acetylcysteine and Liver Dysfunction

acetylcysteine has been researched along with Liver Dysfunction in 104 studies

Research

Studies (104)

Timeframe	Studies, this research(%)	All Research%
pre-1990	16 (15.38)	18.7374
1990's	19 (18.27)	18.2507
2000's	47 (45.19)	29.6817
2010's	18 (17.31)	24.3611
2020's	4 (3.85)	2.80

Authors

Authors	Studies
Dayasiri, K; Rao, S	1
Cumaoğlu, B; Günay, N; Oğuz Cumaoğlu, M; Tekin, Y	1
Dai, X; Kong, L; Li, Z; Sun, Y; Wang, Q; Wang, X; Zhong, W; Zhou, H	1
Güven, BB; Özkan, S; Suakıtıcı, S; Tanoglu, A	1
Graudins, A; Gunja, N; McNulty, R; Sivilotti, MLA; Wong, A	1
Carret, CK; Carvalho, T; Chora, ÂF; Liehl, P; Marreiros, IM; Mello-Vieira, J; Mota, MM; Zuzarte-Luís, V	1
Lu, L; Pu, LY; Rao, JH; Sun, Y; Wang, XH; Zhang, F	1
Allahverdi, A; Jahanshahi, A; Jahanshahi, G; Samiee Amlashi, O; Sotoudeh, A; Takhtfooladi, MA	1
Aleksiejuk, P; Banki, K; Bonilla, E; Francis, L; Landas, SK; Liu, Y; Marchena-Mendez, I; Oaks, Z; Patel, J; Perl, A; Yu, J	1
de Andrade, KQ; de Araújo, OR; de Farias Santos, JC; dos Santos, JM; Goulart, MO; Moura, FA	1
Rice, TW; Stollings, JL; Wheeler, AP	1
Abd-Elbaset, M; Abdel-Bakky, MS; Arafa, EA; El Sherbiny, GA; Elgendy, AN	1
Chen, Y; Li, Y; Su, W; Wang, T; Ying, Z; Zhang, H; Zhang, J; Zhang, L; Zhou, L	1
de Oliveira Menezes, A; Frasson de Souza Montero, E; Lauz Medeiros, SH; Zogbi, L	1
Bartlett, DC; Newsome, PN	1
Alexandropoulos, D; Arkadopoulos, N; Bazigos, GV; Doulamis, IP; Kondi-Pafiti, A; Konstantopoulos, P; Kotsis, T; Perrea, DN; Smyrniotis, V; Tragotsalou, N; Tzani, A	1
Baumann, J; Bogar, L; Ferencz, A; Ghosh, S; Jancso, G; Roth, E; Szakmany, T	1
Leiner, S	1
Bonora, A; Castell, JV; Donato, MT; Gómez-Lechón, MJ; Jiménez, N; Lahoz, A	1
Bateman, DN; Sandilands, EA	1
Ariyananda, PL; Fernando, WK	1
Cooper, J; Webster, CR	1
Lopez, DP	1
Dehpour, AR; Javidnia, K; Kheradpezhouh, E; Miri, R; Monabati, A; Noorafshan, A; Panjehshahin, MR	1
Acharya, M; Lau-Cam, CA	1
Adams, DH; Afford, SC; Bhogal, RH; Curbishley, SM; Weston, CJ	1
Allan, PF; Bloom, BB; Wanek, S	1
Al-Hasan, Y; Evans, L; Hashimoto, K; Liu, H; Pinkas, G; Thompson, LP	1
Fujii, J; Ihara, H; Ikeda, Y; Ito, R; Takahashi, M; Tsukamoto, H	1
Hoppu, K	1
Hori, Y; Iwasaki, Y; Komiyayama, Y; Kuroki, Y; Nakatani, H; Namera, A	1
Abbott, F; Farrell, K; Gopaul, S	1
Ahmad, M; Al-Shabanah, OA; Gado, A; Raza, M	1
Bharadwaj, LA; Davies, GF; Ovsenek, N; Roesler, WJ	1
Dart, RC; Yip, L	1
Hinson, JA; James, LP; Lamps, LW; McCullough, SS	1
Kociancic, T; Reed, MD	1
El-Bahay, C; Hanelt, S; Kahl, R; Lewerenz, V; Nastevska, C; Röhrdanz, E	1
Juurlink, DN	1
Hinson, JA; James, LP; Mayeux, PR	1
Drobnik, W; Fischereder, M; Hoffmann, U; Krämer, BK; Krüger, B	1
Guo, SH; Wu, G	1
Garg, U; Wasserman, GS	1
Buckley, N; Chan, B; Dawson, A; Graudins, A; Kerr, F; Murray, L; Trudinger, B; Whyte, IM	1
Prescott, L	1
Marzullo, L	1
Bond, GR	1
Good, AM; Johnson, DW; Juurlink, DN; Sivilotti, ML; Yarema, MC	1
Aitio, ML	1
Frumin, I; Iancu, TC; Manov, I; Motanis, H	1
Bilodeau, M; Zwingmann, C	1
Baba, A; Itoh, Y; Matsuo, M; Mishima, K; Oishi, R	1
Akieda, K; Inokuchi, S; Inoue, S; Morita, S; Nakagawa, Y; Otuka, H; Sekiguchi, H; Yamamoto, I	1
Durgut, R; Duru, M; Kaya, H; Koc, A; Sogut, S; Uz, E; Yilmaz, HR	1
Callelo, DP; Henretig, FM; Osterhoudt, KC	1
Bijarnia, RK; Kaur, T; Singla, SK; Tandon, C	1
Sawyer, TS; Spiller, HA	1
Ayata, A; Bayram, D; Cim, A; Gokcimen, A; Kocak, A; Ozgüner, F; Tola, HT	1
Dong, T; Liu, Y; Long, J; Wang, X; Zhang, H; Zhang, L; Zhao, W; Zhou, Q	1
Li, YH; Liu, KX; Tian, XF; Wang, YZ; Wang, ZZ; Yao, JH; Yuan, JC; Zhang, XS; Zhou, Q	1
Eşrefoğlu, M; Gül, M; Turan, F	1
Joshi, D; Shrivastava, S; Shukla, S; Singh, V	1
Björnsson, E	1
Miller, LF; Rumack, BH	1
Linden, CH; Rumack, BH	1
Lake, BG	1
Tams, TR	1
Breen, KJ; Bury, RW; Desmond, PV; Forge, BH; Mashford, ML; Whelan, G	1
Ruffalo, RL; Thompson, JF	1
Critchley, JA; Illingworth, RN; Prescott, LF; Proudfoot, AT	1
Heathcote, J; Wanless, IR	1
Alcaraz, MJ; Bustos, G; Ferrándiz, ML; Gunasegaran, R; Payá, M	1
Døssing, M; Sonne, J	1
Donnelly, PJ; Racz, WJ; Walker, RM	1
Hegarty, JE; Mulcahy, HE	1
Kalafatis, N; Macrides, TA; Naylor, LM; Shihata, A; Wright, PF	1
Belpaire, F; Buylaert, W; Calle, P; De Paepe, P; Samyn, N; Vandenbulcke, M; Verstraete, A; Vogelaers, D	1
Devlin, J; Ellis, AE; Heaton, N; McPeake, J; Wendon, JA; Williams, R	1
Bernelli-Zazzera, A; Pogliaghi, G; Radice, L; Tacchini, L	1
Abdul-Cader, Z; Al-Ali, AK; Al-Mustafa, ZH; Qaw, FS	1
Bacon, BR; Bellezzo, JM; Britton, RS; Bulla, GA; Fox, ES; Leingang, KA	1
Tucker, JR	1
Padar, S; Smith, TJ	1
Buckley, NA; Dawson, AH; O'Connell, DL; Whyte, IM	1
Akbay, A; Bozdayi, M; Bozkaya, H; Cinar, K; Eranil, S; Uzunalimoğlu, O; Yurdaydin, C	1
Hudson, M; James, OF; Prince, MI; Thomas, SH	1
Damián, FJ; Jaramillo, F; Llamas, J; Loarca-Piña, MG; Martínez, A; Martínez, C; Ortíz, R; Quezada, T; Reyes, JL; Rodríguez, ML; Valdivia, AG; Yamamoto, L	1
Koren, G; Kozer, E	1
Rumack, BH	1
Kearns, GL	1
Beard, RH; Farrar, HC; James, LP; Wells, E	1
Dillman, RO; Kim, HS; Stewart, DM; Stewart, K	1
Adam, RD; Critchley, JA; Illingworth, RN; Prescott, LF; Proudfoot, AT; Stewart, MJ	1
Prescott, LF	1
Best, L; Krenzelok, EP; Manoguerra, AS	1
Davis, M; Harrison, NG; Simmons, CJ; Williams, R	1
Gustafson, DL; Pritsos, CA; Sokoloff, M	1
De Majo, W; Levy, GA; Sheiner, P	1
Bray, GP; Mowat, C; Muir, DF; Tredger, JM; Williams, R	1
Alexander, GJ; Forbes, A; Gove, C; Harrison, PM; Keays, R; Wendon, JA; Williams, R	1
Chiesura, P; Gioffrè, F; Rizzi, E; Scapinello, A; Trevisan, A	1
Gescher, A; Mráz, J; Shaw, AJ	1
Brodeur, J; Goyal, R	1
Beckett, GJ; Chapman, BJ; Dyson, EH; Hayes, JD	1

Reviews

20 review(s) available for acetylcysteine and Liver Dysfunction

Article	Year
Oxidative Stress and Inflammation in Hepatic Diseases: Therapeutic Possibilities of N-Acetylcysteine. International journal of molecular sciences, 2015, Dec-18, Volume: 16, Issue:12 Topics: Acetylcysteine; Animals; Biomarkers; Humans; Inflammation; Liver Diseases; Models, Biological; Oxidative Stress	2015
Adverse reactions associated with acetylcysteine. Clinical toxicology (Philadelphia, Pa.), 2009, Volume: 47, Issue:2 Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Anaphylaxis; Antidotes; Blood Coagulation; Chemical and Drug Induced Liver Injury; Humans; Infusions, Intravenous; International Normalized Ratio; Liver Diseases; Risk Factors	2009
Therapeutic use of cytoprotective agents in canine and feline hepatobiliary disease. The Veterinary clinics of North America. Small animal practice, 2009, Volume: 39, Issue:3 Topics: Acetylcysteine; Animals; Antioxidants; Biliary Tract Diseases; Cat Diseases; Cats; Cholagogues and Choleretics; Cryoprotective Agents; Dog Diseases; Dogs; Free Radical Scavengers; Liver Diseases; S-Adenosylmethionine; Silymarin; Ursodeoxycholic Acid; Vitamin E	2009
Emergency: acetaminophen poisoning. The American journal of nursing, 2009, Volume: 109, Issue:9 Topics: Acetaminophen; Acetylcysteine; Adolescent; Antidotes; Charcoal; Chemical and Drug Induced Liver Injury; Disease Progression; Drug Labeling; Emergencies; Emergency Treatment; Female; Humans; Liver Diseases; Nonprescription Drugs; Patient Education as Topic; Risk Factors; Substance Abuse Detection; Suicide, Attempted; Time Factors	2009
[Treatment of paracetamol intoxication. Correctly given antidote treatment will prevent liver damage]. Duodecim; laaketieteellinen aikakauskirja, 2002, Volume: 118, Issue:2 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver Diseases; Poisoning; Time Factors; Treatment Outcome	2002
[Practical analysis of toxic substances useful for clinical toxicology--4--Acetaminophen]. Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology, 2002, Volume: 15, Issue:4 Topics: Acetaminophen; Acetylcysteine; Adult; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Colorimetry; Female; Humans; Liver Diseases; Predictive Value of Tests; Severity of Illness Index; Suicide, Attempted; Ultraviolet Rays	2002
Acetaminophen intoxication and length of treatment: how long is long enough? Pharmacotherapy, 2003, Volume: 23, Issue:8 Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver Diseases; Time Factors	2003
Acetaminophen-induced hepatotoxicity. Drug metabolism and disposition: the biological fate of chemicals, 2003, Volume: 31, Issue:12 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Cytokines; Humans; Kupffer Cells; Liver Diseases; Mitochondria, Liver; Oxidative Stress; Tyrosine	2003
[Clinical application of N-acetylcysteine in liver disease]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2004, Volume: 12, Issue:3 Topics: Acetaminophen; Acetylcysteine; Humans; Liver Diseases	2004
An update of N-acetylcysteine treatment for acute acetaminophen toxicity in children. Current opinion in pediatrics, 2005, Volume: 17, Issue:2 Topics: Acetaminophen; Acetylcysteine; Acute Disease; Administration, Oral; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Child; Dose-Response Relationship, Drug; Exanthema; Humans; Infusions, Intravenous; Liver Diseases; Practice Guidelines as Topic; Pruritus	2005
N-acetylcysteine -- passe-partout or much ado about nothing? British journal of clinical pharmacology, 2006, Volume: 61, Issue:1 Topics: Acetylcysteine; Anti-HIV Agents; Antioxidants; Cardiovascular Diseases; Drug Therapy, Combination; Expectorants; HIV Infections; Humans; Kidney Diseases; Liver Diseases; Lung Diseases; Neoplasms; Oxidative Stress; Reactive Oxygen Species	2006
Hepatotoxicity of anti-inflammatory and analgesic drugs: ultrastructural aspects. Acta pharmacologica Sinica, 2006, Volume: 27, Issue:3 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspirin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Drug Overdose; Hepatocytes; Humans; Liver; Liver Diseases; Liver Neoplasms; Verapamil	2006
[Alcohol abuse case of severe liver dysfunction induced by acetaminophen poisoning which was diagnosed as non-hepatic toxicity on admission]. Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology, 2006, Volume: 19, Issue:3 Topics: Acetaminophen; Acetylcysteine; Administration, Rectal; Adult; Alcoholism; Analgesics, Non-Narcotic; Drug Overdose; Female; Humans; Liver Diseases; Plasma Exchange; Severity of Illness Index; Suicide, Attempted; Therapeutics	2006
Hepatotoxicity associated with antiepileptic drugs. Acta neurologica Scandinavica, 2008, Volume: 118, Issue:5 Topics: Acetylcysteine; Animals; Anticonvulsants; Autoimmune Diseases; Carnitine; Chemical and Drug Induced Liver Injury; Disseminated Intravascular Coagulation; Hepatic Encephalopathy; Hepatocytes; Humans; Liver; Liver Diseases	2008
Acetaminophen overdose. Emergency medicine clinics of North America, 1984, Volume: 2, Issue:1 Topics: Acetaminophen; Acetylcysteine; Adult; Alanine Transaminase; Aspartate Aminotransferases; Bilirubin; Biotransformation; Chemical and Drug Induced Liver Injury; Child; Cysteine; Dose-Response Relationship, Drug; Glutathione; History, 20th Century; Humans; Kinetics; Liver Diseases; Prognosis; Prothrombin Time; Time Factors	1984
Hepatotoxicity: newer aspects of pathogenesis and treatment. The Gastroenterologist, 1995, Volume: 3, Issue:2 Topics: Acetaminophen; Acetylcysteine; Adenoma, Liver Cell; Adult; Amoxicillin; Anabolic Agents; Beverages; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Contraceptives, Oral; Female; Humans; Isoniazid; Liver Diseases; Liver Diseases, Alcoholic; Liver Neoplasms; Male; Nonprescription Drugs; Propylthiouracil; Rifampin	1995
Drug-induced hepatic disorders. Incidence, management and avoidance. Drug safety, 1993, Volume: 9, Issue:6 Topics: Acetylcysteine; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Interactions; Humans; Jaundice; Liver; Liver Diseases; Liver Transplantation; Risk Factors	1993
Paracetamol hepatotoxicity. Irish journal of medical science, 1993, Volume: 162, Issue:1 Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Drug Overdose; Hepatic Encephalopathy; Humans; Intubation; Liver Diseases; Prognosis; Stomach	1993
Oral or intravenous N-acetylcysteine: which is the treatment of choice for acetaminophen (paracetamol) poisoning? Journal of toxicology. Clinical toxicology, 1999, Volume: 37, Issue:6 Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Charcoal; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Drug Therapy, Combination; Female; Free Radical Scavengers; Humans; Infant; Injections, Intravenous; Liver Diseases; Male; Middle Aged; Poisoning; Transaminases	1999
Management of paracetamol overdose: current controversies. Drug safety, 2001, Volume: 24, Issue:7 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Child; Drug Interactions; Drug Overdose; Female; Humans; Liver Diseases; Pregnancy; Risk Factors	2001

Trials

5 trial(s) available for acetylcysteine and Liver Dysfunction

Article	Year
A 20-hour treatment for acute acetaminophen overdose. The New England journal of medicine, 2003, Jun-12, Volume: 348, Issue:24 Topics: Acetaminophen; Acetylcysteine; Acute Disease; Administration, Oral; Adolescent; Adult; Drug Administration Schedule; Female; Humans; Liver Diseases; Male; Middle Aged; Poisoning	2003
The value of N-acetylcysteine in the prevention of radiocontrast agent-induced nephropathy seems questionable. Journal of the American Society of Nephrology : JASN, 2004, Volume: 15, Issue:2 Topics: Acetylcysteine; Adult; Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Contrast Media; Female; Humans; Liver Diseases; Male; Prospective Studies; Radiopharmaceuticals	2004
The Australasian Clinical Toxicology Investigators Collaboration randomized trial of different loading infusion rates of N-acetylcysteine. Annals of emergency medicine, 2005, Volume: 45, Issue:4 Topics: Acetaminophen; Acetylcysteine; Adult; Alanine Transaminase; Anaphylaxis; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; International Normalized Ratio; Liver Diseases; Male; Nausea	2005
Clinical safety of high oral doses of acetylcysteine. Seminars in oncology, 1983, Volume: 10, Issue:1 Suppl 1 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Antidotes; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry; Clinical Trials as Topic; Diarrhea; Drug Administration Schedule; Electrocardiography; Electrolytes; Humans; Liver; Liver Diseases; Rats; Vomiting	1983
Intravenous acetylcysteine in paracetamol induced fulminant hepatic failure: a prospective controlled trial. BMJ (Clinical research ed.), 1991, Oct-26, Volume: 303, Issue:6809 Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Hepatic Encephalopathy; Humans; Infusions, Intravenous; Liver Diseases; London; Male; Middle Aged; Prospective Studies; Prothrombin Time; Survival Rate	1991

Other Studies

79 other study(ies) available for acetylcysteine and Liver Dysfunction

Article	Year
Fifteen-minute update: International normalised ratio as the treatment end point in children with acute paracetamol poisoning. Archives of disease in childhood. Education and practice edition, 2023, Volume: 108, Issue:3 Topics: Acetaminophen; Acetylcysteine; Child; Humans; International Normalized Ratio; Liver Diseases; Vitamin K	2023
Therapeutic effect of 6-shogaol on acetaminophen-induced hepatotoxicity in mice: an experimental study. European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:20 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Glutathione; Liver; Liver Diseases; Mice; Nitrates; Nitrites	2022
N-acetylcysteine alleviates liver injury by suppressing macrophage-mediated inflammatory response post microwave ablation. International immunopharmacology, 2020, Volume: 85 Topics: Ablation Techniques; Acetylcysteine; Animals; Anti-Inflammatory Agents; Apoptosis; Carcinoma, Hepatocellular; Humans; Inflammation; Liver; Liver Diseases; Liver Neoplasms; Macrophages; Male; Microwaves; Peroxidase; Rats, Sprague-Dawley	2020
A combination of levosimendan and N-Acetylcysteine shows significant favorable efficacy on experimental liver ischemia/reperfusion injury. Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES, 2021, Volume: 27, Issue:4 Topics: Acetylcysteine; Animals; Liver; Liver Diseases; Oxidative Stress; Protective Agents; Rats; Reperfusion Injury; Simendan	2021
Accuracy of the paracetamol-aminotransferase product to predict hepatotoxicity in paracetamol overdose treated with a 2-bag acetylcysteine regimen. Clinical toxicology (Philadelphia, Pa.), 2018, Volume: 56, Issue:3 Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Liver Diseases; Male; Middle Aged; Retrospective Studies; Risk Factors; Young Adult	2018
Dietary alterations modulate susceptibility to Plasmodium infection. Nature microbiology, 2017, Volume: 2, Issue:12 Topics: Acetylcysteine; Animals; Antioxidants; Diet, High-Fat; Disease Models, Animal; Female; Gene Expression Profiling; Glucose Tolerance Test; Glucosephosphate Dehydrogenase Deficiency; Hep G2 Cells; Hepatocytes; Host-Parasite Interactions; Humans; Liver; Liver Diseases; Macrophages; Malaria; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Parasite Load; Plasmodium berghei; Reactive Oxygen Species; Sickle Cell Trait; Sporozoites	2017
N-acetylcysteine attenuates reactive-oxygen-species-mediated endoplasmic reticulum stress during liver ischemia-reperfusion injury. World journal of gastroenterology, 2014, Nov-07, Volume: 20, Issue:41 Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Cells, Cultured; Cytoprotection; Disease Models, Animal; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Liver; Liver Diseases; Male; Mice, Inbred C57BL; Oxidative Stress; Reactive Oxygen Species; Reperfusion Injury; Signal Transduction	2014
Effects of N-acetylcysteine on liver remote injury after skeletal muscle ischemia reperfusion in rats. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2014, Volume: 25 Suppl 1 Topics: Acetylcysteine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Free Radical Scavengers; Glutathione; Liver Diseases; Male; Malondialdehyde; Muscle, Skeletal; Peroxidase; Rats; Rats, Wistar; Reperfusion Injury	2014
Liver injury correlates with biomarkers of autoimmunity and disease activity and represents an organ system involvement in patients with systemic lupus erythematosus. Clinical immunology (Orlando, Fla.), 2015, Volume: 160, Issue:2 Topics: Acetylcysteine; Adult; Alanine Transaminase; Antibodies, Antinuclear; Aspartate Aminotransferases; Azathioprine; Biomarkers; Cohort Studies; Complement System Proteins; Cyclosporine; Diabetes Mellitus; Female; Free Radical Scavengers; Humans; Immunosuppressive Agents; Liver Diseases; Longitudinal Studies; Lupus Erythematosus, Systemic; Male; Middle Aged; Mycophenolic Acid; Prednisone; Prevalence; Retrospective Studies; Severity of Illness Index; Sex Distribution; Sirolimus	2015
Incidence and characterization of acute kidney injury after acetaminophen overdose. Journal of critical care, 2016, Volume: 35 Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Adult; Analgesics, Non-Narcotic; Biomarkers; Creatinine; Drug Overdose; Female; Humans; Incidence; Intensive Care Units; Liver Diseases; Male; Middle Aged; Retrospective Studies	2016
Thymoquinone mitigate ischemia-reperfusion-induced liver injury in rats: a pivotal role of nitric oxide signaling pathway. Naunyn-Schmiedeberg's archives of pharmacology, 2017, Volume: 390, Issue:1 Topics: Acetylcysteine; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Benzoquinones; Biomarkers; Cytoprotection; Disease Models, Animal; Glutathione; Lipid Peroxidation; Liver; Liver Diseases; Male; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Peroxidase; Rats, Wistar; Reperfusion Injury; Signal Transduction	2017
N-acetylcysteine attenuates intrauterine growth retardation-induced hepatic damage in suckling piglets by improving glutathione synthesis and cellular homeostasis. European journal of nutrition, 2018, Volume: 57, Issue:1 Topics: Acetylcysteine; Alanine Transaminase; Animals; Animals, Suckling; Apoptosis; Aspartate Aminotransferases; Fetal Growth Retardation; Gene Expression; Genes, bcl-2; Glutathione; Homeostasis; Liver; Liver Diseases; Male; Malondialdehyde; Necrosis; Oxidation-Reduction; Sus scrofa	2018
N-Acetylcysteine Use in Hepatic Ischemia/Reperfusion in Rats Minimizing Bowel Injury. Transplantation proceedings, 2016, Volume: 48, Issue:7 Topics: Acetylcysteine; Animals; Disease Models, Animal; Free Radical Scavengers; Intestinal Mucosa; Intestine, Small; Liver; Liver Diseases; Male; Rats; Rats, Wistar; Reperfusion Injury	2016
A Modified Protocol for the Isolation of Primary Human Hepatocytes with Improved Viability and Function from Normal and Diseased Human Liver. Methods in molecular biology (Clifton, N.J.), 2017, Volume: 1506 Topics: Acetylcysteine; Cell Separation; Cell Survival; Cell Transplantation; Cells, Cultured; Collagenases; Hepatocytes; Humans; Liver; Liver Diseases; Primary Cell Culture; Thermolysin; Tissue Donors	2017
Protective effects of N-acetylcystein and atorvastatin against renal and hepatic injury in a rat model of intestinal ischemia-reperfusion. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 89 Topics: Acetylcysteine; Acute Kidney Injury; Animals; Antioxidants; Atorvastatin; Drug Therapy, Combination; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intestines; Kidney Function Tests; Liver Diseases; Liver Function Tests; Male; Protective Agents; Rats; Rats, Wistar; Reperfusion Injury	2017
Short-term effects of N-acetylcysteine and ischemic preconditioning in a canine model of hepatic ischemia-reperfusion injury. European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 2008, Volume: 41, Issue:2 Topics: Acetylcysteine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Coloring Agents; Disease Models, Animal; Dogs; Indocyanine Green; Ischemic Preconditioning; Liver Diseases; Reperfusion Injury	2008
Acetaminophen poisoning. The New England journal of medicine, 2008, Oct-30, Volume: 359, Issue:18 Topics: Acetaminophen; Acetylcysteine; Anti-Inflammatory Agents, Non-Steroidal; Free Radical Scavengers; Humans; Liver; Liver Diseases; Poisoning	2008
Evaluation of drug-metabolizing and functional competence of human hepatocytes incubated under hypothermia in different media for clinical infusion. Cell transplantation, 2008, Volume: 17, Issue:8 Topics: Acetylcysteine; Animals; Apoptosis; Caspases; Cell Adhesion; Cell Culture Techniques; Cell Survival; Cells, Cultured; Culture Media; Cytochrome P-450 Enzyme System; Energy Metabolism; Glucose; Hepatocytes; Humans; Hyperthermia, Induced; Inactivation, Metabolic; Liver Diseases; Male; Rats; Rats, Sprague-Dawley; Tissue Transplantation; Urea	2008
Paracetamol poisoning below toxic level causing liver damage in a fasting adult. The Ceylon medical journal, 2009, Volume: 54, Issue:1 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Fasting; Female; Free Radical Scavengers; Humans; Liver; Liver Diseases; Risk Factors; Young Adult	2009
Curcumin protects rats against acetaminophen-induced hepatorenal damages and shows synergistic activity with N-acetyl cysteine. European journal of pharmacology, 2010, Feb-25, Volume: 628, Issue:1-3 Topics: Acetaminophen; Acetylcysteine; Animals; Biomarkers; Catalase; Curcumin; Drug Synergism; Glutathione Peroxidase; Kidney; Kidney Diseases; Liver; Liver Diseases; Male; Malondialdehyde; Oxidative Stress; Rats; Rats, Sprague-Dawley; Serologic Tests	2010
Comparison of the protective actions of N-acetylcysteine, hypotaurine and taurine against acetaminophen-induced hepatotoxicity in the rat. Journal of biomedical science, 2010, Aug-24, Volume: 17 Suppl 1 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Free Radical Scavengers; Glutathione; Glutathione Disulfide; Glutathione Transferase; Humans; Liver; Liver Diseases; Male; Malondialdehyde; Rats; Rats, Sprague-Dawley; Taurine	2010
Reactive oxygen species mediate human hepatocyte injury during hypoxia/reoxygenation. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2010, Volume: 16, Issue:11 Topics: Acetylcysteine; Annexin A5; Antioxidants; Apoptosis; Female; Flow Cytometry; Hepatocytes; Humans; Hypoxia; Inflammation; Kupffer Cells; Liver; Liver Diseases; Male; Mitochondria; Models, Biological; NADPH Oxidases; Reactive Oxygen Species; Reperfusion Injury; Young Adult	2010
Reversal of hemorrhagic shock-associated hepatic ischemia-reperfusion injury with N-acetylcysteine. Military medicine, 2011, Volume: 176, Issue:3 Topics: Acetylcysteine; Adult; Free Radical Scavengers; Humans; Infusions, Intravenous; Liver Diseases; Male; Reperfusion Injury; Shock, Hemorrhagic	2011
Protective effect of N-acetylcysteine on liver damage during chronic intrauterine hypoxia in fetal guinea pig. Reproductive sciences (Thousand Oaks, Calif.), 2012, Volume: 19, Issue:9 Topics: Acetylcysteine; Animals; Antioxidants; Female; Fetal Hypoxia; Guinea Pigs; Liver Diseases; Organ Size; Oxidative Stress; Pregnancy; Protective Agents	2012
Measurement of peroxiredoxin-4 serum levels in rat tissue and its use as a potential marker for hepatic disease. Molecular medicine reports, 2012, Volume: 6, Issue:2 Topics: Acetylcysteine; Animals; Antibodies; Antibody Specificity; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell Line, Tumor; Culture Media; Diabetes Mellitus, Experimental; Enzyme-Linked Immunosorbent Assay; Female; Immunoglobulin G; Liver; Liver Diseases; Male; Oxidation-Reduction; Oxidative Stress; Peroxiredoxins; Rabbits; Rats; Rats, Inbred LEC; Rats, Sprague-Dawley; Rats, Wistar; Recombinant Proteins; Vaccination	2012
Effects of age and polytherapy, risk factors of valproic acid (VPA) hepatotoxicity, on the excretion of thiol conjugates of (E)-2,4-diene VPA in people with epilepsy taking VPA. Epilepsia, 2003, Volume: 44, Issue:3 Topics: Acetylcysteine; Adolescent; Adult; Age Factors; Anticonvulsants; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Drug Therapy, Combination; Enzyme Induction; Epilepsy; Female; Humans; Liver Diseases; Male; Risk Factors; Valproic Acid	2003
A comparison of hepatoprotective activities of aminoguanidine and N-acetylcysteine in rat against the toxic damage induced by azathioprine. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2003, Volume: 134, Issue:4 Topics: Acetylcysteine; Animals; Azathioprine; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Guanidines; Liver; Liver Diseases; Male; Rats; Rats, Wistar	2003
Troglitazone reduces heat shock protein 70 content in primary rat hepatocytes by a ubiquitin proteasome independent mechanism. Pharmacological research, 2003, Volume: 48, Issue:1 Topics: Acetylcysteine; Animals; Blotting, Northern; Blotting, Western; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chromans; Cysteine Endopeptidases; Dose-Response Relationship, Drug; Gene Expression; Heat-Shock Proteins; Hepatocytes; Histones; Liver Diseases; Male; Mice; Mice, Inbred C57BL; Multienzyme Complexes; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; RNA, Messenger; Thiazolidinediones; Troglitazone; Ubiquitin	2003
Effect of N-acetylcysteine on acetaminophen toxicity in mice: relationship to reactive nitrogen and cytokine formation. Toxicological sciences : an official journal of the Society of Toxicology, 2003, Volume: 75, Issue:2 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Chemokines; Drug Interactions; Immunoenzyme Techniques; Injections, Intraperitoneal; Liver; Liver Diseases; Male; Mice; Mice, Inbred Strains; Necrosis; Nitric Oxide; Reactive Nitrogen Species; Up-Regulation	2003
Antioxidants protect primary rat hepatocyte cultures against acetaminophen-induced DNA strand breaks but not against acetaminophen-induced cytotoxicity. Toxicology, 2003, Sep-30, Volume: 191, Issue:2-3 Topics: Acetaminophen; Acetylcysteine; alpha-Tocopherol; Analgesics, Non-Narcotic; Animals; Antioxidants; Blotting, Northern; Cell Death; Chemical and Drug Induced Liver Injury; Comet Assay; DNA Damage; Dose-Response Relationship, Drug; Formazans; Hepatocytes; Lipid Peroxides; Liver Diseases; Male; Neutral Red; Rats; Rats, Wistar; RNA; Silybin; Silymarin; Tetrazolium Salts	2003
Drug-induced hepatotoxicity. The New England journal of medicine, 2003, Nov-13, Volume: 349, Issue:20 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Humans; Liver; Liver Diseases	2003
Intravenous administration of N-acetylcysteine: interference with coagulopathy testing. Annals of emergency medicine, 2004, Volume: 44, Issue:5 Topics: Acetaminophen; Acetylcysteine; Adult; Chemical and Drug Induced Liver Injury; Child; Female; Humans; Injections, Intravenous; International Normalized Ratio; Liver Diseases; Male; Prothrombin Time	2004
Oral or intravenous N-acetylcysteine for acetaminophen poisoning? Annals of emergency medicine, 2005, Volume: 45, Issue:4 Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Chemical and Drug Induced Liver Injury; Humans; Infusions, Intravenous; Liver Diseases; Time Factors	2005
A new acetaminophen nomogram with a different purpose. Annals of emergency medicine, 2005, Volume: 46, Issue:3 Topics: Acetaminophen; Acetylcysteine; Alcohol Drinking; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Interactions; Drug Overdose; Emergency Medicine; Humans; Liver Diseases; Nomograms; Outcome and Process Assessment, Health Care; Risk Assessment	2005
A risk quantification instrument for acute acetaminophen overdose patients treated with N-acetylcysteine. Annals of emergency medicine, 2005, Volume: 46, Issue:3 Topics: Acetaminophen; Acetylcysteine; Acute Disease; Adolescent; Adult; Alcohol Drinking; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Drug Overdose; Emergency Medicine; Female; Humans; Liver Diseases; Logistic Models; Male; Models, Theoretical; Outcome and Process Assessment, Health Care; Retrospective Studies; Risk Assessment; Risk Factors; Transaminases	2005
Metabolic insights into the hepatoprotective role of N-acetylcysteine in mouse liver. Hepatology (Baltimore, Md.), 2006, Volume: 43, Issue:3 Topics: Acetylcysteine; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Citric Acid Cycle; Cytoprotection; Disease Models, Animal; Glutathione; Liver; Liver Diseases; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred BALB C; Mitochondria, Liver; Nitro Compounds; Oxidative Stress; Propionates; Pyruvate Carboxylase; Pyruvate Dehydrogenase Complex; Taurine; tert-Butylhydroperoxide	2006
Protective effect of cyclic AMP against cisplatin-induced nephrotoxicity. Free radical biology & medicine, 2006, May-01, Volume: 40, Issue:9 Topics: Acetylcysteine; Animals; Antineoplastic Agents; Antioxidants; Apoptosis; Chemical and Drug Induced Liver Injury; Cisplatin; Cyclic AMP; Enzyme Activation; Enzyme Inhibitors; Epoprostenol; Fluorescent Antibody Technique; In Situ Nick-End Labeling; Lipid Peroxidation; Liver Diseases; Male; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Wistar; Reactive Oxygen Species; Superoxide Dismutase; Tumor Necrosis Factor-alpha	2006
The protective effect of N-acetylcysteine against cyclosporine A-induced hepatotoxicity in rats. Journal of applied toxicology : JAT, 2008, Volume: 28, Issue:1 Topics: Acetylcysteine; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cyclosporine; Glutathione Peroxidase; Liver; Liver Diseases; Male; Malondialdehyde; Nitric Oxide; Rats; Rats, Wistar; Superoxide Dismutase	2008
Erratum in intravenous n-acetylcysteine dosing. Pediatric emergency care, 2007, Volume: 23, Issue:5 Topics: Acetylcysteine; Antidotes; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Infusions, Intraosseous; Liver Diseases	2007
Reversal of hyperoxaluria-induced alteration in rat liver by administration of N-acetylcysteine. Drug and chemical toxicology, 2007, Volume: 30, Issue:3 Topics: Acetylcysteine; Animals; Catalase; Disease Models, Animal; Free Radical Scavengers; Hyperoxaluria; Lipid Metabolism; Lipid Peroxidation; Liver; Liver Diseases; Male; Membrane Fluidity; Oxalates; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase	2007
Impact of activated charcoal after acute acetaminophen overdoses treated with N-acetylcysteine. The Journal of emergency medicine, 2007, Volume: 33, Issue:2 Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Charcoal; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver Diseases; Registries; Retrospective Studies	2007
Protective effect of N-acetylcysteine, caffeic acid and vitamin E on doxorubicin hepatotoxicity. Human & experimental toxicology, 2007, Volume: 26, Issue:6 Topics: Acetylcysteine; Administration, Oral; Animals; Antibiotics, Antineoplastic; Caffeic Acids; Chemical and Drug Induced Liver Injury; Doxorubicin; Drug Therapy, Combination; Free Radical Scavengers; Hepatocytes; Injections, Intraperitoneal; Leukocytes, Mononuclear; Liver Diseases; Male; Microscopy, Polarization; Protective Agents; Random Allocation; Rats; Rats, Wistar; Vitamin E; Vitamins	2007
Antioxidant N-acetylcysteine attenuates the acute liver injury caused by X-ray in mice. European journal of pharmacology, 2007, Dec-01, Volume: 575, Issue:1-3 Topics: Acetylcysteine; Acute Disease; Animals; Antioxidants; Apoptosis; Colorimetry; Comet Assay; DNA Damage; Dose-Response Relationship, Drug; Free Radical Scavengers; Glutathione; Lipid Peroxidation; Liver Diseases; Malondialdehyde; Mice; Superoxide Dismutase; X-Rays	2007
Proteasome inhibitor lactacystin ablates liver injury induced by intestinal ischaemia-reperfusion. Clinical and experimental pharmacology & physiology, 2007, Volume: 34, Issue:11 Topics: Acetylcysteine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Cysteine Proteinase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Feasibility Studies; Intercellular Adhesion Molecule-1; Intestines; L-Lactate Dehydrogenase; Liver; Liver Diseases; Male; Neutrophil Infiltration; Peroxidase; Proteasome Endopeptidase Complex; Rats; Rats, Wistar; Reperfusion Injury; Transcription Factor RelA	2007
Comparative effects of several therapatic agents on hepatic damage induced by acute experimental pancreatitis. Digestive diseases and sciences, 2008, Volume: 53, Issue:5 Topics: Acetylcysteine; Acute Disease; Animals; Antioxidants; Arginine; Ascorbic Acid; Ceruletide; Female; Liver Diseases; Melatonin; Pancreatitis; Pentoxifylline; Rats; Rats, Wistar; Statistics, Nonparametric	2008
Effect of monothiol along with antioxidant against mercury-induced oxidative stress in rat. Indian journal of experimental biology, 2007, Volume: 45, Issue:12 Topics: Acetylcysteine; Animals; Antioxidants; Chelating Agents; Chemical and Drug Induced Liver Injury; Dietary Supplements; Drug Therapy, Combination; Liver Diseases; Magnesium; Male; Mercury Poisoning; Oxidative Stress; Penicillamine; Rats; Rats, Sprague-Dawley; Sodium Selenite; Treatment Outcome; Zinc	2007
Investigations into the mechanism of coumarin-induced hepatotoxicity in the rat. Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1984, Volume: 7 Topics: Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Coumarins; Kinetics; Liver; Liver Diseases; Male; Microsomes, Liver; Naphthalenes; Necrosis; Rats; Rats, Inbred Strains; Sulfhydryl Compounds	1984
Management of liver disease in dogs and cats. Modern veterinary practice, 1984, Volume: 65, Issue:2 Topics: Acetylcysteine; Adrenal Cortex Hormones; Animals; Anti-Bacterial Agents; Bacterial Infections; Cat Diseases; Cats; Cimetidine; Diuretics; Dog Diseases; Dogs; Lactulose; Liver Diseases; Prednisolone	1984
Paracetamol self-poisoning: diagnosis, management, and outcome. The Medical journal of Australia, 1982, Jan-23, Volume: 1, Issue:2 Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Australia; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Female; Hospitalization; Humans; Injections, Intravenous; Liver Diseases; Liver Function Tests; Methionine; Middle Aged; Suicide, Attempted; Time Factors	1982
Cimetidine and acetylcysteine as antidote for acetaminophen overdose. Southern medical journal, 1982, Volume: 75, Issue:8 Topics: Acetaminophen; Acetylcysteine; Antidotes; Chemical and Drug Induced Liver Injury; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Drug Therapy, Combination; Guanidines; Humans; Liver Diseases; Time Factors	1982
Intravenous N-acetylcysteine: still the treatment of choice for paracetamol poisoning. British medical journal, 1980, Jan-05, Volume: 280, Issue:6206 Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Humans; Injections, Intravenous; Liver Diseases	1980
Hispidulin protection against hepatotoxicity induced by bromobenzene in mice. Life sciences, 1994, Volume: 55, Issue:8 Topics: Acetylcysteine; Animals; Bromobenzenes; Chemical and Drug Induced Liver Injury; Flavones; Flavonoids; Glutathione; Lipid Peroxides; Liver Diseases; Male; Mice	1994
Inhibition of mitochondrial respiration in vivo is an early event in acetaminophen-induced hepatotoxicity. Archives of toxicology, 1994, Volume: 68, Issue:2 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Liver Diseases; Male; Mice; Mice, Inbred Strains; Mitochondria, Liver; Oxygen Consumption	1994
Hepatoprotective effects of the shark bile salt 5beta-scymnol on acetaminophen-induced liver damage in mice. Fundamental and applied toxicology : official journal of the Society of Toxicology, 1996, Volume: 33, Issue:1 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Cholestanols; Injections, Intraperitoneal; L-Lactate Dehydrogenase; Liver; Liver Diseases; Male; Mice; Necrosis	1996
Hepatotoxicity of N, N-dimethylformamide (DMF) in acute poisoning with the veterinary euthanasia drug T-61. Human & experimental toxicology, 1996, Volume: 15, Issue:8 Topics: Acetylcysteine; Adult; Amides; Animals; Chemical and Drug Induced Liver Injury; Dimethylformamide; Drug Combinations; Free Radical Scavengers; Humans; L-Iditol 2-Dehydrogenase; Liver Diseases; Male; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Suicide, Attempted; Tetracaine	1996
N-acetylcysteine improves indocyanine green extraction and oxygen transport during hepatic dysfunction. Critical care medicine, 1997, Volume: 25, Issue:2 Topics: Acetylcysteine; Adolescent; Adult; Antihypertensive Agents; Epoprostenol; Female; Free Radical Scavengers; Hemodynamics; Humans; Indocyanine Green; Infusions, Intravenous; Liver Diseases; Liver Transplantation; Male; Middle Aged; Oxygen Consumption	1997
Differential activation of heat shock and nuclear factor kappaB transcription factors in postischemic reperfused rat liver. Hepatology (Baltimore, Md.), 1997, Volume: 26, Issue:1 Topics: Acetylcysteine; Animals; Free Radical Scavengers; Gadolinium; Heat-Shock Proteins; Liver Diseases; Male; NF-kappa B; Rats; Rats, Wistar; Receptors, Interleukin-1; Reperfusion Injury	1997
Cimetidine enhances the hepatoprotective action of N-acetylcysteine in mice treated with toxic doses of paracetamol. Toxicology, 1997, Sep-05, Volume: 121, Issue:3 Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; Cimetidine; Free Radical Scavengers; Glutathione; Histamine H2 Antagonists; Liver; Liver Diseases; Male; Mice; Microsomes, Liver; Necrosis; Survival Rate	1997
Modulation of lipopolysaccharide-mediated activation in rat Kupffer cells by antioxidants. The Journal of laboratory and clinical medicine, 1998, Volume: 131, Issue:1 Topics: Acetylcysteine; Animals; Antioxidants; Cell Nucleus; DNA-Binding Proteins; Kupffer Cells; Lipopolysaccharides; Liver Diseases; Macrophage Activation; Male; NF-kappa B; Pyrrolidines; Rats; Rats, Sprague-Dawley; Thiocarbamates; Tumor Necrosis Factor-alpha; Vitamin E	1998
Late-presenting acute acetaminophen toxicity and the role of N-acetylcysteine. Pediatric emergency care, 1998, Volume: 14, Issue:6 Topics: Acetaminophen; Acetylcysteine; Acute Disease; Adult; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Child; Clinical Protocols; Drug Overdose; Humans; Liver Diseases; Risk Factors; Time Factors	1998
Transformation of an acetaminophen toxicity nomogram to an artificial neural network. International journal of clinical pharmacology and therapeutics, 1999, Volume: 37, Issue:9 Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Computer Simulation; Gastrointestinal Transit; Liver Diseases; Neural Networks, Computer	1999
Serum cytotoxin and oxidant stress markers in N-acetylcysteine treated thioacetamide hepatotoxicity of rats. Human & experimental toxicology, 1999, Volume: 18, Issue:11 Topics: Acetylcysteine; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Cytotoxins; Disease Models, Animal; Free Radical Scavengers; Liver Diseases; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Thioacetamide	1999
Reduction in incidence of severe paracetamol poisoning. Lancet (London, England), 2000, Jun-10, Volume: 355, Issue:9220 Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Female; Free Radical Scavengers; Humans; Incidence; Legislation, Drug; Liver Diseases; Male; Poisoning; Severity of Illness Index; United Kingdom	2000
Efficacy of N-acetylcysteine to reduce the effects of aflatoxin B1 intoxication in broiler chickens. Poultry science, 2001, Volume: 80, Issue:6 Topics: Acetylcysteine; Aflatoxin B1; Alanine Transaminase; Animal Feed; Animals; Aspartate Aminotransferases; Blood Proteins; Body Weight; Chemical and Drug Induced Liver Injury; Chickens; Free Radical Scavengers; Glutathione; Glutathione Transferase; Kidney; Kidney Diseases; Liver; Liver Diseases; Male; Poultry Diseases; Random Allocation; Treatment Outcome	2001
Acetaminophen hepatotoxicity: the first 35 years. Journal of toxicology. Clinical toxicology, 2002, Volume: 40, Issue:1 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Anticonvulsants; Aspartate Aminotransferases; Barbiturates; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Drug Therapy, Combination; Enzyme Induction; Ethanol; Humans; Liver; Liver Diseases; Nutritional Physiological Phenomena; Phenytoin	2002
Acetaminophen poisoning in children: treat early and long enough. The Journal of pediatrics, 2002, Volume: 140, Issue:5 Topics: Acetaminophen; Acetylcysteine; Adolescent; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Decision Making; Drug Overdose; Free Radical Scavengers; Humans; Infant; Liver Diseases; Liver Function Tests; Time Factors	2002
Predictors of outcome after acetaminophen poisoning in children and adolescents. The Journal of pediatrics, 2002, Volume: 140, Issue:5 Topics: Acetaminophen; Acetylcysteine; Adolescent; Alanine Transaminase; Analgesics, Non-Narcotic; Arkansas; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Decision Making; Drug Overdose; Female; Free Radical Scavengers; Humans; Infant; Liver Diseases; Liver Function Tests; Male; Predictive Value of Tests; Prothrombin Time; Retrospective Studies; Sensitivity and Specificity	2002
Acetaminophen overdose: a growing health care hazard. Clinical toxicology, 1979, Volume: 14, Issue:5 Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Female; Gastric Lavage; Humans; Liver Diseases; Middle Aged; Time Factors	1979
Intravenous N-acetylcystine: the treatment of choice for paracetamol poisoning. British medical journal, 1979, Nov-03, Volume: 2, Issue:6198 Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Cysteamine; Female; Humans; Infusions, Parenteral; Kidney Diseases; Liver Diseases; Male; Methionine; Middle Aged; Risk; Time Factors	1979
The chief scientist reports ... prevention of hepatic necrosis following paracetamol overdosage. Health bulletin, 1978, Volume: 36, Issue:4 Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Cysteamine; Female; Humans; Liver Diseases; Male; Methionine; Middle Aged; Scotland	1978
Acetaminophen toxity. American journal of hospital pharmacy, 1977, Volume: 34, Issue:4 Topics: Acetaminophen; Acetylcysteine; Adult; Chemical and Drug Induced Liver Injury; Cysteamine; Humans; Liver; Liver Diseases; Liver Function Tests; Male; Necrosis; Sulfhydryl Compounds	1977
Paracetamol overdose in man: relationship between pattern of urinary metabolites and severity of liver damage. The Quarterly journal of medicine, 1976, Volume: 45, Issue:178 Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Cysteine; Female; Glucuronates; Humans; Liver Diseases; Male; Suicide; Sulfates	1976
PZ-51 (Ebselen) in vivo protection against adriamycin-induced mouse cardiac and hepatic lipid peroxidation and toxicity. Biochemical pharmacology, 1992, Aug-18, Volume: 44, Issue:4 Topics: Acetylcysteine; Animals; Antioxidants; Azoles; Body Weight; Chemical and Drug Induced Liver Injury; Creatine Kinase; Doxorubicin; Drug Interactions; Female; Heart Diseases; Isoindoles; Lipid Peroxidation; Liver Diseases; Mice; Mice, Inbred BALB C; Organoselenium Compounds	1992
Acetylcysteine and fulminant hepatic failure. Hepatology (Baltimore, Md.), 1992, Volume: 15, Issue:3 Topics: Acetaminophen; Acetylcysteine; Biological Transport; Chemical and Drug Induced Liver Injury; Hemodynamics; Humans; Liver Circulation; Liver Diseases; Oxygen	1992
The effect of chronic alcohol intake on prognosis and outcome in paracetamol overdose. Human & experimental toxicology, 1991, Volume: 10, Issue:6 Topics: Acetaminophen; Acetylcysteine; Adult; Alcoholism; Aspartate Aminotransferases; Brain Edema; Chemical and Drug Induced Liver Injury; Creatinine; Dialysis; Ethanol; Female; Humans; Hydrogen-Ion Concentration; Liver Diseases; Male; Platelet Count; Positive-Pressure Respiration; Prognosis; Thrombin Time	1991
Liver toxicity due to 1,2-dichloropropane in the rat. Archives of toxicology, 1989, Volume: 63, Issue:6 Topics: Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Glutathione; Glutathione Transferase; Liver Diseases; Male; Propane; Rats; Rats, Inbred Strains; Solvents; Time Factors	1989
Cytotoxicity and metabolism of the hepatotoxin N-methylformamide and related formamides in mouse hepatocytes. Toxicology and applied pharmacology, 1988, Volume: 95, Issue:1 Topics: Acetylcysteine; Animals; Antineoplastic Agents; Carbamates; Chemical and Drug Induced Liver Injury; Formamides; Glutathione; In Vitro Techniques; L-Lactate Dehydrogenase; Liver; Liver Diseases; Male; Mice; Mice, Inbred BALB C; Structure-Activity Relationship	1988
Effect of a cysteine prodrug, L-2-oxothiazolidine-4-carboxylic acid, on the metabolism and toxicity of bromobenzene: an acute study. Canadian journal of physiology and pharmacology, 1987, Volume: 65, Issue:5 Topics: Acetylcysteine; Animals; Bromobenzenes; Chemical and Drug Induced Liver Injury; Liver Diseases; Male; Mice; Phenols; Sulfates; Transaminases	1987
Plasma glutathione S-transferase measurements after paracetamol overdose: evidence for early hepatocellular damage. Gut, 1985, Volume: 26, Issue:1 Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; Glutathione Transferase; Humans; Liver Diseases	1985