Compounds > acetylcysteine

acetylcysteine and Hearing Loss

acetylcysteine has been researched along with Hearing Loss in 23 studies

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19901 (4.35)18.7374
1990's0 (0.00)18.2507
2000's7 (30.43)29.6817
2010's12 (52.17)24.3611
2020's3 (13.04)2.80

Authors

AuthorsStudies
Szymański, M; Zadrożniak, M; Łuszczki, JJ1
Chi, YY; Eisenberg, LS; Freyer, DR; Knight, KR; Malvar, J; Mena, V; Muldoon, LL; Neely, M; Neuwelt, EA; Orgel, E; Rassekh, SR; Ross, CJD; Rushing, T; Scott, EN1
Waissbluth, S1
Bermúdez-Muñoz, JM; García-Alcántara, F; Martínez-Vega, R; Milo, M; Murillo-Cuesta, S; Pulido, S; Rivera, T; Varela-Nieto, I1
Ahmed, J; Eshraghi, AA; Gupta, C; Ila, K; Mittal, J; Tillinger, JA; Van De Water, TR1
Angele, B; Demel, C; Giese, A; Högen, T; Klein, M; Koedel, U; Pfister, HW1
Gratton, MA; Mohan, S; Namin, A; Phillips, G; Smyth, BJ1
Bas, E; Bauer, B; Eshraghi, AA; Guardiola, M; Mittal, J; Rivera, I; Roell, J; Shaikh, N; Telischi, FF; Van De Water, T1
Aladag, I; Guven, M; Songu, M1
Choe, SK; Kim, SJ; Kwak, S; Lee, WK; Moon, SK; Park, C; Park, R1
Graham, M; Ivanova, AV; Navaratnam, D; Santos-Sacchi, J; Schettino, A; Song, L; Tan, WJT; Yarbrough, WG1
Bielefeld, EC; Chen, GD; Henderson, D; Hu, BH; Yang, WP1
Millea, PJ1
Chang, A; Eastwood, H; Galloway, S; James, D; O'Leary, S; Pinder, D; Richardson, R1
Nader, ME; Saliba, I; Théorêt, Y1
Amarantidis, K; Chamalidou, E; Chelis, L; Danielides, V; Dimopoulos, P; Kakolyris, S; Papadopoulos, S; Riga, MG; Stathakidou, S; Xenidis, N1
Chang, A; Connolly, T; Eastwood, H; Kel, G; Marovic, P; Monksfield, P; O'Leary, JS; O'Leary, SJ; Richardson, R; Souter, MA1
Kastenbauer, S; Klein, M; Koedel, U; Pfister, HW1
Kraemer, DF; Muldoon, LL; Neuwelt, EA; Thomas Dickey, D1
Chang, KW; Chinosornvatana, N; Choe, WT1
Abramsohn, R; Averbukh, Z; Efrati, S; Eviatar, E; Feldman, L; Gersch, E; Weissgarten, J; Yarovoy, I1
Tepel, M1
Bock, GR; Miller, JJ; Moorjani, P; Yates, GK1

Reviews

2 review(s) available for acetylcysteine and Hearing Loss

ArticleYear
Clinical trials evaluating transtympanic otoprotectants for cisplatin-induced ototoxicity: what do we know so far?
    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2020, Volume: 277, Issue:9

    Topics: Acetylcysteine; Antineoplastic Agents; Cisplatin; Hearing Loss; Humans; Injections

2020
N-acetylcysteine: multiple clinical applications.
    American family physician, 2009, Aug-01, Volume: 80, Issue:3

    Topics: Acetaminophen; Acetylcysteine; Antidotes; Expectorants; Female; Free Radical Scavengers; Hearing Loss; Humans; Influenza, Human; Neoplasms; Polycystic Ovary Syndrome; Respiratory Tract Diseases

2009

Trials

3 trial(s) available for acetylcysteine and Hearing Loss

ArticleYear
Intravenous N-Acetylcysteine to Prevent Cisplatin-Induced Hearing Loss in Children: A Nonrandomized Controlled Phase I Trial.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2023, 07-05, Volume: 29, Issue:13

    Topics: Acetylcysteine; Administration, Intravenous; Adolescent; Child; Cisplatin; Hearing Loss; Humans; Neoplasms

2023
Transtympanic injections of N-acetylcysteine for the prevention of cisplatin-induced ototoxicity: a feasible method with promising efficacy.
    American journal of clinical oncology, 2013, Volume: 36, Issue:1

    Topics: Acetylcysteine; Adolescent; Adult; Aged; Antineoplastic Agents; Cisplatin; Ear; Feasibility Studies; Female; Free Radical Scavengers; Hearing Loss; Humans; Male; Middle Aged; Tympanic Membrane; Young Adult

2013
Gentamicin-induced ototoxicity in hemodialysis patients is ameliorated by N-acetylcysteine.
    Kidney international, 2007, Volume: 72, Issue:3

    Topics: Acetylcysteine; Administration, Oral; Aged; Aminoglycosides; Anti-Bacterial Agents; Antioxidants; Bacteremia; Cysteine; Female; Gentamicins; Glutathione; Hearing Loss; Humans; Kidney Failure, Chronic; Male; Middle Aged; Oxidative Stress; Prospective Studies; Renal Dialysis

2007

Other Studies

18 other study(ies) available for acetylcysteine and Hearing Loss

ArticleYear
N-Acetyl-L-cysteine Affects Ototoxicity Evoked by Amikacin and Furosemide Either Alone or in Combination in a Mouse Model of Hearing Threshold Decrease.
    International journal of molecular sciences, 2023, Apr-20, Volume: 24, Issue:8

    Topics: Acetylcysteine; Amikacin; Aminoglycosides; Animals; Anti-Bacterial Agents; Auditory Threshold; Deafness; Furosemide; Hearing; Hearing Loss; Mice; Ototoxicity

2023
The expression of oxidative stress response genes is modulated by a combination of resveratrol and N-acetylcysteine to ameliorate ototoxicity in the rat cochlea.
    Hearing research, 2018, Volume: 358

    Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Auditory Fatigue; Brain Stem; Cochlea; Cytoprotection; Disease Models, Animal; Drug Therapy, Combination; Evoked Potentials, Auditory, Brain Stem; Furosemide; Gene Expression Regulation; Hearing; Hearing Loss; Inflammation Mediators; Kanamycin; Male; Oxidative Stress; Rats, Wistar; Reaction Time; Resveratrol

2018
l-N-acetylcysteine protects outer hair cells against TNFα initiated ototoxicity in vitro.
    Acta oto-laryngologica, 2018, Volume: 138, Issue:8

    Topics: Acetylcysteine; Aldehydes; Animals; Drug Evaluation, Preclinical; Free Radical Scavengers; Glutathione; Glutathione Synthase; Hair Cells, Auditory, Outer; Hearing Loss; In Vitro Techniques; Membrane Potential, Mitochondrial; Oxidative Stress; Rats, Sprague-Dawley; Reactive Oxygen Species; Tumor Necrosis Factor-alpha

2018
Adjunctive N-acetyl-L-cysteine in treatment of murine pneumococcal meningitis.
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:10

    Topics: Acetylcysteine; Animals; Anti-Bacterial Agents; Ceftriaxone; Cochlea; Disease Models, Animal; Hearing Loss; Male; Meningitis, Pneumococcal; Mice; Mice, Inbred C57BL

2013
Targeted amelioration of cisplatin-induced ototoxicity in guinea pigs.
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2014, Volume: 151, Issue:5

    Topics: Acetylcysteine; Animals; Cisplatin; Female; Free Radical Scavengers; Guinea Pigs; Hearing Loss; Oxidative Stress; Pilot Projects; Tympanic Membrane

2014
A novel combination of drug therapy to protect residual hearing post cochlear implant surgery.
    Acta oto-laryngologica, 2016, Volume: 136, Issue:4

    Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents; Cochlear Implantation; Dexamethasone; Drug Therapy, Combination; Free Radical Scavengers; Hair Cells, Auditory; Hearing Loss; Mannitol; Postoperative Complications; Rats, Sprague-Dawley

2016
Prevention of gentamicin ototoxicity with N-acetylcysteine and vitamin A.
    The Journal of laryngology and otology, 2016, Volume: 130, Issue:5

    Topics: Acetylcysteine; Animals; Anti-Bacterial Agents; Free Radical Scavengers; Gentamicins; Hearing; Hearing Loss; Male; Otoacoustic Emissions, Spontaneous; Rats; Rats, Wistar; Signal-To-Noise Ratio; Vitamin A; Vitamins

2016
Tetrabromobisphenol-A induces apoptotic death of auditory cells and hearing loss.
    Biochemical and biophysical research communications, 2016, 09-30, Volume: 478, Issue:4

    Topics: Acetylcysteine; Animals; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Cell Line; Evoked Potentials, Auditory, Brain Stem; Flame Retardants; Free Radical Scavengers; Gene Expression; Hair Cells, Auditory; Hearing Loss; Interleukin-6; Lateral Line System; Mechanoreceptors; Mice, Inbred ICR; Microscopy, Fluorescence; Organ of Corti; Polybrominated Biphenyls; Rats, Sprague-Dawley; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Zebrafish

2016
Novel Role of the Mitochondrial Protein Fus1 in Protection from Premature Hearing Loss via Regulation of Oxidative Stress and Nutrient and Energy Sensing Pathways in the Inner Ear.
    Antioxidants & redox signaling, 2017, 09-10, Volume: 27, Issue:8

    Topics: Acetylcysteine; Animals; Antioxidants; Disease Models, Animal; Ear, Inner; Evoked Potentials, Auditory, Brain Stem; Gene Knockout Techniques; Hearing Loss; Humans; Mice; Microscopy, Electron, Transmission; Mitochondria; Oxidative Stress; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Signal Transduction; Spiral Ganglion; TOR Serine-Threonine Kinases; Tumor Suppressor Proteins

2017
Protective effect of N-acetyl-L-cysteine (L-NAC) against styrene-induced cochlear injuries.
    Acta oto-laryngologica, 2009, Volume: 129, Issue:10

    Topics: Acetylcysteine; Animals; Free Radical Scavengers; Glutathione; Hair Cells, Auditory, Outer; Hearing Loss; Rats; Rats, Long-Evans; Styrene

2009
Permanent and transient effects of locally delivered n-acetyl cysteine in a guinea pig model of cochlear implantation.
    Hearing research, 2010, Volume: 259, Issue:1-2

    Topics: Acetylcysteine; Acoustic Stimulation; Animals; Antioxidants; Auditory Threshold; Cochlea; Cochlear Implants; Evoked Potentials, Auditory, Brain Stem; Guinea Pigs; Hearing Loss; Humans; Models, Animal; Round Window, Ear

2010
The role of intratympanic lactate injection in the prevention of cisplatin-induced ototoxicity.
    The Laryngoscope, 2010, Volume: 120, Issue:6

    Topics: Acetylcysteine; Animals; Cisplatin; Guinea Pigs; Hearing Loss; Lactates; Microscopy, Electron, Scanning; Prospective Studies; Statistics, Nonparametric; Tympanic Membrane

2010
Relations between cochlear histopathology and hearing loss in experimental cochlear implantation.
    Hearing research, 2013, Volume: 298

    Topics: Acetylcysteine; Acoustic Stimulation; Administration, Topical; Animals; Audiometry, Pure-Tone; Auditory Threshold; Cochlea; Cochlear Implantation; Cochlear Implants; Dexamethasone; Evoked Potentials, Auditory, Brain Stem; Guinea Pigs; Hair Cells, Auditory, Outer; Hearing Loss; Hemocyanins; Injections, Intravenous; Injections, Subcutaneous; Prosthesis Design; Time Factors

2013
Meningitis-associated hearing loss: protection by adjunctive antioxidant therapy.
    Annals of neurology, 2003, Volume: 54, Issue:4

    Topics: Acetylcysteine; Animals; Anti-Bacterial Agents; Antioxidants; Audiometry; Ceftriaxone; Cell Count; Cochlea; Disease Models, Animal; Drug Interactions; Evans Blue; Evoked Potentials, Auditory, Brain Stem; Hearing Loss; Labyrinthitis; Male; Meningitis, Pneumococcal; Metalloporphyrins; Peroxynitrous Acid; Rats; Rats, Wistar; Spiral Ganglion; Time Factors

2003
Protection against cisplatin-induced ototoxicity by N-acetylcysteine in a rat model.
    Hearing research, 2004, Volume: 193, Issue:1-2

    Topics: Acetylcysteine; Animals; Antineoplastic Agents; Body Weight; Cisplatin; Drug Administration Schedule; Ear Diseases; Evoked Potentials, Auditory, Brain Stem; Hearing Loss; Rats; Rats, Long-Evans

2004
Prevention of cisplatin ototoxicity using transtympanic N-acetylcysteine and lactate.
    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2004, Volume: 25, Issue:6

    Topics: Acetylcysteine; Animals; Antineoplastic Agents; Cisplatin; Cochlea; Disease Models, Animal; Guinea Pigs; Hair Cells, Auditory, Outer; Hearing Loss; Isotonic Solutions; Otoacoustic Emissions, Spontaneous; Random Allocation; Ringer's Lactate; Therapeutics

2004
N-Acetylcysteine in the prevention of ototoxicity.
    Kidney international, 2007, Volume: 72, Issue:3

    Topics: Acetylcysteine; Administration, Oral; Aminoglycosides; Anti-Bacterial Agents; Antioxidants; Bacteremia; Gentamicins; Hearing Loss; Humans; Kidney Failure, Chronic; Renal Dialysis

2007
Effects of N-acetylcysteine on kanamycin ototoxicity in the guinea pig.
    Hearing research, 1983, Volume: 9, Issue:3

    Topics: Acetylcysteine; Action Potentials; Animals; Drug Synergism; Free Radicals; Guinea Pigs; Hair Cells, Auditory; Hearing; Hearing Loss; Kanamycin

1983