acetylcysteine has been researched along with Hepatocellular Carcinoma in 100 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (10.00) | 18.2507 |
| 2000's | 39 (39.00) | 29.6817 |
| 2010's | 43 (43.00) | 24.3611 |
| 2020's | 8 (8.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cao, Y; Che, D; Dai, F; Fan, R; Feng, Y; Gao, L; Gao, M; Ge, C; Li, J; Wang, C; Wang, S; Wang, Y; Xie, S; Xu, X | 1 |
| Ding, Y; Fang, Y; Li, G; Liang, L; Liu, Y; Xie, Y; Zhan, Y; Zhang, Z; Zheng, Y | 1 |
| Claimon, T; Sethasine, S; Simasingha, N; Tanasoontrarat, W | 1 |
| Aki, T; Funakoshi, T; Tanaka, H; Uemura, K; Unuma, K | 1 |
| Banerjee, S; Banki, K; Beckford, M; Grossman, CC; Jimah, J; Kansu, A; Kelly, R; Kuloglu, Z; Lee, W; Miklossy, G; Niland, B; Oaks, Z; Perl, A; Szonyi, L | 1 |
| Dai, X; Kong, L; Li, Z; Sun, Y; Wang, Q; Wang, X; Zhong, W; Zhou, H | 1 |
| Cao, MM; Li, YM; Sun, B; Xu, C; Yang, LY; Yu, L; Zhao, YR | 1 |
| Lee, H; Li, Y; Song, K; Tang, T | 1 |
| Chen, H; Ding, W; Li, M; Li, Y; Lin, N; Meng, J; Su, Q; Tong, X; Wu, L; Yang, D; Zhu, Y | 1 |
| Cao, DD; Chen, X; Deng, JJ; Lei, JJ; Shi, L; Xu, XM; Yuan, GJ | 1 |
| Fang, SH; Fu, YJ; Gao, C; Li, J; Wang, P; Wang, W; Yao, LP; Zhang, J; Zhang, SD | 1 |
| Choi, C; Lee, HS; Lee, YJ; Park, HC; Son, A | 1 |
| Fang, XY; Ren, QC; Shen, XF; Tan, S; Wang, L; Zhang, H; Zhao, L | 1 |
| Chen, JJ; Chen, Y; Shang, XY; Song, SJ; Song, XY; Wang, W; Yao, GD | 1 |
| Bhanthumkomol, P; Chonprasertsuk, S; Kaewmanee, M; Phumyen, A; Pornthisarn, B; Punjachaipornpon, T; Siramolpiwat, S; Tangaroonsanti, A; Vilaichone, RK; Yasiri, A | 1 |
| Ai, W; Chen, E; Chen, H; Cheng, G; Guo, W; Han, L; Kong, L; Li, H; Song, N; Wang, L | 1 |
| He, W; Li, Q; Liu, T; Zhang, B; Zhang, L; Zu, Y | 1 |
| Chou, YC; Guengerich, FP; Huang, C; Kao, FJ; Lai, PS; Lee, HC; Mazumder, N; Nagy, LD; Ueng, YF; Wang, SF | 1 |
| Lu, YX; Yu, XC; Zhu, MY | 1 |
| Hu, ZW; Hua, F; Lin, H; Liu, XB; Yu, JJ | 1 |
| Egnatchik, RA; Leamy, AK; Noguchi, Y; Shiota, M; Young, JD | 1 |
| Bruno, RS; Chong, L; Freake, HC; Sankavaram, K | 1 |
| Dai, Y; Huang, G; Liu, J; Qin, W; Sheng, S; Wang, H; Xiong, X | 1 |
| Ercal, N; Fan, W; Khayyat, A; Tobwala, S | 1 |
| Gao, B; Gao, JP; Li, J; Li, YY; Lin, P; Liu, ZP | 1 |
| Lai, Y; Li, Y; Luo, Q; Zhang, Z | 1 |
| Cao, M; Fang, F; Gao, J; Guo, Z; Huang, J; Song, T; You, A; Zhang, T; Zhang, W; Zhou, H | 1 |
| Jiang, Y; Meng, Z; Wang, P; Xu, L; Yang, P; Yong, P; Zhang, C; Zhang, H; Zhuang, L | 1 |
| Cai, Y; Chen, XL; Liu, RR; Lv, YS; Tang, YX; Wang, YF; Xie, SZ; Yu, J; Zhang, XN; Zheng, XX | 1 |
| Hu, X; Lei, L; Liang, J; Liu, L; Sun, J; Wu, D; Zou, X | 1 |
| He, JD; Li, SP; Shen, ZY; Wang, CY; Wang, Z; Xu, HX; Xu, YJ; Yao, Z; Yu, Y; Zhang, HM; Zhang, JJ; Zhang, RX | 1 |
| Gui, G; Huangfu, CS; Li, LJ; Liang, HX; Liu, B; Meng, SS | 1 |
| Chen, T; Pang, Y; Qin, G; Wang, X; Wu, L; Wu, S; Xi, G | 1 |
| Banerjee, S; Banki, K; Barcza, M; Barrett, D; Doherty, E; Fernandez, DR; Garba, A; Hanczko, R; Landas, SK; Middleton, FA; Niland, B; Perl, A; Qian, Y; Telarico, T; Vas, G | 1 |
| Lee, WY; Liu, KW; Yeung, JH | 1 |
| Hur, JM; Hyun, MS; Kim, D; Lee, WY; Lim, SY | 1 |
| Alisi, A; Bottazzo, GF; Nobili, V; Panera, N; Passarelli, C; Pastore, A; Petrini, S; Piemonte, F; Pietrobattista, A; Tozzi, G | 1 |
| Chang, WY; Choi, YH; Hyun, JW; Kim, GY; Kim, MO; Moon, DO | 1 |
| Czauderna, P; Fuchs, J; Knap, N; Losin, M; Neuwelt, AJ; Neuwelt, EA; Pagel, MA; Warmann, S; Wozniak, M; Wu, YJ | 1 |
| Chen, RH; Feng, B; Guo, YW; Huang, CG; Jiao, BH; Li, L | 1 |
| Dymkowska, D; Wojtczak, L | 1 |
| Fu, Y; Liu, TT; Wang, K; Wang, Q; Yang, XG | 1 |
| Kim, Y; Klaunig, JE; Misse, A; Monga, SP; Singh, S; Tan, X; Zeng, G; Zhang, XF | 1 |
| Deng, R; Feng, GK; Gao, YH; Jiang, S; Li, DD; Li, HJ; Wei, ZX; Wu, KW; Wu, XQ; Yang, F; Zhu, XF | 1 |
| Cao, JG; Liu, F; Lv, Y; Xiang, HL; Yang, XH; Zheng, X | 1 |
| Ha, HL; Yu, DY | 1 |
| Liu, H; Ruan, J; Wei, A; Xiao, Y; Xiong, C | 1 |
| Hanczko, R; Landas, S; Oaks, Z; Perl, A; Telarico, T | 1 |
| Itoh, Y; Iwai, M; Jo, M; Kagawa, K; Minami, M; Mitsuyoshi, H; Nakajima, T; Nishikawa, T; Okada, Y; Yamaguchi, K; Yasui, K; Yoshikawa, T | 1 |
| Aksenov, ND; Filatova, NA; Gamaleĭ, IA; Kirpichnikova, KM; Vakhromova, EA | 1 |
| Jung, G; Lim, SO; Quan, X | 1 |
| Fujita, J; Higashitsuji, H; Itoh, K; Kudo, M; Ryu, U; Sakurai, T | 1 |
| Azzolina, A; Cervello, M; Lampiasi, N; McCubrey, JA; Montalto, G; Umezawa, K | 1 |
| Antus, C; Engelmann, P; Gallyas, F; Lorand, T; Priber, JK; Racz, B; Radnai, B; Sumegi, B; Tucsek, Z; Turi, Z; Veres, B | 1 |
| Fujii, J; Ihara, H; Ikeda, Y; Ito, R; Takahashi, M; Tsukamoto, H | 1 |
| Choi, YH; Choi, YW; Han, MH; Kim, GY; Kim, HJ | 1 |
| Cheng, P; Dai, X; Ding, W; He, F; Lian, J; Ni, Z; Rae Smith, A; Wang, B; Wu, D; Xu, L | 1 |
| Choi, YK; Kim, DG; Liu, MJ; Won, YS; You, KR | 1 |
| Hultberg, B | 1 |
| Barelli, D; Cantoni, L; Castell, JV; Hauri, L; Mangolini, A; Ponsoda, X; Rizzardini, M; Valaperta, R; Villa, P | 1 |
| Bulla, GA; Kraus, DM; Schmitz, EK | 1 |
| Brauchle, MA; Caselmann, WH; Gehrke, R; Gruetzner, U; Hildt, E; Hofschneider, PH; Rabe, C; Reifenberg, K; Schlicht, HJ; Schmitz, V | 1 |
| Chen, J; Kang, J; Lin, C; Liu, Q; Zhang, D | 1 |
| Lin, CC; Ng, LT; Wu, SJ | 1 |
| Mahendran, R; Pook, SH; Toh, CK | 1 |
| Hwang, ES; Jeffery, EH | 1 |
| Brüne, B; Callapina, M; Köhl, R; Schmid, T; Zhou, J | 1 |
| Lim, SC; Oh, SH | 1 |
| Adamsky, K; Amariglio, N; Breda, L; Cabantchik, ZI; Rachmilewitz, EA; Rechavi, G; Rivella, S; Weizer-Stern, O | 1 |
| Hibasami, H; Iwase, H; Takahashi, H; Yoshioka, K | 1 |
| Hwang, ES; Lee, HJ | 2 |
| Fu, Q; Hu, BR; Li, JJ; Li, Y; Ming, ZY; Qian, JQ; Tang, Q; Xiang, JZ | 1 |
| Chang, CH; Chang, YX; Tsai, RK; Wang, S; Wu, JR; Wu, WS | 1 |
| Columbano, A; Deidda, M; Diana, A; Ledda-Columbano, GM; Pibiri, M; Sanna, L; Simbula, G | 1 |
| Hu, DC; Hu, XZ; Hui, Y; Xu, Y; Yang, FX | 1 |
| Arai, T; Hirota, K; Kodaki, T; Makino, K; Miyoshi, T; Mori, H; Sasada, M; Sommani, P; Tsunemine, H; Yamashita, K | 1 |
| He, Q; Hu, Y; Tu, C; Yang, B; Ying, H; Ying, M | 1 |
| Boo, YC; Kim, HJ; Lee, SI | 1 |
| Bonifaci, N; Rubartelli, A; Sitia, R | 1 |
| Kim, HS; Kim, IK; Lee, JH | 1 |
| Galle, J; Galle, PR; Grambihler, A; Hack, V; Hug, H; Krammer, PH; Strand, S; Stremmel, W | 1 |
| Ballatori, N; Clifton, D; Rebbeor, JF; Wang, W | 1 |
| Chou, CK; Huang, YL; Hwang, KC; Luh, TY; Shen, CK; Yang, HC | 1 |
| Gomi, T; Inamoto, T; Kinoshita, K; Nakamura, H; Tanaka, K; Tsuyuki, S; Yamaoka, Y; Yamauchi, A | 1 |
| Fisher, EA; Ginsberg, HN; Zhou, M | 1 |
| Bernier, M; Garant, MJ; Kole, S; Maksimova, EM | 1 |
| Aramaki, Y; Takano, S; Tsuchiya, S | 1 |
| Boulares, AH; Cohen, SD; Giardina, C; Inan, MS; Khairallah, EA | 1 |
| Liu, J; Ong, C; Shen, H; Yang, C | 1 |
| Kang, YS; Kim, JA; Lee, SH; Lee, YS | 1 |
| Ding, WX; Liu, J; Ong, CN; Shen, HM; Yang, CF | 1 |
| DePierre, JW; Grandér, D; Panaretakis, T; Shabalina, IG; Shoshan, MC | 1 |
| Gong, G; Siddiqui, A; Tanveer, R; Waris, G | 1 |
| Amann, A; Amberger, A; Fleischer, M; Hoffmann, G; Marth, C; Niedermüller, P; Nigrovic, V; Pühringer, F; Rieder, J | 1 |
| Ham, YH; Han, SK; Jang, JJ; Jung, YJ; Kim, CM; Kim, KC; Kim, SH; Kwon, H; Lee, KH; Sung, YC | 1 |
| Burrows, J; Hale, PD; Hidvegi, T; Perlmutter, DH; Schmidt, B; Teckman, JH | 1 |
| Carr, BI; Kar, S; Lazo, JS; Rosi, KS; Southwick, EC; Wang, M; Wang, Z; Wilcox, CS | 1 |
| Hirsh, M; Iancu, TC; Manov, I | 1 |
| Critchley, JA; Leung, NW | 1 |
2 review(s) available for acetylcysteine and Hepatocellular Carcinoma
| Article | Year |
|---|---|
Oxidative stress, inflammation and carcinogenesis are controlled through the pentose phosphate pathway by transaldolase.
Topics: Acetylcysteine; Animals; Autoimmunity; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Fatty Liver; Glucose; Humans; Infertility, Male; Inflammation; Male; Mitochondria; Oxidative Stress; Pentose Phosphate Pathway; Sperm Motility; Transaldolase | 2011 |
Role of iron in inducing oxidative stress in thalassemia: Can it be prevented by inhibition of absorption and by antioxidants?
Topics: Acetylcysteine; Animals; Antimicrobial Cationic Peptides; Antioxidants; Bone Marrow; Carcinoma, Hepatocellular; Cell Line, Tumor; Disease Models, Animal; Drug Therapy, Combination; Erythrocytes; Gene Expression Regulation; Genetic Therapy; Hepcidins; Humans; Intestinal Absorption; Iron; Iron Chelating Agents; Iron, Dietary; Liver Neoplasms; Mice; Oxidants; Oxidative Stress; Thalassemia; Vitamin E | 2005 |
2 trial(s) available for acetylcysteine and Hepatocellular Carcinoma
| Article | Year |
|---|---|
Efficacy of dexamethasone and N-acetylcysteine combination in preventing post-embolization syndrome after transarterial chemoembolization in hepatocellular carcinoma.
Topics: Acetylcysteine; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Dexamethasone; Drug Combinations; Humans; Liver Neoplasms; Nausea; Treatment Outcome; Vomiting | 2023 |
N-Acetylcysteine Prevents Post-embolization Syndrome in Patients with Hepatocellular Carcinoma Following Transarterial Chemoembolization.
Topics: Acetylcysteine; Administration, Intravenous; Aged; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Cohort Studies; Female; Free Radical Scavengers; Humans; Inflammation Mediators; Liver Neoplasms; Male; Middle Aged; Prospective Studies; Syndrome; Treatment Outcome | 2019 |
96 other study(ies) available for acetylcysteine and Hepatocellular Carcinoma
| Article | Year |
|---|---|
Reactive Oxygen Species Mediate 6c-Induced Mitochondrial and Lysosomal Dysfunction, Autophagic Cell Death, and DNA Damage in Hepatocellular Carcinoma.
Topics: Acetylcysteine; Adenine; Antioxidants; Autophagic Cell Death; Autophagosomes; Carcinoma, Hepatocellular; DNA Damage; Hep G2 Cells; Humans; Liver Neoplasms; Lysosomes; Microtubule-Associated Proteins; Mitochondria; Naphthalimides; Proteome; Proteomics; Reactive Oxygen Species; Sequestosome-1 Protein | 2021 |
NUPR1 contributes to radiation resistance by maintaining ROS homeostasis via AhR/CYP signal axis in hepatocellular carcinoma.
Topics: Acetylcysteine; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cytochrome P-450 Enzyme System; Homeostasis; Humans; Liver Neoplasms; Nuclear Proteins; Reactive Oxygen Species; Receptors, Aryl Hydrocarbon; Signal Transduction | 2022 |
Excessive N-acetylcysteine exaggerates glutathione redox homeostasis and apoptosis during acetaminophen exposure in Huh-7 human hepatoma cells.
Topics: Acetaminophen; Acetylcysteine; Apoptosis; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Glutathione; Homeostasis; Humans; Liver; Liver Neoplasms; Oxidation-Reduction | 2023 |
Transaldolase haploinsufficiency in subjects with acetaminophen-induced liver failure.
Topics: Acetylcysteine; Adult; Animals; Carcinoma, Hepatocellular; Female; Haploinsufficiency; Humans; Liver Cirrhosis; Liver Failure; Liver Neoplasms; Male; Mice; Mice, Knockout; Mitochondria; Oxidative Stress; Pentose Phosphate Pathway; Transaldolase; Young Adult | 2020 |
N-acetylcysteine alleviates liver injury by suppressing macrophage-mediated inflammatory response post microwave ablation.
Topics: Ablation Techniques; Acetylcysteine; Animals; Anti-Inflammatory Agents; Apoptosis; Carcinoma, Hepatocellular; Humans; Inflammation; Liver; Liver Diseases; Liver Neoplasms; Macrophages; Male; Microwaves; Peroxidase; Rats, Sprague-Dawley | 2020 |
NAD(P)HX epimerase downregulation promotes tumor progression through ROS/HIF-1α signaling in hepatocellular carcinoma.
Topics: Acetylcysteine; Analysis of Variance; Animals; Carcinoma, Hepatocellular; Cell Movement; Disease Progression; Disease-Free Survival; Down-Regulation; Epithelial-Mesenchymal Transition; Female; Free Radical Scavengers; Heterografts; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Male; Mice; Middle Aged; NADP; Neoplasm Invasiveness; Neoplasm Proteins; Neoplasm Transplantation; Oxidation-Reduction; Racemases and Epimerases; Reactive Oxygen Species; Risk Factors | 2021 |
Cold Atmospheric Pressure Plasma-Activated Medium Induces Selective Cell Death in Human Hepatocellular Carcinoma Cells Independently of Singlet Oxygen, Hydrogen Peroxide, Nitric Oxide and Nitrite/Nitrate.
Topics: Acetylcysteine; Aluminum; Antineoplastic Agents; Atmospheric Pressure; Carcinoma, Hepatocellular; Cell Death; Cell Line, Tumor; Cell Proliferation; Cell Survival; Free Radicals; Humans; Hydrogen Peroxide; Liver Neoplasms; Neoplastic Stem Cells; Nitrates; Nitric Oxide; Nitrites; Plasma Gases; Reactive Nitrogen Species; Reactive Oxygen Species; Singlet Oxygen | 2021 |
Advanced glycation end products promote ChREBP expression and cell proliferation in liver cancer cells by increasing reactive oxygen species.
Topics: Acetylcysteine; Apoptosis; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Carcinoma, Hepatocellular; Cell Proliferation; Cell Survival; Glycation End Products, Advanced; Humans; Liver Neoplasms; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; RNA, Messenger; Transcription Factors; Tumor Cells, Cultured | 2017 |
Autophagic cell death induced by reactive oxygen species is involved in hyperthermic sensitization to ionizing radiation in human hepatocellular carcinoma cells.
Topics: Acetylcysteine; Apoptosis; Autophagy; Carcinoma, Hepatocellular; Cell Survival; Hep G2 Cells; Humans; Hyperthermia, Induced; Liver Neoplasms; Microtubule-Associated Proteins; Radiation, Ionizing; Reactive Oxygen Species; RNA-Binding Proteins | 2017 |
Juglone induces apoptosis and autophagy via modulation of mitogen-activated protein kinase pathways in human hepatocellular carcinoma cells.
Topics: Acetylcysteine; Adenine; Amino Acid Chloromethyl Ketones; Androstadienes; Apoptosis; Autophagy; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Cell Proliferation; Enzyme Activation; Hep G2 Cells; Humans; Liver Neoplasms; MAP Kinase Kinase 4; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Naphthoquinones; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Reactive Oxygen Species; Wortmannin | 2018 |
Radiosensitization by Marine Sponge Agelas sp. Extracts in Hepatocellular Carcinoma Cells with Autophagy Induction.
Topics: Acetylcysteine; Agelas; Animals; Apoptosis; Autophagy; Carcinoma, Hepatocellular; Cell Extracts; Cell Line, Tumor; Endoplasmic Reticulum Stress; Humans; Liver Neoplasms; Micronesia; Porifera; Radiation-Sensitizing Agents; Reactive Oxygen Species | 2018 |
A new xanthatin analogue 1β-hydroxyl-5α-chloro-8-epi-xanthatin induces apoptosis through ROS-mediated ERK/p38 MAPK activation and JAK2/STAT3 inhibition in human hepatocellular carcinoma.
Topics: Acetylcysteine; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Furans; Glutathione; Humans; Janus Kinase 2; Liver Neoplasms; Malondialdehyde; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Reactive Oxygen Species; STAT3 Transcription Factor | 2018 |
Daphnegiravone D from Daphne giraldii Nitsche induces p38-dependent apoptosis via oxidative and nitrosative stress in hepatocellular carcinoma cells.
Topics: Acetylcysteine; Apoptosis; Carcinoma, Hepatocellular; Daphne; Flavonoids; Hep G2 Cells; Humans; Liver Neoplasms; Nitrosative Stress; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Protein Prenylation; Reactive Nitrogen Species; Reactive Oxygen Species | 2018 |
Cerium oxide nanoparticles induce cytotoxicity in human hepatoma SMMC-7721 cells via oxidative stress and the activation of MAPK signaling pathways.
Topics: Acetylcysteine; Antioxidants; Apoptosis; Carcinoma, Hepatocellular; Catalase; Cell Line, Tumor; Cell Survival; Cerium; Glutathione Peroxidase; Humans; Malondialdehyde; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Nanoparticles; Oxidative Stress; Reactive Oxygen Species; Superoxide Dismutase | 2013 |
Generation of reactive oxygen species by a novel berberine-bile acid analog mediates apoptosis in hepatocarcinoma SMMC-7721 cells.
Topics: Acetylcysteine; Active Transport, Cell Nucleus; Antineoplastic Agents; Apoptosis; Apoptosis Inducing Factor; Berberine; Bile Acids and Salts; Calcium; Carcinoma, Hepatocellular; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cytochromes c; Cytosol; DNA Fragmentation; Dose-Response Relationship, Drug; Humans; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Membranes; Poly(ADP-ribose) Polymerases; Reactive Oxygen Species; Time Factors | 2013 |
7-Ketocholesterol induces P-glycoprotein through PI3K/mTOR signaling in hepatoma cells.
Topics: Acetylcysteine; Antibiotics, Antineoplastic; Antioxidants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Hepatocellular; Cell Line; Cell Line, Tumor; Cell Survival; Cholesterol; Doxorubicin; Drug Resistance, Neoplasm; Hepatocytes; Humans; Hydroxycholesterols; Ketocholesterols; Lactic Acid; Oligomycins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Signal Transduction; TOR Serine-Threonine Kinases; Up-Regulation | 2013 |
Antitumor effect of fructose 1,6-bisphosphate and its mechanism in hepatocellular carcinoma cells.
Topics: Acetylcysteine; Apoptosis; Carcinoma, Hepatocellular; Catalase; Cell Proliferation; Fructosediphosphates; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Hydrogen Peroxide; Liver Neoplasms; Reactive Oxygen Species | 2014 |
Antioxidant N-acetylcysteine attenuates hepatocarcinogenesis by inhibiting ROS/ER stress in TLR2 deficient mouse.
Topics: Acetylcysteine; Animals; Antioxidants; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line; Diethylnitrosamine; Disease Progression; Endoplasmic Reticulum Stress; Liver Neoplasms; Male; Mice; Reactive Oxygen Species; Signal Transduction; Toll-Like Receptor 2 | 2013 |
Palmitate-induced activation of mitochondrial metabolism promotes oxidative stress and apoptosis in H4IIEC3 rat hepatocytes.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Carbon Isotopes; Carcinoma, Hepatocellular; Caspases, Effector; Cell Line, Tumor; Enzyme Activation; Hepatocytes; Liver Neoplasms; Metabolic Flux Analysis; Mitochondria, Liver; Oxidative Stress; Palmitates; Rats; Reactive Oxygen Species | 2014 |
Zinc status alters growth and oxidative stress responses in rat hepatoma cells.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Caspase 3; Cell Line, Tumor; Cytochromes c; Liver Neoplasms; Mitochondria; Oxidative Stress; Proto-Oncogene Proteins c-mdm2; Rats; Reactive Oxygen Species; Tumor Suppressor Protein p53; Zinc | 2014 |
Dichloroacetate enhances adriamycin-induced hepatoma cell toxicity in vitro and in vivo by increasing reactive oxygen species levels.
Topics: Acetylcysteine; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Dichloroacetic Acid; Doxorubicin; Humans; Liver Neoplasms; Male; Mice; Reactive Oxygen Species; Xenograft Model Antitumor Assays | 2014 |
Comparative evaluation of N-acetylcysteine and N-acetylcysteineamide in acetaminophen-induced hepatotoxicity in human hepatoma HepaRG cells.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Overdose; Free Radical Scavengers; Humans; Lipid Peroxidation; Liver Neoplasms; Mitochondria, Liver; Oxidative Stress; Reactive Oxygen Species | 2015 |
[Feverfew lactone induces autophagic death of hepatocellular carcinoma SMMC 7721 cells].
Topics: Acetylcysteine; Autophagy; Carcinoma, Hepatocellular; Cell Line, Tumor; Humans; Lactones; Liver Neoplasms; Tanacetum parthenium | 2014 |
The role of NF-κB in PARP-inhibitor-mediated sensitization and detoxification of arsenic trioxide in hepatocellular carcinoma cells.
Topics: 1-Naphthylamine; Acetylcysteine; Antineoplastic Agents; Antioxidants; Arsenic Trioxide; Arsenicals; Carcinoma, Hepatocellular; DNA Damage; Hep G2 Cells; Humans; Inactivation, Metabolic; Liver Neoplasms; Naphthalimides; NF-kappa B; Oxidative Stress; Oxides; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Quinolones; Reactive Oxygen Species | 2015 |
HIF-2α regulates CDCP1 to promote PKCδ-mediated migration in hepatocellular carcinoma.
Topics: Acetylcysteine; Animals; Antigens, CD; Antigens, Neoplasm; Basic Helix-Loop-Helix Transcription Factors; Blotting, Western; Carcinoma, Hepatocellular; Cell Adhesion Molecules; Cell Movement; Gene Expression Regulation, Neoplastic; Heterografts; Humans; Immunohistochemistry; Liver Neoplasms; Mice; Mice, Nude; Neoplasm Proteins; Protein Kinase C-delta; Real-Time Polymerase Chain Reaction; Transfection | 2016 |
Na+/K+-ATPase α1 subunit, a novel therapeutic target for hepatocellular carcinoma.
Topics: Acetylcysteine; Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Cell Proliferation; Free Radical Scavengers; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Liver Neoplasms; Molecular Targeted Therapy; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Sodium-Potassium-Exchanging ATPase | 2015 |
Eukaryotic translation initiation factor 5A2 regulates the migration and invasion of hepatocellular carcinoma cells via pathways involving reactive oxygen species.
Topics: Acetylcysteine; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Epithelial-Mesenchymal Transition; Eukaryotic Translation Initiation Factor 5A; Guanine; Hep G2 Cells; Humans; Kaplan-Meier Estimate; Liver Neoplasms; Neoplasm Invasiveness; Peptide Initiation Factors; Reactive Oxygen Species; RNA Interference; RNA-Binding Proteins; Signal Transduction | 2016 |
Allicin sensitizes hepatocellular cancer cells to anti-tumor activity of 5-fluorouracil through ROS-mediated mitochondrial pathway.
Topics: Acetylcysteine; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Cell Line, Tumor; Cell Survival; Disulfides; Drug Synergism; Fluorouracil; Humans; Liver Neoplasms; Membrane Potential, Mitochondrial; Mice; Mitochondria; Poly (ADP-Ribose) Polymerase-1; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Sulfinic Acids; Xenograft Model Antitumor Assays | 2016 |
LncRNA HULC enhances epithelial-mesenchymal transition to promote tumorigenesis and metastasis of hepatocellular carcinoma via the miR-200a-3p/ZEB1 signaling pathway.
Topics: Acetylcysteine; Aged; Animals; Apoptosis; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferation; Cell Transformation, Neoplastic; Disease Progression; Epithelial-Mesenchymal Transition; Female; Humans; Lentivirus; Liver; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; MicroRNAs; Middle Aged; Neoplasm Metastasis; Neoplasm Transplantation; RNA, Long Noncoding; RNA, Small Interfering; Signal Transduction; Zinc Finger E-box-Binding Homeobox 1 | 2016 |
[Sodium nitrite enhanced the potentials of migration and invasion of human hepatocellular carcinoma SMMC-7721 cells through induction of mitophagy].
Topics: Acetylcysteine; Autophagy; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Mitophagy; Neoplasm Invasiveness; Nitrites; Reactive Oxygen Species; Sodium Nitrite | 2016 |
Farnesylthiosalicylic acid sensitizes hepatocarcinoma cells to artemisinin derivatives.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Artemisinins; Carcinoma, Hepatocellular; Drug Synergism; Farnesol; Hep G2 Cells; Humans; Liver Neoplasms; Salicylates | 2017 |
Prevention of hepatocarcinogenesis and increased susceptibility to acetaminophen-induced liver failure in transaldolase-deficient mice by N-acetylcysteine.
Topics: Acetylcysteine; alpha-Fetoproteins; Animals; Apoptosis; beta Catenin; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; fas Receptor; JNK Mitogen-Activated Protein Kinases; Liver Failure; Liver Neoplasms; Male; Mice; Mice, Knockout; Mitochondria; Phosphorylation; Transaldolase | 2009 |
Reactive oxygen species-mediated kinase activation by dihydrotanshinone in tanshinones-induced apoptosis in HepG2 cells.
Topics: Abietanes; Acetylcysteine; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Caspases; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cytochromes c; Dose-Response Relationship, Drug; Enzyme Activation; Furans; Humans; Imidazoles; Inhibitory Concentration 50; JNK Mitogen-Activated Protein Kinases; L-Lactate Dehydrogenase; Liver Neoplasms; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phenanthrenes; Phosphorylation; Poly(ADP-ribose) Polymerases; Protein Kinase Inhibitors; Protein Transport; Pyridines; Quinones; Reactive Oxygen Species; Time Factors | 2009 |
The combination of berberine and irradiation enhances anti-cancer effects via activation of p38 MAPK pathway and ROS generation in human hepatoma cells.
Topics: Acetylcysteine; Apoptosis; Berberine; Carcinoma, Hepatocellular; Caspase 3; Cell Line, Tumor; Cell Survival; Drug Screening Assays, Antitumor; Enzyme Activation; Humans; Liver Neoplasms; Models, Biological; Nitric Oxide; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-bcl-2; Radiation, Ionizing; Reactive Oxygen Species | 2009 |
Glutathionylation of p65NF-kappaB correlates with proliferating/apoptotic hepatoma cells exposed to pro- and anti-oxidants.
Topics: Acetylcysteine; Antioxidants; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; DNA, Neoplasm; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Glutathione; Humans; Hydrogen Peroxide; Liver Neoplasms; Oxidants; Protein Transport; Transcription Factor RelA | 2009 |
Butein induces G(2)/M phase arrest and apoptosis in human hepatoma cancer cells through ROS generation.
Topics: Acetylcysteine; Anthracenes; Antineoplastic Agents; Antioxidants; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Division; Cell Proliferation; Cell Survival; Chalcones; Dose-Response Relationship, Drug; Enzyme Activation; G2 Phase; Glutathione; Hep G2 Cells; Humans; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; Phosphorylation; Protein Kinase Inhibitors; Reactive Oxygen Species | 2010 |
Using acetaminophen's toxicity mechanism to enhance cisplatin efficacy in hepatocarcinoma and hepatoblastoma cell lines.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antineoplastic Agents; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Cisplatin; Cytochrome P-450 CYP2E1; Dose-Response Relationship, Drug; Drug Synergism; Free Radical Scavengers; Glutathione; Hepatoblastoma; Hepatocytes; Humans; Liver Neoplasms; Mice; Rats; Time Factors | 2009 |
2'-epi-2'-O-Acetylthevetin B extracted from seeds of Cerbera manghas L. induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Apocynaceae; Apoptosis; Apoptosis Inducing Factor; Carcinoma, Hepatocellular; Cardiac Glycosides; Caspase 9; CDC2 Protein Kinase; Cyclin B1; G2 Phase; Hep G2 Cells; Humans; Liver Neoplasms; Membrane Potential, Mitochondrial; Reactive Oxygen Species; S Phase; Seeds | 2010 |
Arachidonic acid-induced apoptosis in rat hepatoma AS-30D cells is mediated by reactive oxygen species.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Arachidonic Acid; Carcinoma, Hepatocellular; Cell Line, Tumor; Chromans; Cyclic N-Oxides; Epoxy Compounds; Liver Neoplasms; Rats; Reactive Oxygen Species; Spin Labels | 2009 |
Vanadium compounds discriminate hepatoma and normal hepatic cells by differential regulation of reactive oxygen species.
Topics: Acetylcysteine; Animals; Antioxidants; Carcinoma, Hepatocellular; Cell Cycle; Cell Proliferation; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Hep G2 Cells; Humans; JNK Mitogen-Activated Protein Kinases; Liver; Liver Neoplasms; Reactive Oxygen Species; Signal Transduction; Vanadium Compounds | 2010 |
Conditional beta-catenin loss in mice promotes chemical hepatocarcinogenesis: role of oxidative stress and platelet-derived growth factor receptor alpha/phosphoinositide 3-kinase signaling.
Topics: Acetylcysteine; Administration, Oral; Animals; Apoptosis; beta Catenin; Carcinoma, Hepatocellular; Cell Proliferation; Class I Phosphatidylinositol 3-Kinases; Diethylnitrosamine; Disease Models, Animal; Liver Neoplasms; Male; Mice; Mice, Knockout; NF-kappa B; Oxidative Stress; Phosphatidylinositol 3-Kinases; Receptor, Platelet-Derived Growth Factor alpha; Signal Transduction | 2010 |
A novel sesquiterpene Hirsutanol A induces autophagical cell death in human hepatocellular carcinoma cells by increasing reactive oxygen species.
Topics: Acetylcysteine; Adenine; Agaricales; Antineoplastic Agents; Autophagy; Carcinoma, Hepatocellular; Cell Death; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Free Radical Scavengers; Humans; Liver Neoplasms; Microtubule-Associated Proteins; Reactive Oxygen Species; Sesquiterpenes | 2010 |
8-Bromo-7-methoxychrysin-induced apoptosis of hepatocellular carcinoma cells involves ROS and JNK.
Topics: Acetylcysteine; Anilides; Antineoplastic Agents; Antioxidants; Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Enzyme Activation; Flavonoids; Hep G2 Cells; Humans; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; Reactive Oxygen Species | 2010 |
HBx-induced reactive oxygen species activates hepatocellular carcinogenesis via dysregulation of PTEN/Akt pathway.
Topics: Acetylcysteine; Animals; Blotting, Western; Carcinoma, Hepatocellular; Cell Proliferation; Electrophoresis, Polyacrylamide Gel; Female; Flow Cytometry; Free Radical Scavengers; Hep G2 Cells; Humans; Liver Neoplasms; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Reactive Oxygen Species; Signal Transduction; Time Factors; Trans-Activators; Transfection; Viral Regulatory and Accessory Proteins | 2010 |
Apoptosis induced by a new flavonoid in human hepatoma HepG2 cells involves reactive oxygen species-mediated mitochondrial dysfunction and MAPK activation.
Topics: Acetylcysteine; Anthracenes; Apoptosis; Carcinoma, Hepatocellular; Caspases; Cell Survival; Cyclohexanones; Enzyme Activation; Flavones; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Imidazoles; Intracellular Space; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Mitochondria; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Reactive Oxygen Species | 2011 |
Oxidative stress is closely associated with tumor angiogenesis of hepatocellular carcinoma.
Topics: Acetylcysteine; Adult; Aged; Androstadienes; Antioxidants; Carcinoma, Hepatocellular; Cell Proliferation; Endothelial Cells; Female; Humans; Liver Neoplasms; Male; Middle Aged; Neovascularization, Pathologic; Oxidative Stress; Proto-Oncogene Proteins c-akt; RNA, Messenger; Umbilical Cord; Vascular Endothelial Growth Factor A; Wortmannin | 2011 |
[Decrease in tumorigenic activity of murine hepatoma cells after treatment with antioxidants and melatonin].
Topics: Acetylcysteine; Animals; Antioxidants; Carcinoma, Hepatocellular; Cell Cycle; Flow Cytometry; Humans; Injections, Subcutaneous; Liver Neoplasms; Melatonin; Mice; Mice, Inbred C3H; Thioctic Acid; Transplantation, Isogeneic; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2011 |
Reactive oxygen species downregulate catalase expression via methylation of a CpG island in the Oct-1 promoter.
Topics: Acetylcysteine; Azacitidine; Carcinoma, Hepatocellular; Catalase; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; Down-Regulation; Enzyme Activation; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Neoplasm Invasiveness; Octamer Transcription Factor-1; Promoter Regions, Genetic; Reactive Oxygen Species | 2011 |
Adriamycin enhances proteasome-mediated generation of the proapoptotic processed form of MAGE-A4 in hepatoma cells.
Topics: Acetylcysteine; Animals; Antigens, Neoplasm; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Doxorubicin; HEK293 Cells; Humans; Leupeptins; Liver Neoplasms; Neoplasm Proteins; Proteasome Endopeptidase Complex; Ubiquitin | 2011 |
The novel NF-κB inhibitor DHMEQ synergizes with celecoxib to exert antitumor effects on human liver cancer cells by a ROS-dependent mechanism.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Benzamides; Carcinoma, Hepatocellular; Celecoxib; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cyclohexanones; Cyclooxygenase 2 Inhibitors; Drug Synergism; Endoplasmic Reticulum Stress; fas Receptor; Humans; Liver Neoplasms; NF-kappa B; Poly(ADP-ribose) Polymerases; Protein Serine-Threonine Kinases; Pyrazoles; Reactive Oxygen Species; Repressor Proteins; Sulfonamides | 2012 |
Protective effect of the poly(ADP-ribose) polymerase inhibitor PJ34 on mitochondrial depolarization-mediated cell death in hepatocellular carcinoma cells involves attenuation of c-Jun N-terminal kinase-2 and protein kinase B/Akt activation.
Topics: Acetylcysteine; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Hep G2 Cells; Humans; Liver Neoplasms; Membrane Potential, Mitochondrial; Mitochondria; Mitogen-Activated Protein Kinase 9; Necrosis; Phenanthrenes; Poly(ADP-ribose) Polymerase Inhibitors; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; RNA Interference; Signal Transduction | 2012 |
Measurement of peroxiredoxin-4 serum levels in rat tissue and its use as a potential marker for hepatic disease.
Topics: Acetylcysteine; Animals; Antibodies; Antibody Specificity; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell Line, Tumor; Culture Media; Diabetes Mellitus, Experimental; Enzyme-Linked Immunosorbent Assay; Female; Immunoglobulin G; Liver; Liver Diseases; Male; Oxidation-Reduction; Oxidative Stress; Peroxiredoxins; Rabbits; Rats; Rats, Inbred LEC; Rats, Sprague-Dawley; Rats, Wistar; Recombinant Proteins; Vaccination | 2012 |
Hexane extracts of garlic cloves induce apoptosis through the generation of reactive oxygen species in Hep3B human hepatocarcinoma cells.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist Protein; Carcinoma, Hepatocellular; Caspase 3; Caspase 8; Caspase 9; Caspase Inhibitors; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Down-Regulation; Enzyme Activation; Free Radical Scavengers; Garlic; Humans; Liver Neoplasms; Membrane Potential, Mitochondrial; Mitochondria; Plant Extracts; Reactive Oxygen Species | 2012 |
The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular carcinoma [corrected] cells.
Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Apoptosis Regulatory Proteins; Autophagy; bcl-X Protein; Beclin-1; Carcinoma, Hepatocellular; Cell Line, Tumor; Cyclin D1; Extracellular Signal-Regulated MAP Kinases; Gossypol; Hep G2 Cells; HMGB1 Protein; Humans; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; Membrane Proteins; Microtubule-Associated Proteins; Phosphorylation; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; TOR Serine-Threonine Kinases | 2013 |
GADD153-mediated anticancer effects of N-(4-hydroxyphenyl)retinamide on human hepatoma cells.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; CCAAT-Enhancer-Binding Proteins; Cell Cycle; DNA Fragmentation; Fenretinide; Flow Cytometry; Gene Expression Profiling; Gene Expression Regulation; Genes, Reporter; Humans; Neoplasms; NF-kappa B; Sesquiterpenes; Transcription Factor CHOP; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured | 2002 |
Modulation of extracellular homocysteine concentration in human cell lines.
Topics: Acetylcysteine; Amino Acid Transport Systems; Carcinoma, Hepatocellular; Copper; Cysteine; Dithiothreitol; Extracellular Fluid; HeLa Cells; Homocysteine; Humans; Oxidation-Reduction; Sulfhydryl Compounds; Sulfonic Acids; Tumor Cells, Cultured | 2003 |
Induction of hepatic heme oxygenase-1 by diclofenac in rodents: role of oxidative stress and cytochrome P-450 activity.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Carcinoma, Hepatocellular; Cell Line, Tumor; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diclofenac; Dose-Response Relationship, Drug; Enzyme Induction; Enzyme Inhibitors; Female; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hepatocytes; Humans; Liver; Liver Neoplasms; Male; Membrane Proteins; Mice; Mice, Inbred Strains; Oxidative Stress; Rats | 2003 |
Tissue-specificity of apoptosis in hepatoma-derived cell lines.
Topics: Acetylcysteine; alpha-Tocopherol; Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Culture Media, Serum-Free; Cycloheximide; Electrophoretic Mobility Shift Assay; Interleukin-1; Lipopolysaccharides; Liver Neoplasms; Protein Synthesis Inhibitors; Rats; Sorbitol; Transgenes; Tumor Necrosis Factor-alpha; Vinblastine; Vincristine | 2004 |
Accumulation of 8-hydroxy-2'-deoxyguanosine adducts in HBx recombinant HepG2 cells and HBx transgenic mice.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetylcysteine; Animals; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Deoxyguanosine; DNA Adducts; DNA, Recombinant; Humans; Liver; Liver Neoplasms; Mice; Mice, Transgenic; Trans-Activators; Viral Regulatory and Accessory Proteins | 2004 |
Antioxidants and trichostatin A synergistically protect against in vitro cytotoxicity of Ni2+ in human hepatoma cells.
Topics: Acetylation; Acetylcysteine; Antioxidants; Apoptosis; Ascorbic Acid; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Glutathione; Hepatocytes; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Liver Neoplasms; Nickel; Reactive Oxygen Species | 2005 |
Effects of antioxidants and caspase-3 inhibitor on the phenylethyl isothiocyanate-induced apoptotic signaling pathways in human PLC/PRF/5 cells.
Topics: Acetylcysteine; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Apoptotic Protease-Activating Factor 1; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist Protein; Blotting, Western; Carcinoma, Hepatocellular; Carrier Proteins; Caspase 3; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cell Line, Tumor; Cell Proliferation; Cysteine Proteinase Inhibitors; Cytochromes c; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; fas Receptor; Flow Cytometry; Humans; Intracellular Membranes; Intracellular Signaling Peptides and Proteins; Isothiocyanates; Liver Neoplasms; Membrane Potentials; Mitochondria; Mitochondrial Proteins; Oligopeptides; Proteins; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Time Factors; Tumor Suppressor Protein p53; Up-Regulation; Vitamin E; X-Linked Inhibitor of Apoptosis Protein | 2005 |
Combination of thiol antioxidant Silibinin with Brostallicin is associated with increase in the anti-apoptotic protein Bcl-2 and decrease in caspase 3 activity.
Topics: Acetylcysteine; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Caspases; Cell Line, Tumor; Down-Regulation; Drug Antagonism; Drug Screening Assays, Antitumor; Enzyme Activation; Guanidines; Humans; Nasopharyngeal Neoplasms; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Signal Transduction; Silybin; Silymarin; Sulfhydryl Compounds; Up-Regulation | 2006 |
Induction of quinone reductase by sulforaphane and sulforaphane N-acetylcysteine conjugate in murine hepatoma cells.
Topics: Acetylcysteine; Animals; Anticarcinogenic Agents; Brassica; Carcinoma, Hepatocellular; Dose-Response Relationship, Drug; Enzyme Induction; Glucosinolates; Isothiocyanates; Liver Neoplasms; NAD(P)H Dehydrogenase (Quinone); Phytotherapy; Sulfoxides; Thiocyanates; Tumor Cells, Cultured | 2005 |
NO restores HIF-1alpha hydroxylation during hypoxia: role of reactive oxygen species.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Acetylcysteine; Carcinoma, Hepatocellular; Cell Line; Humans; Hydroxylation; Hypoxia; Naphthoquinones; Nitric Oxide; Nitric Oxide Donors; Procollagen-Proline Dioxygenase; Reactive Oxygen Species; Triazenes; Tumor Cells, Cultured; Von Hippel-Lindau Tumor Suppressor Protein | 2005 |
A rapid and transient ROS generation by cadmium triggers apoptosis via caspase-dependent pathway in HepG2 cells and this is inhibited through N-acetylcysteine-mediated catalase upregulation.
Topics: Acetylcysteine; Apoptosis; Cadmium; Carcinoma, Hepatocellular; Caspases; Catalase; Cell Line; Cell Survival; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Combinations; Environmental Pollutants; fas Receptor; Humans; In Situ Nick-End Labeling; Membrane Potentials; Mitochondria, Liver; Reactive Oxygen Species; Signal Transduction; Up-Regulation | 2006 |
Glycyrrhetic acid (a metabolic substance and aglycon of glycyrrhizin) induces apoptosis in human hepatoma, promyelotic leukemia and stomach cancer cells.
Topics: Acetylcysteine; Antioxidants; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Glycyrrhetinic Acid; Glycyrrhizic Acid; Humans; Leukemia; Lymphocytes; Stomach Neoplasms | 2006 |
Phenylethyl isothiocyanate and its N-acetylcysteine conjugate suppress the metastasis of SK-Hep1 human hepatoma cells.
Topics: Acetylcysteine; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Adhesion; Cell Movement; Drug Screening Assays, Antitumor; Humans; Isothiocyanates; Liver Neoplasms; Matrix Metalloproteinase 14; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Neoplasm Metastasis; Tissue Inhibitor of Metalloproteinase-1; Tumor Cells, Cultured | 2006 |
Allyl isothiocyanate and its N-acetylcysteine conjugate suppress metastasis via inhibition of invasion, migration, and matrix metalloproteinase-2/-9 activities in SK-Hep 1 human hepatoma cells.
Topics: Acetylcysteine; Brassica; Carcinoma, Hepatocellular; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Gene Expression Regulation, Neoplastic; Humans; Isothiocyanates; Liver Neoplasms; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; Neoplasm Metastasis; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2 | 2006 |
Role of oxidative stress in the apoptosis of hepatocellular carcinoma induced by combination of arsenic trioxide and ascorbic acid.
Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Apoptosis; Arsenic Trioxide; Arsenicals; Ascorbic Acid; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Synergism; Free Radical Scavengers; Humans; Liver Neoplasms; Oxidative Stress; Oxides; Proto-Oncogene Proteins c-bcl-2 | 2006 |
Reactive oxygen species mediated sustained activation of protein kinase C alpha and extracellular signal-regulated kinase for migration of human hepatoma cell Hepg2.
Topics: Acetylcysteine; Carcinogens; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Neoplastic; Humans; Indoles; Maleimides; Models, Biological; Protein Kinase C-alpha; Reactive Oxygen Species; Signal Transduction; Tetradecanoylphorbol Acetate | 2006 |
Increased ROS generation and p53 activation in alpha-lipoic acid-induced apoptosis of hepatoma cells.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Ascorbic Acid; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Caspases; Cell Cycle; Cell Line, Tumor; Cell Survival; Cytochromes c; DNA Fragmentation; Enzyme Activation; Humans; Liver Neoplasms; MAP Kinase Kinase 4; Proto-Oncogene Proteins c-akt; Rats; Reactive Oxygen Species; Thioctic Acid; Tumor Suppressor Protein p53 | 2007 |
Apoptosis induction on human hepatoma cells Hep G2 of decabrominated diphenyl ether (PBDE-209).
Topics: Acetylcysteine; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Flow Cytometry; Fluoresceins; Free Radical Scavengers; G1 Phase; Halogenated Diphenyl Ethers; Humans; Liver Neoplasms; Phenyl Ethers; Polybrominated Biphenyls; Reactive Oxygen Species; Resting Phase, Cell Cycle; S Phase; Time Factors | 2007 |
Inhibitory effect of 6-formylpterin on HIF-1alpha protein accumulation.
Topics: Acetylcysteine; Antioxidants; Carcinoma, Hepatocellular; Cell Hypoxia; Cell Line, Tumor; Deferoxamine; Dose-Response Relationship, Drug; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Pterins; Reactive Oxygen Species; RNA, Messenger | 2007 |
MSFTZ, a flavanone derivative, induces human hepatoma cell apoptosis via a reactive oxygen species- and caspase-dependent mitochondrial pathway.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Antioxidants; Apoptosis; Benzopyrans; Carcinoma, Hepatocellular; Caspases; Cell Line, Tumor; Cell Proliferation; Female; Flavanones; Humans; Membrane Potential, Mitochondrial; Mice; Mice, Inbred BALB C; Mitochondria; Mitogen-Activated Protein Kinases; Neoplasm Transplantation; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Thiadiazoles; Tumor Suppressor Protein p53 | 2008 |
Effect of green tea and (-)-epigallocatechin gallate on ethanol-induced toxicity in HepG2 cells.
Topics: Acetylcysteine; Carcinoma, Hepatocellular; Catechin; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Ethanol; gamma-Glutamyltransferase; Glutathione; Humans; Liver Neoplasms; Plant Extracts; Tea | 2008 |
High rates of thioredoxin secretion correlate with growth arrest in hepatoma cells.
Topics: Acetylcysteine; Animals; Carcinoma, Hepatocellular; Cell Division; Cell Line; Humans; Kinetics; L-Lactate Dehydrogenase; Liver; Liver Neoplasms; Lymphoma, B-Cell; Mercaptoethanol; Mice; Oxidation-Reduction; Recombinant Proteins; Reference Values; Thioredoxins; Tumor Cells, Cultured | 1995 |
Intracellular glutathione level modulates the induction of apoptosis by delta 12-prostaglandin J2.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Arsenites; Buthionine Sulfoximine; Carcinoma, Hepatocellular; Cell Division; Cycloheximide; DNA Fragmentation; Electrophoresis, Agar Gel; Enzyme Inhibitors; Glutathione; Humans; Liver Neoplasms; Prostaglandin D2; Sodium Compounds; Structure-Activity Relationship; Sulfhydryl Compounds; Tumor Cells, Cultured | 1996 |
Reactive oxygen intermediates are involved in the induction of CD95 ligand mRNA expression by cytostatic drugs in hepatoma cells.
Topics: Acetylcysteine; Actins; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antioxidants; Apoptosis; Bleomycin; Carcinoma, Hepatocellular; Deferoxamine; Fas Ligand Protein; fas Receptor; Glutathione; Humans; Hydrogen Peroxide; Ligands; Membrane Glycoproteins; Oxidative Stress; Reactive Oxygen Species; RNA, Messenger; Tumor Cells, Cultured; Up-Regulation | 1997 |
Glutathione S-conjugate formation and metabolism in HepG2 cells: a cell model of mercapturic acid biosynthesis.
Topics: Acetylcysteine; Biological Transport; Carcinoma, Hepatocellular; Cysteine; Dinitrochlorobenzene; Glutathione; Humans; Inactivation, Metabolic; Liver Neoplasms; Models, Biological; Tumor Cells, Cultured | 1998 |
Blockage of apoptotic signaling of transforming growth factor-beta in human hepatoma cells by carboxyfullerene.
Topics: Acetylcysteine; Apoptosis; Ascorbic Acid; Carbon; Carboxylic Acids; Carcinoma, Hepatocellular; Cell Survival; Flow Cytometry; Fluorescent Dyes; Free Radical Scavengers; Fullerenes; Humans; Liposomes; Molecular Structure; Plasminogen Activator Inhibitor 1; Promoter Regions, Genetic; Reactive Oxygen Species; Signal Transduction; Stereoisomerism; Transforming Growth Factor beta; Tumor Cells, Cultured | 1998 |
Possible availability of N-acetylcysteine as an adjunct to cytokine therapy for hepatocellular carcinoma.
Topics: Acetylcysteine; Adult; Aged; Carcinoma, Hepatocellular; Cytokines; Cytotoxicity, Immunologic; Female; Glutathione; Humans; Interleukin-2; Leukocytes, Mononuclear; Liver; Liver Neoplasms; Male; Middle Aged; Recombinant Proteins | 1998 |
Regulated Co-translational ubiquitination of apolipoprotein B100. A new paradigm for proteasomal degradation of a secretory protein.
Topics: Acetylcysteine; Animals; Apolipoprotein B-100; Apolipoproteins B; Benzoquinones; Carcinoma, Hepatocellular; CHO Cells; Cricetinae; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytosol; Endoplasmic Reticulum; Enzyme Inhibitors; HSP70 Heat-Shock Proteins; Humans; Lactams, Macrocyclic; Liver Neoplasms; Models, Biological; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Biosynthesis; Protein Processing, Post-Translational; Puromycin; Quinones; Recombinant Proteins; Rifabutin; Transfection; Tumor Cells, Cultured; Ubiquitins | 1998 |
Reversible change in thiol redox status of the insulin receptor alpha-subunit in intact cells.
Topics: Acetylcysteine; Animals; Carcinoma, Hepatocellular; CHO Cells; Cricetinae; Culture Media; Glutathione; Humans; Oxidation-Reduction; Protein Binding; Rats; Receptor, Insulin; Sulfhydryl Compounds; Time Factors; Tumor Cells, Cultured | 1999 |
Induction of apoptosis in macrophages by cationic liposomes.
Topics: Acetylcysteine; Animals; Apoptosis; Carcinoma, Hepatocellular; Cations; Cell Line; DNA; DNA Fragmentation; Humans; Liposomes; Liver Neoplasms; Macrophages; Mice; Mice, Inbred BALB C; Peroxides; Rats; Rats, Wistar; Reactive Oxygen Species; Tumor Cells, Cultured | 1999 |
Acetaminophen inhibits NF-kappaB activation by interfering with the oxidant signal in murine Hepa 1-6 cells.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antioxidants; Blotting, Western; Carcinoma, Hepatocellular; DNA Probes; DNA-Binding Proteins; Fluoresceins; Hydrogen Peroxide; I-kappa B Proteins; Mice; NF-kappa B; NF-KappaB Inhibitor alpha; Oxidation-Reduction; Pyrrolidines; Signal Transduction; Thiocarbamates; Tumor Cells, Cultured | 2000 |
Dual role of glutathione in selenite-induced oxidative stress and apoptosis in human hepatoma cells.
Topics: Acetylcysteine; Apoptosis; Buthionine Sulfoximine; Carcinoma, Hepatocellular; Glutathione; Growth Inhibitors; Humans; Intracellular Fluid; L-Lactate Dehydrogenase; Liver Neoplasms; Oxidative Stress; Reactive Oxygen Species; Sodium Selenite; Tumor Cells, Cultured | 2000 |
Inhibitors of Na+/Ca2+ exchanger prevent oxidant-induced intracellular Ca2+ increase and apoptosis in a human hepatoma cell line.
Topics: Acetylcysteine; Antioxidants; Apoptosis; Calcium; Carcinoma, Hepatocellular; Chelating Agents; Egtazic Acid; Flow Cytometry; Humans; Liver Neoplasms; Oxidants; Oxidative Stress; Phenylenediamines; Reactive Oxygen Species; Sodium; Sodium-Calcium Exchanger; tert-Butylhydroperoxide; Tumor Cells, Cultured | 2000 |
Superoxide radical-initiated apoptotic signalling pathway in selenite-treated HepG(2) cells: mitochondria serve as the main target.
Topics: Acetylcysteine; Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Caspase Inhibitors; Caspases; Cyclic N-Oxides; Cyclosporine; Cytochrome c Group; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Glutathione; Humans; In Situ Nick-End Labeling; Kinetics; Liver Neoplasms; Membrane Potentials; Mitochondria; Signal Transduction; Sodium Selenite; Spin Labels; Superoxides; Trifluoperazine; Tumor Cells, Cultured | 2001 |
Reactive oxygen species and mitochondria mediate the induction of apoptosis in human hepatoma HepG2 cells by the rodent peroxisome proliferator and hepatocarcinogen, perfluorooctanoic acid.
Topics: Acetylcysteine; Apoptosis; Caprylates; Carcinogens; Carcinoma, Hepatocellular; Caspase 9; Caspases; Cyclosporine; Dose-Response Relationship, Drug; Enzyme Activation; Flow Cytometry; Fluorocarbons; Humans; Hydrogen Peroxide; Kinetics; Liver Neoplasms; Membrane Potentials; Mitochondria, Liver; Reactive Oxygen Species; Superoxides; Tumor Cells, Cultured | 2001 |
Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-kappa B.
Topics: Acetylcysteine; Antioxidants; Calcium; Calcium Signaling; Carcinoma, Hepatocellular; Chelating Agents; DNA-Binding Proteins; Egtazic Acid; Gallic Acid; Gene Expression Regulation, Neoplastic; Gene Expression Regulation, Viral; Genes, Reporter; Hepacivirus; Humans; Liver Neoplasms; Luciferases; Neoplasm Proteins; NF-kappa B; Oxidative Stress; Pyrrolidines; Reactive Oxygen Species; Recombinant Fusion Proteins; STAT3 Transcription Factor; Thiocarbamates; Trans-Activators; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Viral Nonstructural Proteins | 2001 |
The influence of atracurium, cisatracurium, and mivacurium on the proliferation of two human cell lines in vitro.
Topics: Acetylcysteine; Atracurium; Carboxylic Ester Hydrolases; Carcinoma, Hepatocellular; Cell Count; Cell Division; Cell Line; Endothelium, Vascular; Free Radical Scavengers; Glutathione; Humans; Isoquinolines; Liver Neoplasms; Mivacurium; Neuromuscular Nondepolarizing Agents | 2001 |
Induction of apoptosis in p53-deficient human hepatoma cell line by wild-type p53 gene transduction: inhibition by antioxidant.
Topics: Acetylcysteine; Antioxidants; Apoptosis; Carcinoma, Hepatocellular; Cell Survival; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; DNA Fragmentation; Free Radical Scavengers; Genes, p53; Glutathione; Humans; In Situ Nick-End Labeling; Liver Neoplasms; Retroviridae; Transduction, Genetic; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2001 |
The proteasome participates in degradation of mutant alpha 1-antitrypsin Z in the endoplasmic reticulum of hepatoma-derived hepatocytes.
Topics: Acetylcysteine; alpha 1-Antitrypsin; Animals; Antibiotics, Antineoplastic; Carcinoma, Hepatocellular; Cell Line; Cells, Cultured; Cysteine Endopeptidases; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Fibroblasts; HeLa Cells; Hepatocytes; Humans; Lactones; Leupeptins; Liver; Mice; Multienzyme Complexes; Mutation; Oligopeptides; Precipitin Tests; Proteasome Endopeptidase Complex; Protein Binding; Rats; Time Factors; Transfection; Tumor Cells, Cultured | 2001 |
Involvement of Cdc25A phosphatase in Hep3B hepatoma cell growth inhibition induced by novel K vitamin analogs.
Topics: Acetylcysteine; Carcinoma, Hepatocellular; Catalase; cdc25 Phosphatases; Cell Division; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases; Drug Interactions; Enzyme Activation; Glutathione; Growth Inhibitors; Humans; Liver Neoplasms; Phosphorylation; Proto-Oncogene Proteins; Retinoblastoma Protein; Sulfhydryl Compounds; Vitamin K | 2001 |
Acetaminophen hepatotoxicity and mechanisms of its protection by N-acetylcysteine: a study of Hep3B cells.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Apoptosis; Carcinoma, Hepatocellular; Cell Nucleus; Cell Survival; Cytoplasm; Dose-Response Relationship, Drug; Drug Antagonism; Flow Cytometry; Free Radical Scavengers; Glutathione; Hepatocytes; Humans; Liver Neoplasms; Oxidative Stress; Reactive Oxygen Species; Tumor Cells, Cultured | 2002 |
Increased oxidative metabolism of paracetamol in patients with hepatocellular carcinoma.
Topics: Acetaminophen; Acetylcysteine; Adult; Carcinoma, Hepatocellular; Chromatography, High Pressure Liquid; Cysteine; Cytochrome P-450 Enzyme System; Hepatitis B; Humans; Liver Neoplasms; Middle Aged; Oxidation-Reduction; Reference Values | 1991 |