acetylcysteine and Encephalopathy, Traumatic

acetylcysteine has been researched along with Encephalopathy, Traumatic in 17 studies

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's11 (64.71)24.3611
2020's6 (35.29)2.80

Authors

AuthorsStudies
Balosso, S; Bañuelos, I; Das Gupta, S; Hämäläinen, E; Hiltunen, M; Kajevu, N; Kyyriäinen, J; Lara, L; Lipponen, A; Natunen, T; Pitkänen, A; Puhakka, N; Ravizza, T; Vezzani, A1
Dhamne, SC; Hameed, MQ; Hensch, TK; Hodgson, N; Jannati, A; Lee, HHC; MacMullin, PC; Pascual-Leone, A; Rotenberg, A1
Bell, MJ; Clark, RSB; Empey, PE; Kochanek, PM1
Bar-Klein, G; Friedman, A; Hameed, MQ; Jozwiak, S; Kaminski, RM; Klein, P; Klitgaard, H; Koepp, M; Löscher, W; Prince, DA; Rotenberg, A; Twyman, R; Vezzani, A; Wong, M1
Celorrio, M; Davies, M; Friess, SH; Rhodes, J; Vadivelu, S1
Alexis, A; Bergold, PJ; Nikulina, E; Rahman, SN; Whitney, K1
Bergold, PJ; Grin'kina, NM; Haber, M; Hartman, I; Ho, J; Irizarry, R; James, J; Kim, J; Nikulina, E; Ramadani, A; Sangobowale, M1
Au, AK; Bayır, H; Bell, MJ; Clark, RSB; Empey, PE; Horvat, CM; Kochanek, PM; Nolin, TD; Poloyac, SM; Rosario, BL; Wisniewski, SR1
Becker, RE; Chiang, YH; Greig, NH; Hoffer, BJ; Hoffer, ME; Pick, CG1
Dai, Z; Shi, H; Wang, L; Wu, P; Zhao, S1
Bayir, H; Bell, MJ; Clark, RSB; Empey, PE; Hagos, FT; Kochanek, PM; Ma, X; Poloyac, SM; Wang, P1
Ding, K; Fang, J; Wang, HD; Zhou, XM; Zhou, Y; Zhu, L1
Bayır, H; Chao, H; Clark, RS; Du, L; Empey, PE; Ji, J; Kochanek, PM1
Cheng, W; Du, X; Ewert, DL; Floyd, RA; Kopke, RD; Li, W; Saunders, D; Towner, RA; West, MB1
Choi, BY; Jung, HJ; Kho, AR; Kim, IY; Kim, JH; Lee, BE; Lee, SH; Sohn, M; Song, HK; Suh, SW1
Hartwell, J; Hiebert, JB; Pierce, JD; Shen, Q; Thimmesch, AR1
Chen, W; Guo, Y; Tong, W; Yang, W; Zeng, J; Zheng, P1

Reviews

4 review(s) available for acetylcysteine and Encephalopathy, Traumatic

ArticleYear
N-Acetylcysteine and Probenecid Adjuvant Therapy for Traumatic Brain Injury.
    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2023, Volume: 20, Issue:6

    Topics: Acetylcysteine; Blood-Brain Barrier; Brain; Brain Injuries, Traumatic; Child; Humans; Pilot Projects; Probenecid

2023
Repurposed molecules for antiepileptogenesis: Missing an opportunity to prevent epilepsy?
    Epilepsia, 2020, Volume: 61, Issue:3

    Topics: Acetylcysteine; Animals; Anticonvulsants; Antioxidants; Atorvastatin; Brain Injuries, Traumatic; Ceftriaxone; Dibenzazepines; Drug Repositioning; Epilepsy; Epilepsy, Post-Traumatic; Erythropoietin; Fingolimod Hydrochloride; GABA Agents; Gabapentin; Humans; Immunologic Factors; Inflammation; Interleukin 1 Receptor Antagonist Protein; Isoflurane; Levetiracetam; Losartan; Neuroprotective Agents; Oxidative Stress; Pregabalin; Pyrrolidinones; Sirolimus; Stroke; Topiramate; Translational Research, Biomedical; Vigabatrin

2020
Repositioning drugs for traumatic brain injury - N-acetyl cysteine and Phenserine.
    Journal of biomedical science, 2017, Sep-09, Volume: 24, Issue:1

    Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents; Brain Injuries, Traumatic; Cholinesterase Inhibitors; Drug Repositioning; Humans; Mice; Physostigmine; Psychotropic Drugs; Rats

2017
Systematic Review of Traumatic Brain Injury and the Impact of Antioxidant Therapy on Clinical Outcomes.
    Worldviews on evidence-based nursing, 2016, Volume: 13, Issue:5

    Topics: Acetylcysteine; Adult; Amino Acids; Antioxidants; Ascorbic Acid; Brain Injuries, Traumatic; Female; Flavonoids; Humans; Male; Progesterone; Quercetin; Treatment Outcome; Vitamin E

2016

Trials

2 trial(s) available for acetylcysteine and Encephalopathy, Traumatic

ArticleYear
Phase I randomized clinical trial of N-acetylcysteine in combination with an adjuvant probenecid for treatment of severe traumatic brain injury in children.
    PloS one, 2017, Volume: 12, Issue:7

    Topics: Acetylcysteine; Adjuvants, Pharmaceutic; Adolescent; Antioxidants; Biomarkers; Body Temperature; Brain Injuries, Traumatic; Child; Child, Preschool; Double-Blind Method; Drug Administration Schedule; Female; Glasgow Coma Scale; Glasgow Outcome Scale; Humans; Intracranial Pressure; Intubation, Gastrointestinal; Male; Probenecid; Survival Analysis

2017
Exploratory Application of Neuropharmacometabolomics in Severe Childhood Traumatic Brain Injury.
    Critical care medicine, 2018, Volume: 46, Issue:9

    Topics: Acetylcysteine; Adjuvants, Pharmaceutic; Adolescent; Brain Injuries, Traumatic; Child; Child, Preschool; Double-Blind Method; Drug Therapy, Combination; Humans; Injury Severity Score; Metabolomics; Probenecid

2018

Other Studies

11 other study(ies) available for acetylcysteine and Encephalopathy, Traumatic

ArticleYear
Targeting Oxidative Stress with Antioxidant Duotherapy after Experimental Traumatic Brain Injury.
    International journal of molecular sciences, 2021, Sep-29, Volume: 22, Issue:19

    Topics: Acetylcysteine; Animals; Antioxidants; Brain; Brain Injuries, Traumatic; Cell Line; Cell Survival; Cells, Cultured; Disease Models, Animal; Gene Expression; Heme Oxygenase-1; Isothiocyanates; Male; Mice, Inbred C57BL; Microglia; Neurons; NF-E2-Related Factor 2; Oxidative Stress; Rats, Sprague-Dawley; Sulfoxides

2021
N-acetylcysteine treatment mitigates loss of cortical parvalbumin-positive interneuron and perineuronal net integrity resulting from persistent oxidative stress in a rat TBI model.
    Cerebral cortex (New York, N.Y. : 1991), 2023, 03-21, Volume: 33, Issue:7

    Topics: Acetylcysteine; Animals; Brain Injuries, Traumatic; Interneurons; Oxidative Stress; Parvalbumins; Rats

2023
N-acetylcysteine reduces brain injury after delayed hypoxemia following traumatic brain injury.
    Experimental neurology, 2021, Volume: 335

    Topics: Acetylcysteine; Animals; Axons; Behavior, Animal; Brain Injuries, Traumatic; Fear; Glutathione; Hippocampus; Hypoxia; Male; Maze Learning; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Psychomotor Performance; Social Behavior

2021
Delayed dosing of minocycline plus N-acetylcysteine reduces neurodegeneration in distal brain regions and restores spatial memory after experimental traumatic brain injury.
    Experimental neurology, 2021, Volume: 345

    Topics: Acetylcysteine; Animals; Brain; Brain Injuries, Traumatic; Drug Administration Schedule; Drug Therapy, Combination; Free Radical Scavengers; Male; Memory Disorders; Mice; Mice, Inbred C57BL; Minocycline; Neurodegenerative Diseases; Neuroprotective Agents; Spatial Memory

2021
Minocycline plus N-acteylcysteine induces remyelination, synergistically protects oligodendrocytes and modifies neuroinflammation in a rat model of mild traumatic brain injury.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2018, Volume: 38, Issue:8

    Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents; Antioxidants; Brain Injuries, Traumatic; Disease Models, Animal; Drug Synergism; Inflammation; Male; Minocycline; Oligodendroglia; Rats; Rats, Sprague-Dawley; Remyelination

2018
Lack of mitochondrial ferritin aggravated neurological deficits via enhancing oxidative stress in a traumatic brain injury murine model.
    Bioscience reports, 2017, Dec-22, Volume: 37, Issue:6

    Topics: Acetylcysteine; Animals; Antioxidants; Brain; Brain Injuries, Traumatic; Cognitive Dysfunction; Disease Models, Animal; Ferritins; Glutathione; Malondialdehyde; Memory Disorders; Mice; Mice, Knockout; Mitochondria; Mitochondrial Proteins; Nitric Oxide; Oxidative Stress; Superoxide Dismutase

2017
N-acetylcysteine amide provides neuroprotection via Nrf2-ARE pathway in a mouse model of traumatic brain injury.
    Drug design, development and therapy, 2018, Volume: 12

    Topics: Acetylcysteine; Animals; Antioxidant Response Elements; Antioxidants; Apoptosis; Behavior, Animal; Brain; Brain Injuries, Traumatic; Caspase 3; Disease Models, Animal; Heme Oxygenase-1; Male; Membrane Proteins; Mice, Inbred ICR; NAD(P)H Dehydrogenase (Quinone); Nerve Degeneration; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Signal Transduction; Time Factors

2018
Probenecid and N-Acetylcysteine Prevent Loss of Intracellular Glutathione and Inhibit Neuronal Death after Mechanical Stretch Injury In Vitro.
    Journal of neurotrauma, 2016, 10-15, Volume: 33, Issue:20

    Topics: Acetylcysteine; Animals; Brain Injuries, Traumatic; Cell Death; Cells, Cultured; Female; Glutathione; Male; Neurons; Neuroprotective Agents; Probenecid; Rats; Rats, Sprague-Dawley; Stress, Mechanical

2016
Ameliorative Effects of Antioxidants on the Hippocampal Accumulation of Pathologic Tau in a Rat Model of Blast-Induced Traumatic Brain Injury.
    Oxidative medicine and cellular longevity, 2016, Volume: 2016

    Topics: Acetylcysteine; Animals; Antioxidants; Benzenesulfonates; Blast Injuries; Brain Injuries, Traumatic; Cytoprotection; Disease Models, Animal; Hippocampus; Male; Neuroprotective Agents; Protein Aggregation, Pathological; Rats; Rats, Long-Evans; tau Proteins

2016
Decreased cysteine uptake by EAAC1 gene deletion exacerbates neuronal oxidative stress and neuronal death after traumatic brain injury.
    Amino acids, 2016, Volume: 48, Issue:7

    Topics: Acetylcysteine; Animals; Brain Injuries, Traumatic; Cell Death; Excitatory Amino Acid Transporter 3; Gene Deletion; Mice; Mice, Knockout; Neurons; Oxidative Stress

2016
Connexin40 correlates with oxidative stress in brains of traumatic brain injury rats.
    Restorative neurology and neuroscience, 2017, Volume: 35, Issue:2

    Topics: Acetylcysteine; Analysis of Variance; Animals; Brain; Brain Edema; Brain Infarction; Brain Injuries, Traumatic; Connexins; Disease Models, Animal; Gap Junction alpha-5 Protein; Gene Expression Regulation; Male; Oxidative Stress; Rats; Rats, Wistar; Time Factors

2017