acetylcysteine has been researched along with Drug Overdose in 358 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 54 (15.08) | 18.2507 |
| 2000's | 97 (27.09) | 29.6817 |
| 2010's | 156 (43.58) | 24.3611 |
| 2020's | 51 (14.25) | 2.80 |
| Authors | Studies |
|---|---|
| Albertson, TE; Chenoweth, JA; Lai, L; Lewis, JC; Lim, M; Mendoza, E | 1 |
| Link, SL; Osmon, S; Rampon, G; Rumack, BH; Scalzo, AJ | 1 |
| Graudins, A; Syafira, N; Wong, A; Yarema, M | 1 |
| Thanacoody, HKR | 1 |
| Bateman, DN | 2 |
| Akakpo, JY; Curry, SC; Jaeschke, H; Ramachandran, A; Rumack, BH | 1 |
| Chomchai, C; Chomchai, S; Mekavuthikul, P; Phuditshinnapatra, J | 1 |
| Akakpo, JY; Begher-Tibbe, B; Brackhagen, L; Brecklinghaus, T; Canbay, A; Copple, IM; Curry, SC; Friebel, A; Ghallab, A; Goldring, C; González, D; Hassan, R; Hengstler, JG; Hobloss, Z; Hoehme, S; Hofmann, U; Jaeschke, H; Kappenberg, F; Longerich, T; Luedde, T; Marchan, R; Murad, W; Myllys, M; Olyaee, M; Overbeck, N; Rahnenführer, J; Reinders, J; Schreiter, T; Seddek, AL; Sezgin, S; Sowa, JP; Trauner, M; Urban, S; Vucur, M; Zühlke, S | 1 |
| Duan, L; Jaeschke, H; Ramachandran, A; Sanchez-Guerrero, G | 1 |
| Camarena-Michel, A; Hoyte, C; Leonard, J; Pennington, S; Sudanagunta, S; Wang, GS | 1 |
| Abbas, AA; Ahmed, AE; Hamdy, A | 1 |
| Wong, A | 1 |
| Abdel Kader, H; Humphries, C; Kidd, R; Roberts, G; Smith, J; Taheem, A | 1 |
| Motohashi, K; Thanacoody, RH | 1 |
| Janković, SM | 1 |
| Dear, JW | 1 |
| Filip, AB; Mullins, ME | 1 |
| Anderson, M; Gray, L; Kelgeri, C; Rajaraman, N | 1 |
| Haar, I; Strehle, EM | 1 |
| Albert, K; Hasara, S; Wilson, K | 1 |
| Buckley, NA; Chan, BSH; Chiew, AL; Isbister, GK; Isoardi, KZ; Page, C; Ress, K; Stathakis, P | 1 |
| Capossela, L; Chiaretti, A; Curatola, A; Ferretti, S; Gatto, A; Graglia, B; Pansini, V | 1 |
| Abdul Rouf, PV; Abushanab, D; Ahmed, N; Azad, A; Devi, D; Elbdairy, M; Elgassim, M; Elkassem, W; Elmoheen, A; Elqasass, H; Gasim, M; Hail, MA; Hanssens, Y; Mohammed, HR; Mohammed, S; Salem, W; Thomas, B; Vincent, M | 1 |
| Brightmore, A; Panetta, M; Waring, WS | 1 |
| Jackson, A; Little, M | 1 |
| Höjer, J; Lindeman, E; Nordmark Grass, J; Personne, M | 1 |
| Buckley, NA; Chan, BSH; Chiew, AL; Isbister, GK; James, LP; McArdle, K; Pickering, JW | 1 |
| Beuhler, MC; Shah, KR | 1 |
| Hays, WB; Patel, KH; Woolum, JA | 1 |
| Buckley, NA; Chiew, AL; Isoardi, KZ; Pomerleau, A; Reith, D; Soderstrom, J; Wong, A | 1 |
| Dart, R; Graudins, A; Heard, K; Sivilotti, MLA; Wong, A | 1 |
| Ahn, JH; Cho, GC; Cho, YS | 1 |
| Boley, SP; Crow, EM; Levine, M; Spyres, MB; Stellpflug, SJ | 1 |
| Beuhler, MC; Dulaney, A; Fox, C; Geib, AJ; Kerns Ii, W; Kopec, K; Murphy, C; Shah, KR | 1 |
| Hayden, JC; Kelly, L; McNicholas, F | 1 |
| Chiew, A; Isbister, GK | 1 |
| Freeman, WE; Mullins, ME; Yeager, LH | 1 |
| Cao, DJ; Epperson, LC; Weiss, ST | 1 |
| Blind, F; Hall, B; Wilson, K | 1 |
| Akakpo, JY; Jaeschke, H; Ramachandran, A | 1 |
| Chabert, A; Gitton, A; Oudart, JB; Schneider, N; Simon, A | 1 |
| Dalhoff, KP; Daoud, A; Petersen, TS | 1 |
| Antonucci, R; Capobianco, G; Cuzzolin, L; Locci, C | 1 |
| Cumpston, KL; Downs, JW; Kershner, EK; Rose, SR; Troendle, MM; Wills, BK | 1 |
| Bateman, DN; Choi, H; Dear, JW; Drum, CL; Ibrahim, B; Khoo, BBJ; Leroy Sivappiragasam, P; Ng, ML | 1 |
| Buckley, NA; Chiew, AL | 1 |
| Chiang, WK; Howland, MA; Mahonski, SG; Melchert, K; Trebach, J | 1 |
| Kewcharoen, J; Narimasu, T; Nishimura, Y | 1 |
| Burnham, K; Knight, S; Smith, H; Yang, T | 1 |
| Graudins, A; O'Callaghan, C; Wong, A | 1 |
| Akakpo, JY; Curry, SC; Jaeschke, H; Jaeschke, MW; Ramachandran, A; Rumack, BH | 1 |
| Gerkin, RD; O'Connor, AD; Spyres, MB | 1 |
| Nettel-Aguirre, A; Rumack, BH; Sivilotti, MLA; Yarema, MC | 1 |
| Graudins, A; Sivilotti, MLA; Wong, A | 1 |
| Liss, D; Mullins, ME; Schwarz, ES | 1 |
| Graudins, A; Landersdorfer, C; Wong, A | 1 |
| Buckley, NA; Chan, BSH; Chiew, AL; Isbister, GK; Kirby, KA; Page, CB | 1 |
| Goldberger, D; Vearrier, D | 1 |
| Graudins, A; Gunja, N; McNulty, R; Sivilotti, MLA; Wong, A | 1 |
| Graudins, A; Gunja, N; McNulty, R; Wong, A | 1 |
| Mullins, ME; O'Grady, L; Schwarz, ES | 1 |
| Allen, L; Antoine, DJ; Clarke, JI; Cooper, J; Dargan, PI; Dear, JW; Francis, B; Jorgensen, AL; Park, BK; Pirmohamed, M; Shen, J; Thomas, SHL; Wood, D; Wraight, J | 1 |
| Chomchai, C; Chomchai, S | 2 |
| Harmouche, E; Howland, MA; K Su, M | 1 |
| Dervay, K; Fixl, AN; Woods, RM | 1 |
| Chandru, P; Gunja, N; Lim, JME; McNulty, R | 1 |
| Serratrice, J; Spahr, L; Verdon, I | 1 |
| Bailey, B; Chopra, P; Gosselin, S; Johnson, D; Nettel-Aguirre, A; Purssell, R; Rumack, B; Sivilotti, MLA; Spyker, D; Thompson, M; Victorino, C; Yarema, M | 1 |
| Howard, L; Reynard, C | 1 |
| Brok, J; Buckley, NA; Chiew, AL; Gluud, C | 1 |
| Cheung, B; Gantier, M; Graudins, A; Nejad, C; Wong, A | 1 |
| Harmouche, E; Hoffman, RS; Howland, MA | 1 |
| Ferreras, D; Lopez-Lopez, V; Martinez, M; Parrilla-Paricio, P; Pons Miñano, JA; Ramirez-Romero, P; Robles-Campos, R; Ros, J; Sanchez-Bueno, F; Sanmartin, J | 1 |
| Lucyk, S | 1 |
| Dalhoff, K; Dart, RC; Kaelin, B; Macias-Perez, IM; Pavliv, L; Petersen, TS; Rasmussen, DN; Schmidt, LE | 1 |
| Achour, S; Benlamkaddem, S; Boukatta, B; Elbouazzaoui, A; Houari, N; Iken, I; Kanjaa, N; Sbai, H | 1 |
| Foex, BA; Woodhead, K | 1 |
| Arce, DY; Boyer, EW; Farber, MK; Gray, KJ; Reale, SC | 1 |
| Archer, J; Dargan, PI; Hope, L; Layne, K; Rab, E; Wood, DM | 1 |
| Choy, KW; Dear, JW; Doery, J; Graudins, A; Homer, N; Wong, A | 1 |
| Dear, J | 1 |
| Dart, RC; Hoyte, C | 1 |
| Green, JP; Johnson, DW; Mutsaers, A; Rumack, BH; Sivilotti, MLA; Spyker, DA; Tucker, D; Yarema, MC | 1 |
| Hendrickson, RG | 1 |
| Choy, KW; Doery, J; Gantier, M; Graudins, A; Nejad, C; Wong, A | 1 |
| Moore, R; Nicholas, WA | 1 |
| Ali, M; Misurati, M; Pooni, J; Rodgers, R | 1 |
| Bateman, DN; Dear, JW | 1 |
| Ignarro, LJ; Jynge, P; Karlsson, JOG; Lundström, I | 1 |
| Black, P; Dear, JW; Gallagher, B; Grahamslaw, J; Henriksen, D; Lee, RJ; Morrison, EE; O'Brien, R; Oatey, K; Oosthuyzen, W; Weir, CJ | 1 |
| Elmgren, A; Helander, A; Nordmark Grass, J | 1 |
| Algren, DA; Beuhler, MC; Holstege, CP; Mullins, ME; Sivilotti, MLA; Thompson, M; Yarema, MC | 1 |
| Caro, J; Gosselin, S; Hoffman, RS; Juurlink, DN; Whyte, I; Yarema, M | 1 |
| Al-Hourani, K; Bateman, DN; Dear, JW; Dow, M; Mansi, R; Pettie, J | 1 |
| Beauchamp, GA; Hart, KW; Lindsell, CJ; Lyons, MS; Otten, EJ; Smith, CL; Ward, MJ; Wright, SW | 1 |
| Kam, RY | 1 |
| Clancy, C; James, L; Mazer-Amirshahi, M; Reid, N; van den Anker, J | 1 |
| Lackey, G; McCulloh, RJ; Vyas, D | 1 |
| Dargan, PI; Spencer, T; Wood, DM; Yamamoto, T | 1 |
| Hewett, DG; Shields, J; Waring, WS | 1 |
| Bass, S; Zook, N | 1 |
| Cooper, JG; Teo, AI | 1 |
| Curry, SC; Jaeschke, H; Li, F; Ma, X; McGill, MR; Sharpe, MR; Williams, CD | 1 |
| Marti, C; Ramlawi, M; Sarasin, F | 1 |
| Freeman, R | 1 |
| Benger, J; Bramley, K; Carroll, R; Griffin, L; Gunnell, D; Potokar, J; Williams, S | 1 |
| Garland, JS; Hanly, LN; Juurlink, DN; Lenga, I; Poley, R; Sivilotti, ML; Thompson, M | 1 |
| Antoine, DJ; Dear, JW | 2 |
| Gosselin, S; Villeneuve, E; Whyte, I | 1 |
| Graudins, A; Greene, SL; Kerr, F; Wong, A | 1 |
| Bronstein, AC; Bucher-Bartelson, B; Dart, RC; Green, JL; Heard, K; Heard, S; Rumack, BH | 1 |
| Chomchai, C; Chomchai, S; Lawattanatrakul, N | 1 |
| Graudins, A | 1 |
| Ercal, N; Fan, W; Khayyat, A; Tobwala, S | 1 |
| Dargan, PI; Greene, SL; Leang, Y; Taylor, DM; Wood, DM | 1 |
| de Wolff, JF; Jiad, E; Palipane, N | 1 |
| Hwang, ES; Kaufman, KR | 1 |
| Arai, T; Kitamura, D; Koyama, R; Mizuta, R; Yuasa, M | 1 |
| Janssen, J; Singh-Saluja, S | 1 |
| Corwin, D; Srinivasan, V; Verceles, AC | 1 |
| Anaradian, PC; Karowski, K; Kirschner, RI; Martin, TG; Schrader, RM; Seifert, SA | 1 |
| Ly, BT; O'Connell, CW; Schneir, A; Villano, JH | 1 |
| Jaeschke, H | 1 |
| Dargan, PI; Greene, SL; Sivilotti, ML; Wong, A; Wood, DM | 1 |
| Curtis, RM; Sivilotti, ML | 1 |
| Gerkin, RD; Levine, M; O'Connor, AD; Padilla-Jones, A | 1 |
| Buckley, NA; Chiew, AL; Duffull, SB; Isbister, GK | 1 |
| Al-Jabi, SW; Awang, R; Sweileh, WM; Waring, WS; Zyoud, SH | 1 |
| Dawson, AH; Galappatthy, P | 1 |
| Gerkin, R; Levine, M; O'Connor, AD; Padilla-Jones, A | 1 |
| Jacobitz, KL; Kirschner, RI; Rozier, CM; Smith, LM | 1 |
| Fernandez, D; Nelson, LS | 1 |
| Graudins, A; Wong, A | 2 |
| Bateman, DN; Dear, JW; Thomas, SH | 2 |
| Berling, I; Downes, MA; Isbister, GK; Mcnamara, K; Page, CB; Whyte, IM | 1 |
| Al-Hourani, K; Bateman, DN; Beckwith, HK; Cairney, DG; Dear, JW; Eddleston, M | 1 |
| Ghannoum, M; Gosselin, S; Grunbaum, AM; Kazim, S; Villeneuve, E | 1 |
| Buckley, NA; Dawson, AH; Isbister, GK | 2 |
| Archer, JR; Bailey, GP; Dargan, PI; Elamin, ME; Najafi, J; Thomas, SH; Waring, WS; Wood, DM | 1 |
| Rice, TW; Stollings, JL; Wheeler, AP | 1 |
| Egashira, T; Fukusaki, M; Goto, S; Terao, Y; Tuji, T; Urabe, S | 1 |
| Archer, JR; Bailey, GP; Dargan, PI; Flanagan, RJ; Rab, E; Wood, DM | 1 |
| Sklar, GE; Tan, CJ | 1 |
| Antoine, DJ; Bateman, DN; Clarke, JI; Cooper, JG; Dargan, PI; Dear, JW; Eddleston, M; Gray, A; Homer, NZ; Kimmitt, RA; Lewis, SC; Seymour, JH; Vliegenthart, A; Webb, DJ; Wood, DM | 1 |
| Broska, J; Cowie, C; Gunja, N; Isbister, GK; Islam, S; Jayaweera, D; Poojara, L; Roberts, MS | 1 |
| Brogren, J; Höjer, J; Salmonson, H; Sjöberg, G; Tellerup, M | 1 |
| Archer, JRH; Dargan, PI; Davies, CL; Dines, AM; Greene, SL; Marks, DJB; Wood, DM | 1 |
| Heppell, SPE; Isbister, GK | 1 |
| Evans, J; Petchey, WG; Sampaziotis, F; Serjeant, L | 1 |
| Arman, Ö; Emir, S; Özbek, N; Özyörük, D; Tunç, B | 1 |
| Dow, MA; Pettie, JM; Robinson, OD; Stephen, AF; Waring, WS | 1 |
| Contractor, N; Kulkarni, N; Nagarajan, V | 1 |
| Hoffman, RS; Howland, MA; Nelson, LS; Smith, SW | 1 |
| Danel, V; Saviuc, P | 1 |
| Cassidy, N; Drew, SA; Tracey, JA | 1 |
| Bateman, DN; Ludlam, C; Megson, I; Pakravan, N; Sharma, S; Waring, WS | 1 |
| Hayes, BD; Sarmiento, KF; Schwartz, EA | 1 |
| Doyon, S; Klein-Schwartz, W | 2 |
| Benhalim, S; Waring, WS | 1 |
| Motha, R; Sesin, P; Zolnierz, M | 1 |
| Busuttil, RW; Chun, LJ; Hiatt, JR; Tong, MJ | 1 |
| Bockewitz, E; Burda, AM; Kubic, A; Wahl, M | 1 |
| Ariyananda, PL; Fernando, WK | 1 |
| Krishnan, GP; Majlesi, N; Nelson, L; Olsen, A; Olsen, D | 1 |
| Capparelli, E; Davern, TJ; Hinson, JA; James, LP; Lee, WM; Letzig, L; Roberts, DW; Simpson, PM | 1 |
| Athuraliya, TN; Jones, AL | 1 |
| Bailey, B; Berlin, RJ; Brant, RF; Chalut, D; Dart, RC; Johnson, DW; Lee, JS; Nettel-Aguirre, A; Plint, AC; Purssell, RA; Rumack, BH; Rutledge, T; Seviour, CA; Sivilotti, ML; Spyker, DA; Stiell, IG; Thompson, M; Tyberg, J; Yarema, MC | 1 |
| Bond, GR | 2 |
| Chan, B; Graudins, A; Naidoo, D; Pham, HN; Salonikas, C | 1 |
| Jaeschke, H; Saito, C; Zwingmann, C | 1 |
| Marchetti, A; Rossiter, R | 1 |
| Connors, NJ; Ghaffari, G; Hernandez, SH; Hoffman, RS; Howland, MA | 1 |
| Chan, GM; Greller, HA; Gupta, AK; Lee, DC; Su, MK | 1 |
| Al-Jabi, SW; Awang, R; Sweileh, WM; Syed Sulaiman, SA; Zyoud, SH | 1 |
| Nevin, DG; Shung, J | 1 |
| Krenzelok, EP; Martello, JL; Pummer, TL | 1 |
| Margaretten, M; Olson, KR; Wiegand, TJ | 1 |
| Mehrpour, O; Sanaei-Zadeh, H; Shadnia, S | 1 |
| Clemmesen, JO; Ott, P; Schmidt, LE | 1 |
| Christensen, HR; Dalhoff, K; Rolff, HC | 1 |
| Al-Jabi, SW; Awang, R; Khan, HR; Sawalha, AF; Sulaiman, SA; Sweileh, WM; Zyoud, SH | 1 |
| de Silva, V; Rathnayake, A | 1 |
| Aguilera, E; Al-Helial, M; Arnold, T; Bebarta, VS; Bogdan, G; Buchanan, J; Clark, RF; Dart, R; Delgado, J; Froberg, B; Haur, W; Heard, K; Hoppe, J; Kao, L; Kokko, J; Lares, C; Lavonas, E; McDonagh, J; Mendoza, C; Mlynarchek, S; O'Malley, G; Odujebe, O; Qi, M; Rhyee, S; Stanford, C; Tan, HH; Tran, NN; Varney, S; Zosel, A | 1 |
| Al-Jabi, SW; Awang, R; Sulaiman, SA; Zyoud, SH | 3 |
| Hirose, Y | 1 |
| Ford, RM; Sakaria, SS; Subramanian, RM | 1 |
| García, C; García-Trevijano, ER; Penella, E; Sandoval, J; Torres, L; Viña, JR; Zaragozá, R | 1 |
| Hoffman, RS; Jang, DH; Punja, M | 1 |
| Offerman, SR | 1 |
| Green, TJ; Johnson, D; Juurlink, D; Langmann, C; Sivilotti, ML; Yarema, M | 1 |
| Beringer, RM; Parry, S; Stoddart, PA; Thompson, JP | 1 |
| Ballali-Mood, M; Mehrpour, O | 1 |
| Bodmer, M; Monte, AA | 1 |
| Arya, S; Contractor, H; Gauge, V; Nabi, S; Naqvi, N; Titu, H | 1 |
| Coleman, P; Leikin, JB; Whiteley, PM; Zell-Kanter, M | 1 |
| Bisschops, LA; Bisschops, WA; Kramers, C; van Rossum, LK; Vroegop, MP | 1 |
| Aleksa, K; Bajcetic, M; Baw, B; Chen, N; Cutler, M; Freeman, D; Hanly, LN; Koren, G; Malkin, B; Palassery, R; Regueira, O; Rieder, MJ; Turner, C; Vasylyeva, TL | 1 |
| James, LP; Khandelwal, N; Larson, AM; Lee, WM; Sanders, C | 1 |
| Bagdure, D; Heard, K; Monte, A; Wang, GS | 1 |
| Bateman, DN; Dear, JW; Ferner, RE | 1 |
| Burda, AT; Ipema, HJ; Wahl, MS | 1 |
| Heard, K; Schaeffer, TH | 1 |
| Anusornsuwan, T; Chomchai, C; Chomchai, S | 1 |
| Coulter, CV; Duffull, SB; Isbister, GK; Shen, F | 1 |
| Cash, WJ; Iqbal, M; McCormick, PA; Sarwar, S | 1 |
| Bersten, AD; Bihari, S; Verghese, S | 1 |
| García, C; Martínez, M; Nicolás, M; Porta, R; Sánchez, L | 1 |
| Dart, RC; Rumack, BH | 2 |
| Bateman, DN; Rumack, BH | 1 |
| Dargan, PI; Keep, J; McQuade, DJ; Wood, DM | 1 |
| Waring, WS | 2 |
| Garrard, AR; Hodgman, MJ | 1 |
| Bryczkowski, C; Geib, AJ | 1 |
| Brent, J; Finkelstein, Y; Gorodetsky, R; Schwartz, T; Wax, PM; Wiegand, TJ | 1 |
| Rollstin, AD; Seifert, SA | 1 |
| Osterhoudt, K; Selbst, SM | 1 |
| Mycyk, MB; Wahl, MS; Williamson, K | 1 |
| Kozer, E; McGuigan, M | 2 |
| Glenthøj, J; Lorentzen, H; Olesen, T | 1 |
| Hoppu, K | 1 |
| Höckerstedt, K; Isoniemi, H; Koivusalo, AM; Nuutinen, H; Vakkuri, A | 1 |
| Bendtsen, F; Dalhoff, K; Knudsen, TT; Schmidt, LE | 1 |
| Gillissen, A | 1 |
| Dargan, PI; Jones, AL | 1 |
| Bétrémieux, PE; Beuchée, A; de la Pintiére, A | 1 |
| Ashtekar, CS; Vyas, H | 1 |
| Alsalim, W; Fadel, M | 1 |
| Kociancic, T; Reed, MD | 1 |
| Abdollahi, M; Jalali, N; Pajoumand, A; Shadnia, S | 1 |
| Fukumoto, M | 1 |
| Brizendine, EJ; Furbee, RB; Kao, LW; Kirk, MA; Mehta, NH; Skinner, JR | 1 |
| Lifshitz, M; Melamed, R | 1 |
| Bartlett, D | 1 |
| Bailey, B; Blais, R; Letarte, A | 1 |
| Dargan, P; Greene, S; Jones, AI; Shin, GY | 1 |
| Bendtsen, F; Dalhoff, KP; Knudsen, TT; Schmidt, LE | 1 |
| Müller, GJ | 1 |
| Andrade, RJ; de la Cuesta, FS; López-Torres, E; Lucena, MI; Puche, MJ; Seoane, J; Verge, C | 1 |
| Caraccio, T; Feinfeld, DA; McGuigan, M; Mour, G | 1 |
| Good, AM; Johnson, DW; Juurlink, DN; Sivilotti, ML; Yarema, MC | 1 |
| Daly, FF; Little, M; McCoubrie, D; Murray, L | 1 |
| Clark, LE; Herrera, JL; Wilkes, JM | 1 |
| Bangh, SA; Klein-Schwartz, W; Spiller, HA; Winter, ML | 1 |
| Ternullo, S | 1 |
| Frumin, I; Iancu, TC; Manov, I; Motanis, H | 1 |
| Deepa, B; Leow, M; Leow, MK; Sule, AA; Tai, DY; Tze, CC | 1 |
| Cantlay, G; Duncan, R; Paterson, B | 1 |
| Aakvik, R; Jacobsen, D | 1 |
| Akieda, K; Inokuchi, S; Inoue, S; Morita, S; Nakagawa, Y; Otuka, H; Sekiguchi, H; Yamamoto, I | 1 |
| Kanter, MZ | 1 |
| Lovecchio, F; Pizon, AF | 1 |
| Maruta, S; Shimoji, H; Suenobu, T; Yoshioka, T | 1 |
| Betten, DP; Cantrell, FL; Clark, RF; Thomas, SC; Williams, SR | 1 |
| Bateman, DN; Beer, C; Hudson, M; Pakravan, N; Simpson, K; Smith, LT; Thomas, SH | 1 |
| Bewley, J; Bourdeaux, C | 1 |
| Draaisma, JM; Hameleers-Snijders, P; Hogeveen, M; Kramers, C; Smeitink, JA | 1 |
| Calvert, SH; Cavell, G; Glucksman, E; Gonzalez, J; Kerins, M; Selvan, VA | 1 |
| Godber, IM; Jarvis, SJ; Maguire, D | 1 |
| Sawyer, TS; Spiller, HA | 1 |
| Dawson, AH; Francis, B; Whyte, IM | 1 |
| Larson, AM | 1 |
| Chong, VH | 1 |
| Kimball, T | 1 |
| Malkowska, AM; Robinson, OD; Stephen, AF; Waring, WS | 1 |
| Brown, JM; Carpenter, AB; Terneus, MV; Valentovic, MA | 1 |
| Johnson, CE; Siden, R | 1 |
| Ali, FM; Bird, SB; Boyer, EW | 1 |
| Fang, CC; Tsai, CL; Walson, PD | 1 |
| Chan, GM; Greller, HA; Majlesi, N; Su, M | 1 |
| Doyon, S; Hayes, BD; Klein-Schwartz, W | 1 |
| Makin, AJ; Wendon, J; Williams, R | 1 |
| Beckett, MW; Bray, GP; Hulbert, DC | 1 |
| Proudfoot, AT; Vale, JA | 1 |
| Whitcomb, DC | 1 |
| Aaron, CK; Graudins, A; Linden, CH | 1 |
| Perrone, J; Southiere, G | 1 |
| Kirsch, RE; Pillans, P; Robson, SC; Spearman, CW | 1 |
| Rose, SR | 1 |
| Tighe, TV; Walter, FG | 1 |
| Davie, A | 1 |
| Diamond, JJ; Grande, GA; Krenzelok, EP; Safir, EF; Spiller, HA | 1 |
| al-Khalil, I; Douidar, SM; Habersang, RW | 1 |
| Jamal, AZ; Mohammed, S; Robison, LR | 1 |
| Harrison, PM; Keays, R; Wendon, JA; Williams, R | 1 |
| Cheung, L; Meyer, KC; Potts, RG | 1 |
| Anantharaman, V | 1 |
| Chan, AY; Chan, TY; Critchley, JA | 1 |
| Banerjee, A; Hassig, SR; Levine, L; Linscheer, WG; Miller, C; Murthy, UK; Oates, RP; Wagner, K | 1 |
| Hegarty, JE; Mulcahy, HE | 1 |
| Bray, GP | 1 |
| Jones, AF; Vale, JA | 1 |
| Cho, CH; Kaan, SK; Woo, PC | 1 |
| Dhawan, A; Sorrell, MF | 1 |
| Burkhart, KK | 1 |
| Dunlevy, TM; Wall, MP | 1 |
| Nielsen, PT; Pfeiffer, P | 1 |
| Stavem, K | 1 |
| Bearer, CF; Dart, RC; Gupta, U; Horowitz, RS; Jarvie, DR | 1 |
| Jalali, Z; Sheikh-Hamad, D; Timmins, K | 1 |
| Falk, JL | 1 |
| Dart, RC; Hurlbut, KM; Yip, L | 1 |
| Kearns, GL; Leeder, JS; Wasserman, GS | 2 |
| Perry, HE; Shannon, MW | 1 |
| Mayer, M; Salpeter, L | 1 |
| Dunn, RJ | 1 |
| Tucker, JR | 1 |
| Anderson, AC; Lesko, SL; Lewander, WJ; Linakis, JG; Woolf, AD; Wright, RO | 1 |
| Ammenti, A; Ferrante, R; Spagna, A | 1 |
| Krenzelok, EP; Zed, PJ | 1 |
| Buckley, NA; Dawson, AH; O'Connell, DL; Whyte, IM | 1 |
| Anderson, IB; Kim, SY; Mueller, PD; Olson, KR; Woo, OF | 1 |
| Barry, P; Casey, P; Laffoy, M; McCormick, PA; Treacy, J | 1 |
| Broughan, TA; Soloway, RD | 1 |
| Isaacson, J | 1 |
| Bates, D; Mintz, M | 1 |
| Barbet, J; d'Athis, P; Ferracci, G; Pons, G; Rey, E; Tran, A; Tréluyer, JM; Vincent, J | 1 |
| Dalhoff, K; Schmidt, LE | 1 |
| Hariram, V; Jain, S; Singh, K; Singh, S | 1 |
| Bakos, A; Hazai, E; Monostory, K; Vereczkey, L; Zacher, G | 1 |
| Bond, GR; Sztajnkrycer, MJ | 1 |
| Koren, G; Kozer, E | 1 |
| Darville, TL; Farrar, HC; Givens, TG; Hinson, JA; James, LP; Kearns, GL; Simpson, PM; Sullivan, JE; Wasserman, GS | 1 |
| Deng, JF; Lin, TJ; Yang, CC | 1 |
| Amirzadeh, A; McCotter, C | 1 |
| Hamm, J | 1 |
| Bondesen, S; Christensen, E; Ott, P; Schiødt, FV | 1 |
| Gyamlani, GG; Parikh, CR | 1 |
| Kearns, GL | 1 |
| Beard, RH; Farrar, HC; James, LP; Wells, E | 1 |
| Brahm, J; Palma, R; Silva, G | 1 |
| Bray, GP; Harrison, PM; O'Grady, JG; Tredger, JM; Williams, R | 1 |
| Reynard, K; Riley, A; Walker, BE | 1 |
| Burkhart, KK; Donovan, JW | 1 |
| Batey, RG; Brotodihardjo, AE; Byth, K; Farrell, GC | 1 |
| Halkin, H; Winkler, E | 1 |
| Bonfiglio, MF; Hulisz, DT; Martin, BR; Traeger, SM | 1 |
| Lewis, RK; Paloucek, FP | 1 |
| Alexander, GJ; Gimson, AE; Harrison, PM; Wendon, JA; Williams, R | 1 |
| Augenstein, WL; Bronstein, AC; Kulig, KW; Linden, C; Rumack, BH; Smilkstein, MJ | 1 |
| Alexander, GJ; Forbes, A; Gove, C; Harrison, PM; Keays, R; Wendon, JA; Williams, R | 1 |
| Marcuard, SP; Rolband, GC | 1 |
| Parker, D; Paton, D; Routledge, PA; White, JP | 1 |
53 review(s) available for acetylcysteine and Drug Overdose
| Article | Year |
|---|---|
Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Fomepizole; Hepatocytes; Humans; Mice | 2022 |
Toxicology in the emergency department: what's new?
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Australia; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Emergency Service, Hospital; Humans | 2022 |
Delayed onset of liver injury after intentional chloroform overdose: a case report and literature review.
Topics: Acetylcysteine; Chloroform; Drug Overdose; Humans; Liver; Male; Middle Aged | 2019 |
Updated guidelines for the management of paracetamol poisoning in Australia and New Zealand.
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Analgesics, Non-Narcotic; Antidotes; Australia; Charcoal; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; New Zealand; Practice Guidelines as Topic | 2020 |
A clinician's guide to self-poisoning with paracetamol in youth: The what, when and why?
Topics: Acetaminophen; Acetylcysteine; Adolescent; Analgesics, Non-Narcotic; Child; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans | 2020 |
Metabolic and mitochondrial treatments for severe paracetamol poisoning: a systematic review.
Topics: Acetaminophen; Acetylcysteine; Acidosis; Animals; Antidotes; Cimetidine; Drug Overdose; Edetic Acid; Fomepizole; Humans; Mitochondria; Pyridoxal Phosphate | 2020 |
Novel strategies for the treatment of acetaminophen hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Animals; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Edetic Acid; Fomepizole; Hepatocytes; Humans; Liver Failure, Acute; Pyridoxal Phosphate | 2020 |
Paracetamol overdose in the newborn and infant: a life-threatening event.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Charcoal; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Humans; Infant; Infant, Newborn; Pregnancy; Prenatal Exposure Delayed Effects | 2021 |
Acetaminophen Poisoning.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans | 2021 |
A review of alternative intravenous acetylcysteine regimens for acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans | 2021 |
Interventions for paracetamol (acetaminophen) overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Charcoal; Cysteamine; Dimercaprol; Drug Overdose; Gastric Lavage; Humans; Intestinal Absorption; Liver Failure, Acute; Liver Transplantation; Methionine; Randomized Controlled Trials as Topic | 2018 |
BET 1: In paracetamol overdose, is oral N-acetylcysteine as effective as intravenous N-acetylcysteine?
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Administration, Oral; Adolescent; Drug Overdose; Humans; Male | 2018 |
What is the most appropriate dose of
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Overdose; Humans | 2019 |
Intravenous acetylcysteine for indications other than acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Animals; Antidotes; Drug Overdose; Hepatitis, Alcoholic; Humans; Liver Failure, Acute | 2013 |
Stratification of paracetamol overdose patients using new toxicity biomarkers: current candidates and future challenges.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antidotes; Biomarkers; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Drug Evaluation, Preclinical; Drug Overdose; Humans | 2014 |
How much did you take? Reviewing acetaminophen toxicity.
Topics: Acetaminophen; Acetylcysteine; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antidotes; Drug Dosage Calculations; Drug Overdose; Female; Humans; Liver; Male; Middle Aged; Practice Guidelines as Topic | 2015 |
Paracetamol poisoning: beyond the nomogram.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Biomarkers; Drug Overdose; Humans; Nomograms; Risk Assessment | 2015 |
Acetaminophen: Dose-Dependent Drug Hepatotoxicity and Acute Liver Failure in Patients.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antidotes; Biomarkers; Cell Death; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Overdose; Free Radical Scavengers; Hepatocytes; Humans; Liver; Liver Failure, Acute; Mice | 2015 |
Evidence for the changing regimens of acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Antidotes; Drug Administration Schedule; Drug Overdose; Humans | 2016 |
Acetaminophen hepatotoxicity and acute liver failure.
Topics: Acetaminophen; Acetylcysteine; Adult; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Liver Failure, Acute; Liver Transplantation; Male; United Kingdom; United States | 2009 |
[Intravenous or oral N acetylcysteine therapy in paracetamol poisoned patients. Should treatment guidelines be reviewed?].
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Drug Administration Schedule; Drug Overdose; Humans; Infusions, Intravenous; Poisoning; Practice Guidelines as Topic | 2010 |
Critical care management of patients before liver transplantation.
Topics: Acetaminophen; Acetylcysteine; Brain Edema; Drug Overdose; End Stage Liver Disease; Hepatopulmonary Syndrome; Homeostasis; Humans; Liver Failure, Acute; Liver Transplantation; Postoperative Period; Preoperative Care; Treatment Outcome | 2010 |
Intravenous acetylcysteine for the treatment of acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Administration, Oral; Antidotes; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Drug Overdose; Free Radical Scavengers; Humans; Injections, Intravenous; Time Factors; Treatment Outcome | 2011 |
[Intentional paracetamol intoxication in children].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Charcoal; Chemical and Drug Induced Liver Injury; Child; Drug Overdose; Humans | 2011 |
Management of paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Ambulatory Care; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver Transplantation; Nomograms; Physical Examination | 2011 |
Lack of toxicity after paracetamol overdose in a extremely preterm neonate.
Topics: Abdominal Pain; Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Free Radical Scavengers; Half-Life; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Infusions, Intravenous; Medication Errors; Metabolic Clearance Rate; Sepsis; Treatment Outcome | 2012 |
Acetaminophen and acetylcysteine dose and duration: past, present and future.
Topics: Acetaminophen; Acetylcysteine; Drug Overdose; Humans; Multicenter Studies as Topic; United States; United States Food and Drug Administration | 2012 |
Criteria for acetylcysteine treatment and clinical outcomes after paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Anti-Inflammatory Agents, Non-Steroidal; Antidotes; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Overdose; Humans; Risk Factors | 2012 |
A review of acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Drug Interactions; Drug Overdose; Ethanol; Humans; Liver Failure, Acute; Liver Transplantation; Nomograms; Time Factors | 2012 |
Combined butalbital/acetaminophen/caffeine overdose: case files of the Robert Wood Johnson Medical School Toxicology Service.
Topics: Acetaminophen; Acetylcysteine; Adult; Barbiturates; Caffeine; Drug Combinations; Drug Overdose; Female; Hemoperfusion; Humans; Renal Dialysis; Treatment Outcome; Vasopressins; Xanthines | 2012 |
[Treatment of paracetamol intoxication. Correctly given antidote treatment will prevent liver damage].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver Diseases; Poisoning; Time Factors; Treatment Outcome | 2002 |
Management of paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Alcoholism; Analgesics, Non-Narcotic; Antidotes; Chemistry, Pharmaceutical; Drug Overdose; Drug Packaging; Humans; Poisoning; Risk Factors; Time Factors; United Kingdom | 2003 |
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Oral methionine compared with intravenous n-acetyl cysteine for paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug Overdose; Evidence-Based Medicine; Humans; Methionine | 2003 |
Acetaminophen intoxication and length of treatment: how long is long enough?
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver Diseases; Time Factors | 2003 |
[Acetaminophen poisoning].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Charcoal; Drug Overdose; Glutathione; Humans; Liver; Prognosis; Time Factors | 2003 |
Acetaminophen toxicity.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Drug Monitoring; Drug Overdose; Emergency Nursing; Emergency Treatment; Gastric Lavage; Humans; Suicide, Attempted; United States | 2004 |
Acetaminophen overdose in pregnancy.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Fetus; Humans; Liver; Pregnancy; Pregnancy Complications | 2005 |
Hepatotoxicity of anti-inflammatory and analgesic drugs: ultrastructural aspects.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspirin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Drug Overdose; Hepatocytes; Humans; Liver; Liver Diseases; Liver Neoplasms; Verapamil | 2006 |
[Alcohol abuse case of severe liver dysfunction induced by acetaminophen poisoning which was diagnosed as non-hepatic toxicity on admission].
Topics: Acetaminophen; Acetylcysteine; Administration, Rectal; Adult; Alcoholism; Analgesics, Non-Narcotic; Drug Overdose; Female; Humans; Liver Diseases; Plasma Exchange; Severity of Illness Index; Suicide, Attempted; Therapeutics | 2006 |
Comparison of oral and i.v. acetylcysteine in the treatment of acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adult; Analgesics, Non-Narcotic; Anaphylaxis; Antidotes; Child; Drug Overdose; Female; Humans; Injections, Intravenous; Pregnancy | 2006 |
Acetaminophen hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver | 2007 |
Paracetamol (acetaminophen) poisoning.
Topics: Acetaminophen; Acetylcysteine; Dose-Response Relationship, Drug; Drug Overdose; Humans; Liver; Methionine | 1995 |
Paracetamol hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Drug Overdose; Hepatic Encephalopathy; Humans; Intubation; Liver Diseases; Prognosis; Stomach | 1993 |
Paracetamol poisoning and the kidney.
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Kidney | 1993 |
Cisplatin-induced renal toxicity: possible reversal by N-acetylcysteine treatment.
Topics: Acetylcysteine; Acute Kidney Injury; Adult; Antineoplastic Agents; Cisplatin; Drug Overdose; Female; Free Radical Scavengers; Humans; Kidney; Medication Errors; Time Factors | 1997 |
Treatment of acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Anti-Ulcer Agents; Antidotes; Charcoal; Child; Cimetidine; Drug Overdose; Female; Humans; Pregnancy; Time Factors | 1999 |
Acetaminophen intoxication during treatment: what you don't know can hurt you.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Child, Preschool; Drug Overdose; Humans; Iatrogenic Disease; Infant; Infant, Newborn; Risk Factors | 2000 |
Phytonadione therapy in a multiple-drug overdose involving warfarin.
Topics: Acetaminophen; Acetylcysteine; Aged; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Anticoagulants; Antidotes; Antifibrinolytic Agents; Azabicyclo Compounds; Charcoal; Drug Interactions; Drug Overdose; Female; Gastric Lavage; Humans; Hypnotics and Sedatives; International Normalized Ratio; Piperazines; Vitamin K; Vitamin K 1; Warfarin | 2000 |
[About paracetamol again].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Cimetidine; Drug Overdose; Humans; Liver; Liver Failure, Acute | 2001 |
Chronic acetaminophen overdosing in children: risk assessment and management.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Child; Drug Overdose; Expectorants; Humans; Liver; Risk Factors | 2001 |
Management of paracetamol overdose: current controversies.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Child; Drug Interactions; Drug Overdose; Female; Humans; Liver Diseases; Pregnancy; Risk Factors | 2001 |
Acute acetaminophen overdose in adolescents and adults.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Adolescent; Adult; Age Factors; Antidotes; Critical Care; Drug Overdose; Free Radical Scavengers; Humans; Liver Failure; Medical History Taking; Metabolic Clearance Rate; Nursing Assessment; Physical Examination; Time Factors; United States | 2000 |
Assessment and treatment of acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Cimetidine; Drug Overdose; Gastric Lavage; Humans; Ipecac | 1991 |
15 trial(s) available for acetylcysteine and Drug Overdose
| Article | Year |
|---|---|
Early acetaminophen-protein adducts predict hepatotoxicity following overdose (ATOM-5).
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Adolescent; Adult; Alanine Transaminase; Analgesics, Non-Narcotic; Australia; Benzoquinones; Biomarkers; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Humans; Imines; Liver; Male; Middle Aged; Prospective Studies; Treatment Outcome; Young Adult | 2020 |
A metabolomic analysis of thiol response for standard and modified N-acetyl cysteine treatment regimens in patients with acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Antidotes; Biomarkers; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Drug Monitoring; Drug Overdose; Female; Humans; Infusions, Intravenous; Male; Metabolomics; Middle Aged; Oxidation-Reduction; ROC Curve; Sulfhydryl Compounds | 2021 |
Paracetamol metabolite concentrations following low risk overdose treated with an abbreviated 12-h versus 20-h acetylcysteine infusion.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Biotransformation; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Humans; Infusions, Intravenous; Male; Poisoning; Treatment Outcome; Victoria; Young Adult | 2019 |
Randomised open label exploratory, safety and tolerability study with calmangafodipir in patients treated with the 12-h regimen of N-acetylcysteine for paracetamol overdose-the PP100-01 for Overdose of Paracetamol (POP) trial: study protocol for a randomi
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Clinical Trials Data Monitoring Committees; Clinical Trials, Phase I as Topic; Data Interpretation, Statistical; Drug Overdose; Drug Therapy, Combination; Edetic Acid; Female; Humans; Male; Outcome Assessment, Health Care; Pyridoxal Phosphate; Randomized Controlled Trials as Topic; Research Design | 2019 |
MicroRNA from a 12-h versus 20-h acetylcysteine infusion for paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Drug Overdose; Female; Humans; Infusions, Intravenous; Male; MicroRNAs; Young Adult | 2019 |
Principal results of a randomised open label exploratory, safety and tolerability study with calmangafodipir in patients treated with a 12 h regimen of N-acetylcysteine for paracetamol overdose (POP trial).
Topics: Acetaminophen; Acetylcysteine; Adult; Biomarkers; Chemical and Drug Induced Liver Injury; Drug Interactions; Drug Overdose; Edetic Acid; Female; Humans; Male; Protective Agents; Pyridoxal Phosphate; Time Factors; Young Adult | 2019 |
A single-arm clinical trial of a 48-hour intravenous N-acetylcysteine protocol for treatment of acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Adolescent; Adult; Antidotes; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Overdose; Female; Humans; Male; Prospective Studies; Time Factors; Transaminases; Treatment Outcome; Young Adult | 2014 |
Lower incidence of anaphylactoid reactions to N-acetylcysteine in patients with high acetaminophen concentrations after overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Anaphylaxis; Antidotes; Drug Interactions; Drug Overdose; Female; Humans; Male; Prospective Studies | 2008 |
N-acetylcysteine as a novel prophylactic treatment for ifosfamide-induced nephrotoxicity in children: translational pharmacokinetics.
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Adolescent; Analgesics, Non-Narcotic; Animals; Antineoplastic Agents, Alkylating; Area Under Curve; Child; Drug Overdose; Female; Humans; Ifosfamide; Male; Protective Agents; Rats; Rats, Wistar | 2012 |
Effects of PEG-electrolyte (Colyte) lavage on serum acetaminophen concentrations. A model for treatment of acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Aged; Blood Glucose; Charcoal; Drug Overdose; Electrolytes; Gastric Lavage; Humans; Intestinal Absorption; Male; Polyethylene Glycols | 1993 |
Efficacy of oral versus intravenous N-acetylcysteine in acetaminophen overdose: results of an open-label, clinical trial.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Drugs, Investigational; Female; Free Radical Scavengers; Humans; Injections, Intravenous; Male; Statistics, Nonparametric | 1998 |
Effect of metoclopramide dose on preventing emesis after oral administration of N-acetylcysteine for acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Antiemetics; Child; Child, Preschool; Drug Overdose; Female; Humans; Male; Metoclopramide; Middle Aged; Prospective Studies; Regression Analysis | 1999 |
Improvement by acetylcysteine of hemodynamics and oxygen transport in fulminant hepatic failure.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Biological Transport; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Hemodynamics; Hepatic Encephalopathy; Hepatitis C; Hepatitis, Alcoholic; Humans; Male; Middle Aged; Oxygen; Oxygen Consumption | 1991 |
Acetaminophen overdose: a 48-hour intravenous N-acetylcysteine treatment protocol.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Child; Drug Overdose; Female; Humans; Injections, Intravenous; Liver; Male; Prospective Studies; Risk Factors; Time Factors | 1991 |
Intravenous acetylcysteine in paracetamol induced fulminant hepatic failure: a prospective controlled trial.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Hepatic Encephalopathy; Humans; Infusions, Intravenous; Liver Diseases; London; Male; Middle Aged; Prospective Studies; Prothrombin Time; Survival Rate | 1991 |
290 other study(ies) available for acetylcysteine and Drug Overdose
| Article | Year |
|---|---|
Evaluation of N-acetylcysteine dose for the treatment of massive acetaminophen ingestion.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Eating; Humans; Retrospective Studies | 2022 |
Fomepizole as an adjunct in acetylcysteine treated acetaminophen overdose patients: a case series.
Topics: Acetaminophen; Acetylcysteine; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Fomepizole; Humans | 2022 |
Comparing development of liver injury using the two versus three bag acetylcysteine regimen despite early treatment in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Canada; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver; Retrospective Studies; Victoria | 2022 |
Large paracetamol overdose - Higher dose NAC is NOT required.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans; Retrospective Studies | 2023 |
Large paracetamol overdose-Higher dose acetylcysteine is required.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans | 2023 |
Sensitivity of dose-estimations for acute acetaminophen overdose in predicting hepatotoxicity risk using the Rumack-Matthew Nomogram.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Antidotes; Charcoal; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Overdose; Female; Humans; Male; Middle Aged; Nomograms; Retrospective Studies; Sensitivity and Specificity; Young Adult | 2022 |
Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Animals; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Drug Overdose; Hepatocytes; Humans; Liver; Mice; Mice, Inbred C57BL | 2022 |
Activation of the adenosine A2B receptor even beyond the therapeutic window of N-acetylcysteine accelerates liver recovery after an acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Liver; Male; Mice; Mice, Inbred C57BL; Receptor, Adenosine A2B | 2022 |
Comparison of Two-Bag Versus Three-Bag N-Acetylcysteine Regimens for Pediatric Acetaminophen Toxicity.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Child; Cohort Studies; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans; Retrospective Studies | 2023 |
Compromised blood-bile barrier after acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Bile; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver | 2022 |
Comment: Comparison of 2-Bag Versus 3-Bag
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Child; Drug Overdose; Humans | 2023 |
SNAPTIMED study: does the Scottish and Newcastle Antiemetic Protocol achieve timely intervention and management from the emergency department to discharge for paracetamol poisoning?
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Anaphylaxis; Antiemetics; Drug Overdose; Emergency Service, Hospital; Humans; Patient Discharge; Retrospective Studies; Scotland | 2023 |
Acetaminophen toxicity and overdose: current understanding and future directions for NAC dosing regimens.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans | 2022 |
Fomepizole should not be used more liberally in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; COVID-19; Drug Overdose; Fomepizole; Humans | 2023 |
Fomepizole should be used more liberally in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Fomepizole; Humans | 2023 |
Paracetamol overdose in children: management following an initial N-acetylcysteine regimen.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Child; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans; Retrospective Studies | 2023 |
Acute kidney injury after treatment of paracetamol overdose using new N-acetylcysteine guideline.
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Analgesics, Non-Narcotic; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans | 2023 |
Implementation of a pharmacist toxicology service on treatment of paracetamol (acetaminophen) overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmacists; Retrospective Studies | 2023 |
Acetaminophen Metabolites on Presentation Following an Acute Acetaminophen Overdose (ATOM-7).
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Australia; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver; Retrospective Studies | 2023 |
Early treatment with N-acetylcysteine reduces hepatotoxicity in acute acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Child; COVID-19; Digestive System Diseases; Drug Overdose; Female; Humans | 2023 |
Patterns and outcomes of paracetamol poisoning management in Hamad Medical Corporation, Qatar: A retrospective cohort study.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans; Qatar; Retrospective Studies; Young Adult | 2023 |
Electronic intravenous N-acetyl cysteine ordering tool: A retrospective review.
Topics: Acetaminophen; Acetylcysteine; Drug Overdose; Electronics; Humans; Retrospective Studies | 2020 |
[Simplified N-acetylcystein treatment after paracetamol overdose - new recommendations from Swedish Poisons Information Centre].
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Antidotes; Drug Overdose; Humans; Poison Control Centers; Poisoning; Practice Guidelines as Topic | 2019 |
Fomepizole as an Adjunctive Treatment in Severe Acetaminophen Toxicity.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Fomepizole; Humans; Male; Treatment Outcome | 2020 |
Use of fomepizole, n-acetylcysteine, and hemodialysis for massive acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Fomepizole; Free Radical Scavengers; Humans; Male; Middle Aged; Renal Dialysis | 2020 |
Adducts Post Acetaminophen Overdose Treated with a 12-Hour vs 20-Hour Acetylcysteine Infusion.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Controlled Clinical Trials as Topic; Drug Overdose; Female; Humans; Infusions, Parenteral; Liver Function Tests; Male; Protein Binding; Time Factors; Treatment Outcome; Young Adult | 2020 |
Elevated procalcitonin levels in patients with acetaminophen intoxication: two case reports: A CARE-compliant article.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Aspartate Aminotransferases; C-Reactive Protein; Drug Overdose; Emergency Service, Hospital; Female; Humans; Male; Middle Aged; Procalcitonin; Treatment Outcome; Young Adult | 2020 |
Delayed peaks of acetaminophen in overdose patients with concomitant abdominal trauma.
Topics: Abdominal Injuries; Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Fatal Outcome; Female; Humans; Suicide, Attempted; Treatment Outcome; Wounds, Nonpenetrating; Wounds, Stab | 2021 |
Fomepizole as an adjunctive treatment in severe acetaminophen ingestions: a case series.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Drug Therapy, Combination; Female; Fomepizole; Humans; Middle Aged; Treatment Outcome | 2021 |
The changing face of paracetamol toxicity and new regimens for an old antidote acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Humans | 2021 |
A Case Report of a Severe, Unusually Delayed Anaphylactoid Reaction to Intravenous N-Acetylcysteine During Treatment of Acute Acetaminophen Toxicity in an Adolescent.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Anaphylaxis; Antidotes; Drug Hypersensitivity; Drug Overdose; Female; Histamine Antagonists; Humans; Infusions, Intravenous; Severity of Illness Index; Time Factors; Treatment Outcome | 2021 |
Clinical Progress Note: Goal-Directed N-acetylcysteine Treatment of Acetaminophen Toxicity.
Topics: Acetaminophen; Acetylcysteine; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Goals; Humans; Motivation | 2021 |
A Mysteriously Low Creatinine Concentration.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Creatinine; Drug Overdose; Female; Humans | 2020 |
Comment on "The changing face of paracetamol toxicity and new regimens for an old antidote acetylcysteine".
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Humans | 2021 |
Clinical outcome of massive acetaminophen overdose treated with standard-dose N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Drug Overdose; Female; Humans; Infusions, Intravenous; Male; Poison Control Centers; Retrospective Studies; Risk Assessment; Risk Factors; Time Factors; Treatment Outcome; Young Adult | 2021 |
Intravenous Acetaminophen Overdose in an Infant With Toxicokinetic Data.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug Overdose; Humans; Infant; Male; Retrospective Studies; Toxicokinetics | 2023 |
Extremely Elevated Procalcitonin in a Case of Acetaminophen Overdose and Acute Liver Injury.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver; Male; Middle Aged; Procalcitonin | 2022 |
A two-bag acetylcysteine regimen is associated with shorter delays and interruptions in the treatment of paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Australia; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans; Retrospective Studies | 2022 |
Delayed administration of N-acetylcysteine blunts recovery after an acetaminophen overdose unlike 4-methylpyrazole.
Topics: Acetaminophen; Acetylcysteine; Animals; Antidotes; Cell Proliferation; Chemical and Drug Induced Liver Injury; Drug Overdose; Fomepizole; Hepatocytes; Humans; Male; Mice; Mice, Inbred C57BL; Time Factors | 2021 |
Limitations of the evidence supporting use of undetectable acetaminophen levels obtained <4 hours post-ingestion to rule out toxicity.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug Overdose; Humans | 2017 |
Reply to: Limitations of the evidence supporting use of undetectable acetaminophen levels obtained <4 hours post-ingestion to rule out toxicity.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug Overdose; Humans | 2017 |
Accuracy of the paracetamol-aminotransferase multiplication product to predict hepatotoxicity in modified-release paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Alanine Transaminase; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Humans; Male; Middle Aged; Retrospective Studies; Sensitivity and Specificity; Young Adult | 2017 |
When two is not better than one.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug Overdose; Humans | 2017 |
Acetylcysteine (Cetylev) for acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Antioxidants; Chemical and Drug Induced Liver Injury; Drug Compounding; Drug Overdose; Humans; Tablets; Treatment Outcome | 2017 |
Pharmacokinetic modelling of modified acetylcysteine infusion regimens used in the treatment of paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Computer Simulation; Drug Overdose; Humans; Infusions, Intravenous; Models, Biological | 2017 |
Massive paracetamol overdose: an observational study of the effect of activated charcoal and increased acetylcysteine dose (ATOM-2).
Topics: Acetaminophen; Acetylcysteine; Adult; Australia; Charcoal; Chemical and Drug Induced Liver Injury; Databases, Factual; Dose-Response Relationship, Drug; Drug Overdose; Early Medical Intervention; Female; Humans; Male; Poison Control Centers; Prospective Studies; Retrospective Studies; Treatment Outcome | 2017 |
Evaluation of a Food and Drug Administration Mandate to Limit Acetaminophen in Prescription Combination Products.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Databases, Factual; Drug and Narcotic Control; Drug Approval; Drug Combinations; Drug Compounding; Drug Overdose; Female; Humans; Male; Middle Aged; Naloxone; Narcotic Antagonists; Poison Control Centers; Policy Making; Pregnancy; Prescription Drugs; Program Evaluation; Protective Factors; Risk Factors; Time Factors; United States; United States Food and Drug Administration; Young Adult | 2017 |
Accuracy of the paracetamol-aminotransferase product to predict hepatotoxicity in paracetamol overdose treated with a 2-bag acetylcysteine regimen.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Liver Diseases; Male; Middle Aged; Retrospective Studies; Risk Factors; Young Adult | 2018 |
Analysis of an 8-hour acetylcysteine infusion protocol for repeated supratherapeutic ingestion (RSTI) of paracetamol.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Australia; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Overdose; Female; Humans; Male; Middle Aged; Prospective Studies; Retrospective Studies | 2018 |
A comment on 'An assessment of the variation in the concentrations of acetylcysteine in infusions for the treatment of paracetamol overdose'.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Humans | 2017 |
Risk stratification after paracetamol overdose using mechanistic biomarkers: results from two prospective cohort studies.
Topics: Acetaminophen; Acetylcysteine; Adult; Antidotes; Biomarkers; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Glutamate Dehydrogenase; HMGB1 Protein; Humans; Keratin-18; Male; MicroRNAs; Middle Aged; Prospective Studies; Risk Assessment; Young Adult | 2018 |
Being overweight or obese as a risk factor for acute liver injury secondary to acute acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Body Mass Index; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Drug Overdose; Female; Follow-Up Studies; Humans; Incidence; Male; Middle Aged; Obesity; Retrospective Studies; Risk Assessment; Risk Factors; Thailand; Young Adult | 2018 |
In response to: "Pharmacokinetic modelling of modified acetylcysteine infusion regimens used in the treatment of paracetamol poisoning".
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans | 2018 |
Intravenous
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Education, Nursing, Continuing; Humans; United States | 2017 |
Fewer adverse effects with a modified two-bag acetylcysteine protocol in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Anaphylaxis; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Humans; Male; Middle Aged | 2018 |
[N-acetylcysteine : effective treatment in severe alcoholic hepatitis ?]
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antiviral Agents; Drug Overdose; Hepatitis, Alcoholic; Humans; Liver Failure, Acute | 2018 |
Anaphylactoid Reactions to Intravenous N-Acetylcysteine during Treatment for Acetaminophen Poisoning.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Anaphylaxis; Antidotes; Canada; Cohort Studies; Drug Overdose; Female; Histamine Antagonists; Humans; Incidence; Male; Middle Aged; Retrospective Studies; Sex Factors; Treatment Outcome; Young Adult | 2018 |
Bet 1: A slower rate of initial N-acetylcysteine infusion in the treatment of acute paracetamol overdose to reduce adverse reactions.
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Antidotes; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans | 2018 |
Hepatotoxicity after paracetamol overdose in a patient with cystic fibrosis despite early acetylcysteine and utility of microRNA to predict hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Adult; Antidotes; Biomarkers; Chemical and Drug Induced Liver Injury; Cystic Fibrosis; Drug Overdose; Female; Humans; MicroRNAs; Retrospective Studies; Risk Factors; Treatment Outcome; Young Adult | 2018 |
In response to: fewer adverse effects with a modified two-bag acetylcysteine protocol in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans | 2018 |
Molecular Adsorbent Recirculating System Treatment Can Reduce Blood Levels of N-Acetylcysteine in Patients With Acetaminophen Overdose: Case Reports.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Drug Overdose; Female; Free Radical Scavengers; Humans; Male; Sorption Detoxification | 2018 |
Calculated decisions: Acetaminophen Overdose and N-Acetylcysteine (NAC) Dosing
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Decision Making; Drug Overdose; Humans; Time Factors | 2018 |
Fewer adverse effects associated with a modified two-bag intravenous acetylcysteine protocol compared to traditional three-bag regimen in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Adolescent; Adult; Aged; Aged, 80 and over; Antidotes; Child; Child, Preschool; Denmark; Dose-Response Relationship, Drug; Drug Overdose; Female; Humans; Infant; Male; Middle Aged; Practice Guidelines as Topic; Young Adult | 2018 |
Paracetamol self-poisoning: when oral N-acetylcysteine saves life? a case report.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Antidotes; Drug Overdose; Female; Humans; Suicide, Attempted; Tablets; Treatment Outcome; Young Adult | 2018 |
Toxic Ingestion of Acetaminophen and Acetylsalicylic Acid in a Parturient at 33 Weeks Gestation: A Case Report.
Topics: Acetaminophen; Acetylcysteine; Adult; Aspirin; Cesarean Section; Charcoal; Drug Overdose; Female; Fetal Heart; Humans; Point-of-Care Systems; Pregnancy; Pregnancy Trimester, Third; Suicide, Attempted; Thrombelastography | 2019 |
An evaluation of the role of mixing techniques in the observed variation in acetylcysteine infusion concentrations.
Topics: Acetaminophen; Acetylcysteine; Dose-Response Relationship, Drug; Drug Compounding; Drug Dosage Calculations; Drug Overdose; Humans; Infusion Pumps; Infusions, Intravenous | 2019 |
Transition to two-bag intravenous acetylcysteine for acetaminophen overdose: a poison center's experience.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Clinical Protocols; Drug Overdose; Drug Packaging; Humans; Infusions, Intravenous | 2019 |
Changing nomogram risk zone classification with serial testing after acute acetaminophen overdose: a retrospective database analysis.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Canada; Chemical and Drug Induced Liver Injury; Clinical Decision-Making; Databases, Factual; Decision Support Techniques; Drug Overdose; Female; Hospitalization; Humans; Male; Nomograms; Patient Selection; Predictive Value of Tests; Prognosis; Retrospective Studies; Risk Assessment; Risk Factors; Time Factors; Time-to-Treatment; Young Adult | 2019 |
Using the 150 rule to prevent hepatotoxicity from acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Diagnosis, Differential; Disease Progression; Drug Overdose; Female; Humans; Liver Failure, Acute | 2019 |
Haemodiafiltration as an effective treatment option for massive paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Aged, 80 and over; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Female; Hemodiafiltration; Humans; Suicide, Attempted; Treatment Outcome | 2019 |
Comment on "What is the most appropriate dose of N acetylcysteine after massive acetaminophen overdose?" by Hendrickson et al.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug Overdose; Humans | 2020 |
Letter in response to: "Randomised open label exploratory, safety and tolerability study with calmangafodipir in patients treated with the 12-h regimen of N acetylcysteine for paracetamol overdose-the PP100-01 for Overdose of Paracetamol (POP) trial: stud
Topics: Acetaminophen; Acetylcysteine; Drug Overdose; Edetic Acid; Humans; Pyridoxal Phosphate; Research Design | 2019 |
[Improved and harmonised laboratory analysis of paracetamol provides safer assessment of poisoning cases].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Clinical Laboratory Services; Drug Overdose; Humans; Poisoning; Practice Guidelines as Topic; Sweden; Time Factors | 2019 |
Comment on "Transition to two-bag intravenous acetylcysteine for acetaminophen overdose".
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug Overdose; Humans; Poisons | 2020 |
Treating acetaminophen overdose: thresholds, costs and uncertainties.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Cost-Benefit Analysis; Drug Overdose; Health Care Costs; Humans; Practice Guidelines as Topic | 2013 |
The predictive value of hospital admission serum alanine transaminase activity in patients treated for paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Analgesics, Non-Narcotic; Biomarkers; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; Drug Overdose; Female; Hospitalization; Humans; Male; Middle Aged; Predictive Value of Tests; Prognosis; Young Adult | 2013 |
Performance of a multi-disciplinary emergency department observation protocol for acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Ambulatory Care; Cohort Studies; Drug Overdose; Emergency Service, Hospital; Emergency Services, Psychiatric; Female; Free Radical Scavengers; Hospitals, University; Humans; Infusions, Intravenous; Interdisciplinary Communication; Length of Stay; Male; Middle Aged; Retrospective Studies; Severity of Illness Index; Young Adult | 2013 |
How safe is acetaminophen?
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Free Radical Scavengers; Humans; Safety | 2013 |
Elevated acetaminophen concentration measured after nasal insufflation of Percocet®.
Topics: Acetaminophen; Acetylcysteine; Administration, Intranasal; Adult; Drug Combinations; Drug Overdose; Female; Free Radical Scavengers; Humans; Insufflation; Nose; Opioid-Related Disorders; Oxycodone | 2013 |
Acute overdose: suicide attempt.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Antidotes; Charcoal; Diphenhydramine; Drug Overdose; Education, Pharmacy; Electrocardiography; Female; Humans; Seizures; Suicide, Attempted | 2013 |
Incidence and management of N-acetylcysteine-related anaphylactoid reactions during the management of acute paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Anaphylaxis; Drug Overdose; Female; Humans; Incidence; Male; Retrospective Studies | 2014 |
Missed paracetamol (acetaminophen) overdose due to confusion regarding drug names.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Delayed Diagnosis; Drug Overdose; Drug Packaging; Humans; Internet; Male; Terminology as Topic; Time Factors; Young Adult | 2013 |
The epidemiology and management of adult poisonings admitted to the short-stay ward of a large Scottish emergency department.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Antidotes; Central Nervous System Depressants; Charcoal; Drug Overdose; Emergency Service, Hospital; Ethanol; Female; Follow-Up Studies; Free Radical Scavengers; Hospitalization; Humans; Length of Stay; Male; Mental Disorders; Middle Aged; Naloxone; Narcotic Antagonists; Patient Admission; Patient Discharge; Public Health; Retrospective Studies; Scotland; Self-Injurious Behavior | 2013 |
Circulating acylcarnitines as biomarkers of mitochondrial dysfunction after acetaminophen overdose in mice and humans.
Topics: Acetaminophen; Acetylcysteine; Animals; Antidotes; Biomarkers; Carnitine; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Male; Metabolomics; Mice; Mice, Inbred C57BL; Mitochondria | 2014 |
[Paracetamol overdose].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Nonprescription Drugs | 2013 |
MHRA recommendations on the use of intravenous acetylcysteine in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Adolescent; Adult; Aged; Aged, 80 and over; Antidotes; Child; Child, Preschool; Drug Overdose; Humans; Middle Aged; Practice Guidelines as Topic; Young Adult | 2014 |
Epidemiology, management and outcome of paracetamol poisoning in an inner city emergency department.
Topics: Acetaminophen; Acetylcysteine; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Anaphylaxis; Antidotes; Disease Management; Drug Overdose; Emergency Service, Hospital; England; Female; Hospitals, Urban; Humans; Male; Outcome Assessment, Health Care; Prospective Studies; Wales | 2015 |
Antidote removal during haemodialysis for massive acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Acidosis, Lactic; Adult; Aged; Analgesics, Non-Narcotic; Antidotes; Coma; Drug Monitoring; Drug Overdose; Female; Free Radical Scavengers; Half-Life; Humans; Liver Failure; Male; Metabolic Clearance Rate; Middle Aged; Renal Dialysis; Young Adult | 2013 |
Four-hour acetaminophen concentration estimation after ingested dose based on pharmacokinetic models.
Topics: Acetaminophen; Acetylcysteine; Adult; Age Factors; Antidotes; Child; Drug Overdose; Humans; Models, Biological; Referral and Consultation; Time Factors; Tissue Distribution; United Kingdom | 2014 |
Paracetamol toxicity: what would be the implications of a change in Australian treatment guidelines?
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Costs and Cost Analysis; Drug Overdose; Emergency Service, Hospital; Free Radical Scavengers; Health Care Costs; Hospitalization; Humans; Practice Guidelines as Topic; Retrospective Studies; Victoria | 2014 |
Acetaminophen Psi Nomogram: a sensitive and specific clinical tool to predict hepatotoxicity secondary to acute acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Nomograms; Predictive Value of Tests; Retrospective Studies; Risk Assessment; Risk Factors; Sensitivity and Specificity; Thailand | 2014 |
Predicting acute acetaminophen hepatotoxicity with acetaminophen-aminotransferase multiplication product and the Psi parameter.
Topics: Acetaminophen; Acetylcysteine; Adult; Alanine Transaminase; Antidotes; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Humans; Likelihood Functions; Male; Retrospective Studies; ROC Curve; Sensitivity and Specificity; Thailand; Time Factors; Young Adult | 2014 |
Overdose with modified-release paracetamol (Panadol Osteo®) presenting to a metropolitan emergency medicine network: a case series.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Aged, 80 and over; Child; Clinical Audit; Delivery of Health Care; Drug Overdose; Emergency Medical Services; Female; Guideline Adherence; Humans; Male; Middle Aged; Practice Guidelines as Topic; Retrospective Studies; Time Factors; Young Adult | 2014 |
Comparative evaluation of N-acetylcysteine and N-acetylcysteineamide in acetaminophen-induced hepatotoxicity in human hepatoma HepaRG cells.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Overdose; Free Radical Scavengers; Humans; Lipid Peroxidation; Liver Neoplasms; Mitochondria, Liver; Oxidative Stress; Reactive Oxygen Species | 2015 |
Reported ingested dose of paracetamol as a predictor of risk following paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Female; Humans; Male; Risk; Self Report; Young Adult | 2014 |
Paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Charcoal; Chemical and Drug Induced Liver Injury; Drug Overdose; Free Radical Scavengers; Humans; Infusions, Intravenous; Practice Guidelines as Topic; Time Factors | 2015 |
Culture, impaired access to mental health care, and bipolar disorder: case analysis.
Topics: Acetylcysteine; Adult; Asian; Bipolar Disorder; Culture; Drug Overdose; Female; Free Radical Scavengers; Health Services Accessibility; Humans; Mental Health Services; Suicide, Attempted; Young Adult | 2015 |
Acrolein, a highly toxic aldehyde generated under oxidative stress in vivo, aggravates the mouse liver damage after acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Acrolein; Animals; Blotting, Western; Cell Culture Techniques; Chemical and Drug Induced Liver Injury; Drug Overdose; Liver; Mesna; Mice; Mice, Inbred C57BL; Oxidative Stress; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction | 2014 |
An accidental overdose of N-acetylcysteine during treatment for acetaminophen toxicity.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Body Weight; Drug Dosage Calculations; Drug Overdose; Female; Humans; Infusions, Intravenous; Medication Errors; Suicide, Attempted; Young Adult | 2015 |
Acetaminophen concentrations prior to 4 hours of ingestion: impact on diagnostic decision-making and treatment.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Child; Decision Making; Dose-Response Relationship, Drug; Drug Overdose; Female; Humans; Male; Retrospective Studies; Toxicity Tests, Acute; Young Adult | 2015 |
Case Files from the University of California San Diego Health System Fellowship Coma and Severe Acidosis: Remember to Consider Acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Acidosis, Lactic; Adult; Antidotes; Biomarkers; Coma; Drug Overdose; Humans; Infusions, Intravenous; Male; Poisoning; Predictive Value of Tests; Risk Factors; Severity of Illness Index; Treatment Outcome | 2015 |
External validation of the paracetamol-aminotransferase multiplication product to predict hepatotoxicity from paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Alanine Transaminase; Analgesics, Non-Narcotic; Antidotes; Biomarkers; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; Databases, Factual; Decision Support Techniques; Drug Overdose; Female; Hospitals, Teaching; Humans; Likelihood Functions; Male; Predictive Value of Tests; Reproducibility of Results; Retrospective Studies; Risk Assessment; Risk Factors; Time Factors; Treatment Outcome; United Kingdom | 2015 |
A descriptive analysis of aspartate and alanine aminotransferase rise and fall following acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Aged; Alanine Transaminase; Analgesics, Non-Narcotic; Antidotes; Aspartate Aminotransferases; Biomarkers; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; Decision Support Techniques; Drug Overdose; Female; Humans; Kaplan-Meier Estimate; Liver Transplantation; Male; Middle Aged; Models, Biological; Predictive Value of Tests; Retrospective Studies; Risk Assessment; Risk Factors; Time Factors; Treatment Outcome; Young Adult | 2015 |
Comparison of Prothrombin Time and Aspartate Aminotransferase in Predicting Hepatotoxicity After Acetaminophen Overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Area Under Curve; Aspartate Aminotransferases; Biomarkers; Blood Coagulation; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; Drug Overdose; Female; Humans; Male; Predictive Value of Tests; Prothrombin Time; Reproducibility of Results; Retrospective Studies; Risk Assessment; Risk Factors; ROC Curve; Young Adult | 2016 |
Global research productivity of N-acetylcysteine use in paracetamol overdose: A bibliometric analysis (1976-2012).
Topics: Acetaminophen; Acetylcysteine; Anti-Inflammatory Agents, Non-Steroidal; Bibliometrics; Biomedical Research; Drug Overdose; Humans; Publishing | 2015 |
Paracetamol overdose: relevance of recent evidence for managing patients in Sri Lanka.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Disease Management; Drug Overdose; Free Radical Scavengers; Humans; Sri Lanka | 2015 |
Comparison of Prothrombin Time and Aspartate Aminotransferase in Predicting Hepatotoxicity After Acetaminophen Overdose: a Response.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Prothrombin Time | 2016 |
Nomogram line crossing after acetaminophen combination product overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Antidotes; Chemical and Drug Induced Liver Injury; Child; Decision Support Techniques; Drug Combinations; Drug Overdose; Female; Histamine Antagonists; Humans; Male; Middle Aged; Nomograms; Poison Control Centers; Predictive Value of Tests; Prospective Studies; Risk Assessment; Risk Factors; Treatment Outcome; Young Adult | 2016 |
In Response to: "Comparison of Prothrombin Time and Aspartate Aminotransferase in Predicting Hepatotoxicity After Acetaminophen Overdose.".
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Prothrombin Time | 2016 |
Simplification of the standard three-bag intravenous acetylcysteine regimen for paracetamol poisoning results in a lower incidence of adverse drug reactions.
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Adolescent; Adult; Anaphylaxis; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Incidence; Male; Retrospective Studies; Young Adult | 2016 |
New regimens for intravenous acetylcysteine, where are we now?
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Antiemetics; Drug Overdose; Endpoint Determination; Humans; Randomized Controlled Trials as Topic | 2016 |
A prospective observational study of a novel 2-phase infusion protocol for the administration of acetylcysteine in paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Overdose; Female; Hospitalization; Humans; Liver; Male; Middle Aged; Prospective Studies; Young Adult | 2016 |
How to treat paracetamol overdose and when to do it.
Topics: Acetaminophen; Acetylcysteine; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans | 2016 |
ACMT Position Statement: Duration of Intravenous Acetylcysteine Therapy Following Acetaminophen Overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antioxidants; Clinical Decision-Making; Drug Administration Schedule; Drug Overdose; Humans; Infusions, Intravenous; Toxicology; Treatment Outcome | 2017 |
Plasma paracetamol concentration at hospital presentation has a dose-dependent relationship with liver injury despite prompt treatment with intravenous acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Adult; Alanine Transaminase; Antidotes; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Overdose; Female; Hospitalization; Humans; Male; Nomograms; Retrospective Studies; Risk Factors; United Kingdom | 2016 |
Massive acetaminophen overdose: effect of hemodialysis on acetaminophen and acetylcysteine kinetics.
Topics: Acetaminophen; Acetylcysteine; Acidosis, Lactic; Adolescent; Coma; Drug Overdose; Emergency Service, Hospital; Ethanol; Female; Half-Life; Humans; Ibuprofen; Lactic Acid; Liver; Renal Dialysis | 2016 |
Treatments for paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Charcoal; Drug Overdose; Female; Humans; Methionine; Time Factors; Young Adult | 2016 |
N-acetylcysteine regimens for paracetamol overdose: Time for a change?
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Analgesics, Non-Narcotic; Antidotes; Drug Administration Schedule; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans; Incidence | 2016 |
Guidance on acetylcysteine for paracetamol ingestion needs review.
Topics: Acetaminophen; Acetylcysteine; Analgesics; Antidotes; Drug Overdose; Health Services Needs and Demand; Humans; Practice Guidelines as Topic; United Kingdom | 2016 |
Authors' reply to Thomas and colleagues.
Topics: Acetaminophen; Acetylcysteine; Analgesics; Antidotes; Dissent and Disputes; Drug Overdose; Humans; Practice Guidelines as Topic | 2016 |
Delays during the administration of acetylcysteine for the treatment of paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Antidotes; Drug Administration Schedule; Drug Overdose; Female; Humans; Infusions, Intravenous; Male; Medication Errors; Retrospective Studies; Time Factors; Young Adult | 2016 |
Incidence and characterization of acute kidney injury after acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Adult; Analgesics, Non-Narcotic; Biomarkers; Creatinine; Drug Overdose; Female; Humans; Incidence; Intensive Care Units; Liver Diseases; Male; Middle Aged; Retrospective Studies | 2016 |
[A Case of Acetaminophen Poisoning Associated with Tramcet Overdose].
Topics: Acetaminophen; Acetylcysteine; Adolescent; Drug Overdose; Female; Humans; Tramadol; Treatment Outcome | 2016 |
An assessment of the variation in the concentration of acetylcysteine in infusions for the treatment of paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chromatography, High Pressure Liquid; Drug Overdose; Hospitals, Teaching; Humans; Infusions, Intravenous; Prospective Studies; United Kingdom | 2017 |
Characterisation and outcomes of adult patients with paracetamol overdose presenting to a tertiary hospital in Singapore.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Anaphylaxis; Drug Overdose; Female; Humans; Liver; Liver Failure, Acute; Liver Transplantation; Male; Middle Aged; Retrospective Studies; Singapore; Suicide, Attempted; Tertiary Care Centers; Treatment Outcome; Young Adult | 2017 |
Circulating acetaminophen metabolites are toxicokinetic biomarkers of acute liver injury.
Topics: Acetaminophen; Acetylcysteine; Adult; Alanine Transaminase; Analgesics, Non-Narcotic; Antiemetics; Area Under Curve; Biomarkers; Chemical and Drug Induced Liver Injury; Cohort Studies; Cytochrome P-450 Enzyme System; Drug Interactions; Drug Overdose; Female; Free Radical Scavengers; Humans; Male; Middle Aged; Ondansetron; Reproducibility of Results; ROC Curve; Toxicokinetics; Young Adult | 2017 |
Chloroform ingestion causing severe gastrointestinal injury, hepatotoxicity and dermatitis confirmed with plasma chloroform concentrations.
Topics: Abdominal Pain; Acetylcysteine; Adult; Antidotes; Chemical and Drug Induced Liver Injury; Chloroform; Drug Eruptions; Drug Overdose; Female; Gastrointestinal Diseases; Half-Life; Humans; Liver Function Tests; Models, Biological; Respiratory Insufficiency | 2017 |
[Overdose of modified-release paracetamol calls for changed treatment routines. New guidelines from the Swedish Poisons Information Centre].
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Delayed-Action Preparations; Drug Overdose; Humans; Male; Poison Control Centers; Practice Guidelines as Topic; Sweden | 2016 |
Outcomes from massive paracetamol overdose: a retrospective observational study.
Topics: Acetaminophen; Acetylcysteine; Adult; Alanine Transaminase; Analgesics, Non-Narcotic; Antidotes; Aspartate Aminotransferases; Biomarkers; Blood Coagulation Disorders; Chemical and Drug Induced Liver Injury; Creatinine; Drug Overdose; Female; Humans; Male; Prevalence; Retrospective Studies; Treatment Outcome; Young Adult | 2017 |
Lack of respiratory depression in paracetamol-codeine combination overdoses.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Aged, 80 and over; Antidotes; Child; Codeine; Critical Care; Drug Combinations; Drug Overdose; Female; Glasgow Coma Scale; Humans; Length of Stay; Male; Middle Aged; Naloxone; Narcotic Antagonists; Respiration, Artificial; Respiratory Insufficiency; Retrospective Studies; Suicide, Attempted; Treatment Outcome; Young Adult | 2017 |
Haemodialysis in acute paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Acidosis, Lactic; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Fluid Therapy; Free Radical Scavengers; Humans; Renal Dialysis; Young Adult | 2017 |
Accidental cisplatin overdose in a child: Successful management with repetitive plasmapheresis and use of chemoprotective agents.
Topics: Acetylcysteine; Adolescent; Amifostine; Antineoplastic Agents; Cisplatin; Drug Overdose; Female; Humans; Plasmapheresis | 2016 |
Intra-arterial N-acetylcysteine.
Topics: Acetylcysteine; Adolescent; Antidotes; Blood Gas Analysis; Drug Overdose; Humans; Hyperemia; Injections, Intra-Arterial; Injections, Intravenous; Male; Medication Errors | 2008 |
Acetaminophen overdose with altered acetaminophen pharmacokinetics and hepatotoxicity associated with premature cessation of intravenous N-acetylcysteine therapy.
Topics: Acetaminophen; Acetylcysteine; Aged; Chemical and Drug Induced Liver Injury; Drug Overdose; Free Radical Scavengers; Half-Life; Humans; Male; Time Factors | 2008 |
[Acute acetaminophen overdose].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans | 2008 |
Cardiac arrest following therapeutic administration of N-acetylcysteine for paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antidotes; Drug Overdose; Heart Arrest; Humans; Male; Suicide, Attempted; Time Factors | 2008 |
Risk factors and mechanisms of anaphylactoid reactions to acetylcysteine in acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Anaphylaxis; Antidotes; Blood Coagulation Factors; Drug Overdose; Female; Histamine Release; Humans; Inflammation Mediators; Logistic Models; Male; Odds Ratio; Pedigree; Prospective Studies; Risk Assessment; Risk Factors; Severity of Illness Index; Sex Factors; Time Factors | 2008 |
Development of hepatic failure despite use of intravenous acetylcysteine after a massive ingestion of acetaminophen and diphenhydramine.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Antidotes; Aspartate Aminotransferases; Charcoal; Diphenhydramine; Drug Combinations; Drug Overdose; Fatal Outcome; Female; Free Radical Scavengers; Histamine H1 Antagonists; Humans; Liver Failure; Middle Aged; Suicide, Attempted | 2009 |
Hepatotoxicity despite early administration of intravenous N-acetylcysteine for acute acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Adult; Aged; Alanine Transaminase; Analgesics, Non-Narcotic; Antidotes; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Drug Overdose; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Observation; Retrospective Studies | 2009 |
Serum acetaminophen concentrations after acute overdose are not altered by opioid co-ingestion.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Interactions; Drug Overdose; Female; Humans; Male; Poisoning; Prospective Studies; Time Factors; Young Adult | 2008 |
Comment: frequency of medication errors with intravenous acetylcysteine for acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Drug Overdose; Humans; Infusions, Intravenous; Medication Errors; Time Factors | 2009 |
Hepatotoxicity in an infant following supratherapeutic dosing of acetaminophen for twenty-four hours.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Antidotes; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug Overdose; Free Radical Scavengers; Humans; Infant; Liver; Male; Poison Control Centers | 2009 |
Paracetamol poisoning below toxic level causing liver damage in a fasting adult.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Fasting; Female; Free Radical Scavengers; Humans; Liver; Liver Diseases; Risk Factors; Young Adult | 2009 |
Hepatotoxicity despite early administration of intravenous N-acetylcysteine for acute acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Drug Overdose; Female; Humans | 2009 |
Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Bayes Theorem; Benzoquinones; Biomarkers; Biotransformation; Databases as Topic; Drug Overdose; Female; Half-Life; Humans; Imines; Liver Failure, Acute; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Models, Statistical; Nonlinear Dynamics; Young Adult | 2009 |
Prolonged N-acetylcysteine therapy in late acetaminophen poisoning associated with acute liver failure--a need to be more cautious?
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antidotes; Drug Administration Schedule; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Liver Failure, Acute; Mice | 2009 |
Comparison of the 20-hour intravenous and 72-hour oral acetylcysteine protocols for the treatment of acute acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Antidotes; Canada; Chemical and Drug Induced Liver Injury; Child; Cohort Studies; Critical Pathways; Drug Administration Schedule; Drug Overdose; Female; Free Radical Scavengers; Humans; Infusions, Intravenous; Male; Retrospective Studies; Risk; United States; Young Adult | 2009 |
Is the oral acetylcysteine protocol the best treatment for late-presenting acetaminophen poisoning?
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Chemical and Drug Induced Liver Injury; Drug Overdose; Free Radical Scavengers; Humans; Infusions, Intravenous; Time Factors | 2009 |
Early presentation following overdose of modified-release paracetamol (Panadol Osteo) with biphasic and prolonged paracetamol absorption.
Topics: Acetaminophen; Acetylcysteine; Aged; Alanine Transaminase; Analgesics, Non-Narcotic; Aspartate Aminotransferases; Delayed-Action Preparations; Drug Overdose; Female; Free Radical Scavengers; Humans; Infusions, Intravenous | 2009 |
Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Drug Overdose; Energy Metabolism; Glutathione; Male; Mice; Mice, Inbred C3H; Mitochondria, Liver; Peroxynitrous Acid; Reactive Oxygen Species; Up-Regulation | 2010 |
Managing acute acetaminophen poisoning with oral versus intravenous N-acetylcysteine: a provider-perspective cost analysis.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Administration, Oral; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Costs and Cost Analysis; Drug Overdose; Humans; Injections, Intravenous; Length of Stay; Models, Economic; Time Factors; United States | 2009 |
Regarding "comparison of the 20-hour intravenous and 72-hour oral acetylcysteine protocols for the treatment of acute acetaminophen poisoning" by Yarema et al.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Drug Administration Schedule; Drug Overdose; Free Radical Scavengers; Humans; Infusions, Intravenous | 2009 |
IV versus oral N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Drug Overdose; Free Radical Scavengers; Humans; Infusions, Intravenous | 2009 |
Incidence of adverse drug reactions induced by N-acetylcysteine in patients with acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Analgesics, Non-Narcotic; Antidotes; Chi-Square Distribution; Drug Overdose; Female; Humans; Infusions, Intravenous; Malaysia; Male; Retrospective Studies; Time Factors; Young Adult | 2010 |
Intravenous paracetamol overdose in a preterm infant during anesthesia.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug Overdose; Free Radical Scavengers; Hernia, Inguinal; Humans; Infant; Infant, Newborn; Infant, Premature; Infusions, Intravenous; International Normalized Ratio; Male; Medical Errors | 2010 |
Cost minimization analysis comparing enteral N-acetylcysteine to intravenous acetylcysteine in the management of acute acetaminophen toxicity.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adult; Aged; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Chemistry, Pharmaceutical; Cohort Studies; Cost-Benefit Analysis; Costs and Cost Analysis; Drug Overdose; Female; Humans; Infusions, Intravenous; Length of Stay; Liver Function Tests; Male; Middle Aged; Retrospective Studies | 2010 |
Massive acetaminophen ingestion with early metabolic acidosis and coma: treatment with IV NAC and continuous venovenous hemodiafiltration.
Topics: Acetaminophen; Acetylcysteine; Acidosis; Analgesics, Non-Narcotic; Antidotes; Coma; Combined Modality Therapy; Drug Overdose; Female; Hemodiafiltration; Humans; Hypotension; Young Adult | 2010 |
Late extensive intravenous administration of N-acetylcysteine can reverse hepatic failure in acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Delayed Diagnosis; Drug Overdose; Free Radical Scavengers; Humans; Infusions, Intravenous; Intensive Care Units; Liver Failure, Acute; Male; Treatment Outcome | 2011 |
[Treatment of paracetamol poisoning to revision].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug Overdose; Humans; Poisoning; Practice Guidelines as Topic | 2010 |
Relationship between serum acetaminophen concentration and N-acetylcysteine-induced adverse drug reactions.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Female; Humans; Male; Middle Aged; Retrospective Studies; Young Adult | 2010 |
Cost of the paracetamol overdose epidemic.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug Overdose; Humans; Methionine; Sri Lanka; Suicide | 2010 |
A multicenter comparison of the safety of oral versus intravenous acetylcysteine for treatment of acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Anaphylaxis; Drug Administration Routes; Drug Overdose; Humans; Infusions, Intravenous; Injections, Intravenous; Nausea; Safety; Treatment Outcome; Vomiting | 2010 |
N-acetylcysteine-induced headache in hospitalized patients with acute acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Antidotes; Cohort Studies; Drug Overdose; Female; Headache; Hospitalization; Humans; Infusions, Intravenous; Male; Retrospective Studies; Risk Factors; Young Adult | 2011 |
[Are nomograms available for the treatment of acetaminophen poisoning? Pros: usefullness of nomogram-based decision-making in the treatment of acute acetaminophen overdose in Japan: single center experience with 61 consecutive patients in Niigata City Gen
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Adolescent; Adult; Biomarkers; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Hospitals, General; Humans; Japan; Liver Function Tests; Male; Nomograms; Young Adult | 2010 |
An analysis of the length of hospital stay after acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Costs and Cost Analysis; Drug Overdose; Female; Humans; Injections, Intravenous; Length of Stay; Male; Time Factors; Young Adult | 2011 |
Effects of delay in infusion of N-acetylcysteine on appearance of adverse drug reactions after acetaminophen overdose: a retrospective study.
Topics: Acetaminophen; Acetylcysteine; Adult; Anaphylaxis; Antidotes; Drug Overdose; Female; Humans; Male; Retrospective Studies; Risk Factors; Time Factors; Young Adult | 2010 |
Molecular mechanisms of Id2 down-regulation in rat liver after acetaminophen overdose. Protection by N-acetyl-L-cysteine.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Cytoprotection; Down-Regulation; Drug Overdose; Gene Expression Regulation; Genes, myc; Glutathione; Inhibitor of Differentiation Protein 2; Liver; Male; Oxidative Stress; Proteasome Endopeptidase Complex; Rats; Rats, Wistar; Signal Transduction | 2010 |
Response to "A multicenter comparison of the safety of oral versus intravenous acetylcysteine for treatment of acetaminophen overdose".
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Drug Overdose; Humans; Injections, Intravenous | 2010 |
The clinical management of acetaminophen poisoning in a community hospital system: factors associated with hospital length of stay.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adult; Analgesics, Non-Narcotic; Antidotes; California; Chemical and Drug Induced Liver Injury; Cohort Studies; Drug Overdose; Female; Hospitals, Community; Humans; Infusions, Intravenous; Length of Stay; Male; Medical Records; Poison Control Centers; Practice Patterns, Physicians'; Retrospective Studies | 2011 |
Multiplying the serum aminotransferase by the acetaminophen concentration to predict toxicity following overdose.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Aspartate Aminotransferases; Cohort Studies; Drug Overdose; Humans; Retrospective Studies | 2010 |
Intravenous paracetamol overdose: two case reports and a change to national treatment guidelines.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Humans; Infant; Injections, Intravenous; Male; Practice Guidelines as Topic; United Kingdom | 2011 |
Why not formulate an acetaminophen tablet containing N-acetylcysteine to prevent poisoning?
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Combinations; Drug Overdose; Humans; Nonprescription Drugs; Poisoning; Tablets | 2011 |
"Massive acetaminophen ingestion with early metabolic acidosis and coma: treatment with iv nac and continuous venovenous hemodiafiltration" by Wiegand et al., Clin Toxicol (Phila) 48:156-159.
Topics: Acetaminophen; Acetylcysteine; Acidosis; Analgesics, Non-Narcotic; Coma; Drug Overdose; Half-Life; Hemodiafiltration; Humans | 2010 |
ST segment elevation secondary to paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Aged; Analgesics, Non-Narcotic; Antidotes; Coronary Angiography; Drug Overdose; Electrocardiography; Female; Heart Diseases; Humans | 2011 |
A gargantuan acetaminophen level in an acidemic patient treated solely with intravenous N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Acidosis; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Female; Humans; Infusions, Intravenous; Middle Aged; Suicide, Attempted | 2013 |
Unrecognized acetaminophen toxicity as a cause of indeterminate acute liver failure.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Bilirubin; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Free Radical Scavengers; Humans; Liver Failure, Acute; Male; Middle Aged; Prognosis; Retrospective Studies; Severity of Illness Index; Survival Rate; Transaminases | 2011 |
Hepatic failure despite early acetylcysteine following large acetaminophen-diphenhydramine overdose.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Child; Cholinergic Antagonists; Diphenhydramine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Overdose; Female; Free Radical Scavengers; Half-Life; Hepatic Encephalopathy; Humans; Infusions, Intravenous; Intensive Care Units, Pediatric; International Normalized Ratio; Liver Failure; Liver Function Tests; Metabolic Clearance Rate; Suicide, Attempted | 2011 |
Self-treatment of acetaminophen overdose with dietary-supplement acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Dietary Supplements; Drug Overdose; Humans; Internet; Male; Self Medication | 2011 |
Massive acetylcysteine overdose associated with cerebral edema and seizures.
Topics: Acetaminophen; Acetylcysteine; Adult; Brain Edema; Drug Overdose; Female; Humans; Medication Errors; Seizures | 2011 |
Acetaminophen psi parameter: a useful tool to quantify hepatotoxicity risk in acute acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Drug Overdose; Female; Humans; Infusions, Intravenous; Logistic Models; Male; Predictive Value of Tests; Retrospective Studies; Risk Assessment; Risk Factors; Thailand; Young Adult | 2011 |
A dosing regimen for immediate N-acetylcysteine treatment for acute paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Antioxidants; Area Under Curve; Computer Simulation; Drug Administration Schedule; Drug Overdose; Humans; Infusions, Intravenous; Models, Biological | 2011 |
Paracetamol overdose: the liver unit perspective.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Early Diagnosis; Humans; Liver Failure, Acute; Liver Transplantation; Time Factors | 2012 |
Delayed and prolonged elevated serum paracetamol level after an overdose - possible causes and implications.
Topics: Acetaminophen; Acetylcysteine; Adult; Drug Overdose; Humans; Liver Function Tests; Male; Nomograms; Time Factors | 2011 |
Intravenous acetaminophen in the United States: iatrogenic dosing errors.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Child; Child, Preschool; Cross-Sectional Studies; Drug Dosage Calculations; Drug Overdose; Free Radical Scavengers; Humans; Iatrogenic Disease; Infant; Infusions, Intravenous; Medication Errors; Nomograms; Poison Control Centers; United States | 2012 |
Paracetamol toxicity: What would be the implications of a change in UK treatment guidelines?
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Cohort Studies; Drug Costs; Drug Overdose; Emergency Service, Hospital; Free Radical Scavengers; Health Care Costs; Hospitals, Urban; Humans; London; Practice Guidelines as Topic; Retrospective Studies; Risk; Risk Assessment; United Kingdom | 2012 |
Paracetamol (acetaminophen) overdose and acetylcysteine administration: should the United Kingdom adopt a single '150-line'?
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Free Radical Scavengers; Humans; Practice Guidelines as Topic; Risk Assessment; Risk Factors; United Kingdom | 2012 |
The Toxicology Investigators Consortium Case Registry--the 2011 experience.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Antidepressive Agents; Child; Child, Preschool; Databases, Factual; Drug Overdose; Emergency Service, Hospital; Female; Humans; Male; Middle Aged; Oxycodone; Prospective Studies; Psychotropic Drugs; Registries; Substance-Related Disorders; Young Adult | 2012 |
Acetaminophen/diphenhydramine overdose in profound hypothermia.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Cholinergic Antagonists; Diphenhydramine; Drug Combinations; Drug Overdose; Female; Humans; Hypothermia; Infusions, Intravenous; Nonprescription Drugs; Rewarming; Treatment Outcome | 2013 |
Pediatric emergency medicine: legal briefs.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aortic Aneurysm; Aortic Dissection; Appendicitis; Asthma; Child; Child, Preschool; Cystic Fibrosis; Diagnostic Errors; Drug Labeling; Drug Overdose; Emergencies; False Negative Reactions; Fatal Outcome; Female; Heart Rate, Fetal; Humans; Ibuprofen; Lymphoma, Non-Hodgkin; Male; Malpractice; Marfan Syndrome; Mediastinal Neoplasms; Medication Errors; Nuchal Cord; Patient Safety; Persistent Vegetative State; Pleurisy; Pregnancy; Respiratory Sounds; Social Media; Stevens-Johnson Syndrome; Suicide; Tomography, X-Ray Computed; Transportation of Patients; Unnecessary Procedures; Young Adult | 2012 |
Direct comparison of 20-hour IV, 36-hour oral, and 72-hour oral acetylcysteine for treatment of acute acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Antidotes; Child; Drug Administration Schedule; Drug Overdose; Female; Humans; Injections, Intravenous; Male; Middle Aged; Retrospective Studies; Treatment Outcome; Young Adult | 2013 |
Approaches toward repeated supratherapeutic doses of paracetamol in children: a survey of medical directors of poison centres in North America and Europe.
Topics: Acetaminophen; Acetylcysteine; Child; Drug Overdose; Europe; Free Radical Scavengers; Health Care Surveys; Humans; North America; Physician Executives; Poison Control Centers; Surveys and Questionnaires | 2002 |
N-acetylcysteine overdosage after insignificant acetaminophen intake.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Analgesics, Non-Narcotic; Drug Overdose; Expectorants; Female; Humans | 2002 |
[Without liver transplantation paracetamol intoxication is often be lethal, in spite of N-acetylcysteine therapy].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Humans; Liver Failure, Acute; Liver Transplantation; Prognosis; Treatment Outcome | 2002 |
Effect of acetylcysteine on prothrombin index in paracetamol poisoning without hepatocellular injury.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Aged, 80 and over; Antidotes; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Drug Overdose; Female; Humans; Infusions, Intravenous; Liver Failure; Male; Middle Aged; Prothrombin Time; Retrospective Studies | 2002 |
[Is systemic administration of N-acetylcysteine effective?].
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Animals; Antidotes; Drug Overdose; Expectorants; Humans; Injections, Intravenous; Pulmonary Disease, Chronic Obstructive | 2003 |
Intravenous propacetamol overdose in a term newborn.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug Overdose; Female; Free Radical Scavengers; Humans; Infant, Newborn; Injections, Intravenous; Medication Errors | 2003 |
Warning note on a blood gas report leading to diagnosis of acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Analgesics, Non-Narcotic; Blood Glucose; Dextropropoxyphene; Drug Combinations; Drug Overdose; Glasgow Coma Scale; Humans; Intensive Care Units, Pediatric; Lactates; Male; Poisoning; Seizures | 2003 |
Successful treatment of acetaminophen overdose associated with hepatic failure.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Female; Humans; Liver; Liver Failure, Acute | 2003 |
What is the rate of adverse events after oral N-acetylcysteine administered by the intravenous route to patients with suspected acetaminophen poisoning?
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Anaphylaxis; Cardiovascular Diseases; Child; Child, Preschool; Drug Eruptions; Drug Hypersensitivity; Drug Interactions; Drug Overdose; Female; Free Radical Scavengers; Histamine H1 Antagonists; Humans; Indiana; Infant; Infusions, Intravenous; Male; Middle Aged; Respiratory Tract Diseases; Retrospective Studies; Survival Analysis | 2003 |
Acetaminophen toxic level and N-acetylcysteine therapy: two patient reports.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Analgesics, Non-Narcotic; Dose-Response Relationship, Drug; Drug Overdose; Female; Free Radical Scavengers; Humans; Time Factors | 2004 |
Status epilepticus after a massive intravenous N-acetylcysteine overdose leading to intracranial hypertension and death.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Child, Preschool; Drug Overdose; Fatal Outcome; Female; Humans; Infusions, Intravenous; Intracranial Hypertension; Medication Errors; Poisoning; Status Epilepticus | 2004 |
Doctors and nurses estimation of the weight of patients: A preventable source of systematic error.
Topics: Acetylcysteine; Adult; Aged; Antidotes; Body Weight; Drug Overdose; Female; Humans; Male; Medical Errors; Middle Aged; Nurses; Perception; Physicians; Poisoning | 2004 |
[Effect of N-acetylcysteine on prothrombin index in patients with uncomplicated paracetamol poisoning].
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Antidotes; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Drug Overdose; Female; Humans; Liver Failure; Male; Middle Aged; Prothrombin Time; Retrospective Studies | 2004 |
Paracetamol (acetaminophen) overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Charcoal; Child; Drug Overdose; Humans; Massive Hepatic Necrosis; Sorption Detoxification | 2004 |
The administration of N-acetylcysteine causes a decrease in prothrombin time in patients with paracetamol overdose but without evidence of liver impairment.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Blood Coagulation; Drug Overdose; False Positive Reactions; Female; Humans; Liver; Male; Prognosis; Prothrombin Time; Retrospective Studies | 2005 |
Acute renal dysfunction in acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Adult; Age Distribution; Aged; Drug Overdose; Emergency Treatment; Female; Follow-Up Studies; Humans; Incidence; Kidney Function Tests; Male; Middle Aged; New York City; Risk Assessment; Severity of Illness Index; Sex Distribution; Treatment Outcome | 2005 |
A new acetaminophen nomogram with a different purpose.
Topics: Acetaminophen; Acetylcysteine; Alcohol Drinking; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Interactions; Drug Overdose; Emergency Medicine; Humans; Liver Diseases; Nomograms; Outcome and Process Assessment, Health Care; Risk Assessment | 2005 |
A risk quantification instrument for acute acetaminophen overdose patients treated with N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Adolescent; Adult; Alcohol Drinking; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Drug Overdose; Emergency Medicine; Female; Humans; Liver Diseases; Logistic Models; Male; Models, Theoretical; Outcome and Process Assessment, Health Care; Retrospective Studies; Risk Assessment; Risk Factors; Transaminases | 2005 |
A potentially fatal prescribing error in the treatment of paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Adult; Aged; Alanine Transaminase; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Drug Prescriptions; Female; Humans; International Normalized Ratio; Medication Errors | 2005 |
Efficacy of activated charcoal administered more than four hours after acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Charcoal; Child; Drug Overdose; Female; Humans; Liver Function Tests; Male; Middle Aged; Poison Control Centers; Prospective Studies; Treatment Outcome; United States | 2006 |
Acetadote (intravenous acetylcysteine): adverse effects more significant than with oral acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Antidotes; Drug Interactions; Drug Overdose; Emergency Treatment; Humans; Infusions, Intravenous; Nausea; Patient Selection; Practice Guidelines as Topic; Safety Management; United States; United States Food and Drug Administration; Vomiting | 2006 |
Potentially fatal paracetamol overdose and successful treatment with 3 days of intravenous N-acetylcysteine regime--a case report.
Topics: Acetaminophen; Acetylcysteine; Adult; Amylases; Antidotes; Codeine; Drug Overdose; Female; Humans; Liver Function Tests; Narcotics; Suicide, Attempted; Tablets; Time Factors | 2006 |
New recommendation for N-acetylcystiene dosing may reduce incidence of adverse effects.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Body Weight; Drug Overdose; Humans; Practice Guidelines as Topic | 2006 |
[Paracetamol poisoning--occurrence and treatment].
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Female; Humans; Liver; Male; Middle Aged; Patient Admission; Retrospective Studies; Time Factors | 2006 |
Adverse reaction from use of intravenous N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Anaphylaxis; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Humans; Infusions, Intravenous; Liver Transplantation | 2006 |
[Post-marketing surveillance of acetylcysteine oral solution 17.6% "SENJU" for the antidote to acetaminophen overdose--use--results surveillance].
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Antidotes; Charcoal; Child; Child, Preschool; Drug Overdose; Female; Gastric Lavage; Humans; Infant; Male; Middle Aged; Pregnancy; Product Surveillance, Postmarketing; Solutions; Treatment Outcome | 2006 |
A prospective evaluation of shortened course oral N-acetylcysteine for the treatment of acute acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Analgesics, Non-Narcotic; California; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Confidence Intervals; Drug Overdose; Female; Humans; Infant; Liver Function Tests; Male; Middle Aged; Prospective Studies; Risk Assessment; Surveys and Questionnaires; Treatment Outcome | 2007 |
Liver unit admission following paracetamol overdose with concentrations below current UK treatment thresholds.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Emergency Service, Hospital; Female; Hospitalization; Humans; Liver Failure; Male; Retrospective Studies; United Kingdom | 2007 |
Patient-tailored acetylcysteine administration.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver Function Tests | 2007 |
Death from paracetamol overdose despite appropriate treatment with N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug Overdose; Fatal Outcome; Free Radical Scavengers; Humans; Male; Middle Aged; Multiple Organ Failure | 2007 |
[Risk of acute hepatic insufficiency in children due to chronic accidental overdose of paracetamol (acetaminophen)].
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Child, Preschool; Drug Overdose; Female; Free Radical Scavengers; Humans; Liver; Liver Failure, Acute; Prognosis; Transaminases | 2007 |
Weight-based N-acetylcysteine dosing chart to minimise the risk of calculation errors in prescribing and preparing N-acetylcysteine infusions for adults presenting with paracetamol overdose in the emergency department.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Clinical Competence; Drug Administration Schedule; Drug Overdose; Emergencies; Expectorants; Humans; Infusions, Parenteral; Medical Staff, Hospital; Medication Errors; Nursing Staff, Hospital | 2007 |
Hypokalaemia following paracetamol overdose in two teenage girls.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Analgesics, Non-Narcotic; Drug Overdose; Female; Humans; Hypokalemia; Liver; Suicide, Attempted | 2007 |
Impact of activated charcoal after acute acetaminophen overdoses treated with N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Charcoal; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver Diseases; Registries; Retrospective Studies | 2007 |
Safety and efficacy of intravenous N-acetylcysteine for acetaminophen overdose: analysis of the Hunter Area Toxicology Service (HATS) database.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Child; Child, Preschool; Database Management Systems; Drug Overdose; Humans; Infant; Infusions, Intravenous; Retrospective Studies | 2007 |
Acetaminophen overdose and N-acetylcysteine therapy.
Topics: Acetaminophen; Acetylcysteine; Brunei; Drug Overdose; Humans | 2007 |
Clinical excellence exemplar.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Free Radical Scavengers; Humans; Patient Care Management; Physician-Nurse Relations; Poison Control Centers | 2007 |
Acute acetaminophen overdose is associated with dose-dependent hypokalaemia: a prospective study of 331 patients.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Dose-Response Relationship, Drug; Drug Overdose; Female; Humans; Hypokalemia; Male; Middle Aged; Nomograms; Predictive Value of Tests; Prospective Studies; Risk Factors; ROC Curve; Statistics, Nonparametric | 2008 |
Comparison of S-adenosyl-L-methionine (SAMe) and N-acetylcysteine (NAC) protective effects on hepatic damage when administered after acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Aldehydes; Analysis of Variance; Animals; Blotting, Western; Drug Overdose; Glutathione; Injections, Intraperitoneal; Lipid Peroxidation; Liver; Liver Failure, Acute; Male; Mice; Mice, Inbred C57BL; Microscopy, Polarization; Organ Size; Protein Carbonylation; S-Adenosylmethionine; Time Factors | 2008 |
Stability of a flavored formulation of acetylcysteine for oral administration.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Antidotes; Chromatography, High Pressure Liquid; Drug Overdose; Drug Stability; Drug Storage; Expectorants; Humans; Pharmaceutical Solutions; Refrigeration; Sweetening Agents; Temperature; Time Factors | 2008 |
Estimated risk of hepatotoxicity after an acute acetaminophen overdose in alcoholics.
Topics: Acetaminophen; Acetylcysteine; Alcoholism; Analgesics, Non-Narcotic; Canada; Chemical and Drug Induced Liver Injury; Drug Overdose; Free Radical Scavengers; Humans; Liver; Models, Statistical; Registries; Risk | 2008 |
Key features of the patient-tailored N-acetylcysteine protocol.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Analgesics, Non-Narcotic; California; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Drug Overdose; Female; Humans; Infant; Liver Function Tests; Male; Middle Aged; Risk Assessment; Surveys and Questionnaires; Treatment Outcome | 2008 |
Comment on "Acute ethanol coingestion confers a lower risk of hepatotoxicity after deliberate acetaminophen overdose".
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Drug Overdose; Ethanol; Free Radical Scavengers; Humans; International Normalized Ratio | 2008 |
Frequency of medication errors with intravenous acetylcysteine for acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Antidotes; Child; Child, Preschool; Databases, Factual; Drug Overdose; Female; Hospitals; Humans; Infusions, Intravenous; Male; Medication Errors; Middle Aged; Personnel Staffing and Scheduling; Poison Control Centers; Retrospective Studies; Time Factors; Treatment Outcome; United States | 2008 |
A 7-year experience of severe acetaminophen-induced hepatotoxicity (1987-1993).
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Brain Edema; Chi-Square Distribution; Drug Overdose; Female; Hepatic Encephalopathy; Humans; Liver; Liver Failure; Liver Transplantation; Male; Middle Aged; Prognosis; Retrospective Studies; Risk Factors; Survival Rate | 1995 |
The management of paracetamol overdose by junior doctors.
Topics: Acetaminophen; Acetylcysteine; Documentation; Drug Overdose; Health Knowledge, Attitudes, Practice; Humans; Medical Audit; Medical Staff, Hospital; Surveys and Questionnaires; Time Factors | 1995 |
Acetaminophen poisoning and liver function.
Topics: Acetaminophen; Acetylcysteine; Adult; Drug Overdose; Female; Humans; Liver | 1994 |
Overdose of extended-release acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Delayed-Action Preparations; Drug Overdose; Female; Half-Life; Humans | 1995 |
Acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Charcoal; Drug Overdose; Humans | 1995 |
Paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Benzoquinones; Chemical and Drug Induced Liver Injury; Clinical Protocols; Drug Overdose; Humans; Imines | 1993 |
Subtleties of managing acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Charcoal; Child, Preschool; Drug Overdose; Humans; Infant; Ipecac; Poisoning; Time Factors | 1994 |
Delayed toxic acetaminophen level after initial four hour nontoxic level.
Topics: Acetaminophen; Acetylcysteine; Adult; Dextropropoxyphene; Drug Overdose; Female; Humans; Naproxen; Time Factors | 1994 |
Acetaminophen poisoning and liver function.
Topics: Acetaminophen; Acetylcysteine; Drug Overdose; Humans | 1994 |
A prospective evaluation of the effect of activated charcoal before oral N-acetylcysteine in acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Charcoal; Child; Child, Preschool; Drug Overdose; Female; Humans; Logistic Models; Male; Middle Aged; Prospective Studies; Treatment Outcome | 1994 |
Severe hepatotoxicity, acute renal failure, and pancytopenia in a young child after repeated acetaminophen overdosing.
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Chemical and Drug Induced Liver Injury; Child, Preschool; Drug Overdose; Female; Humans; Pancytopenia; Peritoneal Dialysis | 1994 |
Serum sickness-like illness associated with N-acetylcysteine therapy.
Topics: Acetaminophen; Acetylcysteine; Adult; Drug Overdose; Humans; Male; Serum Sickness | 1994 |
Cerebral blood flow and metabolism in fulminant liver failure.
Topics: Acetaminophen; Acetylcysteine; Adult; Blood Flow Velocity; Brain; Brain Edema; Drug Overdose; Epoprostenol; Female; Glucose; Hepatic Encephalopathy; Hepatitis, Viral, Human; Humans; Lactates; Male; Mannitol; Middle Aged; Oxygen; Regional Blood Flow; Respiration, Artificial | 1994 |
Acetaminophen treatment nomogram.
Topics: Acetaminophen; Acetylcysteine; Adult; Drug Overdose; Female; Hepatic Encephalopathy; Humans; Reference Values | 1994 |
Paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Charcoal; Drug Overdose; Gastric Lavage; Humans; Liver | 1993 |
Paracetamol poisoning and hepatotoxicity in Chinese--the Prince of Wales Hospital (Hong Kong) experience.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Aged, 80 and over; Alanine Transaminase; China; Drug Combinations; Drug Overdose; Female; Hong Kong; Humans; Liver; Male; Middle Aged; Nausea; Time Factors; Vomiting | 1993 |
Liver failure induced by paracetamol.
Topics: Acetaminophen; Acetylcysteine; Drug Overdose; Humans; Liver Failure, Acute | 1993 |
Evidence for potential application of zinc as an antidote to acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Antidotes; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Overdose; Drug Therapy, Combination; Glutathione; Liver; Malondialdehyde; Mice; Mice, Inbred ICR; Sulfates; Zinc Compounds; Zinc Sulfate | 1995 |
Acetaminophen overdose: need to consider intravenous preparation of N-acetylcysteine in the United States.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Child; Drug Overdose; Humans; Infusions, Intravenous; United States | 1996 |
The acetaminophen nomogram: will it withstand the test of the extended relief formulation?
Topics: Acetaminophen; Acetylcysteine; Delayed-Action Preparations; Drug Overdose; Humans; Reference Values | 1996 |
Pediatric subacute acetaminophen toxicity.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Child; Drug Overdose; Free Radical Scavengers; Humans; Male | 1997 |
Adverse reactions to N-acetylcysteine in Inuit to paracetamol (acetaminophen) overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Drug Overdose; Female; Greenland; Humans; Infusions, Intravenous; Inuit; Poisoning | 1996 |
[Anaphylactic reaction to N-acetylcysteine after poisoning with paracetamol].
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Anaphylaxis; Antidotes; Drug Overdose; Expectorants; Humans; Infusions, Intravenous; Male | 1997 |
Placental transfer of N-acetylcysteine following human maternal acetaminophen toxicity.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Biological Transport; Chromatography, High Pressure Liquid; Drug Overdose; Fatal Outcome; Female; Fetal Blood; Free Radical Scavengers; Humans; Maternal-Fetal Exchange; Placenta; Poisoning; Pregnancy | 1997 |
Oral N-acetylcysteine given intravenously for acetaminophen overdose: we shouldn't have to, but we must.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Drug Overdose; Free Radical Scavengers; Humans; Infusions, Intravenous; Liver Failure; Poisoning | 1998 |
Intravenous administration of oral N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Case-Control Studies; Child; Child, Preschool; Drug Evaluation; Drug Overdose; Drugs, Investigational; Female; Free Radical Scavengers; Humans; Infant; Infant, Newborn; Infusions, Intravenous; Male; Middle Aged; Retrospective Studies; Safety; Survival Rate; Treatment Outcome; United States; United States Food and Drug Administration | 1998 |
Acetaminophen overdose with therapeutic intent.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Child; Drug Overdose; Free Radical Scavengers; Humans | 1998 |
More on interference of N-acetylcysteine in measurement of acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; False Negative Reactions; Female; Humans; Suicide, Attempted | 1998 |
Massive sulfasalazine and paracetamol ingestion causing acidosis, hyperglycemia, coagulopathy, and methemoglobinemia.
Topics: Acetaminophen; Acetylcysteine; Acidosis, Lactic; Acute Disease; Adult; Anti-Inflammatory Agents; Blood Coagulation Disorders; Blood Platelets; Drug Combinations; Drug Overdose; Humans; Hyperglycemia; Infusions, Intravenous; Male; Methemoglobinemia; Methylene Blue; Partial Thromboplastin Time; Sodium Bicarbonate; Suicide, Attempted; Sulfasalazine | 1998 |
Late-presenting acute acetaminophen toxicity and the role of N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Adult; Analgesics, Non-Narcotic; Antidotes; Chemical and Drug Induced Liver Injury; Child; Clinical Protocols; Drug Overdose; Humans; Liver Diseases; Risk Factors; Time Factors | 1998 |
Renal impairment without hepatic damage after acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Adolescent; Charcoal; Drug Overdose; Female; Humans; Kidney; Liver; Treatment Outcome | 1999 |
Activated charcoal reduces the need for N-acetylcysteine treatment after acetaminophen (paracetamol) overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Aged, 80 and over; Charcoal; Drug Overdose; Drug Therapy, Combination; Female; Gastric Lavage; Humans; Male; Middle Aged | 1999 |
Shorter duration of oral N-acetylcysteine therapy for acute acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Adolescent; Adult; Age Distribution; Aged; Analgesics, Non-Narcotic; Child; Drug Overdose; Emergency Service, Hospital; Female; Free Radical Scavengers; Hospitals, Urban; Humans; Liver; Male; Middle Aged; Retrospective Studies; Sex Distribution; Time Factors | 2000 |
Delays in administration of acetylcysteine in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Drug Overdose; Humans; Ireland; Liver Failure; Middle Aged; Professional Practice; Retrospective Studies; Time Factors | 2000 |
Acetaminophen hepatoxicity.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Child; Child, Preschool; Drug Overdose; Female; Humans; Liver; Male; Middle Aged; Poisoning; Pregnancy; Pregnancy in Adolescence; Substance-Related Disorders; Suicide; Suicide, Attempted | 2000 |
Index of suspicion. Case 3. Acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Female; Humans; Poisoning | 1999 |
Protective effect of stiripentol on acetaminophen-induced hepatotoxicity in rat.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Area Under Curve; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Dioxolanes; Drug Combinations; Drug Overdose; Liver; Male; Rats; Rats, Sprague-Dawley; Time Factors | 2001 |
Risk factors in the development of adverse reactions to N-acetylcysteine in patients with paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Child; Denmark; Drug Overdose; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Poisoning; Prognosis; Risk Factors | 2001 |
Paracetamol (acetaminophen) poisoning: report of two cases.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Analgesics, Non-Narcotic; Antidotes; Charcoal; Drug Overdose; Female; Gastric Lavage; Humans; India; Infusions, Intravenous; Poisoning | 2000 |
Elevation of serum interleukin 8 levels in acetaminophen overdose in children and adolescents.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Drug Overdose; Female; Humans; Infant; Interleukin-8; Liver Function Tests; Male; Prothrombin Time | 2001 |
Pancytopenia, hyperglycemia, shock, coma, rhabdomyolysis, and pancreatitis associated with acetaminophen poisoning.
Topics: Acetaminophen; Acetylcysteine; Adult; Anti-Inflammatory Agents, Non-Steroidal; Coma; Diagnosis, Differential; Drug Overdose; Fatal Outcome; Female; Free Radical Scavengers; Humans; Hyperglycemia; Liver Failure; Pancreatitis; Pancytopenia; Renal Insufficiency; Rhabdomyolysis; Shock; Suicide, Attempted | 2001 |
The intravenous use of oral acetylcysteine (mucomyst) for the treatment of acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Drug Overdose; Expectorants; Female; Humans; Infusions, Intravenous | 2002 |
The value of plasma acetaminophen half-life in antidote-treated acetaminophen overdosage.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Analysis of Variance; Antidotes; Drug Overdose; Female; Half-Life; Hepatic Encephalopathy; Humans; Liver Failure, Acute; Male; Middle Aged; Prospective Studies; Statistics, Nonparametric | 2002 |
Acetaminophen toxicity: suicidal vs. accidental.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Child; Drug Overdose; Female; Hospitalization; Hospitals, Urban; Humans; Male; Middle Aged; New York; Retrospective Studies; Suicide, Attempted | 2002 |
Acetaminophen poisoning in children: treat early and long enough.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Decision Making; Drug Overdose; Free Radical Scavengers; Humans; Infant; Liver Diseases; Liver Function Tests; Time Factors | 2002 |
Predictors of outcome after acetaminophen poisoning in children and adolescents.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Alanine Transaminase; Analgesics, Non-Narcotic; Arkansas; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Decision Making; Drug Overdose; Female; Free Radical Scavengers; Humans; Infant; Liver Diseases; Liver Function Tests; Male; Predictive Value of Tests; Prothrombin Time; Retrospective Studies; Sensitivity and Specificity | 2002 |
Treatment strategies for early presenting acetaminophen overdose: a survey of medical directors of poison centers in North America and Europe.
Topics: Acetaminophen; Acetylcysteine; Charcoal; Data Collection; Drug Overdose; Europe; Humans; North America; Physician Executives; Poison Control Centers; Poisoning; Surveys and Questionnaires | 2002 |
[Paracetamol overdose: a new form of suicide in Chile and the value of N-acetylcysteine administration].
Topics: Acetaminophen; Acetylcysteine; Adolescent; Chile; Drug Overdose; Female; Humans; Middle Aged; Suicide, Attempted | 1992 |
Long-term anticonvulsant therapy worsens outcome in paracetamol-induced fulminant hepatic failure.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Anticonvulsants; Drug Interactions; Drug Overdose; Female; Hepatic Encephalopathy; Humans; Longitudinal Studies; Male; Middle Aged; Prognosis; Risk Factors | 1992 |
Respiratory arrest after N-acetylcysteine for paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Drug Overdose; Female; Heart Arrest; Humans | 1992 |
N-acetylcysteine in treatment of acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Cimetidine; Drug Overdose; Drug Therapy, Combination; Humans | 1992 |
Hepatotoxicity from paracetamol self-poisoning in western Sydney: a continuing challenge.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Humans; Infusions, Intravenous; Liver Function Tests; Male; New South Wales; Patient Admission; Prognosis; Retrospective Studies | 1992 |
Paracetamol overdose in Israel--1992.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Drug Overdose; Glutathione; Humans; Inactivation, Metabolic; Israel | 1992 |
Anaphylactoid reaction to intravenous acetylcysteine associated with electrocardiographic abnormalities.
Topics: Acetaminophen; Acetylcysteine; Adult; Anaphylaxis; Drug Overdose; Electrocardiography; Female; Humans; Infusions, Intravenous | 1992 |
Cimetidine in the treatment of acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Adult; Cimetidine; Drug Overdose; Drug Therapy, Combination; Female; Humans | 1991 |
Safety of late acetylcysteine treatment in paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Drug Overdose; Female; Humans; Male; Middle Aged; Time Factors | 1990 |