acetylcysteine and Iron Overload

acetylcysteine has been researched along with Iron Overload in 14 studies

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (7.14)29.6817
2010's11 (78.57)24.3611
2020's2 (14.29)2.80

Authors

AuthorsStudies
Bakr, MH; Ezzat, GM; Kamel, AA; Mohamed, S; Nassar, AY; Nassar, GA1
Chattipakorn, N; Chattipakorn, SC; Fucharoen, S; Khamseekaew, J; Kumfu, S; Siri-Angkul, N; Sumneang, N1
Hou, L; Huang, S; Liang, L; Liu, Z; Meng, Z; Zhang, L1
Ganz, T; Jung, G; Monga, SP; Nagarajan, S; Poddar, M; Popovic, B; Preziosi, ME; Singh, S; Valore, EV1
Jia, Z; Kang, B; Kang, L; Qin, Y; Shen, H; Wang, Y; Wei, J; Zhang, Y; Zheng, X1
Shen, JC; Zhang, YC; Zhao, MF1
Aycicek, A; Koc, A; Kocyigit, A; Ozdemir, ZC1
Cao, XL; Chen, J; Cui, R; He, XY; Jiang, YY; Li, DG; Meng, JX; Mu, J; Wu, RM; Xiao, X; Xing, Y; Zhang, YC; Zhao, MF1
Chattipakorn, N; Chattipakorn, SC; Krintratun, W; Sripetchwandee, J; Wongjaikam, S1
Chattipakorn, N; Chattipakorn, SC; Fucharoen, S; Khamseekaew, J; Kumfu, S; Srichairatanakool, S; Sripetchwandee, J; Wongjaikam, S1
Das, D; Fox, PL; Mukhopadhyay, C; Mukhopadhyay, CK; Tapryal, N1
Biswas, S; Das, D; Mishra, MK; Mukhopadhyay, C; Mukhopadhyay, CK; Tapryal, N1
Boskey, AL; Coleman, R; Cunningham-Rundles, S; Doty, SB; Giardina, PJ; Grady, RW; Lin, H; Mayer-Kuckuk, P; Ross, FP; Tsay, J; Vogiatzi, MG; Yang, Z1
Li, YM; Liu, PJ; Lu, WY; Mu, J; Xiao, X; Xie, F; Xu, XN; Zhao, MF; Zhu, HB1

Trials

1 trial(s) available for acetylcysteine and Iron Overload

ArticleYear
N-Acetylcysteine supplementation reduces oxidative stress and DNA damage in children with β-thalassemia.
    Hemoglobin, 2014, Volume: 38, Issue:5

    Topics: Acetylcysteine; Adolescent; Antioxidants; beta-Thalassemia; Chelation Therapy; Child, Preschool; Combined Modality Therapy; Comet Assay; Dietary Supplements; DNA Damage; Hemoglobins; Humans; Infant; Iron Chelating Agents; Iron Overload; Leukocytes, Mononuclear; Oxidative Stress; Transfusion Reaction; Turkey; Vitamin E

2014

Other Studies

13 other study(ies) available for acetylcysteine and Iron Overload

ArticleYear
Acetylated Oligopeptide and N-acetyl cysteine Protected Against Oxidative Stress, Inflammation, Testicular-Blood Barrier Damage, and Testicular Cell Death in Iron-Overload Rat Model.
    Applied biochemistry and biotechnology, 2023, Volume: 195, Issue:8

    Topics: Acetylcysteine; Animals; Antioxidants; Beclin-1; Cell Death; Claudin-1; Dextrans; Glutathione; Inflammation; Iron; Iron Overload; Male; NF-kappa B; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Rats; Testis; Testosterone

2023
Combined iron chelator with N-acetylcysteine exerts the greatest effect on improving cardiac calcium homeostasis in iron-overloaded thalassemic mice.
    Toxicology, 2019, 11-01, Volume: 427

    Topics: Acetylcysteine; Animals; Calcium; Deferiprone; Heart; Homeostasis; Iron Chelating Agents; Iron Overload; Mice, Inbred C57BL; Myocardium; Myocytes, Cardiac; Thalassemia; Ventricular Function, Left

2019
A mitophagic response to iron overload-induced oxidative damage associated with the PINK1/Parkin pathway in pancreatic beta cells.
    Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 2020, Volume: 60

    Topics: Acetylcysteine; Animals; Cell Proliferation; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Ferric Compounds; Insulin-Secreting Cells; Iron Overload; Membrane Potential, Mitochondrial; Mitochondria; Oxidative Stress; Protein Kinases; Quaternary Ammonium Compounds; Rats; Reactive Oxygen Species; Ubiquitin-Protein Ligases

2020
Mice lacking liver-specific β-catenin develop steatohepatitis and fibrosis after iron overload.
    Journal of hepatology, 2017, Volume: 67, Issue:2

    Topics: Acetylcysteine; Animals; Antioxidants; beta Catenin; Disease Models, Animal; Fatty Liver; Female; Hemochromatosis; Humans; Iron Overload; Liver; Liver Cirrhosis; Male; Mice; Mice, Knockout; Oxidative Stress; Signal Transduction

2017
[Mechanism for the inhibition of proliferation and promotion of apoptosis in Huh7.5 cells by iron overload].
    Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2017, Volume: 33, Issue:8

    Topics: Acetylcysteine; Apoptosis; Cation Transport Proteins; Cell Line, Tumor; Cell Proliferation; Hepatitis C, Chronic; Hepatocytes; Humans; Iron Overload; Oxidative Stress; Receptors, Transferrin

2017
Protective effects of deferasirox and N-acetyl-L-cysteine on iron overload-injured bone marrow.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2017, Oct-19, Volume: 50, Issue:12

    Topics: Acetylcysteine; Animals; Benzoates; Colony-Forming Units Assay; Deferasirox; Disease Models, Animal; Flow Cytometry; Free Radical Scavengers; Hematopoiesis; Hematopoietic Stem Cells; Iron Chelating Agents; Iron Overload; Male; Mice, Inbred C57BL; Protective Agents; Reactive Oxygen Species; Reference Values; Reproducibility of Results; Time Factors; Treatment Outcome; Triazoles

2017
[Establishment of macrophage model of iron overload in vitro and the injury induced by oxidative stress on macrophage with iron overload].
    Zhonghua yi xue za zhi, 2016, Jan-12, Volume: 96, Issue:2

    Topics: Acetylcysteine; Antioxidants; Down-Regulation; Ferric Compounds; Humans; Iron; Iron Overload; Macrophages; Oxidative Stress; Phosphatidylinositol 3-Kinases; Quaternary Ammonium Compounds; Reactive Oxygen Species; Signal Transduction

2016
A combination of an iron chelator with an antioxidant effectively diminishes the dendritic loss, tau-hyperphosphorylation, amyloids-β accumulation and brain mitochondrial dynamic disruption in rats with chronic iron-overload.
    Neuroscience, 2016, 09-22, Volume: 332

    Topics: Acetylcysteine; Amyloid beta-Peptides; Animals; Antioxidants; Apoptosis; Benzoates; Brain; Deferasirox; Deferoxamine; Dendrites; Diet; Disease Models, Animal; Drug Therapy, Combination; Iron; Iron Chelating Agents; Iron Overload; Male; Mitochondrial Dynamics; Neurodegenerative Diseases; Phosphorylation; Random Allocation; Rats, Wistar; tau Proteins; Triazoles

2016
Combined Iron Chelator and Antioxidant Exerted Greater Efficacy on Cardioprotection Than Monotherapy in Iron-Overloaded Rats.
    PloS one, 2016, Volume: 11, Issue:7

    Topics: Acetylcysteine; Animals; Benzoates; Cardiomyopathies; Cardiotonic Agents; Deferasirox; Deferiprone; Deferoxamine; Drug Combinations; Drug Synergism; Humans; Iron; Iron Chelating Agents; Iron Overload; Iron, Dietary; Male; Malondialdehyde; Mitochondria; Pyridones; Rats; Rats, Wistar; Triazoles; Ventricular Function, Left

2016
Reactive oxygen species regulate ceruloplasmin by a novel mRNA decay mechanism involving its 3'-untranslated region: implications in neurodegenerative diseases.
    The Journal of biological chemistry, 2009, Jan-16, Volume: 284, Issue:3

    Topics: 3' Untranslated Regions; Acetylcysteine; Animals; Antifungal Agents; Antimycin A; Cell Line, Tumor; Ceruloplasmin; Free Radical Scavengers; Humans; Hydrogen Peroxide; Iron Overload; Mice; Mice, Knockout; Neurodegenerative Diseases; Organ Specificity; Oxidants; Oxidation-Reduction; Oxidative Stress; RNA Stability; RNA-Binding Proteins; Rotenone; Uncoupling Agents

2009
Glutathione synthesis inhibitor butathione sulfoximine regulates ceruloplasmin by dual but opposite mechanism: Implication in hepatic iron overload.
    Free radical biology & medicine, 2010, Jun-01, Volume: 48, Issue:11

    Topics: 3' Untranslated Regions; Acetylcysteine; Buthionine Sulfoximine; Ceruloplasmin; Glutathione; Hep G2 Cells; Humans; Iron; Iron Overload; Liver; RNA, Messenger

2010
Bone loss caused by iron overload in a murine model: importance of oxidative stress.
    Blood, 2010, Oct-07, Volume: 116, Issue:14

    Topics: Acetylcysteine; Animals; Antioxidants; Bone and Bones; Iron Overload; Iron-Dextran Complex; Male; Mice; Mice, Inbred C57BL; Osteoporosis; Oxidative Stress

2010
[Effects of oxidative stress on hematopoiesis of hematopoietic stem and progenitor cells with iron overload].
    Zhonghua yi xue za zhi, 2011, Dec-13, Volume: 91, Issue:46

    Topics: Acetylcysteine; Antioxidants; Cells, Cultured; Fetal Blood; Glutathione; Hematopoiesis; Hematopoietic Stem Cells; Humans; Iron Overload; Oxidative Stress; Reactive Oxygen Species

2011