acetylcysteine and Encephalopathy, Toxic

acetylcysteine has been researched along with Encephalopathy, Toxic in 28 studies

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (17.86)29.6817
2010's18 (64.29)24.3611
2020's5 (17.86)2.80

Authors

AuthorsStudies
Chang, L; Cheng, Y; Li, X; Niu, Q; Sun, M; Wang, T; Wang, Z; Yang, X; Zhang, H; Zhang, Z1
Admon, A; Arick, MA; Bedrossiantz, J; Ben-Lulu, S; Faria, M; Garcia-Reyero, N; Gómez-Canela, C; Gómez-Oliván, LM; Hsu, CY; Orozco, M; Prats, E; Raldúa, D; Ziv, T1
Bahtiar, Y; Bakri, S; Gumay, AR; Hardian, H; Indraswari, DA; Karlowee, V; Koriyama, C; Maharani, N; Muniroh, M; Yamamoto, M1
Allahyari, A; Barri, A; Bondad, N; Boostani, R; Elyasi, S1
Ji, Z; Liu, Z; Xia, Z; Xu, H; Xu, R; Xu, S; Zhao, W1
Lian, M; Wang, Y; Wu, S; Zhou, J1
Amaral, C; Bastos, ML; Carvalho, F; Carvalho, M; Correia-da-Silva, G; Duarte, JA; Guedes de Pinho, P; Valente, MJ1
Abdel Fattah, S; Mohamed, EA; Motawie, AG; Zaki, SM1
Anstey, M; Murray, R; Triplett, KE1
Koh, HC; Park, A1
Abdel Moneim, AE; El-Yamany, NA; Mahmoud, SM; Qayed, MM1
Mehdizadeh, M; Mousavizadeh, K; Mousavizedeh, K; Pourheydar, B; Rahbar, E; Soleimani Asl, S; Soleimani, M1
Barbosa, DJ; Bastos, Mde L; Branco, PS; Capela, JP; Carvalho, F; Fernandes, E; Ferreira, LM; Silva, R; Vilas-Boas, V1
Barbosa, DJ; Bastos, ML; Branco, PS; Capela, JP; Carvalho, F; Fernandes, E; Ferreira, LM; Silva, R1
Comparsi, B; Dafre, AL; Dalla Corte, CL; De Souza, D; Farina, M; Franco, JL; Meinerz, DF; Posser, T; Prestes, AS; Rocha, JB; Santos, DB; Stefanello, ST1
Aschner, M; Cai, J; Chenjia, G; Guangwei, X; Haifeng, S; Jian, L; Panpan, Z; Rongzhu, L; Suhua, W; Wanxin, P; Wenjun, Z; Yun, F; Yuntao, F1
Deng, JF; Lin, KP; Tsai, WJ; Wang, CL; Wang, TH; Wu, ML; Wu, YH; Yang, CC1
Aschner, M; Cao, Z; Chen, J; Luo, W; Su, P; Wang, D; Wang, S; Zhang, J; Zhao, F1
Chen, D; Liu, F; Liu, X; Zhang, C1
Largeron, M; Martinez, CM; McCann, U; Mechan, A; Mueller, M; Neudörffer, A; Ricaurte, GA1
Braunagel, D; Dransfeld, CL; Ehninger, G; Kramer, M; Mahlknecht, U; Schaich, M1
Buckley, B; DiCicco-Bloom, E; Falluel-Morel, A; Lin, L; McCandlish, E; Sokolowski, K1
Bastos, ML; Branco, PS; Capela, JP; Carvalho, F; Costa, VM; Fernandes, E; Ferreira, LM; Ferreira, PS; Meisel, A; Nogueira, TB1
Ferrando, MD; Peña, JB; Peña-Llopis, S1
Fukami, G; Hashimoto, K; Iyo, M; Koike, K; Okamura, N; Shimizu, E1
Lin, HC; Shiah, IS; Tung, CS; Wan, FJ1
Achat-Mendes, C; Anderson, KL; Itzhak, Y1
Dabarakis, N; Geronikaki, A; Kaloyianni, M; Kosmidis, EK; Moschou, M; Theophilidis, G1

Trials

2 trial(s) available for acetylcysteine and Encephalopathy, Toxic

ArticleYear
Protective effect of N-acetylcysteine on oxaliplatin-induced neurotoxicity in patients with colorectal and gastric cancers: A randomized, double blind, placebo-controlled, clinical trial.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2020, Volume: 26, Issue:7

    Topics: Acetylcysteine; Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Colorectal Neoplasms; Double-Blind Method; Female; Humans; Male; Middle Aged; Neurotoxicity Syndromes; Oxaliplatin; Oxaloacetates; Stomach Neoplasms

2020
The T_T genotype within the NME1 promoter single nucleotide polymorphism -835 C/T is associated with an increased risk of cytarabine induced neurotoxicity in patients with acute myeloid leukemia.
    Leukemia & lymphoma, 2012, Volume: 53, Issue:5

    Topics: Acetylcysteine; Adolescent; Adult; Aged; Apoptosis; Cytarabine; Female; Genotype; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Neurons; Neurotoxicity Syndromes; NM23 Nucleoside Diphosphate Kinases; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Retrospective Studies; Survival Rate; Young Adult

2012

Other Studies

26 other study(ies) available for acetylcysteine and Encephalopathy, Toxic

ArticleYear
Oxidative and nitrosative stress in the neurotoxicity of polybrominated diphenyl ether-153: possible mechanism and potential targeted intervention.
    Chemosphere, 2020, Volume: 238

    Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Cell Survival; Cerebral Cortex; Glutathione; Halogenated Diphenyl Ethers; Male; Malondialdehyde; Nerve Growth Factors; Neurons; Neurotoxicity Syndromes; Neurotrophin 3; Nitric Oxide; Nitric Oxide Synthase Type I; Nitrosative Stress; Oxidative Stress; Polybrominated Biphenyls; Rats; Rats, Sprague-Dawley; Signal Transduction

2020
Therapeutic potential of N-acetylcysteine in acrylamide acute neurotoxicity in adult zebrafish.
    Scientific reports, 2019, 11-11, Volume: 9, Issue:1

    Topics: Acetylcysteine; Acrylamide; Acylation; Animals; Antioxidants; Blood-Brain Barrier; Cell Membrane Permeability; Free Radical Scavengers; Glutathione; Neurotoxicity Syndromes; Oxidative Stress; Proteome; Transcriptome; Zebrafish

2019
Activation of MIP-2 and MCP-5 Expression in Methylmercury-Exposed Mice and Their Suppression by N-Acetyl-L-Cysteine.
    Neurotoxicity research, 2020, Volume: 37, Issue:4

    Topics: Acetylcysteine; Animals; Brain; Chemokine CXCL2; Gene Expression; Male; Methylmercury Compounds; Mice; Mice, Inbred BALB C; Monocyte Chemoattractant Proteins; Neurotoxicity Syndromes; Random Allocation

2020
Mechanistic study of mtROS-JNK-SOD2 signaling in bupivacaine-induced neuron oxidative stress.
    Aging, 2020, 07-13, Volume: 12, Issue:13

    Topics: Acetylcysteine; Animals; Anthracenes; Antioxidants; Bupivacaine; Cell Line, Tumor; Cyclic N-Oxides; Disease Models, Animal; Gene Knockdown Techniques; Humans; Injections, Spinal; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Signaling System; Mitochondria; Neurons; Neurotoxicity Syndromes; Oxidative Stress; Rats; Reactive Oxygen Species; RNA, Small Interfering; Superoxide Dismutase; Transcriptional Activation

2020
Brain Dicer1 Is Down-Regulated in a Mouse Model of Alzheimer's Disease Via Aβ42-Induced Repression of Nuclear Factor Erythroid 2-Related Factor 2.
    Molecular neurobiology, 2020, Volume: 57, Issue:11

    Topics: Acetylcysteine; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidant Response Elements; Apoptosis; Brain; Caspase 3; DEAD-box RNA Helicases; Disease Models, Animal; Down-Regulation; Female; Gene Knockdown Techniques; Hippocampus; Humans; Male; Membrane Potential, Mitochondrial; Mice, Transgenic; Neurons; Neurotoxicity Syndromes; NF-E2-Related Factor 2; Peptide Fragments; Presenilin-1; Reactive Oxygen Species; Ribonuclease III; Spatial Learning

2020
Methylone and MDPV activate autophagy in human dopaminergic SH-SY5Y cells: a new insight into the context of β-keto amphetamines-related neurotoxicity.
    Archives of toxicology, 2017, Volume: 91, Issue:11

    Topics: Acetylcysteine; Amphetamines; Apoptosis; Autophagy; Benzodioxoles; Cell Line; Central Nervous System Stimulants; Dopamine Uptake Inhibitors; Dopaminergic Neurons; Dose-Response Relationship, Drug; Humans; Methamphetamine; Microtubule-Associated Proteins; Neurotoxicity Syndromes; Oxidative Stress; Pyrrolidines; Synthetic Cathinone

2017
N-acetylcysteine versus progesterone on the cisplatin-induced peripheral neurotoxicity.
    Folia morphologica, 2018, Volume: 77, Issue:2

    Topics: Acetylcysteine; Animals; Antioxidants; Cisplatin; Inflammation Mediators; Male; Neurotoxicity Syndromes; Progesterone; Rats; Rats, Sprague-Dawley

2018
Multifactorial non-cirrhotic hyperammonaemic encephalopathy.
    BMJ case reports, 2018, Mar-09, Volume: 2018

    Topics: Acetylcysteine; Aftercare; Anti-Bacterial Agents; Bacteremia; Carnitine; Female; Free Radical Scavengers; Humans; Hyperammonemia; Klebsiella pneumoniae; Magnetic Resonance Imaging; Middle Aged; Neurotoxicity Syndromes; Treatment Outcome; Urinary Tract Infections; Valproic Acid

2018
NF-κB/mTOR-mediated autophagy can regulate diquat-induced apoptosis.
    Archives of toxicology, 2019, Volume: 93, Issue:5

    Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Autophagy; Cell Survival; Diquat; Dose-Response Relationship, Drug; Herbicides; Neurotoxicity Syndromes; NF-kappa B; PC12 Cells; Rats; Reactive Oxygen Species; Signal Transduction; Sirolimus; Time Factors; TOR Serine-Threonine Kinases

2019
Potential role of N-acetylcysteine on chlorpyrifos-induced neurotoxicity in rats.
    Environmental science and pollution research international, 2019, Volume: 26, Issue:20

    Topics: Acetylcysteine; Animals; Antioxidants; Brain; Chlorpyrifos; Insecticides; Male; Neurotoxicity Syndromes; Oxidative Stress; Rats, Wistar

2019
Protective effects of N-acetylcysteine on 3, 4-methylenedioxymethamphetamine-induced neurotoxicity in male Sprague-Dawley rats.
    Metabolic brain disease, 2013, Volume: 28, Issue:4

    Topics: Acetylcysteine; Animals; bcl-2-Associated X Protein; Caspase 3; Cell Death; Down-Regulation; Hippocampus; Male; Maze Learning; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity Syndromes; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley

2013
The mixture of "ecstasy" and its metabolites is toxic to human SH-SY5Y differentiated cells at in vivo relevant concentrations.
    Archives of toxicology, 2014, Volume: 88, Issue:2

    Topics: Acetylcysteine; Calcium; Caspase 3; Cell Differentiation; Cell Line; Deoxyepinephrine; Dopamine; Dopaminergic Neurons; Dose-Response Relationship, Drug; Glutathione; Humans; Mitochondria; N-Methyl-3,4-methylenedioxyamphetamine; Neurons; Neurotoxicity Syndromes; Reactive Oxygen Species

2014
"Ecstasy"-induced toxicity in SH-SY5Y differentiated cells: role of hyperthermia and metabolites.
    Archives of toxicology, 2014, Volume: 88, Issue:2

    Topics: 3,4-Methylenedioxyamphetamine; Acetylcysteine; Caspase 3; Cell Death; Cell Differentiation; Cell Line; Deoxyepinephrine; Fever; Glutathione; Humans; Mitochondria; N-Methyl-3,4-methylenedioxyamphetamine; Neurons; Neurotoxicity Syndromes; Temperature

2014
N-Acetylcysteine does not protect behavioral and biochemical toxicological effect after acute exposure of diphenyl ditelluride.
    Toxicology mechanisms and methods, 2014, Volume: 24, Issue:8

    Topics: Acetylcysteine; Animals; Antioxidants; Behavior, Animal; Benzene Derivatives; Brain; Dose-Response Relationship, Drug; Environmental Pollutants; Glutathione Peroxidase; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Mice; Motor Activity; Nerve Tissue Proteins; Neurons; Neurotoxicity Syndromes; Organometallic Compounds; Oxidative Stress; Thioredoxin-Disulfide Reductase; Toxicity Tests, Acute

2014
Role of autophagy in methylmercury-induced neurotoxicity in rat primary astrocytes.
    Archives of toxicology, 2016, Volume: 90, Issue:2

    Topics: Acetylcysteine; Animals; Apoptosis; Astrocytes; Autophagy; Autophagy-Related Protein 5; Cells, Cultured; Chloroquine; Dose-Response Relationship, Drug; Methylmercury Compounds; Neurotoxicity Syndromes; Rats

2016
Neurotoxicity associated with exposure to 1-bromopropane in golf-club cleansing workers.
    Clinical toxicology (Philadelphia, Pa.), 2015, Volume: 53, Issue:8

    Topics: Acetylcysteine; Adult; Biomarkers; Biotransformation; Chromatography, Liquid; Environmental Monitoring; Female; Golf; Humans; Hydrocarbons, Brominated; Male; Neurotoxicity Syndromes; Occupational Diseases; Occupational Exposure; Occupational Health; Risk Assessment; Risk Factors; Solvents; Sports Equipment; Tandem Mass Spectrometry; Time Factors; Young Adult

2015
Genistein alleviates lead-induced neurotoxicity in vitro and in vivo: Involvement of multiple signaling pathways.
    Neurotoxicology, 2016, Volume: 53

    Topics: Acetylcysteine; Animals; Catalase; Disease Models, Animal; Dose-Response Relationship, Drug; Free Radical Scavengers; Genistein; In Situ Nick-End Labeling; Lead; Male; Maze Learning; Mitogen-Activated Protein Kinase Kinases; Neuroprotective Agents; Neurotoxicity Syndromes; NF-E2-Related Factor 2; PC12 Cells; Protein Kinase C; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Spatial Memory; Superoxide Dismutase

2016
Protective effect of N-acetylcysteine against BDE-209-induced neurotoxicity in primary cultured neonatal rat hippocampal neurons in vitro.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2010, Volume: 28, Issue:6

    Topics: Acetylcysteine; Animals; Animals, Newborn; Apoptosis; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Flame Retardants; Halogenated Diphenyl Ethers; Hippocampus; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Neurotoxins; Rats; Rats, Sprague-Dawley

2010
Synthesis and neurotoxicity profile of 2,4,5-trihydroxymethamphetamine and its 6-(N-acetylcystein-S-yl) conjugate.
    Chemical research in toxicology, 2011, Jun-20, Volume: 24, Issue:6

    Topics: Acetylcysteine; Adrenergic Uptake Inhibitors; Animals; Brain; Hydroxyindoleacetic Acid; Male; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity Syndromes; Neurotoxins; Rats; Rats, Sprague-Dawley; Serotonin

2011
N-acetyl cysteine treatment reduces mercury-induced neurotoxicity in the developing rat hippocampus.
    Journal of neuroscience research, 2012, Volume: 90, Issue:4

    Topics: Acetylcysteine; Analysis of Variance; Animals; Animals, Newborn; Cell Death; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Embryo, Mammalian; Female; Hippocampus; Male; Methylmercury Compounds; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Pregnancy; Rats; Spectrophotometry, Atomic; Thymidine; Tritium

2012
Neurotoxicity of "ecstasy" and its metabolites in human dopaminergic differentiated SH-SY5Y cells.
    Toxicology letters, 2013, Feb-04, Volume: 216, Issue:2-3

    Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Acetylcysteine; Buthionine Sulfoximine; Cell Death; Cell Differentiation; Cell Line, Tumor; Dipeptides; Dopaminergic Neurons; Enzyme Inhibitors; Free Radical Scavengers; Glutathione; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity Syndromes; Piperazines

2013
Fish tolerance to organophosphate-induced oxidative stress is dependent on the glutathione metabolism and enhanced by N-acetylcysteine.
    Aquatic toxicology (Amsterdam, Netherlands), 2003, Dec-10, Volume: 65, Issue:4

    Topics: Acetylcysteine; Analysis of Variance; Animals; Apoptosis; Dichlorvos; Dose-Response Relationship, Drug; Eels; Glutathione; Insecticides; Liver; Muscles; Neurotoxicity Syndromes; Oxidative Stress; Proportional Hazards Models; Toxicity Tests, Acute

2003
Effect of antioxidant N-acetyl-L-cysteine on behavioral changes and neurotoxicity in rats after administration of methamphetamine.
    Brain research, 2004, Jul-30, Volume: 1016, Issue:1

    Topics: Acetylcysteine; Analysis of Variance; Animals; Behavior, Animal; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Dopamine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Free Radical Scavengers; Male; Methamphetamine; Neurotoxicity Syndromes; Rats; Time Factors

2004
Effects of alpha-phenyl-N-tert-butyl nitrone and N-acetylcysteine on hydroxyl radical formation and dopamine depletion in the rat striatum produced by d-amphetamine.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2006, Volume: 16, Issue:2

    Topics: Acetylcysteine; Animals; Body Temperature; Cyclic N-Oxides; Dextroamphetamine; Dopamine; Dopamine Uptake Inhibitors; Free Radical Scavengers; Hydroxybenzoates; Hydroxyl Radical; Lipid Peroxidation; Male; Microdialysis; Neostriatum; Neuroprotective Agents; Neurotoxicity Syndromes; Nitrogen Oxides; Pilot Projects; Rats; Rats, Sprague-Dawley

2006
Impairment in consolidation of learned place preference following dopaminergic neurotoxicity in mice is ameliorated by N-acetylcysteine but not D1 and D2 dopamine receptor agonists.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2007, Volume: 32, Issue:3

    Topics: Acetylcysteine; Animals; Behavior, Animal; Brain Chemistry; Cocaine; Conditioning, Operant; Disease Models, Animal; Dopamine; Dopamine Agents; Dopamine Agonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Free Radical Scavengers; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Glutathione; Learning Disabilities; Male; Methamphetamine; Mice; Neurotoxicity Syndromes; Tyrosine 3-Monooxygenase

2007
In vitro assessment of the neurotoxic and neuroprotective effects of N-acetyl-L-cysteine (NAC) on the rat sciatic nerve fibers.
    Toxicology in vitro : an international journal published in association with BIBRA, 2008, Volume: 22, Issue:1

    Topics: Acetylcysteine; Action Potentials; Animals; Cadmium; Dose-Response Relationship, Drug; Free Radical Scavengers; In Vitro Techniques; Male; Neuroprotective Agents; Neurotoxicity Syndromes; Neurotoxins; Potassium Channels, Voltage-Gated; Rats; Rats, Wistar; Sciatic Nerve; Sodium Channels; Time Factors

2008