; Esophageal Neoplasms; Female; Follow-Up Studies; Free Radicals; Glutathione; Humans; Lung Neoplasms; Male; Middle Aged; Photochemotherapy; Photosensitivity Disorders; Reactive Oxygen Species; Skin | 1995 |
Macrophage activation by N-acetyl-cysteine in COPD patients.
Topics: Acetylcysteine; Bronchoalveolar Lavage Fluid; Candida albicans; Female; Humans; In Vitro Techniques; Leukocytes, Mononuclear; Lung Diseases, Obstructive; Lung Neoplasms; Macrophage Activation; Macrophages, Alveolar; Male; Middle Aged; Neutrophils; Phagocytosis | 1994 |
Chemoprevention of cancer.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Diet; Digestive System Neoplasms; Diterpenes; Head and Neck Neoplasms; Humans; Isotretinoin; Lung Neoplasms; Neoplasms, Second Primary; Retinyl Esters; Smoking Prevention; Vitamin A | 1993 |
Treatment of advanced malignancies with high-dose acetaminophen and N-acetylcysteine rescue.
Topics: Acetaminophen; Acetylcysteine; Adult; Aged; Antineoplastic Agents; Carcinoma, Small Cell; Drug Combinations; Female; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasms; Time Factors | 1996 |
EUROSCAN, a randomized trial of vitamin A and N-acetylcysteine in patients with head and neck cancer or lung cancer. For the EUropean Organization for Research and Treatment of Cancer Head and Neck and Lung Cancer Cooperative Groups.
Topics: Acetylcysteine; Adult; Aged; Aged, 80 and over; Anticarcinogenic Agents; Antineoplastic Combined Chemotherapy Protocols; Disease-Free Survival; Diterpenes; Drug Administration Schedule; Europe; Female; Head and Neck Neoplasms; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasms, Second Primary; Patient Compliance; Retinyl Esters; Risk Factors; Smoking; Survival Analysis; Treatment Failure; Vitamin A | 2000 |
N-acetylcysteine in combination with radiotherapy in the treatment of non-small cell lung cancer: a feasibility study.
Topics: Acetylcysteine; Adult; Aged; Carcinoma, Non-Small-Cell Lung; Combined Modality Therapy; Feasibility Studies; Humans; Lung; Lung Neoplasms; Middle Aged; Radiation Injuries; Radiation-Protective Agents; Radiotherapy Dosage; Tomography, X-Ray Computed | 1992 |
The EUROSCAN Study. EUROSCAN Steering Committee.
Topics: Acetylcysteine; Head and Neck Neoplasms; Humans; Lung Neoplasms; Neoplasm Recurrence, Local; Neoplasms, Second Primary; Survival Analysis; Vitamin A | 1991 |
Peroral N-acetylcysteine as prophylaxis against bronchopulmonary complications of pulmonary surgery.
Topics: Acetylcysteine; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Lung; Lung Neoplasms; Male; Middle Aged; Postoperative Complications; Premedication; Pulmonary Atelectasis; Random Allocation | 1989 |
Ifosfamide plus N-acetylcysteine in the treatment of small cell and non-small cell carcinoma of the lung: a Southeastern Cancer Study Group Trial.
Topics: Acetylcysteine; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Bronchogenic; Carcinoma, Small Cell; Clinical Trials as Topic; Female; Humans; Ifosfamide; Lung Neoplasms; Male; Middle Aged | 1986 |
"Ifosfamide plus N-acetylcysteine in the treatment of small cell and non-small cell carcinoma of the lung: a Southeastern Cancer Study Group Trial".
Topics: Acetylcysteine; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Clinical Trials as Topic; Humans; Ifosfamide; Lung Neoplasms | 1987 |
146 other study(ies) available for acetylcysteine and Lung Neoplasms
| Article | Year |
|---|---|
Xanthatin inhibits non-small cell lung cancer proliferation by breaking the redox balance.
Topics: Acetylcysteine; Antioxidants; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Furans; Humans; Lung Neoplasms; Oxidation-Reduction; Reactive Oxygen Species | 2022 |
Adding of neurotensin to non-small cell lung cancer cells increases tyrosine phosphorylation of HER3.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Acetylcysteine; Antibodies, Monoclonal; Antioxidants; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; ErbB Receptors; Humans; Lung Neoplasms; Matrix Metalloproteinase Inhibitors; Neuregulins; Neurotensin; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptor, ErbB-3; Receptors, Neurotensin; Superoxides; Tyrosine | 2022 |
Anti-Cancer Effects of Auranofin in Human Lung Cancer Cells by Increasing Intracellular ROS Levels and Depleting GSH Levels.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Auranofin; Buthionine Sulfoximine; Cell Line, Tumor; Cell Proliferation; Glutathione; Humans; Lung Neoplasms; Membrane Potential, Mitochondrial; Reactive Oxygen Species | 2022 |
Saikosaponin-D induces the pyroptosis of lung cancer by increasing ROS and activating the NF-κB/NLRP3/caspase-1/GSDMD pathway.
Topics: Acetylcysteine; Carcinoma, Non-Small-Cell Lung; Caspase 1; Humans; Inflammasomes; Lung Neoplasms; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Phosphate-Binding Proteins; Pore Forming Cytotoxic Proteins; Pyroptosis; Reactive Oxygen Species; Tumor Microenvironment | 2023 |
Agnostic Cys34-albumin adductomics and DNA methylation: Implication of N-acetylcysteine in lung carcinogenesis years before diagnosis.
Topics: Acetylcysteine; Biomarkers, Tumor; Carcinogenesis; Case-Control Studies; CpG Islands; DNA Adducts; DNA Methylation; Epigenomics; Female; Follow-Up Studies; Humans; Lung Neoplasms; Male; Middle Aged; Oxidation-Reduction; Prospective Studies; Risk Assessment; Smoking | 2020 |
The antioxidant N-acetylcysteine protects from lung emphysema but induces lung adenocarcinoma in mice.
Topics: Acetylcysteine; Adenocarcinoma of Lung; Animals; Antioxidants; Disease Models, Animal; Female; Humans; Lung; Lung Diseases; Lung Neoplasms; Male; Mice; Mice, Knockout; Oxidative Stress; Proto-Oncogene Proteins c-jun; Pulmonary Emphysema; Reactive Oxygen Species | 2019 |
TIPE2 specifies the functional polarization of myeloid-derived suppressor cells during tumorigenesis.
Topics: Acetylcysteine; Adoptive Transfer; Animals; Carcinogenesis; Cell Polarity; Cell Transformation, Neoplastic; Female; HEK293 Cells; Humans; Intracellular Signaling Peptides and Proteins; Lung Neoplasms; Lysine; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Myeloid Cells; Myeloid-Derived Suppressor Cells; Reactive Oxygen Species; Signal Transduction; Transfection | 2020 |
Combined treatment with N-acetylcysteine and gefitinib overcomes drug resistance to gefitinib in NSCLC cell line.
Topics: Acetylcysteine; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; ErbB Receptors; Gefitinib; Humans; Lung Neoplasms; Mutation; Protein Kinase Inhibitors | 2020 |
[Antioxidant treatment promotes lung cancer while protecting against lung emphysema].
Topics: Acetylcysteine; Animals; Antioxidants; Cell Transformation, Neoplastic; Cellular Senescence; Cytoprotection; Humans; Lung; Lung Neoplasms; Mice; Mice, Knockout; Oxidative Stress; Proto-Oncogene Proteins c-jun; Pulmonary Emphysema | 2020 |
Antioxidant Antagonises Chemotherapeutic Drug Effect in Lung Cancer Cell Line A549.
Topics: Acetylcysteine; Antimetabolites, Antineoplastic; Antioxidants; Apoptosis; Cell Proliferation; Drug Therapy, Combination; Free Radical Scavengers; Humans; Lung Neoplasms; Thioguanine; Tumor Cells, Cultured | 2020 |
Resibufogenin suppresses growth and metastasis through inducing caspase-1-dependent pyroptosis via ROS-mediated NF-κB suppression in non-small cell lung cancer.
Topics: Acetylcysteine; Antioxidants; Bufanolides; Carcinoma, Non-Small-Cell Lung; Caspase 1; Cell Line, Tumor; Cell Proliferation; Cell Survival; Humans; Lung Neoplasms; NF-kappa B; Pyroptosis; Reactive Oxygen Species | 2021 |
Isoorientin induces the apoptosis and cell cycle arrest of A549 human lung cancer cells via the ROS‑regulated MAPK, STAT3 and NF‑κB signaling pathways.
Topics: A549 Cells; Acetylcysteine; Apoptosis; Drug Screening Assays, Antitumor; G2 Phase Cell Cycle Checkpoints; Humans; Lung Neoplasms; Luteolin; MAP Kinase Signaling System; NF-kappa B; Reactive Oxygen Species; STAT3 Transcription Factor | 2020 |
Combination Therapy with Cinnamaldehyde and Hyperthermia Induces Apoptosis of A549 Non-Small Cell Lung Carcinoma Cells via Regulation of Reactive Oxygen Species and Mitogen-Activated Protein Kinase Family.
Topics: A549 Cells; Acetylcysteine; Acrolein; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Proliferation; Cell Survival; Combined Modality Therapy; Drug Screening Assays, Antitumor; Gene Expression Regulation, Neoplastic; Humans; Hyperthermia, Induced; JNK Mitogen-Activated Protein Kinases; Lung Neoplasms; MAP Kinase Signaling System; Phosphorylation; Reactive Oxygen Species | 2020 |
Raddeanin A suppresses lung cancer cell proliferation via induction of apoptosis and increased production of ROS.
Topics: Acetylcysteine; Apoptosis; bcl-2-Associated X Protein; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Cytochromes c; Humans; Lung Neoplasms; Membrane Potential, Mitochondrial; Reactive Oxygen Species; Saponins | 2020 |
Platinum Nanoparticles Enhance Exosome Release in Human Lung Epithelial Adenocarcinoma Cancer Cells (A549): Oxidative Stress and the Ceramide Pathway are Key Players.
Topics: A549 Cells; Acetylcholinesterase; Acetylcysteine; Adenocarcinoma of Lung; Aniline Compounds; Benzylidene Compounds; Cell Proliferation; Cell Survival; Ceramides; Enzyme Activation; Exosomes; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Lutein; Metal Nanoparticles; Neoplasm Proteins; Oxidative Stress; Particle Size; Platinum; RNA, Messenger; Serum; Sphingomyelin Phosphodiesterase; Static Electricity | 2021 |
EGFR tyrosine kinase inhibitor Almonertinib induces apoptosis and autophagy mediated by reactive oxygen species in non-small cell lung cancer cells.
Topics: Acetylcysteine; Acrylamides; Antineoplastic Agents; Apoptosis; Autophagy; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; ErbB Receptors; Humans; Indoles; Lung Neoplasms; Protein Kinase Inhibitors; Pyrimidines; Reactive Oxygen Species | 2021 |
Cigarette smoke extract induces EGFR-TKI resistance via promoting EGFR signaling pathway and ROS generation in NSCLC cell lines.
Topics: A549 Cells; Acetylcysteine; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cigarette Smoking; Drug Resistance, Neoplasm; ErbB Receptors; Free Radical Scavengers; Gefitinib; Humans; Lung Neoplasms; Protein Kinase Inhibitors; Quinazolines; Reactive Oxygen Species; Signal Transduction | 2017 |
Synthetic 8-hydroxydeoxyguanosine inhibited metastasis of pancreatic cancer through concerted inhibitions of ERM and Rho-GTPase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 8-Hydroxy-2'-Deoxyguanosine; Acetylcysteine; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Claudin-1; Deoxyguanosine; DNA-Binding Proteins; Epithelial-Mesenchymal Transition; Focal Adhesion Kinase 1; Gene Expression Regulation, Neoplastic; GTPase-Activating Proteins; Humans; Hyaluronan Receptors; Imidazoles; Lung Neoplasms; Matrix Metalloproteinases; Mice; Mice, Nude; NADPH Oxidases; Pancreatic Neoplasms; Pyrroles; rho-Associated Kinases; Signal Transduction; Transcription Factors; Vimentin; Xenograft Model Antitumor Assays; Zonula Occludens-1 Protein | 2017 |
Pro-oxidant activity of sulforaphane and cisplatin potentiates apoptosis and simultaneously promotes autophagy in malignant mesothelioma cells.
Topics: Acetylcysteine; Antioxidants; Apoptosis; Autophagy; bcl-2-Associated X Protein; Cell Cycle Checkpoints; Cell Line, Tumor; Cisplatin; Glutathione; Humans; Isothiocyanates; Lung Neoplasms; Membrane Potential, Mitochondrial; Mesothelioma; Mesothelioma, Malignant; Microtubule-Associated Proteins; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Sulfoxides; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53; Up-Regulation | 2017 |
Suberoylanilide hydroxamic acid induces thioredoxin1-mediated apoptosis in lung cancer cells via up-regulation of miR-129-5p.
Topics: 3' Untranslated Regions; A549 Cells; Acetylcysteine; Apoptosis; Blotting, Western; Buthionine Sulfoximine; Cell Line; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Glutathione; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Lung Neoplasms; MAP Kinase Kinase Kinase 5; MAP Kinase Signaling System; MicroRNAs; Reactive Oxygen Species; Thioredoxins; Up-Regulation; Vorinostat | 2017 |
Ginsenoside Rh2 Inhibited Proliferation by Inducing ROS Mediated ER Stress Dependent Apoptosis in Lung Cancer Cells.
Topics: Acetylcysteine; Activating Transcription Factor 4; Apoptosis; Caspases, Initiator; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Endoplasmic Reticulum Stress; Ginsenosides; Humans; Lung Neoplasms; Phenylbutyrates; Reactive Oxygen Species; Transcription Factor CHOP; Up-Regulation | 2017 |
IKKα inactivation promotes Kras-initiated lung adenocarcinoma development through disrupting major redox regulatory pathways.
Topics: Acetophenones; Acetylcysteine; Adenocarcinoma; Animals; Cell Proliferation; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p21; Epigenesis, Genetic; Humans; I-kappa B Kinase; Lung Neoplasms; Mice; NADPH Oxidase 2; NF-E2-Related Factor 2; Proto-Oncogene Proteins p21(ras); Reactive Oxygen Species; Tumor Suppressor Protein p53 | 2018 |
Sulforaphane-N-Acetyl-Cysteine inhibited autophagy leading to apoptosis via Hsp70-mediated microtubule disruption.
Topics: Acetylcysteine; Aged; Anticarcinogenic Agents; Apoptosis; Autophagy; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Survival; Female; HSP70 Heat-Shock Proteins; Humans; Isothiocyanates; Lung Neoplasms; Macrolides; Male; Microtubules; Middle Aged; Phenotype; Stathmin; Sulfoxides; Tissue Array Analysis; Tubulin | 2018 |
T59, a New Compound Reconstructed from Curcumin, Induces Cell Apoptosis through Reactive Oxygen Species Activation in Human Lung Cancer Cells.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Curcumin; Humans; Lung Neoplasms; Membrane Potential, Mitochondrial; Membrane Potentials; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; TOR Serine-Threonine Kinases | 2018 |
Glutathione reductase-mediated thiol oxidative stress suppresses metastasis of murine melanoma cells.
Topics: Acetylcysteine; Actins; Animals; Antineoplastic Agents; Cadherins; Carcinogenesis; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; Glutathione Reductase; Isografts; Lung Neoplasms; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Oxidative Stress; Reactive Oxygen Species; Signal Transduction; Skin Neoplasms; Snail Family Transcription Factors; Thiocarbamates; Tumor Burden; Vimentin | 2018 |
Anti-cancer effects of 3,5-dimethylaminophenol in A549 lung cancer cells.
Topics: A549 Cells; Acetylcysteine; Aminophenols; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinogenesis; Cell Proliferation; DNA Damage; Female; Fibroblasts; Free Radical Scavengers; Humans; Lung Neoplasms; Mice; Mice, Nude; Oxidative Stress; Reactive Oxygen Species; Xenograft Model Antitumor Assays | 2018 |
Biomimetic quantum dot-labeled B16F10 murine melanoma cells as a tool to monitor early steps of lung metastasis by in vivo imaging.
Topics: Acetylcysteine; Animals; Biomimetic Materials; Cell Movement; Cell Proliferation; Cell Survival; Diagnostic Imaging; Glutathione; Humans; Hydrodynamics; Lung Neoplasms; Melanoma, Experimental; Mice, Inbred C57BL; Quantum Dots; Reactive Oxygen Species; Staining and Labeling; Static Electricity; Tissue Distribution | 2018 |
Gambogic acid-induced autophagy in nonsmall cell lung cancer NCI-H441 cells through a reactive oxygen species pathway.
Topics: Acetylcysteine; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Survival; Female; Garcinia; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Reactive Oxygen Species; Signal Transduction; Xanthones; Xenograft Model Antitumor Assays | 2018 |
Efficacy of nebulized acetylcysteine for relieving symptoms and reducing usage of expectorants in patients with radiation pneumonitis.
Topics: Acetylcysteine; Adenocarcinoma; Administration, Inhalation; Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Case-Control Studies; Expectorants; Female; Follow-Up Studies; Humans; Lung Neoplasms; Male; Middle Aged; Prognosis; Prospective Studies; Radiation Pneumonitis; Radiotherapy; Retrospective Studies; Small Cell Lung Carcinoma | 2019 |
The design of 1,4-naphthoquinone derivatives and mechanisms underlying apoptosis induction through ROS-dependent MAPK/Akt/STAT3 pathways in human lung cancer cells.
Topics: Acetylcysteine; Apoptosis; Cell Line, Tumor; Drug Design; G1 Phase Cell Cycle Checkpoints; Humans; Lung Neoplasms; Mitogen-Activated Protein Kinases; Naphthoquinones; Phosphorylation; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; STAT3 Transcription Factor | 2019 |
Metabolic dependence of cyclosporine A on cell proliferation of human non‑small cell lung cancer A549 cells and its implication in post‑transplant malignancy.
Topics: A549 Cells; Acetylcysteine; Carcinogenesis; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Cyclosporine; Energy Metabolism; Free Radical Scavengers; Glucose; Graft Rejection; Humans; Immunosuppressive Agents; Lung Neoplasms; Organ Transplantation; Palmitic Acid; Reactive Oxygen Species; Signal Transduction | 2019 |
Mitochondrial dysfunction and therapeutic approaches in respiratory and limb muscles of cancer cachectic mice.
Topics: Acetylcysteine; Animals; Antioxidants; Boronic Acids; Bortezomib; Cachexia; Diaphragm; Electron Transport Chain Complex Proteins; Female; Lung Neoplasms; MAP Kinase Signaling System; Mice; Mitochondria; Mitochondrial Diseases; Mitogen-Activated Protein Kinases; Muscle Strength; Muscle, Skeletal; NF-kappa B; Oxidative Stress; Pyrazines | 2013 |
Zebularine inhibits the growth of A549 lung cancer cells via cell cycle arrest and apoptosis.
Topics: Acetylcysteine; Antioxidants; Apoptosis; Caspase 3; Caspase 8; Cell Line, Tumor; Cell Proliferation; Cytidine; DNA Modification Methylases; Down-Regulation; Fibroblasts; G1 Phase Cell Cycle Checkpoints; Glutathione; Humans; Lung Neoplasms; Membrane Potential, Mitochondrial; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; S Phase Cell Cycle Checkpoints; Thioredoxin Reductase 1; Tumor Suppressor Protein p53 | 2014 |
A hydroalcoholic extract from the leaves of Nerium oleander inhibits glycolysis and induces selective killing of lung cancer cells.
Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; BRCA2 Protein; Cardenolides; Cell Line, Tumor; Cell Survival; Cisplatin; DNA Damage; Glycolysis; Humans; Lung Neoplasms; Nerium; Plant Extracts; Plant Leaves; Plants, Medicinal; Reactive Oxygen Species | 2013 |
The antioxidant N-acetylcysteine prevents HIF-1 stabilization under hypoxia in vitro but does not affect tumorigenesis in multiple breast cancer models in vivo.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Antioxidants; Apoptosis; Carcinogenesis; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Epithelial-Mesenchymal Transition; Female; Glutathione; Hypoxia-Inducible Factor 1, alpha Subunit; Lung Neoplasms; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasm Transplantation; Neovascularization, Pathologic; Phenotype; Protein Stability; Tumor Burden; Vascular Endothelial Growth Factor A | 2013 |
Targeting 3-phosphoinositide-dependent protein kinase 1 by N-acetyl-cysteine through activation of peroxisome proliferators activated receptor alpha in human lung cancer cells, the role of p53 and p65.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Acetylcysteine; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Enzyme Activation; Gene Silencing; Humans; Lung Neoplasms; PPAR alpha; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Transcription Factor RelA; Transcriptional Activation; Tumor Suppressor Protein p53 | 2013 |
Replacement of a quinone by a 5-O-acetylhydroquinone abolishes the accidental necrosis inducing effect while preserving the apoptosis-inducing effect of renieramycin M on lung cancer cells.
Topics: Acetylcysteine; Alkaloids; Antineoplastic Agents; Apoptosis; Humans; Hydroquinones; Lung Neoplasms; Molecular Structure; Necrosis; Structure-Activity Relationship; Tetrahydroisoquinolines; Tumor Suppressor Protein p53 | 2013 |
Curcumin sensitizes lung adenocarcinoma cells to apoptosis via intracellular redox status mediated pathway.
Topics: Acetylcysteine; Adenocarcinoma; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Buthionine Sulfoximine; Caspase 3; Cell Line, Tumor; Curcumin; Drug Screening Assays, Antitumor; Enzyme Activation; Enzyme Induction; Glutamate-Cysteine Ligase; Glutathione; Humans; Lipid Peroxidation; Lung Neoplasms; MAP Kinase Signaling System; Oxidants; Oxidation-Reduction; Phosphorylation; Protein Processing, Post-Translational; Reactive Oxygen Species; RNA, Messenger; RNA, Neoplasm; Superoxides | 2012 |
Resveratrol enhances ionizing radiation-induced premature senescence in lung cancer cells.
Topics: Acetylcysteine; Antioxidants; Apoptosis; beta-Galactosidase; Carcinoma, Non-Small-Cell Lung; Cell Cycle Checkpoints; Cell Line, Tumor; Cellular Senescence; DNA Breaks, Double-Stranded; Humans; Lung Neoplasms; Phosphorylation; Proto-Oncogene Proteins c-akt; Radiation Tolerance; Radiation-Sensitizing Agents; Reactive Oxygen Species; Resveratrol; Ribonucleotide Reductases; Stilbenes; TOR Serine-Threonine Kinases | 2013 |
Antioxidants accelerate lung cancer progression in mice.
Topics: Acetylcysteine; Animals; Antioxidants; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Disease Progression; DNA Damage; Fibroblasts; Humans; Lung Neoplasms; Mice; Reactive Oxygen Species; Solubility; Tumor Suppressor Protein p53; Vitamin E | 2014 |
Biomedical research. Antioxidants could spur tumors by acting on cancer gene.
Topics: Acetylcysteine; Animals; Antioxidants; Carcinogens; Dietary Supplements; DNA Damage; Genes, Neoplasm; Humans; Lung Neoplasms; Mice; Smoking; Tumor Suppressor Protein p53; Vitamin E; Vitamins | 2014 |
ω-Hydroxyundec-9-enoic acid induces apoptosis through ROS-mediated endoplasmic reticulum stress in non-small cell lung cancer cells.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Caspase 6; Caspase 9; Cell Line, Tumor; Endoplasmic Reticulum Stress; Free Radical Scavengers; Gene Knockdown Techniques; Humans; Lung Neoplasms; Poly(ADP-ribose) Polymerases; Reactive Oxygen Species; Transcription Factor CHOP; Undecylenic Acids | 2014 |
Effects of flavonoid-induced oxidative stress on anti-H5N1 influenza a virus activity exerted by baicalein and biochanin A.
Topics: Acetylcysteine; Anticarcinogenic Agents; Antioxidants; Antiviral Agents; Cell Line, Tumor; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Flavanones; Flavonoids; Genistein; Host-Pathogen Interactions; Humans; Influenza A Virus, H5N1 Subtype; Lung Neoplasms; Macrophages; Monocytes; Oxidative Stress; Reactive Oxygen Species; Virus Replication | 2014 |
Enhanced apoptosis by pemetrexed and simvastatin in malignant mesothelioma and lung cancer cells by reactive oxygen species-dependent mitochondrial dysfunction and Bim induction.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Cell Line, Tumor; Drug Synergism; Gene Expression Regulation, Neoplastic; Glutamates; Guanine; Humans; Lung Neoplasms; Membrane Potential, Mitochondrial; Membrane Proteins; Mesothelioma; Mesothelioma, Malignant; Pemetrexed; Proto-Oncogene Proteins; Reactive Oxygen Species; Simvastatin | 2014 |
2014 American Thoracic Society International Conference.
Topics: Acetylcysteine; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal, Humanized; Asthma; Congresses as Topic; Eosinophilia; Expectorants; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Idiopathic Pulmonary Fibrosis; Indoles; Lung Neoplasms; Protein Kinase Inhibitors; Pulmonary Disease, Chronic Obstructive; Pyridones; Respiratory Distress Syndrome | 2014 |
1,3-Butadiene exposure and metabolism among Japanese American, Native Hawaiian, and White smokers.
Topics: Acetylcysteine; Asian; Butadienes; Female; Genotype; Glutathione Transferase; Hawaii; Humans; Japan; Lung Neoplasms; Male; Native Hawaiian or Other Pacific Islander; Sex Factors; Smoking; White People | 2014 |
Reactive oxygen species, glutathione, and thioredoxin influence suberoyl bishydroxamic acid-induced apoptosis in A549 lung cancer cells.
Topics: Acetylcysteine; Apoptosis; Cell Line, Tumor; Cell Proliferation; Glutathione; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Lung Neoplasms; Reactive Oxygen Species; Thioredoxins | 2015 |
Pemetrexed induces apoptosis in malignant mesothelioma and lung cancer cells through activation of reactive oxygen species and inhibition of sirtuin 1.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cytochromes c; Down-Regulation; Free Radical Scavengers; Humans; Lung Neoplasms; Membrane Potential, Mitochondrial; Mesothelioma; Mesothelioma, Malignant; Mitochondria; Pemetrexed; Reactive Oxygen Species; Sirtuin 1 | 2015 |
Cepharanthine induces apoptosis through reactive oxygen species and mitochondrial dysfunction in human non-small-cell lung cancer cells.
Topics: Acetylcysteine; Apoptosis; Benzylisoquinolines; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Humans; Lung Neoplasms; Membrane Potential, Mitochondrial; Reactive Oxygen Species | 2015 |
Elevated levels of mercapturic acids of acrolein and crotonaldehyde in the urine of Chinese women in Singapore who regularly cook at home.
Topics: Acetylcysteine; Acrolein; Aged; Aldehydes; Asian People; Benzene; Biomarkers; Carcinogens; Cooking; Female; Humans; Lung Neoplasms; Middle Aged; Singapore; Smoking | 2015 |
Comparative analysis of cell morphology in sputum samples homogenized with dithiothreitol, N-acetyl-L cysteine, Cytorich(®) red preservative and in cellblock preparations to enhance the sensitivity of sputum cytology for the diagnosis of lung cancer.
Topics: Acetylcysteine; Cytodiagnosis; Dithiothreitol; DNA, Neoplasm; Early Detection of Cancer; Humans; Immunohistochemistry; Lung; Lung Neoplasms; Preservatives, Pharmaceutical; Sensitivity and Specificity; Sputum; Tumor Cells, Cultured | 2015 |
Epigallocatechin-3-gallate enhances the therapeutic effects of leptomycin B on human lung cancer a549 cells.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Catechin; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Cytochrome P-450 CYP3A; Down-Regulation; Fatty Acids, Unsaturated; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Humans; Inhibitor of Apoptosis Proteins; Lung Neoplasms; Reactive Oxygen Species; Superoxide Dismutase; Survivin; Up-Regulation | 2015 |
Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer.
Topics: Acetylcysteine; Acrolein; Aged; Aldehydes; Ethnicity; Female; Hawaii; Humans; Lung Neoplasms; Male; Middle Aged; Risk Factors; Smoking | 2015 |
Sanguinarine-induced apoptosis in lung adenocarcinoma cells is dependent on reactive oxygen species production and endoplasmic reticulum stress.
Topics: Acetylcysteine; Adenocarcinoma; Adenocarcinoma of Lung; Apoptosis; Benzophenanthridines; Cell Line, Tumor; Cell Proliferation; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Gene Expression Regulation, Neoplastic; Humans; Isoquinolines; Lung Neoplasms; Reactive Oxygen Species | 2015 |
The antidiabetic compound 2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione, isolated from Averrhoa carambola L., demonstrates significant antitumor potential against human breast cancer cells.
Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Apoptosis; Averrhoa; Bone Neoplasms; Breast Neoplasms; Caspases; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclohexenes; Cytochromes c; Drug Screening Assays, Antitumor; Enzyme-Linked Immunosorbent Assay; Female; Humans; Hypoglycemic Agents; Inhibitory Concentration 50; Lung Neoplasms; MCF-7 Cells; NF-kappa B; Oxidative Stress; Phosphorylation; Reactive Oxygen Species; Tumor Necrosis Factor-alpha | 2015 |
Inhibition of NADPH oxidase 4 induces apoptosis in malignant mesothelioma: Role of reactive oxygen species.
Topics: Acetylcysteine; Apoptosis; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Mesothelioma; Mesothelioma, Malignant; NADPH Oxidase 4; NADPH Oxidases; Onium Compounds; Oxidative Stress; Reactive Oxygen Species; RNA, Messenger; Signal Transduction | 2015 |
Gallic acid induces apoptosis and enhances the anticancer effects of cisplatin in human small cell lung cancer H446 cell line via the ROS-dependent mitochondrial apoptotic pathway.
Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Cell Line, Tumor; Cell Shape; Cell Survival; Cisplatin; Drug Screening Assays, Antitumor; Drug Synergism; Gallic Acid; Humans; Lung Neoplasms; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Membranes; Reactive Oxygen Species; Small Cell Lung Carcinoma | 2016 |
Physalin A induces G2/M phase cell cycle arrest in human non-small cell lung cancer cells: involvement of the p38 MAPK/ROS pathway.
Topics: Acetylcysteine; Carcinoma, Non-Small-Cell Lung; Cell Division; Cell Line, Tumor; G2 Phase; Humans; Lung Neoplasms; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Reactive Oxygen Species; Withanolides | 2016 |
Cucurbitacin E induces caspase-dependent apoptosis and protective autophagy mediated by ROS in lung cancer cells.
Topics: Acetylcysteine; Apoptosis; Autophagy; Blotting, Western; Caspase 3; Caspase 7; Cell Line, Tumor; Cell Proliferation; Chloroquine; Drug Synergism; Humans; Lung Neoplasms; Macrolides; Membrane Potential, Mitochondrial; Microscopy, Fluorescence; Microtubule-Associated Proteins; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Triterpenes | 2016 |
Cedrol induces autophagy and apoptotic cell death in A549 non-small cell lung carcinoma cells through the P13K/Akt signaling pathway, the loss of mitochondrial transmembrane potential and the generation of ROS.
Topics: A549 Cells; Acetylcysteine; Apoptosis; Autophagosomes; Autophagy; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Cell Shape; Humans; L-Lactate Dehydrogenase; Lung Neoplasms; Membrane Potential, Mitochondrial; Phosphatidylinositol 3-Kinase; Polycyclic Sesquiterpenes; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; Terpenes | 2016 |
Paris Saponin II induced apoptosis via activation of autophagy in human lung cancer cells.
Topics: A549 Cells; Acetylcysteine; Apoptosis; Autophagy; Blotting, Western; Cell Line; Chloroquine; Glutathione; Humans; JNK Mitogen-Activated Protein Kinases; Lung Neoplasms; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Rhizome; Saponins; Signal Transduction | 2016 |
A Quinone-Containing Compound Enhances Camptothecin-Induced Apoptosis of Lung Cancer Through Modulating Endogenous ROS and ERK Signaling.
Topics: A549 Cells; Acetylcysteine; Antineoplastic Agents; Apoptosis; Benzoquinones; Camptothecin; Carcinoma, Non-Small-Cell Lung; Caspases; Cell Proliferation; Drug Resistance, Neoplasm; Drug Synergism; Drug Therapy, Combination; Humans; Lung Neoplasms; MAP Kinase Signaling System; Mitochondria; Putrescine; Reactive Oxygen Species | 2017 |
Effective killing of cancer cells and regression of tumor growth by K27 targeting sulfiredoxin.
Topics: A549 Cells; Acetylcysteine; Adenocarcinoma, Bronchiolo-Alveolar; Animals; Antineoplastic Agents; Antioxidants; Apoptosis; beta-Alanine; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Epithelial Cells; Female; Gene Expression; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mitochondria; Molecular Targeted Therapy; Oxidative Stress; Oxidoreductases Acting on Sulfur Group Donors; Quinazolines; Reactive Oxygen Species; Xenograft Model Antitumor Assays | 2016 |
Hypoxic resistance of KRAS mutant tumor cells to 3-Bromopyruvate is counteracted by Prima-1 and reversed by N-acetylcysteine.
Topics: A549 Cells; Acetylcysteine; Aza Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Cyclin-Dependent Kinase Inhibitor p21; Drug Resistance, Neoplasm; Free Radical Scavengers; Gene Expression Regulation, Neoplastic; Glucose Transporter Type 1; GTP Phosphohydrolases; Humans; Lung Neoplasms; Melanoma; Membrane Proteins; Mutation; Proto-Oncogene Proteins p21(ras); Pyruvates; Reverse Transcriptase Polymerase Chain Reaction; Tumor Suppressor Protein p53 | 2016 |
Genetic Determinants of 1,3-Butadiene Metabolism and Detoxification in Three Populations of Smokers with Different Risks of Lung Cancer.
Topics: Acetylcysteine; Aged; Asian; Biomarkers; Black or African American; Butadienes; Carcinogens; Female; Gene Deletion; Gene Dosage; Genome-Wide Association Study; Glutathione; Glutathione Transferase; Humans; Lung Neoplasms; Male; Middle Aged; Polymorphism, Single Nucleotide; Risk Factors; Smokers; Smoking; White People | 2017 |
Redox regulation in radiation-induced cytochrome c release from mitochondria of human lung carcinoma A549 cells.
Topics: Acetylcysteine; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Caspases; Cell Line, Tumor; Cytochromes c; Electron Spin Resonance Spectroscopy; Humans; Lung Neoplasms; Membrane Potential, Mitochondrial; Mitochondria; Oxidation-Reduction; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Superoxides | 2009 |
Prenatal N-acetylcysteine prevents cigarette smoke-induced lung cancer in neonatal mice.
Topics: Acetylcysteine; Adenocarcinoma, Bronchiolo-Alveolar; Animals; Animals, Newborn; Body Weight; Female; Free Radical Scavengers; Hyperplasia; Lung Neoplasms; Mice; Pregnancy; Prenatal Exposure Delayed Effects; Smoking | 2009 |
The effects of N-acetyl cysteine, buthionine sulfoximine, diethyldithiocarbamate or 3-amino-1,2,4-triazole on antimycin A-treated Calu-6 lung cells in relation to cell growth, reactive oxygen species and glutathione.
Topics: Acetylcysteine; Adenocarcinoma; Amitrole; Antimycin A; Buthionine Sulfoximine; Cell Line, Tumor; Cell Proliferation; Ditiocarb; Glutathione; Humans; Lung Neoplasms; Membrane Potential, Mitochondrial; Reactive Oxygen Species | 2009 |
Polyamine transporter recognization and antitumor effects of anthracenymethyl homospermidine.
Topics: Acetylcysteine; Animals; Anthracenes; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspase 9; Cell Line, Tumor; Cytochrome c Group; Dose-Response Relationship, Drug; Enzyme Activation; Gene Expression Regulation, Enzymologic; Lung Neoplasms; Matrix Metalloproteinases; Melanoma, Experimental; Membrane Transport Proteins; Mice; Mitochondria; Neoplasm Metastasis; Oxidative Stress; Polyamines; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Spermidine; Xenograft Model Antitumor Assays | 2009 |
Prevention of cigarette smoke-induced lung tumors in mice by budesonide, phenethyl isothiocyanate, and N-acetylcysteine.
Topics: Acetylcysteine; Animals; Animals, Newborn; Anticarcinogenic Agents; Budesonide; Disease Models, Animal; Female; Isothiocyanates; Lung Neoplasms; Male; Mice; Tobacco Smoke Pollution | 2010 |
'Flooding' of the lungs and severe dyspnea in a patient with bronchoalveolar carcinoma.
Topics: Acetylcysteine; Adenocarcinoma, Bronchiolo-Alveolar; Administration, Inhalation; Administration, Oral; Dyspnea; Expectorants; Female; Humans; Hyperhomocysteinemia; Lung; Lung Diseases; Lung Neoplasms; Middle Aged; Nebulizers and Vaporizers; Risk Factors; Severity of Illness Index; Sputum | 2011 |
The effects of N-acetyl cysteine on the MG132 proteasome inhibitor-treated lung cancer cells in relation to cell growth, reactive oxygen species and glutathione.
Topics: Acetylcysteine; Apoptosis; Buthionine Sulfoximine; Cell Line, Tumor; Cell Proliferation; Ditiocarb; Glutathione; Humans; Leupeptins; Lung Neoplasms; Membrane Potential, Mitochondrial; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Reactive Oxygen Species | 2010 |
Lack of contribution of covalent benzo[a]pyrene-7,8-quinone-DNA adducts in benzo[a]pyrene-induced mouse lung tumorigenesis.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Acetylcysteine; Animals; Benzo(a)pyrene; Carcinogens; DNA Adducts; Free Radical Scavengers; Humans; Lung Neoplasms; Male; Mice; Mice, Inbred A; Models, Biological; Phosphorus Radioisotopes; Polycyclic Aromatic Hydrocarbons | 2010 |
N-acetyl cysteine mitigates curcumin-mediated telomerase inhibition through rescuing of Sp1 reduction in A549 cells.
Topics: Acetylcysteine; Adenocarcinoma; Cell Line, Tumor; Cell Shape; Cell Survival; Curcumin; Down-Regulation; Humans; Lung Neoplasms; Reactive Oxygen Species; Sp1 Transcription Factor; Telomerase | 2010 |
Gallic acid-induced lung cancer cell death is related to glutathione depletion as well as reactive oxygen species increase.
Topics: Acetylcysteine; Antineoplastic Agents; Ascorbic Acid; Buthionine Sulfoximine; Cell Death; Cell Line, Tumor; Cell Proliferation; Gallic Acid; Glutathione; Humans; Lung Neoplasms; Oxidative Stress; Reactive Oxygen Species | 2010 |
Cytotoxicity and genotoxicity of silver nanoparticles in the human lung cancer cell line, A549.
Topics: Acetylcysteine; Antioxidants; Biological Transport; Carcinoma; Cell Death; Cell Line, Tumor; DNA Adducts; DNA Damage; Humans; Lung Neoplasms; Materials Testing; Metal Nanoparticles; Mitochondria; Mutagens; Oxidative Stress; Povidone; Pulmonary Alveoli; Reactive Oxygen Species; Silver; Silver Nitrate; Surface Properties | 2011 |
Isothiocyanates induce oxidative stress and suppress the metastasis potential of human non-small cell lung cancer cells.
Topics: Acetylcysteine; Antineoplastic Agents, Phytogenic; Antioxidants; beta Catenin; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Flow Cytometry; Glutathione; Humans; Inhibitory Concentration 50; Isothiocyanates; Lung Neoplasms; Matrix Metalloproteinase 2; Neoplasm Invasiveness; NF-kappa B; Nuclear Proteins; Oxidative Stress; Proto-Oncogene Proteins c-akt; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Transfection; Twist-Related Protein 1 | 2010 |
Thromboxane synthase suppression induces lung cancer cell apoptosis via inhibiting NF-κB.
Topics: Acetylcysteine; Active Transport, Cell Nucleus; Antioxidants; Apoptosis; Caspase 3; Caspase 9; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Cell Survival; Cytosol; Drug Synergism; Enzyme Inhibitors; Humans; I-kappa B Proteins; Imidazoles; Lung Neoplasms; Membrane Potential, Mitochondrial; NF-kappa B; NF-KappaB Inhibitor alpha; Nitriles; Phosphorylation; Poly(ADP-ribose) Polymerases; Reactive Oxygen Species; Sulfones; Thromboxane-A Synthase; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2010 |
Hydrogen peroxide inhibits non-small cell lung cancer cell anoikis through the inhibition of caveolin-1 degradation.
Topics: Acetylcysteine; Anoikis; Carcinoma, Non-Small-Cell Lung; Catalase; Caveolin 1; Cell Line, Tumor; Down-Regulation; Free Radical Scavengers; Humans; Hydrogen Peroxide; Lung Neoplasms; Proteasome Endopeptidase Complex; Ubiquitination | 2011 |
Intracellular glutathione content influences the sensitivity of lung cancer cell lines to methylseleninic acid.
Topics: Acetylcysteine; Apoptosis; Buthionine Sulfoximine; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Flow Cytometry; Glutathione; Glutathione Transferase; Humans; Lung Neoplasms; Microscopy, Fluorescence; Organoselenium Compounds; Oxidative Stress; Reactive Oxygen Species | 2012 |
Mitogen-activated protein kinase mediates the apoptosis of highly metastatic human non-small cell lung cancer cells induced by isothiocyanates.
Topics: Acetylcysteine; Antioxidants; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Cycle Checkpoints; Cell Line, Tumor; Cyclin B1; Gene Expression; Humans; Isothiocyanates; Lung Neoplasms; MAP Kinase Signaling System; Neoplasm Metastasis; Transcription Factor AP-1 | 2011 |
Ameliorative effects of dimetylthiourea and N-acetylcysteine on nanoparticles induced cyto-genotoxicity in human lung cancer cells-A549.
Topics: Acetylcysteine; Cell Line, Tumor; Cell Survival; Cytochrome P-450 CYP2E1; Cytokinesis; Cytoprotection; Cytotoxins; Free Radical Scavengers; Humans; Lung Neoplasms; Micronucleus Tests; Mutagens; Nanoparticles; Nanotubes, Carbon; Reactive Oxygen Species; Thiourea; Titanium | 2011 |
Transplacental antioxidants inhibit lung tumors in mice exposed to cigarette smoke after birth: a novel preventative strategy?
Topics: Acetylcysteine; Animals; Animals, Newborn; Antioxidants; Ascorbic Acid; Body Weight; Female; Lung Neoplasms; Maternal-Fetal Exchange; Mice; Nicotiana; Placenta; Pregnancy; Reactive Oxygen Species; Smoke; Survival | 2012 |
[Hypoxia upregulates the expression of annexin A1 in lung adenocarcinoma a549 cells].
Topics: Acetylcysteine; Active Transport, Cell Nucleus; Adenocarcinoma; Annexin A1; Antioxidants; Blotting, Western; Cell Hypoxia; Cell Line, Tumor; Cell Nucleus; Free Radical Scavengers; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; NF-kappa B; Pyrrolidines; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Thiocarbamates; Up-Regulation | 2012 |
Negative regulation of AMP-activated protein kinase (AMPK) activity by macrophage migration inhibitory factor (MIF) family members in non-small cell lung carcinomas.
Topics: Acetylcysteine; AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Antigens, Differentiation, B-Lymphocyte; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Deoxyglucose; Enzyme Activation; Free Radical Scavengers; Glucose; Histocompatibility Antigens Class II; Humans; Immunoblotting; Intramolecular Oxidoreductases; Lung Neoplasms; Macrophage Migration-Inhibitory Factors; Mutation; Oxidation-Reduction; Phosphorylation; Protein Serine-Threonine Kinases; Reactive Oxygen Species; RNA Interference; Signal Transduction; TOR Serine-Threonine Kinases | 2012 |
Chemoprevention by N-acetylcysteine of low-dose CT-induced murine lung tumorigenesis.
Topics: Acetylcysteine; Animals; Carcinogens; Cell Transformation, Neoplastic; Female; Free Radical Scavengers; Lung Neoplasms; Male; Mice; Mice, Inbred A; Neoplasms, Radiation-Induced; Nitrosamines; Tomography, X-Ray Computed | 2013 |
Cucurbitacin B potently suppresses non-small-cell lung cancer growth: identification of intracellular thiols as critical targets.
Topics: Acetylcysteine; Actin Cytoskeleton; Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Shape; Cell Survival; Dose-Response Relationship, Drug; Female; G2 Phase Cell Cycle Checkpoints; Glutathione; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; Humans; Lung Neoplasms; Mass Spectrometry; Mice; Mice, Nude; Mitochondria; Molecular Chaperones; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Signal Transduction; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Sulfhydryl Compounds; Time Factors; Triterpenes; Tumor Burden; Xenograft Model Antitumor Assays | 2013 |
N-acetil-l-cysteine and 2-amino-2-thiiazoline N-acetyl-l-cysteinate as a possible cancer chemopreventive agents in murine models.
Topics: Acetylcysteine; Adenoma; Animals; Anticarcinogenic Agents; Dose-Response Relationship, Drug; Female; Lung Neoplasms; Mice; Mice, Inbred BALB C; Models, Animal; Thiazoles | 2002 |
Nonradioactive iodide effectively induces apoptosis in genetically modified lung cancer cells.
Topics: Acetylcysteine; Animals; Apoptosis; Down-Regulation; Female; Humans; Inhibitor of Apoptosis Proteins; Iodide Peroxidase; Iodides; Lung Neoplasms; Mice; Mice, SCID; Microtubule-Associated Proteins; Neoplasm Proteins; Neoplasm Transplantation; Survivin; Symporters; Transplantation, Heterologous; Tumor Cells, Cultured | 2003 |
Suppression of metastasis by nuclear factor kappaB inhibitors in an in vivo lung metastasis model of chemically induced hepatocellular carcinoma.
Topics: Acetylcysteine; Animals; Aspirin; Blotting, Western; Carcinogens; Diethylnitrosamine; E-Selectin; Enzyme Inhibitors; Free Radical Scavengers; Intercellular Adhesion Molecule-1; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Neoplasm Metastasis; NF-kappa B; Nitrosamines; Pentoxifylline; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Vascular Cell Adhesion Molecule-1 | 2004 |
Prevention of hepatotoxicity but loss of antimelanoma effect with combined fotemustine and anti-oxidant treatment.
Topics: Acetylcysteine; Adult; Antineoplastic Agents; Antioxidants; Brain Neoplasms; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Lung Neoplasms; Melanoma; Nitrosourea Compounds; Organophosphorus Compounds; Treatment Outcome | 2004 |
Proteasomes act in the pre-mitochondrial signal transduction route towards roscovitine-induced apoptosis.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cysteine Proteinase Inhibitors; Humans; Leupeptins; Lung Neoplasms; Membrane Potentials; Mitochondria; Proteasome Endopeptidase Complex; Purines; Roscovitine; Signal Transduction; Tumor Cells, Cultured | 2004 |
Carcinogenic activity of cigarette smoke gas phase and its modulation by beta-carotene and N-acetylcysteine.
Topics: Acetylcysteine; Animals; Atmosphere Exposure Chambers; beta Carotene; Carcinogens; Free Radical Scavengers; Lung Neoplasms; Male; Metals; Mice; Nicotiana; Nitrosamines; Polycyclic Aromatic Hydrocarbons; Smoke | 2005 |
The role of reactive oxygen species (ROS) production on diallyl disulfide (DADS) induced apoptosis and cell cycle arrest in human A549 lung carcinoma cells.
Topics: Acetylcysteine; Allyl Compounds; Antineoplastic Agents; Antioxidants; Apoptosis; Carcinoma; Cell Cycle; Cell Proliferation; Cell Survival; Disulfides; Dose-Response Relationship, Drug; Humans; Lung Neoplasms; Reactive Oxygen Species; Tumor Cells, Cultured | 2005 |
Accumulation of p53 in response to adenovirus early region 1A sensitizes human cells to tumor necrosis factor alpha-induced apoptosis.
Topics: Acetylcysteine; Adenovirus E1A Proteins; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Humans; Lung Neoplasms; Recombinant Proteins; Transfection; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53 | 2005 |
Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice.
Topics: Acetylcysteine; Adenocarcinoma; Adenoma; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Body Weight; Carcinogens; Caspase 3; Caspases; Cell Growth Processes; Disease Progression; Female; In Situ Nick-End Labeling; Isothiocyanates; Lung Neoplasms; Mice; Mice, Inbred A; Nitrosamines; Smoking; Sulfoxides; Thiocyanates | 2005 |
Non-destructive micromethod for MRP1 functional assay in human lung tumor cells.
Topics: Acetylcysteine; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Buthionine Sulfoximine; Cell Culture Techniques; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Fluorometry; Glutathione; Humans; Immunohistochemistry; Lung Neoplasms; Multidrug Resistance-Associated Proteins; Propionates; Quinolines; Sensitivity and Specificity; Verapamil | 2006 |
Accumulation of hydrogen peroxide is an early and crucial step for paclitaxel-induced cancer cell death both in vitro and in vivo.
Topics: Acetylcysteine; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Free Radical Scavengers; Glutathione; Humans; Hydrogen Peroxide; Lung Neoplasms; Paclitaxel; Reactive Oxygen Species; Spectrometry, Fluorescence | 2006 |
The effect of N-acetylcysteine in combination with vitamin C on the activity of ornithine decarboxylase of lung carcinoma cells--In vitro.
Topics: Acetylcysteine; Ascorbic Acid; Cell Line, Tumor; Cell Proliferation; Cell Survival; DNA, Neoplasm; Dose-Response Relationship, Drug; Free Radical Scavengers; Humans; Lung Neoplasms; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; RNA, Neoplasm; Thymidine | 2006 |
Degradation of insulin-like growth factor-I receptor occurs via ubiquitin-proteasome pathway in human lung cancer cells.
Topics: Acetylcysteine; Cell Line; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Down-Regulation; Humans; Kinetics; Lung Neoplasms; Phosphorylation; Proteasome Endopeptidase Complex; Receptor, IGF Type 1; Tyrosine; Ubiquitin | 2006 |
Activation of ATM and histone H2AX phosphorylation induced by mitoxantrone but not by topotecan is prevented by the antioxidant N-acetyl-L-cysteine.
Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Cell Cycle; Cell Cycle Proteins; DNA Damage; DNA-Binding Proteins; Flow Cytometry; Fluorescent Antibody Technique; Histones; HL-60 Cells; Humans; Lung Neoplasms; Mitoxantrone; Phosphorylation; Protein Serine-Threonine Kinases; Topotecan; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2006 |
Protein kinase C-ERK1/2 signal pathway switches glucose depletion-induced necrosis to apoptosis by regulating superoxide dismutases and suppressing reactive oxygen species production in A549 lung cancer cells.
Topics: Acetylcysteine; Antioxidants; Apoptosis; Apoptosis Inducing Factor; Caspase 3; Caspase 9; Catalase; Cell Line, Tumor; Cell Survival; Endodeoxyribonucleases; Enzyme Activation; Enzyme Induction; Enzyme Stability; Extracellular Signal-Regulated MAP Kinases; Glucose; HMGB1 Protein; Humans; Lung Neoplasms; Mitochondria; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Necrosis; Protein Kinase C; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Time Factors | 2007 |
Reactive oxygen species independent cytotoxicity induced by radiocontrast agents in tubular cells (LLC-PK1 and MDCK).
Topics: Acetylcysteine; Animals; Antioxidants; Cell Hypoxia; Cell Line; Cell Line, Tumor; Cell Survival; Contrast Media; Dogs; Kidney; L-Lactate Dehydrogenase; Lung Neoplasms; Necrosis; Radioisotopes; Reactive Oxygen Species; Swine | 2007 |
Kaempferol induces apoptosis in human lung non-small carcinoma cells accompanied by an induction of antioxidant enzymes.
Topics: Acetylcysteine; Adenosine Triphosphate; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Apoptosis Inducing Factor; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Caspase 3; Cell Line, Tumor; Cell Survival; Enzyme Induction; Flow Cytometry; Free Radical Scavengers; Humans; Immunohistochemistry; Kaempferols; L-Lactate Dehydrogenase; Lung Neoplasms; Membrane Potentials; Mitochondria; Neoplasm Proteins; Reactive Oxygen Species | 2007 |
Lung cancer chemoprevention: ACCP evidence-based clinical practice guidelines (2nd Edition).
Topics: Acetylcysteine; alpha-Tocopherol; Anticarcinogenic Agents; Aspirin; beta Carotene; Chemoprevention; Clinical Trials, Phase III as Topic; Evidence-Based Medicine; Humans; Isotretinoin; Lung Neoplasms; United States; Vitamin A | 2007 |
Constitutive activation of c-Met is correlated with c-Met overexpression and dependent on cell-matrix adhesion in lung adenocarcinoma cell lines.
Topics: Acetylcysteine; Adenocarcinoma; Animals; Antibodies; Blotting, Western; Cadherins; Cell Adhesion; Cell Line, Tumor; Culture Media, Conditioned; DNA, Neoplasm; Dogs; Down-Regulation; Extracellular Matrix; Hepatocyte Growth Factor; Humans; Lung Neoplasms; Oligonucleotide Array Sequence Analysis; Phosphorylation; Polymorphism, Single Nucleotide; Proto-Oncogene Proteins c-met; Tyrosine | 2008 |
N-Acetylcysteine enhances the lung cancer inhibitory effect of epigallocatechin-3-gallate and forms a new adduct.
Topics: Acetylcysteine; Animals; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Apoptosis; Catechin; Cell Line, Tumor; Cell Proliferation; Chromatography, High Pressure Liquid; Flow Cytometry; Humans; Lung Neoplasms; Mice; Radiation-Protective Agents | 2008 |
A combination of sulindac and arsenic trioxide synergistically induces apoptosis in human lung cancer H1299 cells via c-Jun NH2-terminal kinase-dependent Bcl-xL phosphorylation.
Topics: Acetylcysteine; Apoptosis; Arsenic Trioxide; Arsenicals; bcl-X Protein; Carcinoma, Non-Small-Cell Lung; Caspases; Cell Line, Tumor; Drug Synergism; Humans; JNK Mitogen-Activated Protein Kinases; Lung Neoplasms; Membrane Potential, Mitochondrial; Mitochondria; Oxides; Phosphorylation; Reactive Oxygen Species; Signal Transduction; Sulindac | 2008 |
Pilot study of intravenous ifosfamide plus oral acetylcysteine in the treatment of non-small cell lung cancer.
Topics: Acetylcysteine; Adenocarcinoma; Administration, Oral; Carcinoma; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Cyclophosphamide; Drug Therapy, Combination; Female; Humans; Ifosfamide; Infusions, Parenteral; Lung Neoplasms; Male; Pilot Projects | 1981 |
N-acetylcysteine: its bioavailability and interaction with ifosfamide metabolites.
Topics: Acetates; Acetylcysteine; Biological Availability; Carcinoma, Bronchogenic; Chemical Phenomena; Chemistry; Chromatography, Gas; Chromatography, Ion Exchange; Cyclophosphamide; Drug Interactions; Humans; Ifosfamide; Kinetics; Lung Neoplasms; Time Factors | 1983 |
Phase I clinical study of acetylcysteine's preventing ifosfamide-induced hematuria.
Topics: Acetylcysteine; Acrolein; Adenocarcinoma; Carcinoma, Squamous Cell; Cyclophosphamide; Cystitis; Dose-Response Relationship, Drug; Drug Evaluation; Drug Therapy, Combination; Hematuria; Humans; Ifosfamide; Lung Neoplasms | 1983 |
The control of ifosfamide-induced hematuria with N-acetylcysteine in patients with advanced carcinoma of the lung.
Topics: Acetylcysteine; Administration, Oral; Cyclophosphamide; Female; Hematuria; Humans; Ifosfamide; Lung Neoplasms; Male; Random Allocation | 1982 |
Inhibition of invasion, gelatinase activity, tumor take and metastasis of malignant cells by N-acetylcysteine.
Topics: 3T3 Cells; Acetylcysteine; Animals; Carcinoma, Lewis Lung; Cell Movement; Gelatinases; Glutathione; Glutathione Disulfide; Humans; Lung Neoplasms; Melanoma; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Mice, Nude; Neoplasm Invasiveness; Sarcoma, Experimental; Tumor Cells, Cultured | 1995 |
N-acetylcysteine for lung cancer prevention.
Topics: Acetylcysteine; Humans; Lung Neoplasms | 1995 |
Effect of N-acetyl cysteine on the concentrations of thiols in plasma, bronchoalveolar lavage fluid, and lung tissue.
Topics: Acetylcysteine; Adult; Aged; Bronchoalveolar Lavage Fluid; Bronchoscopy; Carcinoma, Bronchogenic; Drug Administration Schedule; Female; Glutathione; Humans; Lung; Lung Diseases, Obstructive; Lung Neoplasms; Male; Middle Aged; Pneumonectomy | 1994 |
Activation of potassium channels by hypoxia and reoxygenation in the human lung adenocarcinoma cell line A549.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcysteine; Adenocarcinoma; Alkaloids; Free Radical Scavengers; Humans; Hypoxia; Isoquinolines; Lung Neoplasms; Oxidation-Reduction; Oxygen; Piperazines; Potassium Channels; Protein Kinase Inhibitors; Protein Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Tetraethylammonium; Tetraethylammonium Compounds; Time Factors; Tumor Cells, Cultured | 1993 |
Bronchoalveolar lavage fluid findings following radiotherapy for non-small cell lung cancer.
Topics: Acetylcysteine; Adult; Aged; Bronchoalveolar Lavage Fluid; Carcinoma, Non-Small-Cell Lung; Female; Humans; Interferon-alpha; Lung Neoplasms; Male; Middle Aged; Pneumonia; Radiation-Protective Agents; Radiation-Sensitizing Agents; Radiotherapy | 1993 |
Chemopreventive efficacy of arylalkyl isothiocyanates and N-acetylcysteine for lung tumorigenesis in Fischer rats.
Topics: Acetylcysteine; Analysis of Variance; Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Chi-Square Distribution; Diet; Free Radical Scavengers; Incidence; Isothiocyanates; Leukemia, Experimental; Leydig Cell Tumor; Lung Neoplasms; Lymphoma; Male; Nicotiana; Nitrosamines; Pancreatic Neoplasms; Plants, Toxic; Rats; Rats, Inbred F344; Survival Rate; Testicular Neoplasms | 1996 |
Synergism between N-acetylcysteine and doxorubicin in the prevention of tumorigenicity and metastasis in murine models.
Topics: Acetylcysteine; Animals; Antineoplastic Combined Chemotherapy Protocols; Disease Models, Animal; Doxorubicin; Drug Screening Assays, Antitumor; Drug Synergism; Female; Lung Neoplasms; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Mice, Nude; Survival Analysis | 1996 |
Studies on the basis for the toxicity of acrolein mercapturates.
Topics: Acetylcysteine; Acrolein; Adenocarcinoma; Cyclophosphamide; Growth Inhibitors; Humans; Lung Neoplasms; Tumor Cells, Cultured | 1996 |
Smokers and urinary genotoxins: implications for selection of cohorts and modulation of endpoints in chemoprevention trials.
Topics: Acetylcysteine; Adult; Anticarcinogenic Agents; Biomarkers, Tumor; Chemoprevention; China; Clinical Trials, Phase II as Topic; Cohort Studies; DNA Repair; Female; Humans; Lung Neoplasms; Male; Middle Aged; Mutagenicity Tests; Mutagens; Netherlands; Pyrazines; Research Design; Smoking; Thiones; Thiophenes | 1996 |
Role of oxidants in influenza virus-induced gene expression.
Topics: Acetylcysteine; Animals; Base Sequence; Binding Sites; Chick Embryo; Epithelial Cells; Gene Expression Regulation; Humans; Influenza A virus; Interleukin-8; Lung Neoplasms; NF-kappa B; Nuclear Proteins; Oligodeoxyribonucleotides; Reactive Oxygen Species; RNA, Messenger; Sp1 Transcription Factor; Superoxide Dismutase; Transcription, Genetic; Tumor Cells, Cultured | 1998 |
Chemopreventive potential of fumaric acid, N-acetylcysteine, N-(4-hydroxyphenyl) retinamide and beta-carotene for tobacco-nitrosamine-induced lung tumors in A/J mice.
Topics: Acetylcysteine; Animals; Anticarcinogenic Agents; beta Carotene; Carcinogens; Dose-Response Relationship, Drug; Female; Fenretinide; Fumarates; Lung Neoplasms; Mice; Mice, Inbred A; Nicotiana; Nitrosamines; Plants, Toxic | 1998 |
Activator protein-1 is the preferred transcription factor for cooperative interaction with nuclear factor-kappaB in respiratory syncytial virus-induced interleukin-8 gene expression in airway epithelium.
Topics: Acetylcysteine; Antioxidants; Cell Line; Cell Nucleus; Chloramphenicol O-Acetyltransferase; Cyclic N-Oxides; Dimethyl Sulfoxide; Epithelial Cells; Gene Expression Regulation, Neoplastic; Humans; Interleukin-8; Lung Neoplasms; NF-kappa B; Recombinant Proteins; Respiratory Syncytial Viruses; Transcription Factor AP-1; Transfection; Tumor Cells, Cultured | 1998 |
Chemoprevention by N-acetylcysteine of urethane-induced clastogenicity and lung tumors in mice.
Topics: Acetylcysteine; Administration, Oral; Animals; Anticarcinogenic Agents; Antimutagenic Agents; Body Weight; Carcinogens; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Micronuclei, Chromosome-Defective; Time Factors; Urethane | 1998 |
Inhibition by oral N-acetylcysteine of doxorubicin-induced clastogenicity and alopecia, and prevention of primary tumors and lung micrometastases in mice.
Topics: Acetylcysteine; Administration, Oral; Alopecia; Animals; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Doxorubicin; Drug Synergism; Erythrocytes; Female; Free Radical Scavengers; Lung Neoplasms; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Micronuclei, Chromosome-Defective; Mutagens; Neoplasm Transplantation | 1998 |
Effects of Cr(VI) on the expression of the oxidative stress genes in human lung cells.
Topics: Acetylcysteine; Actins; Carcinogens, Environmental; Cell Line; Chromium; Glutathione; Heme Oxygenase (Decyclizing); Humans; Lung Neoplasms; Oxidative Stress; Polymerase Chain Reaction; RNA, Messenger; Superoxide Dismutase; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1998 |
Environmental particulate-mediated cytokine production in lung epithelial cells (A549): role of preexisting inflammation and oxidant stress.
Topics: Acetylcysteine; Adenocarcinoma, Bronchiolo-Alveolar; Air Pollution; Antioxidants; Carbon; Chromans; Coal Ash; Dose-Response Relationship, Drug; Epithelial Cells; Flow Cytometry; Fluoresceins; Free Radical Scavengers; Humans; Industrial Waste; Interleukin-8; Lung; Lung Neoplasms; Oxidative Stress; Particle Size; Particulate Matter; Petroleum; Piperazines; Pneumonia; Quartz; Titanium; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1998 |
The effects of phenethyl isothiocyanate, N-acetylcysteine and green tea on tobacco smoke-induced lung tumors in strain A/J mice.
Topics: Acetylcysteine; Animals; Anticarcinogenic Agents; Female; Isothiocyanates; Lung Neoplasms; Male; Mice; Nicotiana; Plants, Toxic; Smoke; Tea | 1998 |
Hydrogen peroxide mediates doxorubicin-induced transglutaminase 2 expression in PC-14 human lung cancer cell line.
Topics: Acetylcysteine; Antineoplastic Agents; Doxorubicin; Enzyme Induction; Gene Expression Regulation, Enzymologic; Glutathione; Humans; Hydrogen Peroxide; Lung Neoplasms; Reactive Oxygen Species; Transglutaminases; Tumor Cells, Cultured | 1999 |
Induction of tumor suppression and glandular differentiation of A549 lung carcinoma cells by dominant-negative IGF-I receptor.
Topics: Acetylcysteine; Adenocarcinoma; Animals; Apoptosis; Carcinogenicity Tests; Cell Differentiation; Cell Division; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Genes, Dominant; Genes, Tumor Suppressor; Humans; Leupeptins; Lung Neoplasms; Mice; Mice, Nude; Multienzyme Complexes; Phosphorylation; Proteasome Endopeptidase Complex; Receptor, IGF Type 1; Tumor Cells, Cultured; Ultraviolet Rays | 1999 |
Effective elimination of lung metastases induced by tumor cells treated with hydrostatic pressure and N-acetyl-L-cysteine.
Topics: Acetylcysteine; Adenosine; Animals; CD4 Antigens; CD8 Antigens; Female; Humans; Hydrostatic Pressure; Hypersensitivity, Delayed; Lung; Lung Neoplasms; Lymphocyte Culture Test, Mixed; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasm Metastasis; Spleen | 2000 |
Chemoprevention of lung cancer is proving difficult and frustrating, requiring new approaches.
Topics: Acetylcysteine; Anticarcinogenic Agents; beta Carotene; Carcinogens; Diterpenes; Glucuronides; Glutathione; Humans; Lung Neoplasms; Randomized Controlled Trials as Topic; Retinyl Esters; Vitamin A | 2000 |
[Arg(6), D-Trp(7,9), N(me)Phe(8)]-substance P (6-11) (antagonist G) induces AP-1 transcription and sensitizes cells to chemotherapy.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Small Cell; Cell Division; CHO Cells; Cricetinae; Drug Synergism; Etoposide; Free Radical Scavengers; Glutathione; Growth Inhibitors; JNK Mitogen-Activated Protein Kinases; Lipid Peroxidation; Lung Neoplasms; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Oligopeptides; Oxidation-Reduction; Reactive Oxygen Species; Stimulation, Chemical; Transcription Factor AP-1; Transcription, Genetic; Tumor Cells, Cultured | 2000 |
Interactions between N-acetylcysteine and ascorbic acid in modulating mutagenesis and carcinogenesis.
Topics: Acetylcysteine; Animals; Ascorbic Acid; Carcinogenicity Tests; Cell Transformation, Neoplastic; Chromium; Drug Stability; Female; Lung Neoplasms; Mice; Mutagenesis; Urethane | 2000 |
Pilot studies evaluating the lung tumor yield in cigarette smoke-exposed mice.
Topics: Acetylcysteine; Adenoma; Animals; Body Weight; Butylated Hydroxytoluene; Chlorodiphenyl (54% Chlorine); Cytogenetic Analysis; DNA Damage; DNA, Neoplasm; Female; Incidence; Injections, Intraperitoneal; Lung Neoplasms; Mice; Mice, Hairless; Mice, Inbred C57BL; Pilot Projects; Smoking | 2001 |
Therapeutic efficacy of aortic administration of N-acetylcysteine as a chemoprotectant against bone marrow toxicity after intracarotid administration of alkylators, with or without glutathione depletion in a rat model.
Topics: Acetylcysteine; Animals; Antimetabolites; Antineoplastic Agents, Alkylating; Aorta, Thoracic; Blood-Brain Barrier; Bone Marrow Diseases; Brain; Brain Neoplasms; Buthionine Sulfoximine; Carcinoma, Small Cell; Dose-Response Relationship, Drug; Drug Interactions; Female; Glutathione; Infusions, Intra-Arterial; Lung Neoplasms; Rats; Rats, Long-Evans; Tissue Distribution; Xenograft Model Antitumor Assays | 2001 |
Inhibition of benzo(a)pyrene-induced lung tumorigenesis in A/J mice by dietary N-acetylcysteine conjugates of benzyl and phenethyl isothiocyanates during the postinitiation phase is associated with activation of mitogen-activated protein kinases and p53 a
Topics: Acetylcysteine; Animals; Anticarcinogenic Agents; Apoptosis; bcl-2-Associated X Protein; Benzo(a)pyrene; Carcinogens; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Enzyme Activation; Female; Gene Expression Regulation, Neoplastic; Isothiocyanates; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Mitogen-Activated Protein Kinases; NF-kappa B; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Transcription Factor AP-1; Tumor Suppressor Protein p53 | 2002 |
Expression of cyclin D1/2 in the lungs of strain A/J mice fed chemopreventive agents.
Topics: Acetylcysteine; Animals; Anticarcinogenic Agents; Aspirin; Blotting, Western; Cell Nucleus; Cyclin D1; Cyclin D2; Cyclins; Cyclohexenes; Dexamethasone; Free Radical Scavengers; Immunohistochemistry; Inositol; Isothiocyanates; Limonene; Lung; Lung Neoplasms; Male; Mice; Nicotiana; Organoselenium Compounds; Tea; Terpenes; Time Factors | 2002 |
Respiratory syncytial virus and TNF alpha induction of chemokine gene expression involves differential activation of Rel A and NF-kappa B1.
Topics: Acetylcysteine; Antiviral Agents; Chemokines; Dexamethasone; Free Radical Scavengers; Gene Expression Regulation, Neoplastic; Glucocorticoids; Humans; Lung Neoplasms; NF-kappa B; Oxidation-Reduction; Respiratory Syncytial Viruses; Signal Transduction; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2002 |
Biomarker assessments in asbestos-exposed workers as indicators for selective prevention of mesothelioma or bronchogenic carcinoma: rationale and practical implementations.
Topics: Acetylcysteine; Antigens, Neoplasm; Asbestos; Ascorbic Acid; beta Carotene; Biomarkers, Tumor; Carcinoembryonic Antigen; Carcinoma, Bronchogenic; Carotenoids; Cohort Studies; Ferritins; Humans; Hyaluronic Acid; Longitudinal Studies; Lung Neoplasms; Male; Mesothelioma; Middle Aged; Occupational Diseases; Occupational Exposure; Peptides; Riboflavin; Selenium; Tissue Polypeptide Antigen; Vitamin A; Vitamin E | 1992 |
Effect of N-acetylcysteine on the antiproliferative action of X-rays or bleomycin in cultured human lung tumor cells.
Topics: Acetylcysteine; Bleomycin; Cell Survival; Glutathione; Humans; Lung Neoplasms; Radiation Tolerance; Tumor Cells, Cultured | 1989 |
Inhibition of urethan-induced lung tumors in mice by dietary N-acetylcysteine.
Topics: Acetylcysteine; Animals; Diet; Glutathione; Lung Neoplasms; Male; Mice; Urethane | 1986 |
Metabolic, desmutagenic and anticarcinogenic effects of N-acetylcysteine.
Topics: Acetylcysteine; Animals; Biotransformation; Carcinogens; Glutathione; Humans; Lung Neoplasms; Mutagens; Mutation; Smoking | 1986 |
Potentially useful combinations of chemotherapy detected in mouse tumor systems.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Azauridine; Bleomycin; Camptothecin; Cyclic P-Oxides; Cyclophosphamide; Cytarabine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Ethylamines; Fluorouracil; Imidazoles; Leukemia L1210; Lung Neoplasms; Methotrexate; Mice; Neoplasms, Experimental; Oxazines; Piperazines; Procarbazine; Propane; Triazenes | 1974 |
[Use of acetylcysteine combined with thiamphenicol by intramuscular route in the preparation of the tracheo-bronchial tree for oncological thoracic surgery].
Topics: Acetylcysteine; Bronchial Neoplasms; Chloramphenicol; Esophageal Neoplasms; Humans; Injections, Intramuscular; Lung Neoplasms; Male; Preoperative Care; Thoracic Neoplasms; Tracheal Neoplasms | 1971 |