acetylcysteine and Liver Neoplasms

acetylcysteine has been researched along with Liver Neoplasms in 111 studies

Research

Studies (111)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's9 (8.11)18.2507
2000's41 (36.94)29.6817
2010's52 (46.85)24.3611
2020's9 (8.11)2.80

Authors

AuthorsStudies
Du, XM; Guo, SJ; Liu, GY; Sun, YZ; Yang, J; Zhou, N1
Cao, Y; Che, D; Dai, F; Fan, R; Feng, Y; Gao, L; Gao, M; Ge, C; Li, J; Wang, C; Wang, S; Wang, Y; Xie, S; Xu, X1
Ding, Y; Fang, Y; Li, G; Liang, L; Liu, Y; Xie, Y; Zhan, Y; Zhang, Z; Zheng, Y1
Claimon, T; Sethasine, S; Simasingha, N; Tanasoontrarat, W1
Aki, T; Funakoshi, T; Tanaka, H; Uemura, K; Unuma, K1
Banerjee, S; Banki, K; Beckford, M; Grossman, CC; Jimah, J; Kansu, A; Kelly, R; Kuloglu, Z; Lee, W; Miklossy, G; Niland, B; Oaks, Z; Perl, A; Szonyi, L1
Dai, X; Kong, L; Li, Z; Sun, Y; Wang, Q; Wang, X; Zhong, W; Zhou, H1
Cao, MM; Li, YM; Sun, B; Xu, C; Yang, LY; Yu, L; Zhao, YR1
Lee, H; Li, Y; Song, K; Tang, T1
Chen, A; Chen, L; Chen, S; Dai, X; He, F; Huang, C; Jiang, Y; Li, S; Li, T; Lian, J; Sun, L; Xiang, L; Xiao, H; Yan, X; Yang, M; Zhang, Y1
Chen, H; Ding, W; Li, M; Li, Y; Lin, N; Meng, J; Su, Q; Tong, X; Wu, L; Yang, D; Zhu, Y1
Cao, DD; Chen, X; Deng, JJ; Lei, JJ; Shi, L; Xu, XM; Yuan, GJ1
Satoh, K1
Bai, Y; Chu, Q; Jiang, L; Liu, X; Sun, M; Sun, X; Wang, S; Wu, X; Yang, G; Yao, X; Zhang, C1
Fang, SH; Fu, YJ; Gao, C; Li, J; Wang, P; Wang, W; Yao, LP; Zhang, J; Zhang, SD1
Choi, C; Lee, HS; Lee, YJ; Park, HC; Son, A1
Fang, XY; Ren, QC; Shen, XF; Tan, S; Wang, L; Zhang, H; Zhao, L1
Chen, JJ; Chen, Y; Shang, XY; Song, SJ; Song, XY; Wang, W; Yao, GD1
Alarifi, S; Ali, D; Alkahtani, S; Almeer, RS1
Nazim, UM; Park, SY1
Bhanthumkomol, P; Chonprasertsuk, S; Kaewmanee, M; Phumyen, A; Pornthisarn, B; Punjachaipornpon, T; Siramolpiwat, S; Tangaroonsanti, A; Vilaichone, RK; Yasiri, A1
Ahmad Khan, MK; Khan, M; Li, T; Ma, T; Nawaz, F; Rasul, A; Sun, M; Zheng, Y1
Lu, YX; Yu, XC; Zhu, MY1
Hu, ZW; Hua, F; Lin, H; Liu, XB; Yu, JJ1
Bagia, S; Quinn, L1
Egnatchik, RA; Leamy, AK; Noguchi, Y; Shiota, M; Young, JD1
Bruno, RS; Chong, L; Freake, HC; Sankavaram, K1
Wang, H; Ye, Y; Yu, ZL1
Dai, Y; Huang, G; Liu, J; Qin, W; Sheng, S; Wang, H; Xiong, X1
Ercal, N; Fan, W; Khayyat, A; Tobwala, S1
Gao, B; Gao, JP; Li, J; Li, YY; Lin, P; Liu, ZP1
Fujii, H; Hai, H; Kawada, N; Kubo, S; Matsumoto, Y; Morita, T; Motoyama, H; Suoh, M; Takemura, S; Tamori, A; Thuy, le TT; Thuy, TT; Urahara, Y; Yoshizato, K1
Lai, Y; Li, Y; Luo, Q; Zhang, Z1
Cao, M; Fang, F; Gao, J; Guo, Z; Huang, J; Song, T; You, A; Zhang, T; Zhang, W; Zhou, H1
Jiang, Y; Meng, Z; Wang, P; Xu, L; Yang, P; Yong, P; Zhang, C; Zhang, H; Zhuang, L1
Cai, Y; Chen, XL; Liu, RR; Lv, YS; Tang, YX; Wang, YF; Xie, SZ; Yu, J; Zhang, XN; Zheng, XX1
Cimino, M; Corazzi, F; Costa, G; Donadon, M; Molinari, AF; Raimondi, F; Rocchi, L; Torzilli, G; Zito, P1
Hu, X; Lei, L; Liang, J; Liu, L; Sun, J; Wu, D; Zou, X1
He, JD; Li, SP; Shen, ZY; Wang, CY; Wang, Z; Xu, HX; Xu, YJ; Yao, Z; Yu, Y; Zhang, HM; Zhang, JJ; Zhang, RX1
Gui, G; Huangfu, CS; Li, LJ; Liang, HX; Liu, B; Meng, SS1
Chen, T; Pang, Y; Qin, G; Wang, X; Wu, L; Wu, S; Xi, G1
Lim, IK; Lim, YB; Park, TJ1
Banerjee, S; Banki, K; Barcza, M; Barrett, D; Doherty, E; Fernandez, DR; Garba, A; Hanczko, R; Landas, SK; Middleton, FA; Niland, B; Perl, A; Qian, Y; Telarico, T; Vas, G1
Guo, Q; Liu, W; Lu, N; Nie, F; Qi, Q; Wu, Z; Yang, L; Yang, Y; You, Q; Zhang, X1
Lee, WY; Liu, KW; Yeung, JH1
Hur, JM; Hyun, MS; Kim, D; Lee, WY; Lim, SY1
Alisi, A; Bottazzo, GF; Nobili, V; Panera, N; Passarelli, C; Pastore, A; Petrini, S; Piemonte, F; Pietrobattista, A; Tozzi, G1
Chang, WY; Choi, YH; Hyun, JW; Kim, GY; Kim, MO; Moon, DO1
Czauderna, P; Fuchs, J; Knap, N; Losin, M; Neuwelt, AJ; Neuwelt, EA; Pagel, MA; Warmann, S; Wozniak, M; Wu, YJ1
Chen, RH; Feng, B; Guo, YW; Huang, CG; Jiao, BH; Li, L1
Dymkowska, D; Wojtczak, L1
Unger, EC1
Chen, CY; Chen, YZ; Cheng, JT; Chern, CL; Liu, TZ; Tai, CJ; Yiin, SJ; Zheng, JJ1
Fu, Y; Liu, TT; Wang, K; Wang, Q; Yang, XG1
Edwards, F; Haile, S; Tchounwou, CK; Tchounwou, PB; Yedjou, CG1
Kim, Y; Klaunig, JE; Misse, A; Monga, SP; Singh, S; Tan, X; Zeng, G; Zhang, XF1
Deng, R; Feng, GK; Gao, YH; Jiang, S; Li, DD; Li, HJ; Wei, ZX; Wu, KW; Wu, XQ; Yang, F; Zhu, XF1
Cao, JG; Liu, F; Lv, Y; Xiang, HL; Yang, XH; Zheng, X1
Ha, HL; Yu, DY1
Liu, H; Ruan, J; Wei, A; Xiao, Y; Xiong, C1
Itoh, Y; Iwai, M; Jo, M; Kagawa, K; Minami, M; Mitsuyoshi, H; Nakajima, T; Nishikawa, T; Okada, Y; Yamaguchi, K; Yasui, K; Yoshikawa, T1
Aksenov, ND; Filatova, NA; Gamaleĭ, IA; Kirpichnikova, KM; Vakhromova, EA1
Jung, G; Lim, SO; Quan, X1
Fujita, J; Higashitsuji, H; Itoh, K; Kudo, M; Ryu, U; Sakurai, T1
Azzolina, A; Cervello, M; Lampiasi, N; McCubrey, JA; Montalto, G; Umezawa, K1
Antus, C; Engelmann, P; Gallyas, F; Lorand, T; Priber, JK; Racz, B; Radnai, B; Sumegi, B; Tucsek, Z; Turi, Z; Veres, B1
Akimoto, M; Hisanaga, T; Honma, Y; Shimojo, Y; Tajima, Y; Takenaga, K; Tanaka, T1
Choi, YH; Choi, YW; Han, MH; Kim, GY; Kim, HJ1
Cheng, P; Dai, X; Ding, W; He, F; Lian, J; Ni, Z; Rae Smith, A; Wang, B; Wu, D; Xu, L1
Chang, C; Chapman, PB; Fleisher, M; Hwu, WJ; Krown, SE; Livingston, PO; Pinto, JT; Williams, L; Wolchok, JD1
Barelli, D; Cantoni, L; Castell, JV; Hauri, L; Mangolini, A; Ponsoda, X; Rizzardini, M; Valaperta, R; Villa, P1
Hirsh, M; Iancu, TC; Manov, I2
Bulla, GA; Kraus, DM; Schmitz, EK1
Brauchle, MA; Caselmann, WH; Gehrke, R; Gruetzner, U; Hildt, E; Hofschneider, PH; Rabe, C; Reifenberg, K; Schlicht, HJ; Schmitz, V1
Chen, J; Kang, J; Lin, C; Liu, Q; Zhang, D1
Goldenberg, JA; Kobrinsky, NL; Ortmeier, TC; Sjolander, DE1
Lin, CC; Ng, LT; Wu, SJ1
Hwang, ES; Jeffery, EH1
Fukushima, S; Hayashi, S; Kinoshita, A; Morimura, K; Nishikawa, T; Nishikawa-Ogawa, M; Wanibuchi, H; Yano, Y1
Adamsky, K; Amariglio, N; Breda, L; Cabantchik, ZI; Rachmilewitz, EA; Rechavi, G; Rivella, S; Weizer-Stern, O1
Frumin, I; Iancu, TC; Manov, I; Motanis, H1
Hwang, ES; Lee, HJ2
Fu, Q; Hu, BR; Li, JJ; Li, Y; Ming, ZY; Qian, JQ; Tang, Q; Xiang, JZ1
Columbano, A; Deidda, M; Diana, A; Ledda-Columbano, GM; Pibiri, M; Sanna, L; Simbula, G1
Hu, DC; Hu, XZ; Hui, Y; Xu, Y; Yang, FX1
Tchounwou, PB; Yedjou, CG1
Arai, T; Hirota, K; Kodaki, T; Makino, K; Miyoshi, T; Mori, H; Sasada, M; Sommani, P; Tsunemine, H; Yamashita, K1
Boo, YC; Kim, HJ; Lee, SI1
Arellanes-Robledo, J; Beltrán-Ramírez, O; Fattel-Fazenda, S; García-Román, R; Rosas, S; Salazar-González, D; Villa-Treviño, S1
Heathcote, J; Wanless, IR1
Bonifaci, N; Rubartelli, A; Sitia, R1
Kim, HS; Kim, IK; Lee, JH1
Ballatori, N; Clifton, D; Rebbeor, JF; Wang, W1
Gomi, T; Inamoto, T; Kinoshita, K; Nakamura, H; Tanaka, K; Tsuyuki, S; Yamaoka, Y; Yamauchi, A1
Fisher, EA; Ginsberg, HN; Zhou, M1
Egner, PA; Groopman, JD; He, X; Helzlsouer, KJ; Jacobson, LP; Kensler, TW; Kuang, SY; Muñoz, A; Qian, GS; Shen, X; Wang, JB; Wang, JS; Zarba, A; Zhang, BC; Zhu, YR1
Aramaki, Y; Takano, S; Tsuchiya, S1
Chen, CL; Chi, CW; Liu, TY1
Liu, J; Ong, C; Shen, H; Yang, C1
Kang, YS; Kim, JA; Lee, SH; Lee, YS1
Ding, WX; Liu, J; Ong, CN; Shen, HM; Yang, CF1
DePierre, JW; Grandér, D; Panaretakis, T; Shabalina, IG; Shoshan, MC1
Gong, G; Siddiqui, A; Tanveer, R; Waris, G1
Amann, A; Amberger, A; Fleischer, M; Hoffmann, G; Marth, C; Niedermüller, P; Nigrovic, V; Pühringer, F; Rieder, J1
Ham, YH; Han, SK; Jang, JJ; Jung, YJ; Kim, CM; Kim, KC; Kim, SH; Kwon, H; Lee, KH; Sung, YC1
Carr, BI; Kar, S; Lazo, JS; Rosi, KS; Southwick, EC; Wang, M; Wang, Z; Wilcox, CS1
Balansky, RM; D'Agostini, F; De Flora, S; Ganchev, G1
Malkiewicz, I; Neuman, MG; Popat, A; Shear, NH; Thomson, S1
Critchley, JA; Leung, NW1

Reviews

3 review(s) available for acetylcysteine and Liver Neoplasms

ArticleYear
Role of iron in inducing oxidative stress in thalassemia: Can it be prevented by inhibition of absorption and by antioxidants?
    Annals of the New York Academy of Sciences, 2005, Volume: 1054

    Topics: Acetylcysteine; Animals; Antimicrobial Cationic Peptides; Antioxidants; Bone Marrow; Carcinoma, Hepatocellular; Cell Line, Tumor; Disease Models, Animal; Drug Therapy, Combination; Erythrocytes; Gene Expression Regulation; Genetic Therapy; Hepcidins; Humans; Intestinal Absorption; Iron; Iron Chelating Agents; Iron, Dietary; Liver Neoplasms; Mice; Oxidants; Oxidative Stress; Thalassemia; Vitamin E

2005
Hepatotoxicity of anti-inflammatory and analgesic drugs: ultrastructural aspects.
    Acta pharmacologica Sinica, 2006, Volume: 27, Issue:3

    Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspirin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Drug Overdose; Hepatocytes; Humans; Liver; Liver Diseases; Liver Neoplasms; Verapamil

2006
Hepatotoxicity: newer aspects of pathogenesis and treatment.
    The Gastroenterologist, 1995, Volume: 3, Issue:2

    Topics: Acetaminophen; Acetylcysteine; Adenoma, Liver Cell; Adult; Amoxicillin; Anabolic Agents; Beverages; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Contraceptives, Oral; Female; Humans; Isoniazid; Liver Diseases; Liver Diseases, Alcoholic; Liver Neoplasms; Male; Nonprescription Drugs; Propylthiouracil; Rifampin

1995

Trials

5 trial(s) available for acetylcysteine and Liver Neoplasms

ArticleYear
Efficacy of dexamethasone and N-acetylcysteine combination in preventing post-embolization syndrome after transarterial chemoembolization in hepatocellular carcinoma.
    World journal of gastroenterology, 2023, Feb-07, Volume: 29, Issue:5

    Topics: Acetylcysteine; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Dexamethasone; Drug Combinations; Humans; Liver Neoplasms; Nausea; Treatment Outcome; Vomiting

2023
N-Acetylcysteine Prevents Post-embolization Syndrome in Patients with Hepatocellular Carcinoma Following Transarterial Chemoembolization.
    Digestive diseases and sciences, 2019, Volume: 64, Issue:11

    Topics: Acetylcysteine; Administration, Intravenous; Aged; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Cohort Studies; Female; Free Radical Scavengers; Humans; Inflammation Mediators; Liver Neoplasms; Male; Middle Aged; Prospective Studies; Syndrome; Treatment Outcome

2019
Pharmacological Modulation of Ischemic-Reperfusion Injury during Pringle Maneuver in Hepatic Surgery. A Prospective Randomized Pilot Study.
    World journal of surgery, 2016, Volume: 40, Issue:9

    Topics: Acetylcysteine; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Bilirubin; Double-Blind Method; Female; Free Radical Scavengers; Glucocorticoids; Hepatectomy; Humans; Liver Function Tests; Liver Neoplasms; Male; Methylprednisolone; Middle Aged; Pilot Projects; Prospective Studies; Reperfusion Injury; Surgical Instruments; Tourniquets; Young Adult

2016
Phase I trial of high dose paracetamol and carmustine in patients with metastatic melanoma.
    Melanoma research, 2003, Volume: 13, Issue:2

    Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antineoplastic Agents, Alkylating; Carmustine; Cohort Studies; Dose-Response Relationship, Drug; Female; Free Radical Scavengers; Glutathione; Glutathione Reductase; Humans; Leukocytes, Mononuclear; Liver Neoplasms; Lymphatic Metastasis; Male; Maximum Tolerated Dose; Melanoma; Neoplasm Metastasis; Skin Neoplasms; Time Factors

2003
Protective alterations in phase 1 and 2 metabolism of aflatoxin B1 by oltipraz in residents of Qidong, People's Republic of China.
    Journal of the National Cancer Institute, 1999, Feb-17, Volume: 91, Issue:4

    Topics: Acetylcysteine; Aflatoxin B1; Anticarcinogenic Agents; Carcinogens; China; Cytochrome P-450 CYP1A2; Double-Blind Method; Drug Administration Schedule; Feasibility Studies; Gas Chromatography-Mass Spectrometry; Glutathione Transferase; Humans; Liver Neoplasms; Pyrazines; Reproducibility of Results; Thiones; Thiophenes; Treatment Outcome

1999

Other Studies

103 other study(ies) available for acetylcysteine and Liver Neoplasms

ArticleYear
3,3'-OH curcumin causes apoptosis in HepG2 cells through ROS-mediated pathway.
    European journal of medicinal chemistry, 2016, Apr-13, Volume: 112

    Topics: Antineoplastic Agents; Apoptosis; Curcumin; Hep G2 Cells; Humans; Hydroxyl Radical; Liver; Liver Neoplasms; Reactive Oxygen Species

2016
Reactive Oxygen Species Mediate 6c-Induced Mitochondrial and Lysosomal Dysfunction, Autophagic Cell Death, and DNA Damage in Hepatocellular Carcinoma.
    International journal of molecular sciences, 2021, Oct-12, Volume: 22, Issue:20

    Topics: Acetylcysteine; Adenine; Antioxidants; Autophagic Cell Death; Autophagosomes; Carcinoma, Hepatocellular; DNA Damage; Hep G2 Cells; Humans; Liver Neoplasms; Lysosomes; Microtubule-Associated Proteins; Mitochondria; Naphthalimides; Proteome; Proteomics; Reactive Oxygen Species; Sequestosome-1 Protein

2021
NUPR1 contributes to radiation resistance by maintaining ROS homeostasis via AhR/CYP signal axis in hepatocellular carcinoma.
    BMC medicine, 2022, 10-19, Volume: 20, Issue:1

    Topics: Acetylcysteine; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cytochrome P-450 Enzyme System; Homeostasis; Humans; Liver Neoplasms; Nuclear Proteins; Reactive Oxygen Species; Receptors, Aryl Hydrocarbon; Signal Transduction

2022
Excessive N-acetylcysteine exaggerates glutathione redox homeostasis and apoptosis during acetaminophen exposure in Huh-7 human hepatoma cells.
    Biochemical and biophysical research communications, 2023, 10-08, Volume: 676

    Topics: Acetaminophen; Acetylcysteine; Apoptosis; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Glutathione; Homeostasis; Humans; Liver; Liver Neoplasms; Oxidation-Reduction

2023
Transaldolase haploinsufficiency in subjects with acetaminophen-induced liver failure.
    Journal of inherited metabolic disease, 2020, Volume: 43, Issue:3

    Topics: Acetylcysteine; Adult; Animals; Carcinoma, Hepatocellular; Female; Haploinsufficiency; Humans; Liver Cirrhosis; Liver Failure; Liver Neoplasms; Male; Mice; Mice, Knockout; Mitochondria; Oxidative Stress; Pentose Phosphate Pathway; Transaldolase; Young Adult

2020
N-acetylcysteine alleviates liver injury by suppressing macrophage-mediated inflammatory response post microwave ablation.
    International immunopharmacology, 2020, Volume: 85

    Topics: Ablation Techniques; Acetylcysteine; Animals; Anti-Inflammatory Agents; Apoptosis; Carcinoma, Hepatocellular; Humans; Inflammation; Liver; Liver Diseases; Liver Neoplasms; Macrophages; Male; Microwaves; Peroxidase; Rats, Sprague-Dawley

2020
NAD(P)HX epimerase downregulation promotes tumor progression through ROS/HIF-1α signaling in hepatocellular carcinoma.
    Cancer science, 2021, Volume: 112, Issue:7

    Topics: Acetylcysteine; Analysis of Variance; Animals; Carcinoma, Hepatocellular; Cell Movement; Disease Progression; Disease-Free Survival; Down-Regulation; Epithelial-Mesenchymal Transition; Female; Free Radical Scavengers; Heterografts; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Male; Mice; Middle Aged; NADP; Neoplasm Invasiveness; Neoplasm Proteins; Neoplasm Transplantation; Oxidation-Reduction; Racemases and Epimerases; Reactive Oxygen Species; Risk Factors

2021
Cold Atmospheric Pressure Plasma-Activated Medium Induces Selective Cell Death in Human Hepatocellular Carcinoma Cells Independently of Singlet Oxygen, Hydrogen Peroxide, Nitric Oxide and Nitrite/Nitrate.
    International journal of molecular sciences, 2021, May-24, Volume: 22, Issue:11

    Topics: Acetylcysteine; Aluminum; Antineoplastic Agents; Atmospheric Pressure; Carcinoma, Hepatocellular; Cell Death; Cell Line, Tumor; Cell Proliferation; Cell Survival; Free Radicals; Humans; Hydrogen Peroxide; Liver Neoplasms; Neoplastic Stem Cells; Nitrates; Nitric Oxide; Nitrites; Plasma Gases; Reactive Nitrogen Species; Reactive Oxygen Species; Singlet Oxygen

2021
Dichloroacetate enhances the anti-tumor effect of sorafenib via modulating the ROS-JNK-Mcl-1 pathway in liver cancer cells.
    Experimental cell research, 2021, 09-01, Volume: 406, Issue:1

    Topics: Acetylcysteine; Animals; Anthracenes; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Dichloroacetic Acid; Drug Resistance, Neoplasm; Drug Synergism; Gene Expression Regulation, Neoplastic; Hepatocytes; Humans; Liver Neoplasms; Male; MAP Kinase Kinase 4; Mice, Nude; Myeloid Cell Leukemia Sequence 1 Protein; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Signal Transduction; Sorafenib; Tumor Burden; Xenograft Model Antitumor Assays

2021
Advanced glycation end products promote ChREBP expression and cell proliferation in liver cancer cells by increasing reactive oxygen species.
    Medicine, 2017, Volume: 96, Issue:33

    Topics: Acetylcysteine; Apoptosis; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Carcinoma, Hepatocellular; Cell Proliferation; Cell Survival; Glycation End Products, Advanced; Humans; Liver Neoplasms; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; RNA, Messenger; Transcription Factors; Tumor Cells, Cultured

2017
Autophagic cell death induced by reactive oxygen species is involved in hyperthermic sensitization to ionizing radiation in human hepatocellular carcinoma cells.
    World journal of gastroenterology, 2017, Aug-14, Volume: 23, Issue:30

    Topics: Acetylcysteine; Apoptosis; Autophagy; Carcinoma, Hepatocellular; Cell Survival; Hep G2 Cells; Humans; Hyperthermia, Induced; Liver Neoplasms; Microtubule-Associated Proteins; Radiation, Ionizing; Reactive Oxygen Species; RNA-Binding Proteins

2017
Strong carcinogenic stress response induction of preneoplastic cells positive for GST-P in the rat liver: Physiological mechanism for initiation.
    Life sciences, 2018, May-01, Volume: 200

    Topics: 2-Acetylaminofluorene; Acetylcysteine; Animals; Bile Ducts; Enzyme Induction; Gene Expression Regulation, Neoplastic; Glutathione S-Transferase pi; Hepatectomy; Hepatocytes; Liver Neoplasms; Male; Neoplasm Proteins; Precancerous Conditions; Rats; Rats, Sprague-Dawley

2018
Patulin induced ROS-dependent autophagic cell death in Human Hepatoma G2 cells.
    Chemico-biological interactions, 2018, May-25, Volume: 288

    Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Autophagy; Down-Regulation; Hep G2 Cells; Humans; Liver Neoplasms; Membrane Potential, Mitochondrial; Microtubule-Associated Proteins; Patulin; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; RNA-Binding Proteins; TOR Serine-Threonine Kinases; Up-Regulation

2018
Juglone induces apoptosis and autophagy via modulation of mitogen-activated protein kinase pathways in human hepatocellular carcinoma cells.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2018, Volume: 116, Issue:Pt B

    Topics: Acetylcysteine; Adenine; Amino Acid Chloromethyl Ketones; Androstadienes; Apoptosis; Autophagy; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Cell Proliferation; Enzyme Activation; Hep G2 Cells; Humans; Liver Neoplasms; MAP Kinase Kinase 4; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Naphthoquinones; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Reactive Oxygen Species; Wortmannin

2018
Radiosensitization by Marine Sponge Agelas sp. Extracts in Hepatocellular Carcinoma Cells with Autophagy Induction.
    Scientific reports, 2018, 04-20, Volume: 8, Issue:1

    Topics: Acetylcysteine; Agelas; Animals; Apoptosis; Autophagy; Carcinoma, Hepatocellular; Cell Extracts; Cell Line, Tumor; Endoplasmic Reticulum Stress; Humans; Liver Neoplasms; Micronesia; Porifera; Radiation-Sensitizing Agents; Reactive Oxygen Species

2018
A new xanthatin analogue 1β-hydroxyl-5α-chloro-8-epi-xanthatin induces apoptosis through ROS-mediated ERK/p38 MAPK activation and JAK2/STAT3 inhibition in human hepatocellular carcinoma.
    Biochimie, 2018, Volume: 152

    Topics: Acetylcysteine; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Furans; Glutathione; Humans; Janus Kinase 2; Liver Neoplasms; Malondialdehyde; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Reactive Oxygen Species; STAT3 Transcription Factor

2018
Daphnegiravone D from Daphne giraldii Nitsche induces p38-dependent apoptosis via oxidative and nitrosative stress in hepatocellular carcinoma cells.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 107

    Topics: Acetylcysteine; Apoptosis; Carcinoma, Hepatocellular; Daphne; Flavonoids; Hep G2 Cells; Humans; Liver Neoplasms; Nitrosative Stress; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Protein Prenylation; Reactive Nitrogen Species; Reactive Oxygen Species

2018
Silver-doped graphene oxide nanocomposite triggers cytotoxicity and apoptosis in human hepatic normal and carcinoma cells.
    International journal of nanomedicine, 2018, Volume: 13

    Topics: Acetylcysteine; Apoptosis; Catalase; Cell Shape; Cell Survival; DNA Damage; Glutathione; Graphite; Hep G2 Cells; Humans; Lipid Peroxides; Liver; Liver Neoplasms; Membrane Potential, Mitochondrial; Metal Nanoparticles; Nanocomposites; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; RNA, Messenger; Silver; Superoxide Dismutase

2018
Attenuation of autophagy flux by 6-shogaol sensitizes human liver cancer cells to TRAIL-induced apoptosis via p53 and ROS.
    International journal of molecular medicine, 2019, Volume: 43, Issue:2

    Topics: Acetylcysteine; Apoptosis; Autophagy; Caspases, Initiator; Catechols; Cell Line, Tumor; Chloroquine; Drug Synergism; Drug Therapy, Combination; Humans; Liver Neoplasms; Membrane Potential, Mitochondrial; Mutagens; Plant Extracts; Reactive Oxygen Species; TNF-Related Apoptosis-Inducing Ligand; Tumor Suppressor Protein p53; Zingiber officinale

2019
Alantolactone induces apoptosis in HepG2 cells through GSH depletion, inhibition of STAT3 activation, and mitochondrial dysfunction.
    BioMed research international, 2013, Volume: 2013

    Topics: Acetylcysteine; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Glutathione; Hep G2 Cells; Humans; Lactones; Liver Neoplasms; Membrane Potential, Mitochondrial; Reactive Oxygen Species; Sesquiterpenes, Eudesmane; Signal Transduction; STAT3 Transcription Factor; Transcriptional Activation

2013
Antitumor effect of fructose 1,6-bisphosphate and its mechanism in hepatocellular carcinoma cells.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2014, Volume: 35, Issue:2

    Topics: Acetylcysteine; Apoptosis; Carcinoma, Hepatocellular; Catalase; Cell Proliferation; Fructosediphosphates; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Hydrogen Peroxide; Liver Neoplasms; Reactive Oxygen Species

2014
Antioxidant N-acetylcysteine attenuates hepatocarcinogenesis by inhibiting ROS/ER stress in TLR2 deficient mouse.
    PloS one, 2013, Volume: 8, Issue:10

    Topics: Acetylcysteine; Animals; Antioxidants; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line; Diethylnitrosamine; Disease Progression; Endoplasmic Reticulum Stress; Liver Neoplasms; Male; Mice; Reactive Oxygen Species; Signal Transduction; Toll-Like Receptor 2

2013
Effective palliation of obstructive jaundice due to colorectal cancer liver metastasis.
    ANZ journal of surgery, 2014, Volume: 84, Issue:6

    Topics: Acetylcysteine; Aged, 80 and over; Colectomy; Colorectal Neoplasms; Drainage; Female; Follow-Up Studies; Humans; Jaundice, Obstructive; Liver Neoplasms; Monitoring, Physiologic; Palliative Care; Risk Assessment; Stents; Tomography, X-Ray Computed

2014
Palmitate-induced activation of mitochondrial metabolism promotes oxidative stress and apoptosis in H4IIEC3 rat hepatocytes.
    Metabolism: clinical and experimental, 2014, Volume: 63, Issue:2

    Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Carbon Isotopes; Carcinoma, Hepatocellular; Caspases, Effector; Cell Line, Tumor; Enzyme Activation; Hepatocytes; Liver Neoplasms; Metabolic Flux Analysis; Mitochondria, Liver; Oxidative Stress; Palmitates; Rats; Reactive Oxygen Species

2014
Zinc status alters growth and oxidative stress responses in rat hepatoma cells.
    Nutrition and cancer, 2014, Volume: 66, Issue:1

    Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Caspase 3; Cell Line, Tumor; Cytochromes c; Liver Neoplasms; Mitochondria; Oxidative Stress; Proto-Oncogene Proteins c-mdm2; Rats; Reactive Oxygen Species; Tumor Suppressor Protein p53; Zinc

2014
Proteomic and functional analyses demonstrate the involvement of oxidative stress in the anticancer activities of oridonin in HepG2 cells.
    Oncology reports, 2014, Volume: 31, Issue:5

    Topics: Acetylcysteine; Apoptosis; Caspase 3; Caspase 9; Cell Line, Tumor; Cell Survival; Diterpenes, Kaurane; Hep G2 Cells; Homeodomain Proteins; HSP70 Heat-Shock Proteins; Humans; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; Membrane Potential, Mitochondrial; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Peroxiredoxins; Proteomics; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Signal Transduction; Tumor Suppressor Protein p53; Tumor Suppressor Proteins

2014
Dichloroacetate enhances adriamycin-induced hepatoma cell toxicity in vitro and in vivo by increasing reactive oxygen species levels.
    PloS one, 2014, Volume: 9, Issue:4

    Topics: Acetylcysteine; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Dichloroacetic Acid; Doxorubicin; Humans; Liver Neoplasms; Male; Mice; Reactive Oxygen Species; Xenograft Model Antitumor Assays

2014
Comparative evaluation of N-acetylcysteine and N-acetylcysteineamide in acetaminophen-induced hepatotoxicity in human hepatoma HepaRG cells.
    Experimental biology and medicine (Maywood, N.J.), 2015, Volume: 240, Issue:2

    Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Overdose; Free Radical Scavengers; Humans; Lipid Peroxidation; Liver Neoplasms; Mitochondria, Liver; Oxidative Stress; Reactive Oxygen Species

2015
[Feverfew lactone induces autophagic death of hepatocellular carcinoma SMMC 7721 cells].
    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2014, Volume: 45, Issue:4

    Topics: Acetylcysteine; Autophagy; Carcinoma, Hepatocellular; Cell Line, Tumor; Humans; Lactones; Liver Neoplasms; Tanacetum parthenium

2014
Cytoglobin deficiency promotes liver cancer development from hepatosteatosis through activation of the oxidative stress pathway.
    The American journal of pathology, 2015, Volume: 185, Issue:4

    Topics: Acetylcysteine; Animals; Antioxidants; Cytoglobin; Diet; Globins; Hepatic Stellate Cells; Humans; Inflammation; Liver; Liver Cirrhosis; Liver Neoplasms; Macrophages; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidation-Reduction; Oxidative Stress; Precancerous Conditions

2015
The role of NF-κB in PARP-inhibitor-mediated sensitization and detoxification of arsenic trioxide in hepatocellular carcinoma cells.
    The Journal of toxicological sciences, 2015, Volume: 40, Issue:3

    Topics: 1-Naphthylamine; Acetylcysteine; Antineoplastic Agents; Antioxidants; Arsenic Trioxide; Arsenicals; Carcinoma, Hepatocellular; DNA Damage; Hep G2 Cells; Humans; Inactivation, Metabolic; Liver Neoplasms; Naphthalimides; NF-kappa B; Oxidative Stress; Oxides; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Quinolones; Reactive Oxygen Species

2015
HIF-2α regulates CDCP1 to promote PKCδ-mediated migration in hepatocellular carcinoma.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016, Volume: 37, Issue:2

    Topics: Acetylcysteine; Animals; Antigens, CD; Antigens, Neoplasm; Basic Helix-Loop-Helix Transcription Factors; Blotting, Western; Carcinoma, Hepatocellular; Cell Adhesion Molecules; Cell Movement; Gene Expression Regulation, Neoplastic; Heterografts; Humans; Immunohistochemistry; Liver Neoplasms; Mice; Mice, Nude; Neoplasm Proteins; Protein Kinase C-delta; Real-Time Polymerase Chain Reaction; Transfection

2016
Na+/K+-ATPase α1 subunit, a novel therapeutic target for hepatocellular carcinoma.
    Oncotarget, 2015, Sep-29, Volume: 6, Issue:29

    Topics: Acetylcysteine; Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Cell Proliferation; Free Radical Scavengers; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Liver Neoplasms; Molecular Targeted Therapy; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Sodium-Potassium-Exchanging ATPase

2015
Eukaryotic translation initiation factor 5A2 regulates the migration and invasion of hepatocellular carcinoma cells via pathways involving reactive oxygen species.
    Oncotarget, 2016, Apr-26, Volume: 7, Issue:17

    Topics: Acetylcysteine; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Epithelial-Mesenchymal Transition; Eukaryotic Translation Initiation Factor 5A; Guanine; Hep G2 Cells; Humans; Kaplan-Meier Estimate; Liver Neoplasms; Neoplasm Invasiveness; Peptide Initiation Factors; Reactive Oxygen Species; RNA Interference; RNA-Binding Proteins; Signal Transduction

2016
Allicin sensitizes hepatocellular cancer cells to anti-tumor activity of 5-fluorouracil through ROS-mediated mitochondrial pathway.
    Journal of pharmacological sciences, 2016, Volume: 131, Issue:4

    Topics: Acetylcysteine; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Cell Line, Tumor; Cell Survival; Disulfides; Drug Synergism; Fluorouracil; Humans; Liver Neoplasms; Membrane Potential, Mitochondrial; Mice; Mitochondria; Poly (ADP-Ribose) Polymerase-1; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Sulfinic Acids; Xenograft Model Antitumor Assays

2016
LncRNA HULC enhances epithelial-mesenchymal transition to promote tumorigenesis and metastasis of hepatocellular carcinoma via the miR-200a-3p/ZEB1 signaling pathway.
    Oncotarget, 2016, Jul-05, Volume: 7, Issue:27

    Topics: Acetylcysteine; Aged; Animals; Apoptosis; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferation; Cell Transformation, Neoplastic; Disease Progression; Epithelial-Mesenchymal Transition; Female; Humans; Lentivirus; Liver; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; MicroRNAs; Middle Aged; Neoplasm Metastasis; Neoplasm Transplantation; RNA, Long Noncoding; RNA, Small Interfering; Signal Transduction; Zinc Finger E-box-Binding Homeobox 1

2016
[Sodium nitrite enhanced the potentials of migration and invasion of human hepatocellular carcinoma SMMC-7721 cells through induction of mitophagy].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2016, Volume: 51, Issue:1

    Topics: Acetylcysteine; Autophagy; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Mitophagy; Neoplasm Invasiveness; Nitrites; Reactive Oxygen Species; Sodium Nitrite

2016
Farnesylthiosalicylic acid sensitizes hepatocarcinoma cells to artemisinin derivatives.
    PloS one, 2017, Volume: 12, Issue:2

    Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Artemisinins; Carcinoma, Hepatocellular; Drug Synergism; Farnesol; Hep G2 Cells; Humans; Liver Neoplasms; Salicylates

2017
B cell translocation gene 2 enhances susceptibility of HeLa cells to doxorubicin-induced oxidative damage.
    The Journal of biological chemistry, 2008, Nov-28, Volume: 283, Issue:48

    Topics: Acetylcysteine; Antibiotics, Antineoplastic; Apoptosis; Catalase; Chromatin; Doxorubicin; Free Radical Scavengers; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Glutathione Peroxidase; Glutathione Peroxidase GPX1; HeLa Cells; Humans; Hydrogen Peroxide; Immediate-Early Proteins; Lamin Type A; Liver Neoplasms; Oxidative Stress; Poly(ADP-ribose) Polymerases; Superoxide Dismutase; Tumor Suppressor Protein p53; Tumor Suppressor Proteins

2008
Prevention of hepatocarcinogenesis and increased susceptibility to acetaminophen-induced liver failure in transaldolase-deficient mice by N-acetylcysteine.
    The Journal of clinical investigation, 2009, Volume: 119, Issue:6

    Topics: Acetylcysteine; alpha-Fetoproteins; Animals; Apoptosis; beta Catenin; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; fas Receptor; JNK Mitogen-Activated Protein Kinases; Liver Failure; Liver Neoplasms; Male; Mice; Mice, Knockout; Mitochondria; Phosphorylation; Transaldolase

2009
Reactive oxygen species accumulation contributes to gambogic acid-induced apoptosis in human hepatoma SMMC-7721 cells.
    Toxicology, 2009, Jun-16, Volume: 260, Issue:1-3

    Topics: Acetylcysteine; Adenosine Triphosphate; Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Inducing Factor; Blotting, Western; Cell Line, Tumor; Cell Survival; Cytochromes c; Flow Cytometry; Free Radical Scavengers; Glutathione; Humans; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; Membrane Potential, Mitochondrial; Microscopy, Confocal; Mitochondria, Liver; p38 Mitogen-Activated Protein Kinases; Reactive Oxygen Species; Signal Transduction; Xanthones

2009
Reactive oxygen species-mediated kinase activation by dihydrotanshinone in tanshinones-induced apoptosis in HepG2 cells.
    Cancer letters, 2009, Nov-18, Volume: 285, Issue:1

    Topics: Abietanes; Acetylcysteine; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Caspases; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cytochromes c; Dose-Response Relationship, Drug; Enzyme Activation; Furans; Humans; Imidazoles; Inhibitory Concentration 50; JNK Mitogen-Activated Protein Kinases; L-Lactate Dehydrogenase; Liver Neoplasms; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phenanthrenes; Phosphorylation; Poly(ADP-ribose) Polymerases; Protein Kinase Inhibitors; Protein Transport; Pyridines; Quinones; Reactive Oxygen Species; Time Factors

2009
The combination of berberine and irradiation enhances anti-cancer effects via activation of p38 MAPK pathway and ROS generation in human hepatoma cells.
    Journal of cellular biochemistry, 2009, Aug-01, Volume: 107, Issue:5

    Topics: Acetylcysteine; Apoptosis; Berberine; Carcinoma, Hepatocellular; Caspase 3; Cell Line, Tumor; Cell Survival; Drug Screening Assays, Antitumor; Enzyme Activation; Humans; Liver Neoplasms; Models, Biological; Nitric Oxide; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-bcl-2; Radiation, Ionizing; Reactive Oxygen Species

2009
Glutathionylation of p65NF-kappaB correlates with proliferating/apoptotic hepatoma cells exposed to pro- and anti-oxidants.
    International journal of molecular medicine, 2009, Volume: 24, Issue:3

    Topics: Acetylcysteine; Antioxidants; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; DNA, Neoplasm; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Glutathione; Humans; Hydrogen Peroxide; Liver Neoplasms; Oxidants; Protein Transport; Transcription Factor RelA

2009
Butein induces G(2)/M phase arrest and apoptosis in human hepatoma cancer cells through ROS generation.
    Cancer letters, 2010, Feb-28, Volume: 288, Issue:2

    Topics: Acetylcysteine; Anthracenes; Antineoplastic Agents; Antioxidants; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Division; Cell Proliferation; Cell Survival; Chalcones; Dose-Response Relationship, Drug; Enzyme Activation; G2 Phase; Glutathione; Hep G2 Cells; Humans; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; Phosphorylation; Protein Kinase Inhibitors; Reactive Oxygen Species

2010
Using acetaminophen's toxicity mechanism to enhance cisplatin efficacy in hepatocarcinoma and hepatoblastoma cell lines.
    Neoplasia (New York, N.Y.), 2009, Volume: 11, Issue:10

    Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antineoplastic Agents; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Cisplatin; Cytochrome P-450 CYP2E1; Dose-Response Relationship, Drug; Drug Synergism; Free Radical Scavengers; Glutathione; Hepatoblastoma; Hepatocytes; Humans; Liver Neoplasms; Mice; Rats; Time Factors

2009
2'-epi-2'-O-Acetylthevetin B extracted from seeds of Cerbera manghas L. induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells.
    Chemico-biological interactions, 2010, Jan-05, Volume: 183, Issue:1

    Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Apocynaceae; Apoptosis; Apoptosis Inducing Factor; Carcinoma, Hepatocellular; Cardiac Glycosides; Caspase 9; CDC2 Protein Kinase; Cyclin B1; G2 Phase; Hep G2 Cells; Humans; Liver Neoplasms; Membrane Potential, Mitochondrial; Reactive Oxygen Species; S Phase; Seeds

2010
Arachidonic acid-induced apoptosis in rat hepatoma AS-30D cells is mediated by reactive oxygen species.
    Acta biochimica Polonica, 2009, Volume: 56, Issue:4

    Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Arachidonic Acid; Carcinoma, Hepatocellular; Cell Line, Tumor; Chromans; Cyclic N-Oxides; Epoxy Compounds; Liver Neoplasms; Rats; Reactive Oxygen Species; Spin Labels

2009
Science to practice: will randomized prospective clinical trials be necessary for RF ablation of large liver tumors with liposomal doxorubicin?
    Radiology, 2010, Volume: 255, Issue:1

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetylcysteine; Adenocarcinoma; Aldehydes; Animals; Antibiotics, Antineoplastic; Apoptosis; Caspase 3; Catheter Ablation; Chemotherapy, Adjuvant; Combined Modality Therapy; Deoxyguanosine; DNA Damage; Doxorubicin; Histones; HSP70 Heat-Shock Proteins; Humans; Liver Neoplasms; Mammary Neoplasms, Experimental; Oxidative Stress; Prospective Studies; Randomized Controlled Trials as Topic; Rats; Tyrosine

2010
6-dehydrogingerdione sensitizes human hepatoblastoma Hep G2 cells to TRAIL-induced apoptosis via reactive oxygen species-mediated increase of DR5.
    Journal of agricultural and food chemistry, 2010, May-12, Volume: 58, Issue:9

    Topics: Acetylcysteine; Apoptosis; Cell Line, Tumor; Guaiacol; Hepatoblastoma; Humans; Liver Neoplasms; Reactive Oxygen Species; Receptors, TNF-Related Apoptosis-Inducing Ligand; TNF-Related Apoptosis-Inducing Ligand

2010
Vanadium compounds discriminate hepatoma and normal hepatic cells by differential regulation of reactive oxygen species.
    Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2010, Volume: 15, Issue:7

    Topics: Acetylcysteine; Animals; Antioxidants; Carcinoma, Hepatocellular; Cell Cycle; Cell Proliferation; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Hep G2 Cells; Humans; JNK Mitogen-Activated Protein Kinases; Liver; Liver Neoplasms; Reactive Oxygen Species; Signal Transduction; Vanadium Compounds

2010
N-acetyl-cysteine protects against DNA damage associated with lead toxicity in HepG2 cells.
    Ethnicity & disease, 2010,Winter, Volume: 20, Issue:1 Suppl 1

    Topics: Acetylcysteine; Cell Survival; Comet Assay; DNA Damage; Free Radical Scavengers; Hep G2 Cells; Humans; Lead; Liver Neoplasms; Oxidative Stress

2010
Conditional beta-catenin loss in mice promotes chemical hepatocarcinogenesis: role of oxidative stress and platelet-derived growth factor receptor alpha/phosphoinositide 3-kinase signaling.
    Hepatology (Baltimore, Md.), 2010, Volume: 52, Issue:3

    Topics: Acetylcysteine; Administration, Oral; Animals; Apoptosis; beta Catenin; Carcinoma, Hepatocellular; Cell Proliferation; Class I Phosphatidylinositol 3-Kinases; Diethylnitrosamine; Disease Models, Animal; Liver Neoplasms; Male; Mice; Mice, Knockout; NF-kappa B; Oxidative Stress; Phosphatidylinositol 3-Kinases; Receptor, Platelet-Derived Growth Factor alpha; Signal Transduction

2010
A novel sesquiterpene Hirsutanol A induces autophagical cell death in human hepatocellular carcinoma cells by increasing reactive oxygen species.
    Chinese journal of cancer, 2010, Volume: 29, Issue:7

    Topics: Acetylcysteine; Adenine; Agaricales; Antineoplastic Agents; Autophagy; Carcinoma, Hepatocellular; Cell Death; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Free Radical Scavengers; Humans; Liver Neoplasms; Microtubule-Associated Proteins; Reactive Oxygen Species; Sesquiterpenes

2010
8-Bromo-7-methoxychrysin-induced apoptosis of hepatocellular carcinoma cells involves ROS and JNK.
    World journal of gastroenterology, 2010, Jul-21, Volume: 16, Issue:27

    Topics: Acetylcysteine; Anilides; Antineoplastic Agents; Antioxidants; Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Enzyme Activation; Flavonoids; Hep G2 Cells; Humans; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; Reactive Oxygen Species

2010
HBx-induced reactive oxygen species activates hepatocellular carcinogenesis via dysregulation of PTEN/Akt pathway.
    World journal of gastroenterology, 2010, Oct-21, Volume: 16, Issue:39

    Topics: Acetylcysteine; Animals; Blotting, Western; Carcinoma, Hepatocellular; Cell Proliferation; Electrophoresis, Polyacrylamide Gel; Female; Flow Cytometry; Free Radical Scavengers; Hep G2 Cells; Humans; Liver Neoplasms; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Reactive Oxygen Species; Signal Transduction; Time Factors; Trans-Activators; Transfection; Viral Regulatory and Accessory Proteins

2010
Apoptosis induced by a new flavonoid in human hepatoma HepG2 cells involves reactive oxygen species-mediated mitochondrial dysfunction and MAPK activation.
    European journal of pharmacology, 2011, Mar-11, Volume: 654, Issue:3

    Topics: Acetylcysteine; Anthracenes; Apoptosis; Carcinoma, Hepatocellular; Caspases; Cell Survival; Cyclohexanones; Enzyme Activation; Flavones; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Imidazoles; Intracellular Space; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Mitochondria; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Reactive Oxygen Species

2011
Oxidative stress is closely associated with tumor angiogenesis of hepatocellular carcinoma.
    Journal of gastroenterology, 2011, Volume: 46, Issue:6

    Topics: Acetylcysteine; Adult; Aged; Androstadienes; Antioxidants; Carcinoma, Hepatocellular; Cell Proliferation; Endothelial Cells; Female; Humans; Liver Neoplasms; Male; Middle Aged; Neovascularization, Pathologic; Oxidative Stress; Proto-Oncogene Proteins c-akt; RNA, Messenger; Umbilical Cord; Vascular Endothelial Growth Factor A; Wortmannin

2011
[Decrease in tumorigenic activity of murine hepatoma cells after treatment with antioxidants and melatonin].
    Tsitologiia, 2011, Volume: 53, Issue:5

    Topics: Acetylcysteine; Animals; Antioxidants; Carcinoma, Hepatocellular; Cell Cycle; Flow Cytometry; Humans; Injections, Subcutaneous; Liver Neoplasms; Melatonin; Mice; Mice, Inbred C3H; Thioctic Acid; Transplantation, Isogeneic; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2011
Reactive oxygen species downregulate catalase expression via methylation of a CpG island in the Oct-1 promoter.
    FEBS letters, 2011, Nov-04, Volume: 585, Issue:21

    Topics: Acetylcysteine; Azacitidine; Carcinoma, Hepatocellular; Catalase; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; Down-Regulation; Enzyme Activation; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Neoplasm Invasiveness; Octamer Transcription Factor-1; Promoter Regions, Genetic; Reactive Oxygen Species

2011
Adriamycin enhances proteasome-mediated generation of the proapoptotic processed form of MAGE-A4 in hepatoma cells.
    Oncology, 2011, Volume: 81 Suppl 1

    Topics: Acetylcysteine; Animals; Antigens, Neoplasm; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Doxorubicin; HEK293 Cells; Humans; Leupeptins; Liver Neoplasms; Neoplasm Proteins; Proteasome Endopeptidase Complex; Ubiquitin

2011
The novel NF-κB inhibitor DHMEQ synergizes with celecoxib to exert antitumor effects on human liver cancer cells by a ROS-dependent mechanism.
    Cancer letters, 2012, Sep-01, Volume: 322, Issue:1

    Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Benzamides; Carcinoma, Hepatocellular; Celecoxib; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cyclohexanones; Cyclooxygenase 2 Inhibitors; Drug Synergism; Endoplasmic Reticulum Stress; fas Receptor; Humans; Liver Neoplasms; NF-kappa B; Poly(ADP-ribose) Polymerases; Protein Serine-Threonine Kinases; Pyrazoles; Reactive Oxygen Species; Repressor Proteins; Sulfonamides

2012
Protective effect of the poly(ADP-ribose) polymerase inhibitor PJ34 on mitochondrial depolarization-mediated cell death in hepatocellular carcinoma cells involves attenuation of c-Jun N-terminal kinase-2 and protein kinase B/Akt activation.
    Molecular cancer, 2012, May-14, Volume: 11

    Topics: Acetylcysteine; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Hep G2 Cells; Humans; Liver Neoplasms; Membrane Potential, Mitochondrial; Mitochondria; Mitogen-Activated Protein Kinase 9; Necrosis; Phenanthrenes; Poly(ADP-ribose) Polymerase Inhibitors; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; RNA Interference; Signal Transduction

2012
Attenuation of reactive oxygen species by antioxidants suppresses hypoxia-induced epithelial-mesenchymal transition and metastasis of pancreatic cancer cells.
    Clinical & experimental metastasis, 2013, Volume: 30, Issue:2

    Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Blotting, Western; Cell Adhesion; Cell Movement; Cell Proliferation; Epithelial-Mesenchymal Transition; Female; Fluorescent Antibody Technique; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Mice; Mice, Nude; NF-kappa B; Pancreatic Neoplasms; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Snail Family Transcription Factors; Transcription Factors; Tumor Cells, Cultured; Twist-Related Protein 1

2013
Hexane extracts of garlic cloves induce apoptosis through the generation of reactive oxygen species in Hep3B human hepatocarcinoma cells.
    Oncology reports, 2012, Volume: 28, Issue:5

    Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist Protein; Carcinoma, Hepatocellular; Caspase 3; Caspase 8; Caspase 9; Caspase Inhibitors; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Down-Regulation; Enzyme Activation; Free Radical Scavengers; Garlic; Humans; Liver Neoplasms; Membrane Potential, Mitochondrial; Mitochondria; Plant Extracts; Reactive Oxygen Species

2012
The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular carcinoma [corrected] cells.
    Cell death & disease, 2013, Feb-07, Volume: 4

    Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Apoptosis Regulatory Proteins; Autophagy; bcl-X Protein; Beclin-1; Carcinoma, Hepatocellular; Cell Line, Tumor; Cyclin D1; Extracellular Signal-Regulated MAP Kinases; Gossypol; Hep G2 Cells; HMGB1 Protein; Humans; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; Membrane Proteins; Microtubule-Associated Proteins; Phosphorylation; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; TOR Serine-Threonine Kinases

2013
Induction of hepatic heme oxygenase-1 by diclofenac in rodents: role of oxidative stress and cytochrome P-450 activity.
    Journal of hepatology, 2003, Volume: 38, Issue:6

    Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Carcinoma, Hepatocellular; Cell Line, Tumor; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diclofenac; Dose-Response Relationship, Drug; Enzyme Induction; Enzyme Inhibitors; Female; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hepatocytes; Humans; Liver; Liver Neoplasms; Male; Membrane Proteins; Mice; Mice, Inbred Strains; Oxidative Stress; Rats

2003
N-acetylcysteine does not protect HepG2 cells against acetaminophen-induced apoptosis.
    Basic & clinical pharmacology & toxicology, 2004, Volume: 94, Issue:5

    Topics: Acetaminophen; Acetylcysteine; Antioxidants; Apoptosis; Calcium; Cations, Divalent; Cell Line, Tumor; Cell Nucleus; Flow Cytometry; Glutathione; Hepatoblastoma; Humans; Liver Neoplasms; Microscopy, Electron; Necrosis; Oxidation-Reduction; Oxidative Stress; Phosphatidylserines

2004
Tissue-specificity of apoptosis in hepatoma-derived cell lines.
    Apoptosis : an international journal on programmed cell death, 2004, Volume: 9, Issue:3

    Topics: Acetylcysteine; alpha-Tocopherol; Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Culture Media, Serum-Free; Cycloheximide; Electrophoretic Mobility Shift Assay; Interleukin-1; Lipopolysaccharides; Liver Neoplasms; Protein Synthesis Inhibitors; Rats; Sorbitol; Transgenes; Tumor Necrosis Factor-alpha; Vinblastine; Vincristine

2004
Accumulation of 8-hydroxy-2'-deoxyguanosine adducts in HBx recombinant HepG2 cells and HBx transgenic mice.
    Digestion, 2004, Volume: 70, Issue:2

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetylcysteine; Animals; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Deoxyguanosine; DNA Adducts; DNA, Recombinant; Humans; Liver; Liver Neoplasms; Mice; Mice, Transgenic; Trans-Activators; Viral Regulatory and Accessory Proteins

2004
Antioxidants and trichostatin A synergistically protect against in vitro cytotoxicity of Ni2+ in human hepatoma cells.
    Toxicology in vitro : an international journal published in association with BIBRA, 2005, Volume: 19, Issue:2

    Topics: Acetylation; Acetylcysteine; Antioxidants; Apoptosis; Ascorbic Acid; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Glutathione; Hepatocytes; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Liver Neoplasms; Nickel; Reactive Oxygen Species

2005
Successful treatment of doxorubicin and cisplatin resistant hepatoblastoma in a child with Beckwith-Wiedemann syndrome with high dose acetaminophen and N-acetylcysteine rescue.
    Pediatric blood & cancer, 2005, Volume: 45, Issue:2

    Topics: Acetaminophen; Acetylcysteine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Beckwith-Wiedemann Syndrome; Cisplatin; Doxorubicin; Drug Resistance, Neoplasm; Drug Therapy, Combination; Female; Hepatoblastoma; Humans; Infant; Liver Neoplasms

2005
Effects of antioxidants and caspase-3 inhibitor on the phenylethyl isothiocyanate-induced apoptotic signaling pathways in human PLC/PRF/5 cells.
    European journal of pharmacology, 2005, Aug-22, Volume: 518, Issue:2-3

    Topics: Acetylcysteine; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Apoptotic Protease-Activating Factor 1; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist Protein; Blotting, Western; Carcinoma, Hepatocellular; Carrier Proteins; Caspase 3; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cell Line, Tumor; Cell Proliferation; Cysteine Proteinase Inhibitors; Cytochromes c; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; fas Receptor; Flow Cytometry; Humans; Intracellular Membranes; Intracellular Signaling Peptides and Proteins; Isothiocyanates; Liver Neoplasms; Membrane Potentials; Mitochondria; Mitochondrial Proteins; Oligopeptides; Proteins; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Time Factors; Tumor Suppressor Protein p53; Up-Regulation; Vitamin E; X-Linked Inhibitor of Apoptosis Protein

2005
Induction of quinone reductase by sulforaphane and sulforaphane N-acetylcysteine conjugate in murine hepatoma cells.
    Journal of medicinal food, 2005,Summer, Volume: 8, Issue:2

    Topics: Acetylcysteine; Animals; Anticarcinogenic Agents; Brassica; Carcinoma, Hepatocellular; Dose-Response Relationship, Drug; Enzyme Induction; Glucosinolates; Isothiocyanates; Liver Neoplasms; NAD(P)H Dehydrogenase (Quinone); Phytotherapy; Sulfoxides; Thiocyanates; Tumor Cells, Cultured

2005
N-acetylcysteine and S-methylcysteine inhibit MeIQx rat hepatocarcinogenesis in the post-initiation stage.
    Carcinogenesis, 2006, Volume: 27, Issue:5

    Topics: Acetylcysteine; Animals; Anticarcinogenic Agents; Carcinogens; Cell Proliferation; Cysteine; Down-Regulation; Glutathione Transferase; Insulin-Like Growth Factor I; Liver Neoplasms; Nitric Oxide Synthase Type II; Placenta; Quinoxalines; Rats; Silver Staining; Time Factors

2006
Phenylethyl isothiocyanate and its N-acetylcysteine conjugate suppress the metastasis of SK-Hep1 human hepatoma cells.
    The Journal of nutritional biochemistry, 2006, Volume: 17, Issue:12

    Topics: Acetylcysteine; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Adhesion; Cell Movement; Drug Screening Assays, Antitumor; Humans; Isothiocyanates; Liver Neoplasms; Matrix Metalloproteinase 14; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Neoplasm Metastasis; Tissue Inhibitor of Metalloproteinase-1; Tumor Cells, Cultured

2006
Allyl isothiocyanate and its N-acetylcysteine conjugate suppress metastasis via inhibition of invasion, migration, and matrix metalloproteinase-2/-9 activities in SK-Hep 1 human hepatoma cells.
    Experimental biology and medicine (Maywood, N.J.), 2006, Volume: 231, Issue:4

    Topics: Acetylcysteine; Brassica; Carcinoma, Hepatocellular; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Gene Expression Regulation, Neoplastic; Humans; Isothiocyanates; Liver Neoplasms; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; Neoplasm Metastasis; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2

2006
Role of oxidative stress in the apoptosis of hepatocellular carcinoma induced by combination of arsenic trioxide and ascorbic acid.
    Acta pharmacologica Sinica, 2006, Volume: 27, Issue:8

    Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Apoptosis; Arsenic Trioxide; Arsenicals; Ascorbic Acid; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Synergism; Free Radical Scavengers; Humans; Liver Neoplasms; Oxidative Stress; Oxides; Proto-Oncogene Proteins c-bcl-2

2006
Increased ROS generation and p53 activation in alpha-lipoic acid-induced apoptosis of hepatoma cells.
    Apoptosis : an international journal on programmed cell death, 2007, Volume: 12, Issue:1

    Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Ascorbic Acid; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Caspases; Cell Cycle; Cell Line, Tumor; Cell Survival; Cytochromes c; DNA Fragmentation; Enzyme Activation; Humans; Liver Neoplasms; MAP Kinase Kinase 4; Proto-Oncogene Proteins c-akt; Rats; Reactive Oxygen Species; Thioctic Acid; Tumor Suppressor Protein p53

2007
Apoptosis induction on human hepatoma cells Hep G2 of decabrominated diphenyl ether (PBDE-209).
    Toxicology letters, 2007, Jun-15, Volume: 171, Issue:1-2

    Topics: Acetylcysteine; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Flow Cytometry; Fluoresceins; Free Radical Scavengers; G1 Phase; Halogenated Diphenyl Ethers; Humans; Liver Neoplasms; Phenyl Ethers; Polybrominated Biphenyls; Reactive Oxygen Species; Resting Phase, Cell Cycle; S Phase; Time Factors

2007
N-acetyl-l-cysteine affords protection against lead-induced cytotoxicity and oxidative stress in human liver carcinoma (HepG2) cells.
    International journal of environmental research and public health, 2007, Volume: 4, Issue:2

    Topics: Acetylcysteine; Cell Proliferation; Cell Survival; Chelating Agents; Free Radicals; Humans; Lead; Lipid Peroxidation; Liver Neoplasms; Mutation; Nitrates; Oxidative Stress; Thiobarbiturates

2007
Inhibitory effect of 6-formylpterin on HIF-1alpha protein accumulation.
    Biological & pharmaceutical bulletin, 2007, Volume: 30, Issue:11

    Topics: Acetylcysteine; Antioxidants; Carcinoma, Hepatocellular; Cell Hypoxia; Cell Line, Tumor; Deferoxamine; Dose-Response Relationship, Drug; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Pterins; Reactive Oxygen Species; RNA, Messenger

2007
Effect of green tea and (-)-epigallocatechin gallate on ethanol-induced toxicity in HepG2 cells.
    Phytotherapy research : PTR, 2008, Volume: 22, Issue:5

    Topics: Acetylcysteine; Carcinoma, Hepatocellular; Catechin; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Ethanol; gamma-Glutamyltransferase; Glutathione; Humans; Liver Neoplasms; Plant Extracts; Tea

2008
The differential NF-kB modulation by S-adenosyl-L-methionine, N-acetylcysteine and quercetin on the promotion stage of chemical hepatocarcinogenesis.
    Free radical research, 2008, Volume: 42, Issue:4

    Topics: Acetylcysteine; Animals; Antioxidants; Biomarkers, Tumor; Gene Expression Regulation; Lipid Peroxidation; Liver Neoplasms; Male; NF-kappa B; Oxidative Stress; Quercetin; Rats; Rats, Inbred F344; S-Adenosylmethionine; Signal Transduction

2008
High rates of thioredoxin secretion correlate with growth arrest in hepatoma cells.
    Cancer research, 1995, Feb-01, Volume: 55, Issue:3

    Topics: Acetylcysteine; Animals; Carcinoma, Hepatocellular; Cell Division; Cell Line; Humans; Kinetics; L-Lactate Dehydrogenase; Liver; Liver Neoplasms; Lymphoma, B-Cell; Mercaptoethanol; Mice; Oxidation-Reduction; Recombinant Proteins; Reference Values; Thioredoxins; Tumor Cells, Cultured

1995
Intracellular glutathione level modulates the induction of apoptosis by delta 12-prostaglandin J2.
    Prostaglandins, 1996, Volume: 51, Issue:6

    Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Arsenites; Buthionine Sulfoximine; Carcinoma, Hepatocellular; Cell Division; Cycloheximide; DNA Fragmentation; Electrophoresis, Agar Gel; Enzyme Inhibitors; Glutathione; Humans; Liver Neoplasms; Prostaglandin D2; Sodium Compounds; Structure-Activity Relationship; Sulfhydryl Compounds; Tumor Cells, Cultured

1996
Glutathione S-conjugate formation and metabolism in HepG2 cells: a cell model of mercapturic acid biosynthesis.
    Journal of toxicology and environmental health. Part A, 1998, Apr-24, Volume: 53, Issue:8

    Topics: Acetylcysteine; Biological Transport; Carcinoma, Hepatocellular; Cysteine; Dinitrochlorobenzene; Glutathione; Humans; Inactivation, Metabolic; Liver Neoplasms; Models, Biological; Tumor Cells, Cultured

1998
Possible availability of N-acetylcysteine as an adjunct to cytokine therapy for hepatocellular carcinoma.
    Clinical immunology and immunopathology, 1998, Volume: 88, Issue:2

    Topics: Acetylcysteine; Adult; Aged; Carcinoma, Hepatocellular; Cytokines; Cytotoxicity, Immunologic; Female; Glutathione; Humans; Interleukin-2; Leukocytes, Mononuclear; Liver; Liver Neoplasms; Male; Middle Aged; Recombinant Proteins

1998
Regulated Co-translational ubiquitination of apolipoprotein B100. A new paradigm for proteasomal degradation of a secretory protein.
    The Journal of biological chemistry, 1998, Sep-18, Volume: 273, Issue:38

    Topics: Acetylcysteine; Animals; Apolipoprotein B-100; Apolipoproteins B; Benzoquinones; Carcinoma, Hepatocellular; CHO Cells; Cricetinae; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytosol; Endoplasmic Reticulum; Enzyme Inhibitors; HSP70 Heat-Shock Proteins; Humans; Lactams, Macrocyclic; Liver Neoplasms; Models, Biological; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Biosynthesis; Protein Processing, Post-Translational; Puromycin; Quinones; Recombinant Proteins; Rifabutin; Transfection; Tumor Cells, Cultured; Ubiquitins

1998
Induction of apoptosis in macrophages by cationic liposomes.
    FEBS letters, 1999, Nov-05, Volume: 460, Issue:3

    Topics: Acetylcysteine; Animals; Apoptosis; Carcinoma, Hepatocellular; Cations; Cell Line; DNA; DNA Fragmentation; Humans; Liposomes; Liver Neoplasms; Macrophages; Mice; Mice, Inbred BALB C; Peroxides; Rats; Rats, Wistar; Reactive Oxygen Species; Tumor Cells, Cultured

1999
Enhanced hydroxychavicol-induced cytotoxic effects in glutathione-depleted HepG2 cells.
    Cancer letters, 2000, Jul-03, Volume: 155, Issue:1

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetylcysteine; Antimetabolites, Antineoplastic; Apoptosis; Buthionine Sulfoximine; Catalase; Cell Survival; Deoxyguanosine; DNA; DNA Fragmentation; Dose-Response Relationship, Drug; Electrons; Eugenol; Free Radical Scavengers; Glutathione; Humans; Liver Neoplasms; Mutagens; Oxidative Stress; Reactive Oxygen Species; Time Factors; Tumor Cells, Cultured

2000
Dual role of glutathione in selenite-induced oxidative stress and apoptosis in human hepatoma cells.
    Free radical biology & medicine, 2000, Apr-01, Volume: 28, Issue:7

    Topics: Acetylcysteine; Apoptosis; Buthionine Sulfoximine; Carcinoma, Hepatocellular; Glutathione; Growth Inhibitors; Humans; Intracellular Fluid; L-Lactate Dehydrogenase; Liver Neoplasms; Oxidative Stress; Reactive Oxygen Species; Sodium Selenite; Tumor Cells, Cultured

2000
Inhibitors of Na+/Ca2+ exchanger prevent oxidant-induced intracellular Ca2+ increase and apoptosis in a human hepatoma cell line.
    Free radical research, 2000, Volume: 33, Issue:3

    Topics: Acetylcysteine; Antioxidants; Apoptosis; Calcium; Carcinoma, Hepatocellular; Chelating Agents; Egtazic Acid; Flow Cytometry; Humans; Liver Neoplasms; Oxidants; Oxidative Stress; Phenylenediamines; Reactive Oxygen Species; Sodium; Sodium-Calcium Exchanger; tert-Butylhydroperoxide; Tumor Cells, Cultured

2000
Superoxide radical-initiated apoptotic signalling pathway in selenite-treated HepG(2) cells: mitochondria serve as the main target.
    Free radical biology & medicine, 2001, Jan-01, Volume: 30, Issue:1

    Topics: Acetylcysteine; Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Caspase Inhibitors; Caspases; Cyclic N-Oxides; Cyclosporine; Cytochrome c Group; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Glutathione; Humans; In Situ Nick-End Labeling; Kinetics; Liver Neoplasms; Membrane Potentials; Mitochondria; Signal Transduction; Sodium Selenite; Spin Labels; Superoxides; Trifluoperazine; Tumor Cells, Cultured

2001
Reactive oxygen species and mitochondria mediate the induction of apoptosis in human hepatoma HepG2 cells by the rodent peroxisome proliferator and hepatocarcinogen, perfluorooctanoic acid.
    Toxicology and applied pharmacology, 2001, May-15, Volume: 173, Issue:1

    Topics: Acetylcysteine; Apoptosis; Caprylates; Carcinogens; Carcinoma, Hepatocellular; Caspase 9; Caspases; Cyclosporine; Dose-Response Relationship, Drug; Enzyme Activation; Flow Cytometry; Fluorocarbons; Humans; Hydrogen Peroxide; Kinetics; Liver Neoplasms; Membrane Potentials; Mitochondria, Liver; Reactive Oxygen Species; Superoxides; Tumor Cells, Cultured

2001
Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-kappa B.
    Proceedings of the National Academy of Sciences of the United States of America, 2001, Aug-14, Volume: 98, Issue:17

    Topics: Acetylcysteine; Antioxidants; Calcium; Calcium Signaling; Carcinoma, Hepatocellular; Chelating Agents; DNA-Binding Proteins; Egtazic Acid; Gallic Acid; Gene Expression Regulation, Neoplastic; Gene Expression Regulation, Viral; Genes, Reporter; Hepacivirus; Humans; Liver Neoplasms; Luciferases; Neoplasm Proteins; NF-kappa B; Oxidative Stress; Pyrrolidines; Reactive Oxygen Species; Recombinant Fusion Proteins; STAT3 Transcription Factor; Thiocarbamates; Trans-Activators; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Viral Nonstructural Proteins

2001
The influence of atracurium, cisatracurium, and mivacurium on the proliferation of two human cell lines in vitro.
    Anesthesia and analgesia, 2001, Volume: 93, Issue:3

    Topics: Acetylcysteine; Atracurium; Carboxylic Ester Hydrolases; Carcinoma, Hepatocellular; Cell Count; Cell Division; Cell Line; Endothelium, Vascular; Free Radical Scavengers; Glutathione; Humans; Isoquinolines; Liver Neoplasms; Mivacurium; Neuromuscular Nondepolarizing Agents

2001
Induction of apoptosis in p53-deficient human hepatoma cell line by wild-type p53 gene transduction: inhibition by antioxidant.
    Molecules and cells, 2001, Aug-31, Volume: 12, Issue:1

    Topics: Acetylcysteine; Antioxidants; Apoptosis; Carcinoma, Hepatocellular; Cell Survival; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; DNA Fragmentation; Free Radical Scavengers; Genes, p53; Glutathione; Humans; In Situ Nick-End Labeling; Liver Neoplasms; Retroviridae; Transduction, Genetic; Tumor Cells, Cultured; Tumor Suppressor Protein p53

2001
Involvement of Cdc25A phosphatase in Hep3B hepatoma cell growth inhibition induced by novel K vitamin analogs.
    Cancer research, 2001, Oct-01, Volume: 61, Issue:19

    Topics: Acetylcysteine; Carcinoma, Hepatocellular; Catalase; cdc25 Phosphatases; Cell Division; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases; Drug Interactions; Enzyme Activation; Glutathione; Growth Inhibitors; Humans; Liver Neoplasms; Phosphorylation; Proto-Oncogene Proteins; Retinoblastoma Protein; Sulfhydryl Compounds; Vitamin K

2001
Effects of N-acetylcysteine in an esophageal carcinogenesis model in rats treated with diethylnitrosamine and diethyldithiocarbamate.
    International journal of cancer, 2002, Apr-01, Volume: 98, Issue:4

    Topics: Acetylcysteine; Animals; Diethylnitrosamine; Ditiocarb; Drug Synergism; Esophageal Neoplasms; Esophagus; Free Radical Scavengers; Hyperplasia; Keratosis; Liver Neoplasms; Rats; Rats, Inbred Strains; Survival Rate

2002
Acetaminophen hepatotoxicity and mechanisms of its protection by N-acetylcysteine: a study of Hep3B cells.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2002, Volume: 53, Issue:6

    Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Apoptosis; Carcinoma, Hepatocellular; Cell Nucleus; Cell Survival; Cytoplasm; Dose-Response Relationship, Drug; Drug Antagonism; Flow Cytometry; Free Radical Scavengers; Glutathione; Hepatocytes; Humans; Liver Neoplasms; Oxidative Stress; Reactive Oxygen Species; Tumor Cells, Cultured

2002
Mechanism of Impila (Callilepis laureola)-induced cytotoxicity in Hep G2 cells.
    Clinical biochemistry, 2002, Volume: 35, Issue:1

    Topics: Acetylcysteine; Cell Division; Cell Survival; Dose-Response Relationship, Drug; Formazans; Glutathione; Hepatoblastoma; Humans; Liver Neoplasms; Medicine, African Traditional; Plant Extracts; Plants, Medicinal; Tetrazolium Salts; Time Factors; Tumor Cells, Cultured

2002
Increased oxidative metabolism of paracetamol in patients with hepatocellular carcinoma.
    Cancer letters, 1991, Volume: 57, Issue:1

    Topics: Acetaminophen; Acetylcysteine; Adult; Carcinoma, Hepatocellular; Chromatography, High Pressure Liquid; Cysteine; Cytochrome P-450 Enzyme System; Hepatitis B; Humans; Liver Neoplasms; Middle Aged; Oxidation-Reduction; Reference Values

1991